SGK
La quinasa regulada por suero y glucocorticoides (SGK) es una proteína quinasa involucrada en la regulación de varios procesos celulares, incluidos el transporte de iones, la supervivencia celular y el metabolismo de la glucosa. Los inhibidores de SGK son valiosos en el estudio de condiciones como la hipertensión, la diabetes y el cáncer, donde la actividad de SGK juega un papel crucial. Estos inhibidores ayudan a comprender las vías de señalización reguladas por SGK y sus implicaciones en enfermedades. En CymitQuimica, ofrecemos inhibidores de SGK para apoyar su investigación en transducción de señales, enfermedades metabólicas y terapia contra el cáncer.
Se han encontrado 11 productos de "SGK"
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SGK1-IN-3 hydrochloride
<p>SGK1-IN-3 hydrochloride (compound 3a) is an efficacious, orally bioavailable SGK1 inhibitor. The serine/threonine kinase SGK1 acts as an activator of the β-catenin pathway and strongly stimulates cartilage degradation, being upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride holds potential for osteoarthritis research.</p>Fórmula:C23H21Cl3N6O3SPeso molecular:566.04614PROTAC SGK3 degrader-1
CAS:<p>PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligands to VH032 VHL to induce endogenous SGK3 degradation.</p>Fórmula:C57H73FN10O11S2Pureza:98%Forma y color:SolidPeso molecular:1157.38SGK1-IN-4
CAS:<p>SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.</p>Fórmula:C23H21ClFN5O4SPureza:97.03%Forma y color:SolidPeso molecular:517.96SI-113
CAS:<p>SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.</p>Fórmula:C23H24N6OPureza:98.93%Forma y color:SolidPeso molecular:400.48CKI-7
CAS:<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Fórmula:C11H14Cl3N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:358.67GSK 650394
CAS:<p>GSK 650394 is an inhibitor of serum- and glucocorticoid-regulated kinases (SGK). GSK 650394 has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C25H22N2O2Pureza:97.46% - >99.99%Forma y color:SolidPeso molecular:382.45EMD638683
CAS:<p>EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).</p>Fórmula:C18H18F2N2O4Pureza:98%Forma y color:SolidPeso molecular:364.34SGK1-IN-1
CAS:<p>SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitor</p>Fórmula:C17H12ClFN6O2SPureza:98%Forma y color:SolidPeso molecular:418.83BRD7389
CAS:<p>BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.</p>Fórmula:C24H18N2O2Pureza:99.51%Forma y color:SolidPeso molecular:366.41EMD638683 R-Form
CAS:<p>EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.</p>Fórmula:C18H18F2N2O4Forma y color:SolidPeso molecular:364.34SGK1-IN-6
CAS:<p>SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.</p>Fórmula:C30H30F3N5O4Forma y color:SolidPeso molecular:581.586
