ROR
Los receptores órfanos relacionados con el ácido retinoico (RORs) son receptores nucleares que regulan diversos procesos fisiológicos, incluyendo el ritmo circadiano, la respuesta inmunitaria y el metabolismo. Los inhibidores de ROR son de interés en el estudio de enfermedades autoinmunes, trastornos metabólicos y cáncer, ya que pueden modular la expresión génica e influir en las funciones celulares. En CymitQuimica, ofrecemos inhibidores de ROR para apoyar su investigación en inmunología, endocrinología y oncología.
Se han encontrado 48 productos para "ROR".
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S18-000003
CAS:S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.Fórmula:C26H25F3N2O4SPureza:99.24% - 99.31%Forma y color:White SolidPeso molecular:518.548Nobiletin
CAS:Nobiletin: a citrus-derived flavone with anti-inflammatory and anti-cancer properties; water-insoluble, very weak acid.Fórmula:C21H22O8Pureza:98.65% - 99.95%Forma y color:Yellow SolidPeso molecular:402.3946SR3335
CAS:SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).Fórmula:C13H9F6NO3S2Pureza:99.77%Forma y color:SolidPeso molecular:405.336SR1078
CAS:SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.Fórmula:C17H10F9NO2Pureza:99.58%Forma y color:SolidPeso molecular:431.25ROR1-IN-2
ROR1-IN-2 (compound 9I) is a potent and selective inhibitor of ROR1. It exhibits antiproliferative activity in various cancer cell lines and significantly inhibits tumor growth in vivo.Fórmula:C30H27N3O4Forma y color:SolidPeso molecular:493.20016TF-S14
CAS:TF-S14 is an inverse agonist of RORγt. It functions by binding to RORγt and inhibiting its activity, leading to a reduction in Th17 cell-associated cytokine production, including IL-17A, IL-21, and IL-22. TF-S14 is applicable in research related to autoimmune diseases and allogeneic transplant rejection.Fórmula:C22H27N3O2SForma y color:SolidPeso molecular:397.53XY101
CAS:XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).Fórmula:C25H20F7NO4SPureza:99.83%Forma y color:SolidPeso molecular:563.484GNE-0946
CAS:GNE-0946 is an effective and selective RORγ/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. autoimmune disease research.Fórmula:C22H12ClF3N2O4Pureza:98.11%Forma y color:SolidPeso molecular:460.79MRL-871
CAS:MRL-871 is a selective RORγt allosteric inhibitor, reducing IL-17a mRNA production in EL4 cells, interacting with PPARgamma in partial agonistic binding modes.Fórmula:C22H12ClF3N2O3Pureza:99.66%Forma y color:SolidPeso molecular:444.79RORγt Inverse agonist 8
CAS:RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist(human RORγt-LBD with an IC50 of 19 nM).Fórmula:C26H33N7O2Pureza:98%Forma y color:SolidPeso molecular:475.59ML 209
CAS:ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcriptionFórmula:C25H31NO6Pureza:99.87%Forma y color:SolidPeso molecular:441.5167AZD-0284
CAS:AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].Fórmula:C21H18F6N2O5SPureza:99.82%Forma y color:SolidPeso molecular:524.433SR2211
CAS:SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).Fórmula:C26H24F7N3OPureza:98.75%Forma y color:White SolidPeso molecular:527.48GNE-6468
CAS:GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell).Fórmula:C23H16ClN3O4Pureza:98.68% - 99.73%Forma y color:SolidPeso molecular:433.844FM26
CAS:FM26, an isoxazole-based RORγt inverse agonist, cuts EL4 IL-17a mRNA; potent with 264 nM IC50.Fórmula:C22H15ClF3N3O3Pureza:98%Forma y color:SolidPeso molecular:461.82RORγt Inverse agonist 6
CAS:RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.Fórmula:C28H29ClN6O5Pureza:99.52%Forma y color:SolidPeso molecular:565.02RORγt inverse agonist 14
CAS:RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, exhibiting anti-inflammatory activity.Fórmula:C26H26F8N2O6S2Pureza:98%Forma y color:SolidPeso molecular:678.613-Oxo-5β-cholanoic acid
CAS:3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directlyFórmula:C24H38O3Pureza:98.01% - 99.86%Forma y color:White SolidPeso molecular:374.5567TMP780
CAS:TMP780 is an inverse RORγt agonist (IC50: 13 nM). RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders.Fórmula:C31H30N2O4Pureza:98%Forma y color:SolidPeso molecular:494.5809RORγt inverse agonist 32
CAS:RORγt inverse agonist 32 (compound b14) exhibits oral activity and can be utilized in inflammatory research studies.Fórmula:C24H28F3NO5SForma y color:SolidPeso molecular:499.54
