Deshidrogenasa
Las deshidrogenasas son enzimas involucradas en las reacciones de oxidación-reducción de las vías metabólicas, desempeñando un papel central en la producción de energía y la respiración celular. Estas enzimas son cruciales para procesos como el ciclo del ácido cítrico, la glucólisis y la oxidación de ácidos grasos. Los inhibidores de deshidrogenasas son herramientas importantes en el estudio de enfermedades metabólicas, cáncer y estrés oxidativo. En CymitQuimica, ofrecemos una selección completa de inhibidores de deshidrogenasas para apoyar su investigación en metabolismo, biología del cáncer y bioquímica.
Se han encontrado 302 productos de "Deshidrogenasa"
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DHODH-IN-13
CAS:<p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>Fórmula:C10H6F3N3O3Pureza:99.66%Forma y color:SolidPeso molecular:273.17DHODH-IN-15
CAS:DHODH-IN-15, a hydroxyfuran analogue of A771726, inhibits rat liver DHODH with an IC50 of 11 μM, and is used for rheumatoid arthritis.Fórmula:C15H11N3O3Pureza:99.8%Forma y color:SolidPeso molecular:281.27Ref: TM-T11024
1mg115,00€5mg255,00€10mg375,00€25mg562,00€50mg787,00€100mg1.074,00€200mg1.454,00€1mL*10mM (DMSO)239,00€DHODH-IN-1
CAS:<p>DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.</p>Fórmula:C21H20F3N3O2Pureza:99.76%Forma y color:SolidPeso molecular:403.4DHODH-IN-17
CAS:DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM.Fórmula:C12H9ClN2O2Pureza:99.52% - 99.99%Forma y color:SolidPeso molecular:248.67Ref: TM-T60364
5mg46,00€10mg69,00€25mg126,00€50mg182,00€100mg269,00€200mg376,00€1mL*10mM (DMSO)48,00€DHODH-IN-4
CAS:DHODH-IN-4 inhibits human & Plasmodium DHODH; IC50: 4 μM (Pf), 0.18 μM (Hs). It has antimalarial properties.Fórmula:C17H12Cl2N2O2Pureza:99.34%Forma y color:SolidPeso molecular:347.2Ref: TM-T11027
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)261,00€DHODH-IN-8
CAS:DHODH-IN-8 is a DHODH inhibitor with antimalarial properties, IC50: 0.13 μM (human), 47.4 μM (P. falciparum); Ki: 0.016 μM (human), 5.6 μM (P. falciparum).Fórmula:C17H13ClN2O2Pureza:99.78%Forma y color:SolidPeso molecular:312.75Ref: TM-T11030
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mgA consultar1mL*10mM (DMSO)249,00€BRD9185
CAS:BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.Fórmula:C23H21F6N3O2Pureza:98%Forma y color:SolidPeso molecular:485.42ML-148
CAS:ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).Fórmula:C20H21N3OPureza:99.88%Forma y color:SolidPeso molecular:319.4Ref: TM-T38163
1mg60,00€5mg165,00€10mg254,00€25mg459,00€50mg658,00€100mg935,00€200mg1.283,00€1mL*10mM (DMSO)188,00€hDHODH-IN-5
CAS:hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).Fórmula:C21H21F3N2O2Pureza:99.55%Forma y color:SolidPeso molecular:390.4Ref: TM-T11029
1mg85,00€5mg166,00€10mg234,00€25mg376,00€50mg560,00€100mg797,00€1mL*10mM (DMSO)175,00€11β-HSD1-IN-1
CAS:11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.Fórmula:C18H14ClF4N3OPureza:99.84%Forma y color:SolidPeso molecular:399.77Ref: TM-T10160
1mg52,00€5mg111,00€10mg163,00€25mg235,00€50mg330,00€100mg452,00€1mL*10mM (DMSO)118,00€hDHODH-IN-4
CAS:hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.Fórmula:C21H24N4O2Pureza:99.87%Forma y color:SolidPeso molecular:364.44AZD8329
CAS:AZD8329 is an 11β-HSD1 inhibitor that inhibits 11β-HSD2, 17β-HSD1, 17β-HSD3, and can be used to study allergic reactions in humans.Fórmula:C25H31N3O3Pureza:99.31%Forma y color:SolidPeso molecular:421.53Ref: TM-T14383
