SGK
La quinasa regulada por suero y glucocorticoides (SGK) es una proteína quinasa involucrada en la regulación de varios procesos celulares, incluidos el transporte de iones, la supervivencia celular y el metabolismo de la glucosa. Los inhibidores de SGK son valiosos en el estudio de condiciones como la hipertensión, la diabetes y el cáncer, donde la actividad de SGK juega un papel crucial. Estos inhibidores ayudan a comprender las vías de señalización reguladas por SGK y sus implicaciones en enfermedades. En CymitQuimica, ofrecemos inhibidores de SGK para apoyar su investigación en transducción de señales, enfermedades metabólicas y terapia contra el cáncer.
Se han encontrado 10 productos de "SGK"
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SGK1-IN-3 hydrochloride
SGK1-IN-3 hydrochloride (compound 3a) is an efficacious, orally bioavailable SGK1 inhibitor. The serine/threonine kinase SGK1 acts as an activator of the β-catenin pathway and strongly stimulates cartilage degradation, being upregulated under genomic control in diseased osteoarthritic cartilage. SGK1-IN-3 hydrochloride holds potential for osteoarthritis research.Fórmula:C23H21Cl3N6O3SPeso molecular:566.04614308-R-C4-PEG3-C1-Boc
CAS:308-R-C4-PEG3-C1-Boc is an SGK3 ligand-linker conjugate, utilized in the synthesis of PROTAC SGK3 degrader-2.Fórmula:C39H53FN6O9SForma y color:SolidPeso molecular:800.94SGK1-IN-4
CAS:SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.Fórmula:C23H21ClFN5O4SPureza:97.03%Forma y color:SolidPeso molecular:517.96Ref: TM-T9977
1mg105,00€5mg250,00€10mg356,00€25mg580,00€50mg782,00€100mg1.044,00€200mg1.404,00€1mL*10mM (DMSO)301,00€SI-113
CAS:SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.Fórmula:C23H24N6OPureza:98.93%Forma y color:SolidPeso molecular:400.48Ref: TM-T9589
1mg43,00€2mg56,00€5mg93,00€10mg133,00€25mg236,00€50mg354,00€100mg518,00€1mL*10mM (DMSO)101,00€CKI-7
CAS:CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.Fórmula:C11H14Cl3N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:358.67Ref: TM-T19913
1mg73,00€5mg128,00€10mg185,00€25mg299,00€50mg405,00€100mg545,00€1mL*10mM (DMSO)140,00€GSK 650394
CAS:GSK 650394 is an inhibitor of serum- and glucocorticoid-regulated kinases (SGK). GSK 650394 has antitumor activity. Cost-effective and quality-assured.Fórmula:C25H22N2O2Pureza:97.46% - >99.99%Forma y color:SolidPeso molecular:382.45Ref: TM-T2622
1mg38,00€2mg50,00€5mg84,00€10mg105,00€25mg197,00€50mg313,00€100mg447,00€200mg623,00€1mL*10mM (DMSO)93,00€EMD638683
CAS:EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).Fórmula:C18H18F2N2O4Pureza:98%Forma y color:SolidPeso molecular:364.34Ref: TM-T6635
1mg74,00€2mg92,00€5mg150,00€10mg233,00€25mg358,00€50mg517,00€100mg737,00€200mg982,00€1mL*10mM (DMSO)120,00€SGK1-IN-1
CAS:SGK1-IN-1 (compound 14n) is a highly potent SGK1 (Serum/Glucocorticoid Regulated Kinase 1) inhibitorFórmula:C17H12ClFN6O2SPureza:98%Forma y color:SolidPeso molecular:418.83EMD638683 R-Form
CAS:EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.Fórmula:C18H18F2N2O4Forma y color:SolidPeso molecular:364.34SGK1-IN-6
CAS:SGK1-IN-6 (compound 12f) is an SGK1 inhibitor with an IC50 value of 0.39 μM. In PC3 xenograft models using BALB/c nude mice, SGK1-IN-6 effectively hinders tumor growth without causing any observable toxicity.Fórmula:C30H30F3N5O4Forma y color:SolidPeso molecular:581.586
