HIF / HIF Prolilhidroxilasa
El Factor Inducible por Hipoxia (HIF) es un factor de transcripción que desempeña un papel crucial en las respuestas celulares a bajos niveles de oxígeno (hipoxia). La actividad del HIF está regulada estrictamente por las prolil-hidroxilasas de HIF, que dirigen al HIF para su degradación en condiciones normóxicas. Los inhibidores de la prolil-hidroxilasa de HIF pueden estabilizar el HIF, promoviendo la expresión de genes involucrados en la angiogénesis, la eritropoyesis y el metabolismo. Estos inhibidores son de gran interés en el tratamiento de afecciones como la anemia, las enfermedades isquémicas y el cáncer. En CymitQuimica, ofrecemos inhibidores de HIF/prolil-hidroxilasa HIF para apoyar su investigación en biología de la hipoxia, terapia del cáncer y regulación metabólica.
Se han encontrado 150 productos para "HIF / HIF Prolilhidroxilasa".
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1,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFórmula:C13H8N2O3Pureza:97.77%Forma y color:SolidPeso molecular:240.21Ref: TM-T21653
5mg49,00€1mL*10mM (DMSO)54,00€10mg79,00€25mg144,00€50mg222,00€100mg356,00€200mg525,00€500mg837,00€Zifcasiran
CAS:Zifcasiran reduces HIF synthesis, has antitumor properties, useful in renal carcinoma studies.Fórmula:C737H972F20N211O349P43S8Forma y color:SolidPeso molecular:20339.13HIF-1 inhibitor-5
HIF-1 inhibitor-5 (Compound 16e) is a potent inhibitor of HIF-1, exhibiting an IC50 value of 2.38 μM and demonstrating significant anti-angiogenic potential [1Fórmula:C28H35NO5Forma y color:SolidPeso molecular:465.58KG-548
CAS:KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, inhibiting lactate production, and can be used in cancer research.Fórmula:C9H4F6N4Pureza:99.62%Forma y color:SolidPeso molecular:282.151,4-DPCA ethyl ester
CAS:1,4-DPCA ethyl ester is a form of 1,4-DPCA modified, which has potential anticancer activity based on growth inhibition assays with the mlh1 rad18 yeast strain.Fórmula:C15H12N2O3Pureza:99.54%Forma y color:SolidPeso molecular:268.27Ref: TM-T36796
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg84,00€25mg145,00€50mg236,00€100mg400,00€200mg585,00€HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Fórmula:C21H19N3OSPureza:99.90% - >99.99%Forma y color:White SolidPeso molecular:361.46Ref: TM-T61349
2mg85,00€5mg124,00€1mL*10mM (DMSO)133,00€10mg175,00€25mg293,00€50mg434,00€100mg622,00€HIF-IN-1
CAS:HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.Fórmula:C17H12N2OPureza:99.48%Forma y color:Orange SolidPeso molecular:260.29N-Oxalylglycine
CAS:N-Oxalylglycine (Oxalylglycine) is a cell permeable inhibitor of α-ketoglutarate-dependent enzymes.Fórmula:C4H5NO5Pureza:99.23%Forma y color:SolidPeso molecular:147.09TP0463518
CAS:TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).Fórmula:C20H18ClN3O6Pureza:99.52%Forma y color:SolidPeso molecular:431.83HNHA
CAS:HNHA is an inhibitor of HDAC.Fórmula:C17H21NO2SPureza:98.04%Forma y color:SolidPeso molecular:303.42Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Fórmula:C9H10O4Pureza:99.88%Forma y color:SolidPeso molecular:182.17Fraxinellone
CAS:1.Fórmula:C14H16O3Pureza:99.35% - 99.88%Forma y color:Yellow SolidPeso molecular:232.27Ref: TM-T6S0071
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg84,00€25mg152,00€50mg222,00€100mg334,00€200mg494,00€AKBA
