PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Fórmula:C19H18N4O2Pureza:99.91%Forma y color:White SolidPeso molecular:334.37Pumafentrine
CAS:Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Fórmula:C29H39N3O3Pureza:99.85%Forma y color:White SolidPeso molecular:477.64MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Forma y color:SolidPeso molecular:441.71Ref: TM-T12103
1mg138,00€2mg197,00€5mg334,00€1mL*10mM (DMSO)358,00€10mg500,00€25mg807,00€50mg1.099,00€100mg1.485,00€500mg2.962,00€Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Fórmula:C24H32N6O3Pureza:98.96% - 99.89%Forma y color:White SolidPeso molecular:452.55Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Fórmula:C21H15ClF3NO2Pureza:98.20%Forma y color:SolidPeso molecular:405.8Ref: TM-T10590
1mg66,00€5mg128,00€1mL*10mM (DMSO)141,00€10mg231,00€25mg388,00€50mg532,00€100mg740,00€200mg973,00€Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Fórmula:C12H9N3OPureza:99.22% - 99.92%Forma y color:SolidPeso molecular:211.22Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Fórmula:C15H22ClN5O4SPureza:99.83%Forma y color:SoildPeso molecular:403.88Zomepirac sodium salt
CAS:Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.Fórmula:C15H13ClNNaO3Pureza:98.65% - ≥95%Forma y color:Yellow SolidPeso molecular:313.71ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Fórmula:C29H29FN7O5PPureza:98.21%Forma y color:SolidPeso molecular:605.56Ref: TM-T11689
1mg71,00€2mg92,00€5mg158,00€1mL*10mM (DMSO)207,00€10mg286,00€25mg505,00€50mg712,00€100mg1.009,00€Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFórmula:C17H14Cl2F2N2O3Pureza:99.76% - 99.86%Forma y color:SolidPeso molecular:403.21Amrinone
CAS:Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.Fórmula:C10H9N3OPureza:98.88% - 99.45%Forma y color:SolidPeso molecular:187.2EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Fórmula:C22H23N3O4SPureza:99.35% - 99.57%Forma y color:SolidPeso molecular:425.5Trapidil
CAS:Trapidil (Avantrin) is a coronary vasodilator agent.Fórmula:C10H15N5Pureza:99.42%Forma y color:White SolidPeso molecular:205.26NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Fórmula:C17H19N3O2Pureza:99.85%Forma y color:Yellow SolidPeso molecular:297.35Ref: TM-T12267
1mg38,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg129,00€25mg216,00€50mg309,00€100mg427,00€200mg577,00€ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Fórmula:C21H23Cl2N2O6PPureza:99.52%Forma y color:White SolidPeso molecular:501.3N-Methylbenzamide
CAS:N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Fórmula:C8H9NOPureza:99.83%Forma y color:Physical Description Off-White Crystalline Solid (Ntp 1992)Peso molecular:135.16Menabitan dihydrochloride
CAS:Menabitan dihydrochloride (SP-204 dihydrochloride), the dihydrochloride salt of Menabitan, serves as a non-opioid analgesic agent by inhibiting phosphodiesterase 9 (PDE 9). Additionally, it has been shown to reduce intraocular pressure in a rabbit model .Fórmula:C37H58Cl2N2O3Forma y color:SolidPeso molecular:649.77PDE10A-IN-5
PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.Forma y color:Odour SolidBAY 2666605
CAS:BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.Fórmula:C17H12F4N2O2Pureza:99.81%Forma y color:SolidPeso molecular:352.28Ref: TM-T9805
1mg92,00€5mg222,00€1mL*10mM (DMSO)245,00€10mg356,00€25mg785,00€50mg1.251,00€100mg2.008,00€UK 227786
CAS:UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.Fórmula:C22H22Cl2N4O4Pureza:99.9%Forma y color:White SolidPeso molecular:477.34Ref: TM-T11220L
1mg109,00€2mg163,00€5mg243,00€1mL*10mM (DMSO)289,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€500mg2.035,00€PDE4-IN-21
PDE4-IN-21 (Compound L19) is an effective PDE4 inhibitor with an IC50 of 0.48 μM. It demonstrates substantial inhibitory activity and notable metabolic stability in rat liver microsomes.Fórmula:C15H10Cl2N6SForma y color:SolidPeso molecular:377.25Dazonone
CAS:Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.Fórmula:C11H10ClN3OPureza:99.54% - 99.73%Forma y color:SolidPeso molecular:235.67Ref: TM-T9871
1mg73,00€1mL*10mM (DMSO)131,00€5mg149,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€200mg802,00€PDE4-IN-17
PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor. It effectively inhibits PDE4B and PDE4D with IC50 values of 10.0 nM and 15.2 nM, respectively. In SD rats, PDE4-IN-17 demonstrates good oral bioavailability (F=66%) and a relatively long half-life (t1/2=2.0 h).Fórmula:C17H16N2O3Forma y color:SolidPeso molecular:296.11609(1R,2R)-MK-8189
CAS:(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.Fórmula:C19H22N6OSPureza:>99.99% - >99.99%Forma y color:SoildPeso molecular:382.48JNJ 42396302