1mg92,00€5mg188,00€10mg311,00€25mg645,00€50mg947,00€100mg1.644,00€1mL*10mM (DMSO)215,00€ALDH1A1-IN-2
CAS:ALDH1A1-IN-2 is an aldehyde dehydrogenase 1a1 inhibitor with anticancer activity.ALDH1A1-IN-2 may be used in the study of breast cancer, inflammation or obesityFórmula:C25H23ClN4O3SPureza:99.48%Forma y color:SolidPeso molecular:494.99Manitimus
CAS:Manitimus is a potent immunosuppressive drug, and is an inhibitor of dehydroorotate dehydrogenase,.Fórmula:C15H11F3N2O2Pureza:99.75% - 99.75%Forma y color:SolidPeso molecular:308.26NCT-506
CAS:NCT-506 is an orally bioavailable inhibitors of aldehyde dehydrogenase 1A1 (ALDH1A1) (IC50 of 7 nM).Fórmula:C25H23FN4O3SPureza:98%Forma y color:SolidPeso molecular:478.54Metapramine
CAS:Metapramine, a tricyclic antidepressant, blocks norepinephrine reuptake and is a low-affinity NMDA antagonist.Fórmula:C16H18N2Pureza:99.03% - 99.67%Forma y color:SolidPeso molecular:238.33DS18561882
CAS:DS18561882: Potent MTHFD2 inhibitor (IC50=0.0063), inhibits MTHFD1 (IC50=0.57), good oral kinetics.Fórmula:C28H31F3N4O6SPureza:98.19% - >99.99%Forma y color:SolidPeso molecular:608.63Ref: TM-T11103
1mg115,00€5mg274,00€10mg432,00€25mg777,00€50mg1.264,00€100mg1.700,00€1mL*10mM (DMSO)378,00€PBRM
CAS:PBRM (17β-HSD1-IN-2) is a selective covalent inhibitor of 17β-HSD1, used in breast cancer and endometriosis research.Fórmula:C28H34BrNO2Pureza:99.56% - 99.59%Forma y color:SolidPeso molecular:496.48CPS-11
CAS:CPS-11, a Thalidomide analogue, shows potent, broad antitumor activity, especially in multiple myeloma cells.Fórmula:C14H12N2O5Pureza:99.8% - 99.98%Forma y color:SolidPeso molecular:288.26IDH2R140Q-IN-2
CAS:IDH2R140Q-IN-2 is an IDH2R140Q inhibitor indicated for the study of acute myeloid leukaemia (AML).Fórmula:C21H18F6N6OPureza:99.92%Forma y color:SolidPeso molecular:484.4ALDH1A3-IN-2
CAS:ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.Fórmula:C13H17NOPureza:99.84%Forma y color:SolidPeso molecular:203.28BMS-823778
CAS:BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.Fórmula:C18H18ClN3OPureza:99.39% - 99.75%Forma y color:SolidPeso molecular:327.81Ref: TM-T71394
1mg167,00€2mg246,00€5mg411,00€10mg562,00€25mg867,00€50mg1.121,00€100mg1.425,00€200mg1.882,00€HSD-016
CAS:HSD-016: Oral 11β-HSD1 inhibitor, active in humans, mice, rats (IC50: 11, 1, 8 nM), potential for type 2 diabetes research.Fórmula:C21H21F7N2O3SPureza:99.40% - >99.99%Forma y color:SolidPeso molecular:514.46Ref: TM-T63569
1mg88,00€5mg296,00€10mg464,00€25mg938,00€50mg1.568,00€100mg2.490,00€1mL*10mM (DMSO)328,00€Qc1
CAS:Qc1 is an inhibitor of threonine dehydrogenase (TDH) inhibitor and can be used in studies about metabolic diseases.Fórmula:C23H16F3N3O2SPureza:99.75%Forma y color:SolidPeso molecular:455.45G6PD activator AG1
CAS:G6PD activator AG1 is a G6PD agonist that promotes G6PD oligomerization to a catalytically competent form.Fórmula:C24H30N4S2Pureza:98.38% - 99.51%Forma y color:SolidPeso molecular:438.65Olorofim
CAS:Olorofim（F-901318）is a new selective antifungal compound that inhibits Aspergillus fumigatus DHODH (IC50: 44 nM). Cost-effective and quality-assured.Fórmula:C28H27FN6O2Pureza:99.28%Forma y color:SolidPeso molecular:498.55IGP-1
CAS:iGP-1 is a cell-permeable mitochondrial sn-Glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor.Fórmula:C17H15N3O3Pureza:99.12% - 99.15%Forma y color:SolidPeso molecular:309.32Ref: TM-T25526
