Metabolismo

<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>

<p>Eliglustat hemitartrate (Genz-112638) , with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.</p>

<p>Vasopressin acetate: cyclic nonapeptide synthesized in the hypothalamus, functions as a neurotransmitter via G protein-coupled receptors.</p>

<p>Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.</p>

<p>P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.</p>

<p>2-Methoxy Phenothiazine is light yellow or light gray solid.</p>

<p>Cotinine (NIH-10498) is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.</p>

<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>

<p>HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).</p>

<p>Mefentrifluconazole: potent, selective oral fungicide; strong CYP51 blocker, weaker on human aromatase; novel azole for broad-spectrum use.</p>

<p>AR-9281 (APAU) is a potent and selective inhibitor of soluble epoxide hydrolase (s-EH) potentially for the treatment of hypertension and type 2 diabetes</p>

<p>N1-Acetylspermine trihydrochloride: monoacetylated spermine, aids in bleomycin-A5 uptake studies via SLC22A16.</p>

<p>Nitisinone (SC0735)(SC0735) is an enzyme 4-hydroxyphenylpyruvate dioxygenase inhibitor.</p>

<p>Phenindione, an obsolete anticoagulant with warfarin-like effects, is rarely used due to severe side effects.</p>

<p>DATPT is a 12WLVSKF17 peptide mimetic molecule with anti-inflammatory and antimicrobial activities.DATPT inhibits the production of reactive oxygen species.</p>

<p>Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.</p>

<p>Aldose reductase-IN-1 (AT-001, Caficrestat) is a highly potent inhibitor of aldose reductase.Cost-effective and quality-assured.</p>

<p>BAY-2402234: a selective DHODH inhibitor targeting myeloid cancers with low-nanomolar potency.</p>

<p>CVT-10216 inhibits ALDH2 (IC50: 29 nM) and ALDH-1 (IC50: 1.3 μM), reducing alcohol intake and anxiety in rats.</p>

<p>Diethylcarbamazine citrate treats filariasis, targeting W. bancrofti and L. loa by inhibiting arachidonic acid in microfilaria.</p>

<p>Epalrestat (ONO2235), an aldose reductase inhibitor, helps manage diabetic neuropathy symptoms and slows disease progression.</p>

<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>

<p>KPLH1130, a PDK inhibitor, boosts glucose tolerance and reduces inflammation in high-fat diet mice.</p>

<p>CRAC intermediate 1 (5-(S)-Fluorowillardiine) is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors.</p>

<p>NE 10790, similar to risedronate, is a mild bone resorption inhibitor but poorly blocks FPP synthase.</p>

<p>N-(1-Adamantyl)acetamide is used as intermediates for synthesis of amantadine hydrochloride.</p>

<p>Brinzolamide (AL-4862) is a Carbonic Anhydrase Inhibitor. The mechanism of action of brinzolamide is as a Carbonic Anhydrase Inhibitor.</p>

<p>MDCG sodium (N-methyl-N-dithiocarboxyglucamine sodium) is a metal chelator that promotes biliary excretion of Cd.</p>

<p>Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity.</p>

<p>LY 195448 (4-(3-(2-Hydroxy-2-phenyl)ethylamino-3-methylbutyl)benzamide) shows antitumor activity in a mouse tumor model, blocking cells in the mid-stage.</p>

<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>

<p>It is an organic compounds with molecular fomula C5H9NO3.</p>

<p>Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide.</p>

<p>Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-</p>

<p>(S)-(+)-N-3-Benzylnirvanol is a cytochrome P450 CYP2C19 inhibitor with a ki value of 82.5μM for CYP2C9 and 0.25μM for CYP2C19.Cost-effective and quality-assured.</p>

<p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>

<p>N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.</p>

<p>Adrenochrome (Adraxone), an epinephrine derivative, is cytotoxic, has cardiotoxic effects, and may aid neuro-disease research.</p>

<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>

<p>Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.</p>

<p>Hi 76-0079: HSL inhibitor, IC50=184 nM; potential for obesity and diabetes research.</p>

<p>IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.</p>

<p>1-Phenyl-1, 2-ethanediol is O-benzyl oxime ether derivatives and used as pesticides.</p>

<p>Cefadroxil (BL-S 578) is a Cephalosporin Antibacterial. The chemical classification of cefadroxil anhydrous is Cephalosporins.</p>

<p>IDH-305: Oral, mutation-specific IDH1 inhibitor, 200x selective for R132 mutants; IC50: 27/28/6.14 nM for R132H/C/WT.</p>

<p>5-Phenylhydantoin is a Mephenytoin metabolite with anti-epileptic effects, targeting NVSCs.</p>

