Lipasa

<p>Lipase 14 recombinantly expressed in E. coli comes in a spray-dried formulation. It has its pH optimum at 6-8 and temp. optimum at 30-40°C. Lipases belong to the family of esterases and naturally act on triglycerides at lipid-water interfaces catalyzing hydrolytic reactions, esterifications and transesterification reactions in industrial and food applications. Lipase 14 was shown to hydrolyze p-Nitrophenyl esters of butyrate (74 % activity compared to octanoate), octanoate (100 %), laurate (8 %), palmitate (5 %), stearate (4 %), arachidate (1 %) and behenate (0.6 %).</p>

<p>HSL-IN-5 (Example 21) is a hormone-sensitive lipase (HSL) inhibitor with an IC₅₀ value of 0.2 μM, suitable for diabetes research.</p>

<p>Phospholipases D belong to the family of esterases and act on phosphatidylcholine in the plasma membrane to release phosphatidic acid (PA) and choline. Phospholipases D can be used as versatile tools in hydrolysis and transphosphatidylation reactions for industrial, chemical and food applications. The Phospholipase D Kit contains 4 enzymes with a broad pH range for transphosphatidylation activity.</p>

<p>MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM.</p>

<p>BemPPOX is a potent inhibitor of DGL.</p>

<p>SMP-028 is a neutral cholesterol esterase (CEase) inhibitor(IC50 : 1.01 μM).</p>

HSL-IN-1 is an HSL inhibitor that significantly reduces the reactive metabolite load and reduces the release of free fatty acids from stored fat.

<p>HSL-IN-2 is a selective inhibitor of Hormone Sensitive Lipase (HSL; IC50: 0.023 μM).</p>

<p>Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.</p>

<p>NF-1819: strong, selective MGL inhibitor; eases MS symptoms; analgesic; penetrates brain with high permeability.</p>

<p>endothelial lipase and lipoprotein lipase inhibitor</p>

<p>JJKK 048 is a potent and selective MAGL inhibitor.</p>

<p>JNJ-42226314 is a MAGL inhibitor with anti-injury effects and has shown efficacy in neuropathic pain and inflammatory pain models.</p>

<p>NG-497, a selective inhibitor of human ATGL, blocks lipolysis in adipocytes and aids cancer research.</p>

<p>ERX-41 is an orally active, stereospecific small molecule that targets lysosomal acid lipase A (LIPA).</p>

<p>PNPLA3 Modifier 1 (Compound 10), a modifier of patatin-like phospholipase domain-containing protein 3 (pnpla3), exhibits a geometric mean EC50 of 4.9 nM.</p>

<p>PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).</p>

<p>Salacinol is a naturally occurring alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata.</p>