CAS:AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.Fórmula:C32H48O5Pureza:97.85% - 99.75%Forma y color:SolidPeso molecular:512.72Izilendustat hydrochloride
CAS:Izilendustat hydrochloride inhibits prolyl hydroxylase, stabilizing HIF-1α/HIF-2, with potential to treat various HIF-1α diseases.Fórmula:C22H29Cl2N3O4Forma y color:SolidPeso molecular:470.39FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Fórmula:C12H9ClN2O4Pureza:97.1% - >99.99%Forma y color:SolidPeso molecular:280.66IDF-11774
CAS:IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).Fórmula:C23H32N2O2Pureza:98.05%Forma y color:SolidPeso molecular:368.51IOX2
CAS:IOX2 is a selective HIF PHD inhibitor, active in cells with 21 nM IC50 for PHD2/ELGN-1, not inhibiting FIH at 20uM.Fórmula:C19H16N2O5Pureza:98% - 99.59%Forma y color:SolidPeso molecular:352.34ZINC13466751
CAS:ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Fórmula:C20H21N5O2Pureza:99.8%Forma y color:SolidPeso molecular:363.41Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Fórmula:C6H13NO5·H2SO4Pureza:99.64%Forma y color:SolidPeso molecular:277.25M1001
CAS:M1001 is a HIF-2α agonist.Fórmula:C17H17N3O2SPureza:98.83%Forma y color:Yellow SolidPeso molecular:327.4VH-298
CAS:VH-298 blocks VHL:HIF-α interaction, stabilizes HIF-α, and triggers hypoxic response differently by inhibiting VHL post-HIF-α PHD hydroxylation.Fórmula:C27H33N5O4SPureza:99.06% - >99.99%Forma y color:SolidPeso molecular:523.65PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Fórmula:C13H8N4Pureza:99.74%Forma y color:White SolidPeso molecular:220.23Ref: TM-T9627
1mg42,00€1mL*10mM (DMSO)90,00€5mg92,00€10mg132,00€25mg231,00€50mg349,00€100mg522,00€200mg710,00€Amifostine sodium
CAS:Amifostine sodium is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.Fórmula:C5H15N2NaO3PSForma y color:SolidPeso molecular:237.21GN44028
CAS:GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.Fórmula:C18H15N3O2Pureza:99.52%Forma y color:SolidPeso molecular:305.33B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFórmula:C20H17ClN4O3Pureza:99.66%Forma y color:SolidPeso molecular:396.83BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Fórmula:C26H26F3N7O2Pureza:98% - 99.95%Forma y color:White SolidPeso molecular:525.53Ref: TM-T2488
1mg34,00€2mg40,00€5mg59,00€1mL*10mM (DMSO)70,00€10mg96,00€25mg200,00€50mg334,00€100mg557,00€Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Fórmula:C16H18O9Pureza:98.84% - 99.67%Forma y color:White SolidPeso molecular:354.31JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Fórmula:C12H6ClF3N4O3Pureza:99.58% - ≥95%Forma y color:SolidPeso molecular:346.65Ref: TM-T3180
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg200,00€50mg334,00€100mg537,00€500mg1.134,00€dencichine
CAS:Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.Fórmula:C5H8N2O5Pureza:99.93% - ≥95%Forma y color:SolidPeso molecular:176.13Dapagliflozin
CAS:Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.Fórmula:C21H25ClO6Pureza:99.5% - 99.93%Forma y color:SolidPeso molecular:408.87Ref: TM-T2389
1500mgA consultar5mg47,00€1mL*10mM (DMSO)52,00€10mg60,00€25mg77,00€50mg94,00€100mg107,00€200mg142,00€DMOG
CAS:DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.Fórmula:C6H9NO5Pureza:80.23% - 99.98%Forma y color:SolidPeso molecular:175.14MK-8617