<p>Ranolazine 2HCl, an antianginal, treats arrhythmia by inhibiting sodium current without changing blood pressure or heart rate.</p>

<p>Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.</p>

<p>Hyaluronic acid sodium (MW 20 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM).</p>

<p>Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.</p>

<p>Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.</p>

<p>Diphenyl phosphate (Phenyl hydrogen phosphate) is capable of gender-specific inhibition of growth and energy metabolism in zebrafish.</p>

<p>CCI-006, a selective inhibitor and chemosensitizer for MLL-rearranged leukemia cells, disrupts mitochondrial respiration.</p>

<p>Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.</p>

<p>Pramiracetam, an advanced nootropic from piracetam, enhances cognitive function post-brain trauma and treats cerebrovascular disorders.</p>

<p>Hyaluronic acid sodium (MW 300 kDa) is a medium molecule sodium hyaluronate that penetrates into the dermis and stimulates skin metabolism.</p>

<p>Osocimab (BAY 1213790) is a strong FXIa inhibitor, Ki 2.4 nM, EC50 0.2 nM, and reduces thrombosis in research.</p>

<p>Clarithromycin (A-56268), a macrolide antibiotic, inhibits Cytochrome P450 3A4 and P-Glycoprotein.</p>

<p>Oxolamine citrate (AF-438 citrate) is a cough suppressant that is able to be used as a generic drug in many jurisdictions.</p>

<p>Diltiazem hydrochloride (RG 83606 HCl) is a benzothiazepine calcium channel blocking agent with vasodilating action.</p>

<p>MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.</p>

<p>Glucosamine (Chitosamine) is used as a dietary supplement. Glucosamine has pharmacological effects on osteoarthritis cartilage. High-Quality, Low-Cost!</p>

<p>Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rabbit PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rabbit PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rabbit PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll.</p>

<p>NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor,</p>

<p>Pyrithioxin (Encefabol), a nootropic, enhances cerebral metabolism and, with HV, aids hemiplegic stroke recovery.</p>

<p>SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties.</p>

<p>PKR-IN-2 is a activator of pyruvate kinase (PKR).</p>

<p>Hyaluronic acid sodium (MW 100 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>Hyaluronic acid sodium (MW 200 kDa) is a medium molecule sodium hyaluronate that penetrates into the dermis and stimulates skin metabolism.</p>

<p>Potent, reversible, non-toxic MPO inhibitor; reduces stroke damage &amp; study aid for bronchial dysplasia.</p>

<p>Etofylline (Oxyphylline) is used for difficulty in breathing, asthma, breathing difficulty and other conditions.</p>

<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>

<p>5-Chloroanthranilic Acid is a metabolite of the pesticide Chlordimeform. It can be used in the preparation of disease-modifying antirheumatic drugs (DMARDs).</p>

<p>3-Pyridinemethanol (Roniacol) is an alcohol analog of nicotinic acid which is a peripheral vasodilator that causes flushing and may decrease blood pressure.</p>

<p>Sodium 2-mercaptoethanesulfonate (Uromitexan) is a sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from antineoplastic.</p>

<p>1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium, a phosphatidic acid, is a human endogenous metabolite.</p>

<p>N-Desethyl Chloroquine Hydrochloride ((±)-Desethylchloroquine 2HCl) is a desethylchloroquine derivative.</p>

<p>p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1].</p>

<p>Sodium stibogluconate (Stibogluconate trisodium nonahydrate) is a potent protein tyrosine phosphatase inhibitor.</p>

<p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>

<p>4-Diethylaminobenzaldehyde: reversible ALDH1 inhibitor (Ki: 4 nM), potent anti-androgen (IC50: 1.71μM).</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling</p>

<p>Oxiconazole nitrate (Ro 13-8996) is an antifungal imidazole inhibiting fungal growth by blocking ergosterol synthesis, disrupting cell membranes.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).</p>

<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>

<p>Modaline, a 2-methyl-3-piperidinopyrazine, inhibits MAO, acts as an antidepressant, and increases tryptamine convulsions and dopa-induced hyperthermia.</p>

<p>4-(Aminomethyl)benzoic acid (PAMBA), an antifibrinolytic, is an unnatural amino acid derivative.</p>

<p>ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).</p>

<p>CBR-5884: active PHGDH inhibitor, IC50=33μM, disrupts serine synthesis, selectively targets high-serine cancers.</p>

<p>JW 642 inhibits MAGL in mouse, rat, human brains (IC50: 7.6, 14, 3.7 nM).</p>

<p>Denatonium benzoate, a salt with an inert anion, resembles lidocaine but has a benzyl group on its amino nitrogen.</p>