PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 165 productos de "PDE"
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Z-HA155
CAS:<p>Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.</p>Fórmula:C24H19BFNO5SPureza:99.18%Forma y color:SolidPeso molecular:463.29ML-030
CAS:<p>ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.</p>Fórmula:C20H20N4O4SPureza:97.93%Forma y color:SolidPeso molecular:412.46GSK256066
CAS:<p>GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold</p>Fórmula:C27H26N4O5SPureza:99.60% - 99.66%Forma y color:SolidPeso molecular:518.58MBCQ
CAS:<p>MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.</p>Fórmula:C16H12ClN3O2Pureza:99.45%Forma y color:SolidPeso molecular:313.74ICI 63197
CAS:<p>ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.</p>Fórmula:C9H13N5OPureza:99.70%Forma y color:White SolidPeso molecular:207.23Amino Tadalafil
CAS:<p>Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.</p>Fórmula:C21H18N4O4Pureza:99.85%Forma y color:White PowderPeso molecular:390.39PDE10-IN-1
CAS:<p>PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.</p>Fórmula:C21H19N7Pureza:99.65%Forma y color:SolidPeso molecular:369.42Cilomilast
CAS:<p>Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.</p>Fórmula:C20H25NO4Pureza:97.37% - 99.52%Forma y color:White SolidPeso molecular:343.42K-Ras-PDEδ-IN-1
CAS:<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>Fórmula:C25H26FN5O2Pureza:99.48%Forma y color:SolidPeso molecular:447.5THPP-1
CAS:<p>THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).</p>Fórmula:C23H21ClN6O3Pureza:99.46%Forma y color:SolidPeso molecular:464.9Piclamilast
CAS:<p>Piclamilast (RP 73401) is a PDE4 inhibitor.</p>Fórmula:C18H18Cl2N2O3Pureza:98.28% - 99.57%Forma y color:SolidPeso molecular:381.25Irsogladine
CAS:<p>Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.</p>Fórmula:C9H7Cl2N5Pureza:99.74% - 99.91%Forma y color:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterPeso molecular:256.09Homo Sildenafil
CAS:<p>Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.</p>Fórmula:C23H32N6O4SPureza:99.88%Forma y color:White SolidPeso molecular:488.6Balipodect
CAS:<p>Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.</p>Fórmula:C23H17FN6O2Pureza:98% - 99.79%Forma y color:SolidPeso molecular:428.42BRL-50481
CAS:<p>BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.</p>Fórmula:C9H12N2O4SPureza:99.66%Forma y color:SolidPeso molecular:244.27Lodenafil
CAS:<p>Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)</p>Fórmula:C23H32N6O5SPureza:99.92%Forma y color:SolidPeso molecular:504.6BW-A 78U
CAS:<p>BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.</p>Fórmula:C13H12FN5Pureza:99.45%Forma y color:SolidPeso molecular:257.27RS-25344 hydrochloride
CAS:<p>RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor</p>Fórmula:C19H14ClN5O4Pureza:99.25%Forma y color:SolidPeso molecular:411.8[11C]MP 10
CAS:<p>[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.</p>Fórmula:C25H20N4OPureza:99.5%Forma y color:SolidPeso molecular:391.45Roflumilast N-oxide
CAS:<p>Roflumilast N-oxide is an inhibitor of PDE type 4.</p>Fórmula:C17H14Cl2F2N2O4Pureza:98.19% - 99.69%Forma y color:SolidPeso molecular:419.21
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