2mg35,00€5mg52,00€10mg74,00€25mg133,00€50mg202,00€100mg321,00€200mg469,00€1mL*10mM (DMSO)88,00€CM037
CAS:CM037 (A-37) is a selective ALDH1A1 (acetaldehyde dehydrogenase 1A1) inhibitor (IC50; 4.6 µM) with antitumor activity and may be used in studies to eliminateFórmula:C21H25N3O3S2Pureza:99.77%Forma y color:SolidPeso molecular:431.57DSM421
CAS:DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shownFórmula:C14H11F5N6Pureza:99.67% - 99.82%Forma y color:SolidPeso molecular:358.27Ref: TM-T27214
1mg116,00€5mg273,00€10mg373,00€25mg563,00€50mg758,00€100mg998,00€200mg1.320,00€1mL*10mM (DMSO)319,00€IMPDH2-IN-2
CAS:IMPDH2-IN-2 is an IMPDH inhibitor with antimicrobial activity and potential anti-tuberculosis activity for the study of inflammation and immune dysfunction.Fórmula:C21H15Cl2N3O3Pureza:99.02%Forma y color:SolidPeso molecular:428.27PHGDH-IN-3
CAS:PHGDH-IN-3, an oral PHGDH blocker with 2.8 μM IC50, may help in cancer research.Fórmula:C24H18FN3O4S2Pureza:97.24% - 99.1%Forma y color:SolidPeso molecular:495.55PKUMDL-WQ-2101
CAS:PKUMDL-WQ-2101 is a selective allosteric inhibitor of phosphoglycerate dehydrogenase with anti-tumor activity.Fórmula:C14H11N3O6Pureza:99.57%Forma y color:SolidPeso molecular:317.25hDHODH-IN-7
CAS:hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor.Fórmula:C21H23FN4OPureza:99.87%Forma y color:SolidPeso molecular:366.43Ref: TM-T11031
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)266,00€15-PGDH-IN-2
CAS:15-PGDH-IN-2 (Compound 2) is an inhibitor of 15-PGDH with an IC50 value of 0.274 nM. This compound is useful for research into hair loss, bone formation, gastric ulcer healing, and dermal wound healing [1].Fórmula:C16H13NO3S2Forma y color:SolidPeso molecular:331.41Tetrahydro-11-dehydrocorticosterone
CAS:Tetrahydro-11-dehydrocorticosterone is an inhibitor of 11β-hydroxysteroid dehydrogenase [1].Fórmula:C21H32O4Forma y color:SolidPeso molecular:348.48AKR1C3-IN-6
CAS:AKR1C3-IN-6: Strong AKR1C3 inhibitor (IC50: 0.31 μM); weak on AKR1C2 (IC50: 73.23 μM); shows antitumor effects.Fórmula:C18H15F3N4O3Forma y color:SolidPeso molecular:392.33Anticancer agent 121
CAS:Anticancer agent 121, a human lactate dehydrogenase A (hLDHA) inhibitor, exhibits potent anticancer activities, suitable for use in anticancer research [1].Fórmula:C19H18N2O3SForma y color:SolidPeso molecular:354.42YG1702
CAS:YG1702, a potent inhibitor specific to ALDH18A1, suppresses the proliferation of MYCN-amplified neuroblastoma (NB) and reduces MYCN expression.Fórmula:C23H30N2O7SForma y color:SolidPeso molecular:478.56MK-0736 hydrochloride
CAS:MK-0736 hydrochloride is a potent and selective 11β-HSD-1 inhibitor.Fórmula:C23H31ClF3N3O2SForma y color:SolidPeso molecular:506.03DHODH-IN-22
CAS:DHODH-IN-22: potent, selective DHODH inhibitor, orally active, IC50: 0.3 nM, for AML research.Fórmula:C21H21ClF4N6O5Forma y color:SolidPeso molecular:548.88CHK-336
CAS:CHK-336 (Example 1), an orally active LDHA inhibitor (IC50 <1 nM), suppresses lactate production in mouse hepatocytes and is applicable in hyperoxaluriaFórmula:C24H20F2N4O4S2Forma y color:SolidPeso molecular:530.57MK-0736
CAS:MK-0736 is a potent and selective 11β-HSD-1 inhibitor.Fórmula:C23H30F3N3O2SForma y color:SolidPeso molecular:469.56PF-915275
CAS:PF-915275 inhibits 11βHSD1 in humans (Ki=2.3 nM, EC50=15 nM) and affects cortisone-cortisol conversion in hepatocytes.Fórmula:C18H14N4O2SPureza:99.58% - 99.61%Forma y color:SolidPeso molecular:350.39Ref: TM-T16510
