PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
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BAY 73-6691 racemate
CAS:BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.Fórmula:C15H12ClF3N4OForma y color:White SolidPeso molecular:356.73ENPP1 Inhibitor C
CAS:ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Fórmula:C15H18N6Pureza:99.28%Forma y color:Yellow ViscousPeso molecular:282.34Ref: TM-T37431
2mg105,00€1mL*10mM (DMSO)178,00€5mg222,00€10mg356,00€25mg715,00€50mg1.134,00€100mg1.521,00€200mg2.062,00€Anti-ALDH7A1 Antibody (5P692)
Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.Forma y color:Odour LiquidAnti-ALDH7A1 Antibody (3P955)
Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.Forma y color:Odour LiquidAnti-ALDH7A1 Antibody-FITC (5P692)
Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.Forma y color:Odour LiquidAnti-ALDH7A1 Antibody (1G435)
Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.Forma y color:Odour LiquidEnoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Fórmula:C12H12N2O2SPureza:98.53%Forma y color:SolidPeso molecular:248.3PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Fórmula:C22H21Cl2N3O5Pureza:98.70% - 99.25%Forma y color:SolidPeso molecular:478.33PQ-10
CAS:PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.Fórmula:C22H21N5O3Pureza:99.86%Forma y color:White SolidPeso molecular:403.43Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Fórmula:C17H14Cl2F2N2O4Pureza:98.19% - 99.69%Forma y color:SolidPeso molecular:419.21Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Fórmula:C23H17FN6O2Pureza:98% - 99.79%Forma y color:SolidPeso molecular:428.42Ref: TM-T1745
1mg37,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg87,00€25mg147,00€50mg244,00€100mg421,00€200mg617,00€THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Fórmula:C23H21ClN6O3Pureza:99.46%Forma y color:SolidPeso molecular:464.9K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).Fórmula:C25H26FN5O2Pureza:99.48%Forma y color:SolidPeso molecular:447.5Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Fórmula:C20H25NO4Pureza:97.37% - 99.52%Forma y color:White SolidPeso molecular:343.42ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Fórmula:C9H13N5OPureza:99.70%Forma y color:White SolidPeso molecular:207.23IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFórmula:C10H14N4O2Pureza:98% - >99.99%Forma y color:Off-WhitePeso molecular:222.242,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Fórmula:C9H9Cl2F2NO3SPureza:98.60%Forma y color:SolidPeso molecular:320.14Ref: TM-T50062
1mg52,00€2mg71,00€5mg98,00€1mL*10mM (DMSO)102,00€10mg146,00€25mg243,00€50mg355,00€100mg507,00€200mg690,00€Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFórmula:C14H10N4OPureza:99.68%Forma y color:SolidPeso molecular:250.26HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Fórmula:C24H19BFNO5SPureza:98.26% - ≥95%Forma y color:SolidPeso molecular:463.29Ref: TM-T2646
2mg37,00€5mg54,00€1mL*10mM (DMSO)55,00€10mg88,00€25mg138,00€50mg222,00€100mg334,00€200mg500,00€Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Fórmula:C15H22N2O3Pureza:98.82% - 99.79%Forma y color:SolidPeso molecular:278.35Mardepodect
CAS:Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.Fórmula:C25H20N4OPureza:99.81% - 99.94%Forma y color:SolidPeso molecular:392.45Ref: TM-T16499
1mg40,00€5mg87,00€1mL*10mM (DMSO)96,00€10mg142,00€25mg222,00€50mg346,00€100mg518,00€200mg742,00€BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Fórmula:C13H12FN5Pureza:99.45%Forma y color:SolidPeso molecular:257.27Ref: TM-T5101
1mg37,00€1mL*10mM (DMSO)42,00€5mg96,00€10mg144,00€25mg235,00€50mg339,00€100mg480,00€200mg658,00€MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Fórmula:C16H12ClN3O2Pureza:99.45%Forma y color:SolidPeso molecular:313.74Ref: TM-T21965
5mg44,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg138,00€50mg220,00€100mg318,00€200mg442,00€HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Fórmula:C24H19BFNO5SPureza:99.88%Forma y color:White SolidPeso molecular:463.29Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Fórmula:C14H18N2OPureza:99.83% - >99.99%Forma y color:White SolidPeso molecular:230.31ML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Fórmula:C20H20N4O4SPureza:97.93%Forma y color:White SolidPeso molecular:412.46SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Fórmula:C21H19N7Pureza:99.29%Forma y color:SolidPeso molecular:369.42Ref: TM-T8454
