NAMPT
La nicotinamida fosforribosiltransferasa (NAMPT) es una enzima involucrada en la biosíntesis de nicotinamida adenina dinucleótido (NAD+), un coenzima crítico en el metabolismo celular y la producción de energía. Los inhibidores de NAMPT son de interés en la investigación del cáncer debido a su capacidad para interrumpir el metabolismo de NAD+ e inducir la muerte celular en células cancerosas. Estos inhibidores también se exploran en el contexto de trastornos metabólicos y envejecimiento. En CymitQuimica, ofrecemos inhibidores de NAMPT para apoyar su investigación en biología del cáncer, metabolismo y envejecimiento.
Se han encontrado 39 productos para "NAMPT".
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GNE-617 hydrochloride
CAS:GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).Fórmula:C21H16ClF2N3O3SForma y color:SolidPeso molecular:463.88GNE-617
CAS:GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.Fórmula:C21H15F2N3O3SPureza:99.38% - 99.71%Forma y color:White SolidPeso molecular:427.42Ref: TM-T4335
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)81,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€Nampt-IN-12
CAS:Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.Fórmula:C10H8N2OSForma y color:SolidPeso molecular:204.25Nampt-IN-7
CAS:Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).Fórmula:C20H21N5O3Forma y color:SolidPeso molecular:379.41Teglarinad chloride
CAS:Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.Fórmula:C30H43Cl2N5O8Pureza:98.09%Forma y color:SolidPeso molecular:672.6Nampt-IN-9
CAS:Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.Fórmula:C26H33N3O4Forma y color:SolidPeso molecular:451.56Nampt activator-3
CAS:NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.Fórmula:C19H20N2O3Forma y color:SolidPeso molecular:324.37Nampt activator-2
CAS:Nampt activator-2: Potent NAMPT activator (EC50: 0.023 μM), binds CYP2C9 (0.060 μM), 2D6 (0.41 μM), 2C19 (0.59 μM); useful in metabolic disease research.Fórmula:C17H15ClN4O3SPureza:98.59% - 98.88%Forma y color:SolidPeso molecular:390.84GNE-618
CAS:GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).Fórmula:C21H15F3N4O3SForma y color:SolidPeso molecular:460.43Nampt-IN-10 TFA
CAS:Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.Fórmula:C29H29F4N5O4Forma y color:SolidPeso molecular:587.21557JGB-1-155
CAS:JGB-1-155 is a positive allosteric modulator of nicotinamide phosphoribosyltransferase that enhances NAMPT enzymatic activity, elevates intracellular NAD⁺ levels in human monocytes, counteracts oxidative stress, and attenuates TNFα-induced reactive oxygen species production, supporting its application in studies of redox balance and inflammatory signaling.Fórmula:C26H38N2O3Pureza:99.33%Forma y color:White SolidPeso molecular:426.59LB-60-OF61
CAS:LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.Fórmula:C29H30N6O2Pureza:99.47%Forma y color:White SolidPeso molecular:494.59Ref: TM-T11823
1mg154,00€5mg371,00€1mL*10mM (DMSO)404,00€10mg612,00€25mg1.189,00€50mg2.008,00€100mg3.132,00€NAMPT activator-6
CAS:NAMPT activator-6 regulates NAMPT/NAD⁺ optogenetic systems, used to construct PS-PROTACs for light-dependent reversible regulation and reduced toxicity.Fórmula:C17H21N5O3SForma y color:SolidPeso molecular:375.45Nampt-IN-15
CAS:Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Fórmula:C24H30N4O2Forma y color:SolidPeso molecular:406.52Nampt activator-4
CAS:Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].Fórmula:C26H22F3N7OSForma y color:SolidPeso molecular:537.56Nampt-IN-14
CAS:Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).Fórmula:C33H35N7O2Forma y color:SolidPeso molecular:561.68Nampt-IN-13
CAS:Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Fórmula:C24H30N6O2Forma y color:SolidPeso molecular:434.53PD-L1/Nampt-IN-1
CAS:PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.Fórmula:C28H28N4O2Forma y color:SolidPeso molecular:452.55CB30865
CAS:CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Fórmula:C26H22BrN5O2Pureza:99.04%Forma y color:SolidPeso molecular:516.39