1mg38,00€2mg49,00€5mg81,00€10mg127,00€25mg255,00€50mg499,00€100mg723,00€500mg1.510,00€1mL*10mM (DMSO)89,00€DHODH-IN-14
CAS:DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726.Fórmula:C15H7F4N3O3Pureza:99.81%Forma y color:SolidPeso molecular:353.23Ref: TM-T11023
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mgA consultar1mL*10mM (DMSO)264,00€S07-1066
CAS:S07-1066, an aldo-keto reductase 1C3 (AKR1C3) inhibitor, enhances doxorubicin (DOX) cytotoxicity by selectively inhibiting AKR1C3-mediated reduction of DOX andFórmula:C16H11Cl2FO2Pureza:98%Forma y color:SolidPeso molecular:325.16hDHODH-IN-1
CAS:hDHODH-IN-1 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an anti-inflammatory effect.Fórmula:C17H14N2O2Pureza:99.97%Forma y color:SolidPeso molecular:278.31Ref: TM-T11546
1mg35,00€5mg74,00€10mg109,00€25mg210,00€50mg306,00€100mg426,00€200mg575,00€1mL*10mM (DMSO)82,00€IDH889
CAS:IDH889: Brain-penetrant, mutant-specific IDH1 inhibitor; selective for IDH1 R132* mutations. IC50: 0.02μM (R132H), 0.072μM (R132C), 1.38μM (wild-type).Fórmula:C23H25FN6O2Pureza:≥98%Forma y color:SolidPeso molecular:436.4811α-Hydroxyprogesterone
CAS:11alpha-Hydroxyprogesterone, an inactive analogue of 11beta-Hydroxyprogesterone, serves as an experimental control. Meanwhile, 11beta-Hydroxyprogesterone functions as a potent inhibitor of 11β-Hydroxysteroid dehydrogenase and activates the human mineralocorticoid receptor in COS-7 cells, with an effective dose (ED)50 of 10 nM.Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.468HSD17B13-IN-2
CAS:HSD17B13-IN-2 (compound 1) serves as a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) with demonstrable activity in cellular experiments [1Fórmula:C21H23F2NO4Forma y color:SolidPeso molecular:391.41IDH1 Inhibitor 2
CAS:IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).Fórmula:C26H22N4OPureza:98%Forma y color:SolidPeso molecular:406.48AZD 4017
CAS:AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).Fórmula:C22H33N3O3SPureza:99.61%Forma y color:SolidPeso molecular:419.58Ref: TM-T14388
1mg73,00€5mg160,00€10mg274,00€25mg550,00€50mg792,00€100mg1.093,00€1mL*10mM (DMSO)170,00€Anticancer agent 122
CAS:Anticancer agent 122, a potent inhibitor of human lactate dehydrogenase A (h LDHA), exhibits significant anticancer activities, rendering it suitable for use inFórmula:C18H15ClN2O2SForma y color:SolidPeso molecular:358.84α-Pyridoin
CAS:α-Pyridoin (α-pyridoin) is an enediol (enediol) compound that acts as a unique antioxidant.Fórmula:C12H12N2O2Forma y color:SolidPeso molecular:216.24HSD17B13-IN-3
CAS:HSD17B13-IN-3 (compound 2) is a potent inhibitor of hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13), lacking cellular experimental activity [1].Fórmula:C22H21NO6S2Forma y color:SolidPeso molecular:459.5415-PGDH-IN-1
CAS:15-PGDH-IN-1: potent oral 15-PGDH inhibitor, IC50=3nM, useful for tissue repair research.Fórmula:C24H22N4O2Forma y color:SolidPeso molecular:398.46GSK321
CAS:GSK321 is an IDH1 inhibitor that prevents cytoplasmic glutamine reductive carboxylation.GSK321 is used in the study of leukemia.Fórmula:C28H28FN5O3Pureza:99.73%Forma y color:SolidPeso molecular:501.55CB29
CAS:<p>CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).</p>Fórmula:C15H15N3O5SPureza:99.36%Forma y color:SolidPeso molecular:349.36ALDH2 modulator 1
