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PDE

PDE

Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.

Se han encontrado 165 productos de "PDE"

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  • Nortadalafil
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    Nortadalafil

    CAS:
    <p>Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.</p>
    Fórmula:C21H17N3O4
    Pureza:99.42%
    Forma y color:Solid
    Peso molecular:375.38

    Ref: TM-T6147

  • Homo Sildenafil
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    Homo Sildenafil

    CAS:
    <p>Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.</p>
    Fórmula:C23H32N6O4S
    Pureza:99.88%
    Forma y color:White Solid
    Peso molecular:488.6

    Ref: TM-T8919

  • GEBR-7b
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    GEBR-7b

    CAS:
    <p>GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.</p>
    Fórmula:C13H16O3
    Pureza:99.533%
    Forma y color:Solid
    Peso molecular:220.26

    Ref: TM-T19865

  • Enoximone
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    Enoximone

    CAS:
    <p>Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.</p>
    Fórmula:C12H12N2O2S
    Pureza:98.53%
    Forma y color:Solid
    Peso molecular:248.3

    Ref: TM-T8462

  • MY-5445
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    MY-5445

    CAS:
    <p>MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).</p>
    Fórmula:C20H14ClN3
    Pureza:99.77%
    Forma y color:Solid
    Peso molecular:331.8

    Ref: TM-T16164

  • Amino Tadalafil
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    Amino Tadalafil

    CAS:
    <p>Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.</p>
    Fórmula:C21H18N4O4
    Pureza:99.85%
    Forma y color:White Powder
    Peso molecular:390.39

    Ref: TM-T7542

  • Sildenafil Mesylate
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    Sildenafil Mesylate

    CAS:
    <p>Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.</p>
    Fórmula:C22H30N6O4S·xCH4O3S
    Pureza:99.84%
    Forma y color:Solid
    Peso molecular:570.68

    Ref: TM-T6983

  • Lodenafil
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    Lodenafil

    CAS:
    <p>Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)</p>
    Fórmula:C23H32N6O5S
    Pureza:99.92%
    Forma y color:Solid
    Peso molecular:504.6

    Ref: TM-T7346

  • [11C]MP 10
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    [11C]MP 10

    CAS:
    <p>[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.</p>
    Fórmula:C25H20N4O
    Pureza:99.5%
    Forma y color:Solid
    Peso molecular:391.45

    Ref: TM-T6042

  • Osoresnontrine
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    Osoresnontrine

    CAS:
    <p>Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.</p>
    Fórmula:C16H17N5O2
    Pureza:99.93%
    Forma y color:Solid
    Peso molecular:311.34

    Ref: TM-T8515

  • CP671305
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    CP671305

    CAS:
    <p>CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.</p>
    Fórmula:C23H19FN2O7
    Pureza:99.39%
    Forma y color:Solid
    Peso molecular:454.4

    Ref: TM-T4695

  • Ziritaxestat
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    Ziritaxestat

    CAS:
    <p>Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.</p>
    Fórmula:C30H33FN8O2S
    Pureza:97% - 99.85%
    Forma y color:Solid
    Peso molecular:588.7

    Ref: TM-T4041

  • PDE10-IN-1
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    PDE10-IN-1

    CAS:
    <p>PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.</p>
    Fórmula:C21H19N7
    Pureza:99.65%
    Forma y color:Solid
    Peso molecular:369.42

    Ref: TM-T5411

  • RS-25344
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    RS-25344

    CAS:
    <p>RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.</p>
    Fórmula:C19H13N5O4
    Pureza:98.98%
    Forma y color:Solid
    Peso molecular:375.34

    Ref: TM-T9239

  • Lotamilast
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    Lotamilast

    CAS:
    <p>Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.</p>
    Fórmula:C26H24N4O5
    Pureza:97.03% - 99.29%
    Forma y color:Solid
    Peso molecular:472.49

    Ref: TM-T3987

  • Enpp-1-IN-1
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    Enpp-1-IN-1

    CAS:
    <p>Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)</p>
    Fórmula:C17H17N3O3S
    Pureza:97.52%
    Forma y color:Solid
    Peso molecular:343.4

    Ref: TM-T7888

  • GSK256066 Trifluoroacetate
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    GSK256066 Trifluoroacetate

    CAS:
    <p>GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.</p>
    Fórmula:C29H27F3N4O7S
    Forma y color:Solid
    Peso molecular:632.61

    Ref: TM-T11483

  • Crisaborole-d4
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    Crisaborole-d4

    <p>Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.</p>
    Fórmula:C14H6D4BNO3
    Forma y color:Solid
    Peso molecular:255.07

    Ref: TM-TMIJ-0249

  • ent-Tadalafil
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    ent-Tadalafil

    CAS:
    <p>ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).</p>
    Fórmula:C22H19N3O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:389.4

    Ref: TM-T11206

  • Deltarasin
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    Deltarasin

    CAS:
    <p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>
    Fórmula:C40H37N5O
    Pureza:99.4%
    Forma y color:Solid
    Peso molecular:603.75

    Ref: TM-T6462