PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 165 productos de "PDE"
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PQ-10
CAS:<p>PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.</p>Fórmula:C22H21N5O3Pureza:99.86%Forma y color:SolidPeso molecular:403.43Roflumilast N-oxide
CAS:<p>Roflumilast N-oxide is an inhibitor of PDE type 4.</p>Fórmula:C17H14Cl2F2N2O4Pureza:98.19% - 99.69%Forma y color:SolidPeso molecular:419.21Balipodect
CAS:<p>Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.</p>Fórmula:C23H17FN6O2Pureza:98% - 99.79%Forma y color:SolidPeso molecular:428.42Irsogladine
CAS:<p>Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.</p>Fórmula:C9H7Cl2N5Pureza:99.74% - 99.91%Forma y color:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterPeso molecular:256.09K-Ras-PDEδ-IN-1
CAS:<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>Fórmula:C25H26FN5O2Pureza:99.48%Forma y color:SolidPeso molecular:447.5Cilomilast
CAS:<p>Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.</p>Fórmula:C20H25NO4Pureza:97.37% - 99.52%Forma y color:White SolidPeso molecular:343.42ICI 63197
CAS:<p>ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.</p>Fórmula:C9H13N5OPureza:99.70%Forma y color:White SolidPeso molecular:207.23IBMX
CAS:<p>IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM</p>Fórmula:C10H14N4O2Pureza:98% - >99.99%Forma y color:Off-WhitePeso molecular:222.242,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:<p>2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.</p>Fórmula:C9H9Cl2F2NO3SPureza:98.60%Forma y color:SolidPeso molecular:320.14Olprinone
CAS:<p>Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate</p>Fórmula:C14H10N4OPureza:99.68%Forma y color:SolidPeso molecular:250.26HA130
CAS:<p>HA130 is a selective ATX (autotaxin) inhibitor.</p>Fórmula:C24H19BFNO5SPureza:98.26% - ≥95%Forma y color:SolidPeso molecular:463.29Ro 20-1724
CAS:<p>Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1</p>Fórmula:C15H22N2O3Pureza:98.82% - 99.79%Forma y color:SolidPeso molecular:278.35Mardepodect
CAS:<p>Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.</p>Fórmula:C25H20N4OPureza:99.81% - 99.94%Forma y color:SolidPeso molecular:392.45BW-A 78U
CAS:<p>BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.</p>Fórmula:C13H12FN5Pureza:99.45%Forma y color:SolidPeso molecular:257.27MBCQ
CAS:<p>MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.</p>Fórmula:C16H12ClN3O2Pureza:99.45%Forma y color:SolidPeso molecular:313.74HA 155
CAS:<p>HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.</p>Fórmula:C24H19BFNO5SPureza:99.88%Forma y color:SolidPeso molecular:463.29Ibudilast
CAS:<p>Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.</p>Fórmula:C14H18N2OPureza:99.83% - >99.99%Forma y color:White SolidPeso molecular:230.31ML-030
CAS:<p>ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.</p>Fórmula:C20H20N4O4SPureza:97.93%Forma y color:SolidPeso molecular:412.46SEP-0372814
CAS:<p>SEP-0372814 is a potent inhibitor of PDE10.</p>Fórmula:C21H19N7Pureza:99.29%Forma y color:SolidPeso molecular:369.42YM976
CAS:<p>YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)</p>Fórmula:C17H16ClN3OPureza:99.84%Forma y color:SolidPeso molecular:313.78Cilostamide
CAS:<p>Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)</p>Fórmula:C20H26N2O3Pureza:98.87%Forma y color:White To Off-White SolidPeso molecular:342.43D159687
CAS:<p>D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.</p>Fórmula:C21H19ClN2O2Pureza:97.57%Forma y color:SolidPeso molecular:366.84RS-25344 hydrochloride
CAS:<p>RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor</p>Fórmula:C19H14ClN5O4Pureza:99.25%Forma y color:SolidPeso molecular:411.8BRL-50481
CAS:<p>BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.</p>Fórmula:C9H12N2O4SPureza:99.66%Forma y color:SolidPeso molecular:244.27Piclamilast