CAS:MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).Fórmula:C24H21N5O4Pureza:99.38% - >99.99%Forma y color:SolidPeso molecular:443.45KC7F2
CAS:KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Fórmula:C16H16Cl4N2O4S4Pureza:98% - 99.11%Forma y color:SolidPeso molecular:570.382,4-DPD
CAS:2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)Fórmula:C11H13NO4Pureza:99.74%Forma y color:SolidPeso molecular:223.23HIF-2α-IN-4
CAS:HIF-2a translation inhibitor is a compound used as a molecular building block.Fórmula:C9H9N3O4S2Pureza:99.92%Forma y color:Yellow SolidPeso molecular:287.32Ref: TM-T50099
5mg37,00€1mL*10mM (DMSO)44,00€10mg60,00€25mg111,00€50mg200,00€100mg299,00€200mg430,00€PT-2385
CAS:PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).Fórmula:C17H12F3NO4SPureza:98.91% - 99.55%Forma y color:White SolidPeso molecular:383.34Ref: TM-T7848
1mg63,00€2mg93,00€1mL*10mM (DMSO)119,00€5mg144,00€10mg222,00€25mg379,00€50mg532,00€100mg740,00€200mg982,00€Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Fórmula:C16H12O5Pureza:98.72% - 99.98%Forma y color:White SolidPeso molecular:284.26Ref: TM-T6S1315
1mg37,00€5mg71,00€1mL*10mM (DMSO)84,00€10mg90,00€25mg147,00€50mg208,00€100mg309,00€200mg447,00€IOX4
CAS:IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)Fórmula:C15H16N6O3Pureza:99.97%Forma y color:SolidPeso molecular:328.33Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Fórmula:C30H52O3Pureza:98% - 99.9%Forma y color:SolidPeso molecular:460.73LW6
CAS:LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.Fórmula:C26H29NO5Pureza:98.1% - 98.22%Forma y color:SolidPeso molecular:435.51Ref: TM-T3494
2mg44,00€5mg65,00€1mL*10mM (DMSO)65,00€10mg94,00€25mg173,00€50mg281,00€100mg424,00€500mg888,00€Belzutifan
CAS:"Belzutifan (MK-6482) is an oral HIF-2α inhibitor for ccRCC, with enhanced potency (IC50: 9 nM)."Fórmula:C17H12F3NO4SPureza:99.34% - 99.88%Forma y color:White SolidPeso molecular:383.34Ref: TM-T16679
1mg66,00€5mg144,00€1mL*10mM (DMSO)158,00€10mg205,00€25mg389,00€50mg625,00€100mg888,00€200mg1.198,00€Amifostine trihydrate
CAS:Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.Fórmula:C5H15N2O3PS·3H2OPureza:99.71% - 99.80%Forma y color:SolidPeso molecular:268.27PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Fórmula:C13H20Cl4N2O3Pureza:97% - 99.79%Forma y color:SolidPeso molecular:394.12Ref: TM-T6961
1mg39,00€5mg84,00€1mL*10mM (DMSO)84,00€10mg130,00€25mg193,00€50mg261,00€100mg411,00€200mg605,00€UNC6934
CAS:UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Fórmula:C24H21N5O4Pureza:98.67%Forma y color:SolidPeso molecular:443.45Ref: TM-T9584
1mg47,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg152,00€25mg326,00€50mg485,00€100mg670,00€200mg888,00€Diethyl bipy55'DC
CAS:"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."Fórmula:C16H16N2O4Pureza:98%Forma y color:SolidPeso molecular:300.31E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Fórmula:C21H30O6Pureza:99.52%Forma y color:SolidPeso molecular:378.46KCN1
CAS:KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.Fórmula:C26H27NO5SForma y color:SolidPeso molecular:465.56HIF-1α-IN-6
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.Pureza:98%Forma y color:Odour SolidHIF-1/2α-IN-2
CAS:HIF-1/2α-IN-2 is a selective HIF-1伪/2伪 inhibitor that induces ferroptosis via ISCA2 inhibition.Fórmula:C16H11FN4O2SForma y color:White SolidPeso molecular:342.35