1mg58,00€5mg116,00€1mL*10mM (DMSO)129,00€10mg172,00€25mg281,00€50mg396,00€100mg537,00€200mg712,00€YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Fórmula:C17H16ClN3OPureza:99.84%Forma y color:SolidPeso molecular:313.78Cilostamide
CAS:Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)Fórmula:C20H26N2O3Pureza:98.87%Forma y color:White To Off-White SolidPeso molecular:342.43D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Fórmula:C21H19ClN2O2Pureza:97.57%Forma y color:SolidPeso molecular:366.84RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFórmula:C19H14ClN5O4Pureza:99.25%Forma y color:SolidPeso molecular:411.8BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Fórmula:C9H12N2O4SPureza:99.66%Forma y color:SolidPeso molecular:244.27Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Fórmula:C18H18Cl2N2O3Pureza:98.28% - 99.57%Forma y color:White SolidPeso molecular:381.25Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFórmula:C26H31N5O4Pureza:99.76% - 99.94%Forma y color:Green SolidPeso molecular:477.56Ref: TM-T25376
1mg34,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg136,00€25mg268,00€50mg429,00€100mg685,00€200mg888,00€Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Fórmula:C24H19BFNO5SPureza:99.18%Forma y color:SolidPeso molecular:463.29Ref: TM-T11533
1mg34,00€5mg71,00€1mL*10mM (DMSO)73,00€10mg101,00€25mg200,00€50mg321,00€100mg475,00€200mg680,00€Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Fórmula:C14H10BNO3Pureza:99.70%Forma y color:SolidPeso molecular:251.05Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Fórmula:C25H36N6O4SPureza:99.90%Forma y color:SolidPeso molecular:516.66Ref: TM-T17199
5mg48,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg133,00€50mg207,00€100mg301,00€200mg434,00€GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFórmula:C27H26N4O5SPureza:99.60% - 99.66%Forma y color:Yellow SolidPeso molecular:518.58Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Fórmula:C21H17N3O4Pureza:99.42%Forma y color:White SolidPeso molecular:375.38Ref: TM-T6147
1mg34,00€2mg49,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg192,00€50mg334,00€100mg537,00€200mg762,00€500mg1.134,00€Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Fórmula:C23H32N6O4SPureza:99.88%Forma y color:SolidPeso molecular:488.6Ref: TM-T8919
2mg39,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg177,00€50mg266,00€100mg371,00€200mg523,00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Fórmula:C13H16O3Pureza:99.53%Forma y color:SolidPeso molecular:220.26MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Fórmula:C20H14ClN3Pureza:99.77%Forma y color:White SolidPeso molecular:331.8Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Fórmula:C21H18N4O4Pureza:99.85%Forma y color:White PowderPeso molecular:390.39Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Forma y color:SolidPeso molecular:570.68Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Fórmula:C23H32N6O5SPureza:99.92%Forma y color:SolidPeso molecular:504.6Ref: TM-T7346
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg122,00€50mg177,00€100mg245,00€200mg353,00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Fórmula:C25H20N4OPureza:99.5%Forma y color:SolidPeso molecular:391.45Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Fórmula:C16H17N5O2Pureza:99.93%Forma y color:SolidPeso molecular:311.34Ref: TM-T8515
1mg35,00€2mg52,00€5mg77,00€1mL*10mM (DMSO)85,00€10mg113,00€25mg178,00€50mg333,00€100mg495,00€200mg710,00€CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Fórmula:C23H19FN2O7Pureza:99.39%Forma y color:SolidPeso molecular:454.4Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Fórmula:C30H33FN8O2SPureza:97% - 99.85%Forma y color:White SolidPeso molecular:588.7PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Fórmula:C21H19N7Pureza:99.65%Forma y color:SolidPeso molecular:369.42
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