CAS:<p>Piclamilast (RP 73401) is a PDE4 inhibitor.</p>Fórmula:C18H18Cl2N2O3Pureza:98.28% - 99.57%Forma y color:SolidPeso molecular:381.25Ensifentrine
CAS:<p>Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that</p>Fórmula:C26H31N5O4Pureza:99.76% - 99.94%Forma y color:SolidPeso molecular:477.56Z-HA155
CAS:<p>Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.</p>Fórmula:C24H19BFNO5SPureza:99.18%Forma y color:SolidPeso molecular:463.29Crisaborole
CAS:<p>Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.</p>Fórmula:C14H10BNO3Pureza:99.70%Forma y color:SolidPeso molecular:251.05Udenafil
CAS:<p>Udenafil is an inhibitor of PDE5 .</p>Fórmula:C25H36N6O4SPureza:99.90%Forma y color:Off-White SolidPeso molecular:516.66GSK256066
CAS:<p>GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold</p>Fórmula:C27H26N4O5SPureza:99.60% - 99.66%Forma y color:SolidPeso molecular:518.58Nortadalafil
CAS:<p>Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.</p>Fórmula:C21H17N3O4Pureza:99.42%Forma y color:SolidPeso molecular:375.38Homo Sildenafil
CAS:<p>Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.</p>Fórmula:C23H32N6O4SPureza:99.88%Forma y color:White SolidPeso molecular:488.6GEBR-7b
CAS:<p>GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.</p>Fórmula:C13H16O3Pureza:99.533%Forma y color:SolidPeso molecular:220.26Enoximone
CAS:<p>Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.</p>Fórmula:C12H12N2O2SPureza:98.53%Forma y color:SolidPeso molecular:248.3MY-5445
CAS:<p>MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).</p>Fórmula:C20H14ClN3Pureza:99.77%Forma y color:SolidPeso molecular:331.8Amino Tadalafil
CAS:<p>Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.</p>Fórmula:C21H18N4O4Pureza:99.85%Forma y color:White PowderPeso molecular:390.39Sildenafil Mesylate
CAS:<p>Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.</p>Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Forma y color:SolidPeso molecular:570.68Lodenafil
CAS:<p>Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)</p>Fórmula:C23H32N6O5SPureza:99.92%Forma y color:SolidPeso molecular:504.6[11C]MP 10
CAS:<p>[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.</p>Fórmula:C25H20N4OPureza:99.5%Forma y color:SolidPeso molecular:391.45Osoresnontrine
CAS:<p>Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.</p>Fórmula:C16H17N5O2Pureza:99.93%Forma y color:SolidPeso molecular:311.34CP671305
CAS:<p>CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.</p>Fórmula:C23H19FN2O7Pureza:99.39%Forma y color:SolidPeso molecular:454.4Ziritaxestat
CAS:<p>Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.</p>Fórmula:C30H33FN8O2SPureza:97% - 99.85%Forma y color:SolidPeso molecular:588.7PDE10-IN-1
CAS:<p>PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.</p>Fórmula:C21H19N7Pureza:99.65%Forma y color:SolidPeso molecular:369.42RS-25344
CAS:<p>RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.</p>Fórmula:C19H13N5O4Pureza:98.98%Forma y color:SolidPeso molecular:375.34Lotamilast
CAS:<p>Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.</p>Fórmula:C26H24N4O5Pureza:97.03% - 99.29%Forma y color:SolidPeso molecular:472.49Enpp-1-IN-1
CAS:<p>Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)</p>Fórmula:C17H17N3O3SPureza:97.52%Forma y color:SolidPeso molecular:343.4GSK256066 Trifluoroacetate
CAS:<p>GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.</p>Fórmula:C29H27F3N4O7SForma y color:SolidPeso molecular:632.61Crisaborole-d4
<p>Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.</p>Fórmula:C14H6D4BNO3Forma y color:SolidPeso molecular:255.07ent-Tadalafil
CAS:<p>ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).</p>Fórmula:C22H19N3O4Pureza:98%Forma y color:SolidPeso molecular:389.4Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Fórmula:C40H37N5OPureza:99.4%Forma y color:SolidPeso molecular:603.75
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