Transferasa
Las transferasas son una gran clase de enzimas que catalizan la transferencia de grupos funcionales, como grupos metilo, glicosilo y fosfato, de una molécula a otra. Los inhibidores de transferasas se utilizan para estudiar una amplia gama de procesos biológicos, incluyendo la transducción de señales, el metabolismo y la expresión génica. Estos inhibidores son herramientas esenciales en áreas de investigación como el cáncer, las enfermedades metabólicas y la epigenética, donde está implicada la disfunción de la actividad de las transferasas. En CymitQuimica, ofrecemos una selección integral de inhibidores de transferasas para apoyar su investigación en enzimología, señalización celular y mecanismos de enfermedad.
Se han encontrado 30 productos de "Transferasa"
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Cycloleucine
CAS:<p>Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM.</p>Fórmula:C6H11NO2Pureza:99.90%Forma y color:SolidPeso molecular:129.16Opicapone
CAS:<p>Opicapone (BIA 9-1067), a potent COMT inhibitor for Parkinson's studies, lowers cell ATP (IC50: 98 μM).</p>Fórmula:C15H10Cl2N4O6Pureza:98.17% - 99.36%Forma y color:SolidPeso molecular:413.17Sinbaglustat
CAS:<p>Sinbaglustat (OGT2378), an oral N-alkyl iminosugar, inhibits GCS/GBA2 and treats lysosomal storage and neurodegenerative disorders.</p>Fórmula:C11H23NO4Pureza:99.93%Forma y color:SolidPeso molecular:233.3Histamine glutarimide
CAS:<p>Histamine glutarimide is a novel QPCT inhibitor that targets inflammatory processes like eosinophil migration, showing anti-asthmatic effects in animal models.</p>Fórmula:C10H13N3O2Pureza:99.79%Forma y color:SolidPeso molecular:207.23FUT8-IN-1
<p>FUT8-IN-1 (Compound 37) is an inhibitor of α-1,6-fucosyltransferase (FUT8), with a dissociation constant (KD) of 49 nM and an IC50 around 50 µM. In the presence of FUT8, FUT8-IN-1 forms a highly active naphthoquinone imine intermediate, thereby inhibiting FUT8's enzymatic activity.</p>Fórmula:C23H25ClN2OForma y color:SolidPeso molecular:380.91β-1,4-GALT1-IN-1
<p>β-1,4-GALT1-IN-1 (Compound 6) is a β-1,4-GALT1 inhibitor with an IC50 value of 6.2 μM. It is applicable in studying various pathological conditions, including cancer, autoimmune diseases, and viral infections.</p>Fórmula:C29H23NO10Forma y color:SolidPeso molecular:545.494ST6 Sialyltransferase 5
<p>ST6Sialyltransferase5 (EC:2.4.3.3, ST6GALNAC5, SIAT7E, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) transfers sialic acid to N-acetylgalactosamine (GalNAc) residues. It may serve as a biomarker in cervical screening samples.</p>L-739750 2HCl
<p>L-739750 2HCl is a potent inhibitor of peptidomimetic farnesyltransferase, a novel pseudopeptide mimetic with potential anticancer activity.</p>Fórmula:C23H41Cl2N3O6S2Pureza:98.69% - 99.16%Forma y color:SoildPeso molecular:590.62Tipifarnib
CAS:<p>Tipifarnib (IND 58359), a quinolinone, inhibits farnesyl transferase, blocks Ras activation, arrests cell growth, and curbs angiogenesis.</p>Fórmula:C27H22Cl2N4OPureza:97.1% - 99.22%Forma y color:Off-White To Pale Beige SolidPeso molecular:489.4Ibiglustat
CAS:<p>Ibiglustat (GZ402671) inhibits Glucosylceramide synthase, may treat Fabry disease by preventing GL-3 synthesis.</p>Fórmula:C20H24FN3O2SPureza:97.97% - 98.81%Forma y color:SolidPeso molecular:389.49Entacapone
CAS:<p>Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).</p>Fórmula:C14H15N3O5Pureza:98.80% - >99.99%Forma y color:Yellow Crystalline SolidPeso molecular:305.29Tipifarnib (S enantiomer)
CAS:<p>Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).</p>Fórmula:C27H22Cl2N4OPureza:99.05%Forma y color:SolidPeso molecular:489.4PD 128042