CAS:JNJ 42396302 is an effective PDE10A inhibitor that enhances motility and viability in human sperm cells.Fórmula:C19H23N5O2Pureza:99.36%Forma y color:Yellow SolidPeso molecular:353.42KR-40795
KR-40795 is an effective inhibitor of ATX (autotaxin) with an IC50 of 0.13 μM. This compound plays a crucial role in liver diseases.Fórmula:C26H20ClNO5Forma y color:SolidPeso molecular:461.89PDE5-IN-9
CAS:WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Fórmula:C18H14N4SPureza:99.98%Forma y color:SolidPeso molecular:318.4Nerandomilast
CAS:Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.Fórmula:C20H25ClN6O2SPureza:98.06% - 99.96%Forma y color:SoildPeso molecular:448.97PDE3/4-IN-2
CAS:PDE3/4-IN-2 is a potent dual PDE3/PDE4 inhibitor with IC50 values of 0.13 nM for PDE3A and 50 nM for PDE4B1. It is used to investigate PDE-related diseases such as asthma, COPD, sepsis, and nephritis. the dual-target activity of PDE3/4-IN-2 provides a mechanistic basis for dissecting cAMP regulation and inflammatory signaling pathways.Fórmula:C28H33N5O4Pureza:99.99%Peso molecular:503.59Oglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Fórmula:C20H13Cl2F2N3O5SPureza:99.82%Forma y color:Yellow SolidPeso molecular:516.3Enpp-1-IN-27
Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.Forma y color:Odour SolidBC 11-38
CAS:BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).Fórmula:C15H16N2OS2Pureza:98.95% - 99.28%Forma y color:SolidPeso molecular:304.43Ref: TM-T21865
1mg34,00€5mg66,00€1mL*10mM (DMSO)77,00€10mg92,00€25mg192,00€50mg313,00€100mg500,00€200mg708,00€Acetildenafil
CAS:Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.Fórmula:C25H34N6O3Forma y color:Off-White To Pale Yelow SolidPeso molecular:466.58PDE4B-IN-6
PDE4B-IN-6 is a highly selective PDE4B inhibitor (IC50=7.42 nM) that exerts anti-inflammatory effects by elevating cAMP and inhibiting TNF-α, used in COPD research.Fórmula:C22H24F2N2O7Pureza:99.20%Peso molecular:466.43Theodrenaline hydrochloride
CAS:Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.Fórmula:C17H22ClN5O5Pureza:97.05% - 98.18%Forma y color:SolidPeso molecular:411.84OPC18750 HCl
CAS:OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Fórmula:C20H23ClN2O4Pureza:98.92%Forma y color:SolidPeso molecular:390.86Ref: TM-T83974
1mL*10mM (DMSO)33,00€1mg109,00€5mg261,00€10mg374,00€25mg583,00€50mg803,00€100mg1.063,00€PDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Fórmula:C26H27N5O5Forma y color:SolidPeso molecular:489.52ONO-8430506
CAS:ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Fórmula:C27H28FN3O3Pureza:98.34%Forma y color:SolidPeso molecular:461.53Ref: TM-T38759
1mg103,00€5mg244,00€1mL*10mM (DMSO)271,00€10mg338,00€25mg510,00€50mg687,00€100mg919,00€Arofylline
CAS:Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.Fórmula:C14H13ClN4O2Pureza:98.19%Forma y color:SolidPeso molecular:304.73FCPR03
CAS:FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.Fórmula:C15H19F2NO3Pureza:99.94%Forma y color:White SolidPeso molecular:299.31Ref: TM-T39341
1mg38,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg126,00€25mg207,00€50mg294,00€100mg400,00€200mg540,00€cis-Tadalafil
CAS:Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.Fórmula:C22H19N3O4Pureza:99.89%Forma y color:SolidPeso molecular:389.4Anti-ALDH7A1 Antibody (3P955)
Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.Forma y color:Odour LiquidN-Ethyl tadalafil
CAS:N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.Fórmula:C23H21N3O4Pureza:99.58%Forma y color:SolidPeso molecular:403.43Anti-ALDH7A1 Antibody (5P692)
Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.Forma y color:Odour LiquidAnti-ALDH7A1 Antibody (6G475)
Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.Forma y color:Odour LiquidBay 60-7550
CAS:Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.Fórmula:C27H32N4O4Pureza:98.14%Forma y color:SolidPeso molecular:476.57BAY 73-6691 racemate
CAS:BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.Fórmula:C15H12ClF3N4OForma y color:White SolidPeso molecular:356.73BI-2545
CAS:BI-2545 is a potent and selective autotaxin (ATX) inhibitor with IC50 values of 2.2 nM and 3.4 nM for human and rat ATX, reduces plasma LPA levels.Fórmula:C23H19F6N5O3Pureza:98.85%Forma y color:White SolidPeso molecular:527.42ENPP1 Inhibitor C
CAS:ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Fórmula:C15H18N6Pureza:99.28%Forma y color:Yellow ViscousPeso molecular:282.34Ref: TM-T37431
2mg105,00€1mL*10mM (DMSO)178,00€5mg222,00€10mg356,00€25mg715,00€50mg1.134,00€100mg1.521,00€200mg2.062,00€DNMDP
CAS:DNMDP is a potent and selective PDE3A inhibitor with anticancer activity. It binds to PDE3A, promoting its interaction with Schlafen 12 (SLFN12).Fórmula:C15H20N4O3Forma y color:Orange SolidPeso molecular:304.34
