Receptor de retinoides

Acitretin is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.

Etodolac inhibits the activity of cyclooxygenase I and II, thereby preventing the formation of prostaglandin …

Liarozole is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor …

TTNPB, a potent RAR agonist, inhibits binding of [3H]tRA of human RARα (IC50: 5.1 nM), …

Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.

Adapalene is a dual RAR and RXR agonist, utilized in the treatment of skin conditions.

LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM …

Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription …

Magnolol is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced …

Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression …

AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of …

Cecropin B acetate induces NF-κB activation and suppresses CYP3A29 by disrupting the association of the …

K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an …

Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene is …

BMS453, a synthetic retinoid, is a potent and selective agonist of RARβ and a potent …

BMS 753 is an agonist of isotype-selective retinoic acid receptor α (RARα, Ki= 2 nM).

Ch55 is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) …

LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) …

BMS 195614 is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.

AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.

CD2665 is an orally active antagonist of retinoic acid receptor (RAR). For RARγ and RARβ, …

Tamibarotene is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, …

Bexarotene is a retinoid analogue that is used to treat the skin manifestations of cutaneous …

trifarotene is a potent and selective RARγ agonist with 65-fold and 16-fold selectivitiy for the …

R-flurbiprofen is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed …

Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both …

Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear …

AM580 is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 …

HX 531 is a potent antagonist of the retinoid X receptor with an IC50 value …

Tazarotene is a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), …

Fenretinide is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.

CD437 is a specifc Retinoic Acid Receptor γ (RARγ) agonist.

WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets …

AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 …

Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing …

UVI 3003 is a highly selective antagonist of the retinoid X receptor. UVI 3003 inhibits …

AR7 is a retinoic acid receptor α (RARα) antagonist.

Palovarotene is an agonist of nuclear retinoic acid receptor γ (RAR-γ).

PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of …

MM 11253 is a RARγ antagonist with IC50 of 44nM.

BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 also could prevent retinoic acid-induced …

AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, …

CD3254 a selective agonist of retinoid-X-receptor (RXR).

LY 178002 is an effective inhibitor of 5-lipoxygenase (5-LPO), phospholipase A2 (IC50: 0.6 μM for …

LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = …