PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 165 productos de "PDE"
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PDE9-IN-(S)-C33
CAS:<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Fórmula:C18H20ClN5OPureza:98.75%Forma y color:SolidPeso molecular:357.84Enpp-1-IN-16
CAS:<p>Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.</p>Fórmula:C23H32N4O4Pureza:99.87%Forma y color:SolidPeso molecular:428.52TPN171
CAS:<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Fórmula:C24H35N5O3Pureza:>99.99%Forma y color:SolidPeso molecular:441.57AMG 579
CAS:<p>AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).</p>Fórmula:C25H23N5O3Pureza:99.87%Forma y color:SolidPeso molecular:441.48Cudetaxestat
CAS:<p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>Fórmula:C21H15Cl2F2N3O2SPureza:99.9%Forma y color:SolidPeso molecular:482.33TP-10
CAS:<p>TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.</p>Fórmula:C26H19F3N4OPureza:99.21%Forma y color:SolidPeso molecular:460.45Thioquinapiperifil dihydrochloride
CAS:<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Fórmula:C24H29ClN6OSPureza:98.73%Forma y color:SolidPeso molecular:485.05PF-00489791
CAS:<p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>Fórmula:C20H28N8O4SPureza:99.97%Forma y color:SolidPeso molecular:476.55Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Fórmula:C30H40Cl2N6O4S2Pureza:98%Forma y color:SolidPeso molecular:683.71ASP9831
CAS:<p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>Fórmula:C20H23N3O3Forma y color:SolidPeso molecular:353.42Tovinontrine
CAS:<p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>Fórmula:C21H26N6O2Pureza:98.14%Forma y color:SolidPeso molecular:394.47BMS-341400 mesylate
CAS:<p>BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.</p>Fórmula:C24H26ClN9O5SForma y color:SolidPeso molecular:588.039TAK-915
CAS:<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Fórmula:C19H18F4N4O5Pureza:98%Forma y color:SolidPeso molecular:458.36Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Fórmula:C12H14ClN3O3Forma y color:SolidPeso molecular:283.71NHTD
CAS:<p>NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).</p>Fórmula:C24H26N2O5Forma y color:SolidPeso molecular:422.47