CAS:<p>PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor.</p>Fórmula:C23H39NO4Pureza:99.79%Forma y color:SolidPeso molecular:393.56CP-609754
CAS:<p>CP-609754 shows selective inhibition of farnesyltransferase.</p>Fórmula:C29H22ClN3O2Pureza:99.04% - 99.86%Forma y color:SolidPeso molecular:479.96Nitecapone
CAS:<p>Nitecapone is a reversible inhibitor of S-COMT (IC50 values of 300 nM in rat liver)</p>Fórmula:C12H11NO6Pureza:98.39%Forma y color:SolidPeso molecular:265.22Ervogastat
CAS:<p>Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor.</p>Fórmula:C21H21N5O4Pureza:99.97%Forma y color:SolidPeso molecular:407.423-O-Methyltolcapone
CAS:<p>3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor.</p>Fórmula:C15H13NO5Pureza:98%Forma y color:SolidPeso molecular:287.27AMP-Deoxynojirimycin
CAS:<p>AMP-Deoxynojirimycin (AMP-DNM) is a ceramide glucosyltransferase and GCase 2 inhibitor for the study of Parkinson's and diabetes.</p>Fórmula:C22H39NO5Pureza:>99.99%Forma y color:SolidPeso molecular:397.55Lucerastat
CAS:<p>Lucerastat（NBDGJ） is an orally available inhibitor of GCS for Fabry disease by reducing harmful substrates.. GCS is a key enzyme in sphingolipid synthesiss.</p>Fórmula:C10H21NO4Pureza:98%Forma y color:SolidPeso molecular:219.28P-3FAX-Neu5Ac
CAS:<p>P-3FAX-Neu5Ac is a sialic acid analog and a sialyltransferase inhibitor.</p>Fórmula:C22H30FNO14Pureza:97.08%Forma y color:SolidPeso molecular:551.47Prenyl-IN-1
CAS:<p>Prenyl-IN-1 inhibits prenylation selectively, counters oxidative stress in Parkinson's.</p>Fórmula:C28H24ClN5O2Pureza:>99.99%Forma y color:SolidPeso molecular:497.98α-2,3-sialyltransferase-IN-1
CAS:<p>α-2,3-sialyltransferase-IN-1 is a noncompetitive inhibitor of α-2,3-sialyltransferase(IC50 of 6 μM).</p>Fórmula:C28H45NO6Pureza:98% - 98%Forma y color:SolidPeso molecular:491.66Ibiglustat (L-Malic acid)
CAS:<p>Ibiglustat (L-Malic acid) (Ibiglustat L-Malic acid) is a selective, brain-penetrant, and allosteric inhibitor of glucosylceramide synthase.</p>Fórmula:C24H30FN3O7SPureza:99.54%Forma y color:SolidPeso molecular:523.57OSMI-1
CAS:<p>OSMI-1: cell-permeable OGT inhibitor, blocks O-GlcNAcylation (IC50: 2.7 μM), no effect on other cell glycans.</p>Fórmula:C28H25N3O6S2Pureza:96.79% - 99.39%Forma y color:SolidPeso molecular:563.64Miglustat hydrochloride
CAS:<p>Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an inhibitor of glucosylceramide synthase and can be used for studies about Type I Gaucher</p>Fórmula:C10H22ClNO4Pureza:99.85%Forma y color:SolidPeso molecular:255.74FGTI-2734
CAS:<p>FGTI-2734, a dual FT/GGT-1 inhibitor (IC50: 250/520 nM), blocks KRAS membrane binding and curbs KRAS-driven pancreatic cancer.</p>Fórmula:C26H31FN6O2SPureza:99.69%Forma y color:SolidPeso molecular:510.63BMS-214662 mesylate
CAS:<p>BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.</p>Fórmula:C26H27N5O5S3Forma y color:SolidPeso molecular:585.718ICMT-IN-55
CAS:<p>ICMT-IN-55 (compound 31) acts as an ICMT inhibitor, exhibiting an IC50 value of 90 nM [1].</p>Fórmula:C22H26F3NO2Forma y color:SolidPeso molecular:393.44Glucosylceramide synthase-IN-4
CAS:<p>Glucosylceramide Synthase-IN-4 (compound 12) serves as a potent inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 of 6.8 nM. It demonstrates superior pharmacokinetic properties and robust stability in human hepatocytes. Additionally, this compound is noted for its effective CNS penetration and acceptable PXR selectivity [1].</p>Fórmula:C22H18F5N3O3Forma y color:SolidPeso molecular:467.39Darlifarnib
CAS:<p>Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.</p>Fórmula:C29H20N6OForma y color:SolidPeso molecular:468.509