CAS:<p>ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.</p>Fórmula:C18H18ClFN2O3Pureza:99.68%Forma y color:SoildPeso molecular:364.8BI-3231
CAS:BI-3231 is a hydroxysteroid 17ß-dehydrogenase 13 HSD17B13 inhibitor that inhibits hHSD17B13 .BI-3231 can be used to study cirrhosis.Fórmula:C16H14F2N4O3SPureza:98.2%Forma y color:SolidPeso molecular:380.37Ref: TM-T73446
1mg72,00€5mg156,00€10mg235,00€25mg378,00€50mg540,00€100mg747,00€200mg1.035,00€1mL*10mM (DMSO)167,00€KB-74935
CAS:KB-74935: enzyme inhibitor, mineralocorticoid blocker, treats cholesterol, hypolipidemia, neurological issues, Alzheimer's.Fórmula:C19H18ClF4N3O3SPureza:99.4%Forma y color:SolidPeso molecular:479.88HSD17B13-IN-84
CAS:HSD17B13-IN-84 (182) serves as an inhibitor of 17β-Hydroxysteroid dehydrogenases (HSD17B13), exhibiting an IC50 of less than 0.1 μM for Estradiol. It is primarily utilized in the study of NAFLD (Nonalcoholic fatty liver diseases) [1].Fórmula:C19H12Cl2F3N3O3SPeso molecular:490.28Oxamic acid
CAS:Oxamic acid is an LDHA inhibitor, antitumor, induces apoptosis, downregulates EGFR expression, and inhibits cancer stem cell properties and EMT.Fórmula:C2H3NO3Forma y color:SolidPeso molecular:89.05HSD17B13-IN-95
CAS:HSD17B13-IN-95 (1) serves as an inhibitor for 17 β-hydroxysteroid dehydrogenase (HSD17B13), exhibiting an IC50 value of <0.1 μM for estradiol. It is applicable in researching nonalcoholic fatty liver disease [1].Fórmula:C24H16F6N4O4Peso molecular:538.40Mirivadelgat
CAS:Mirivadelgat is an activator of aldehyde dehydrogenase 2 (aldehyde dehydrogenase2). It is anticipated to be useful in research related to interstitial lung disease, pulmonary arterial hypertension, and cancer.Fórmula:C30H34FN3O5Peso molecular:535.607DSM705 hydrochloride
DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.Fórmula:C19H20ClF3N6OForma y color:SolidPeso molecular:440.85Deamino-NAD sodium
CAS:Deamino-NAD sodium, a structural analog of NAD+, serves as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH) in glycolysis. It exhibits a Km of 2300 pm and a Kd of 112 pm.Fórmula:C21H25N6NaO15P2Forma y color:SolidPeso molecular:686.39GSK864
CAS:GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).Fórmula:C30H31FN6O4Pureza:97.07%Forma y color:SolidPeso molecular:558.6T-3764518
CAS:T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).Fórmula:C20H17F6N5O2Pureza:98%Forma y color:SolidPeso molecular:473.37BRD7539
CAS:BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.Fórmula:C23H22FN3O2Pureza:98%Forma y color:SolidPeso molecular:391.44BI-4916
CAS:BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.Fórmula:C23H24Cl2N2O6SPureza:98.55%Forma y color:SolidPeso molecular:527.427-Hydroxy-4-phenylcoumarin
CAS:7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.Fórmula:C15H10O3Forma y color:SolidPeso molecular:238.238AXKO-0046
AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.Fórmula:C25H33N3Forma y color:SolidPeso molecular:375.55Etamicastat
CAS:Etamicastat can be used in the research of cardiovascular diseases.Fórmula:C14H15F2N3OSPureza:98%Forma y color:SolidPeso molecular:311.3511β-HSD2-IN-2
CAS:<p>11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.</p>Fórmula:C22H21NO2Pureza:99.61%Forma y color:SolidPeso molecular:331.41PDHK-IN-3
PDHK-IN-3 (compound 7) is a potent inhibitor of pyruvate dehydrogenase kinase(PDHK) with IC50s of 0.21 and 1.54 μM for PDHK2 and PDHK4, respectively [1].Fórmula:C17H16N2O2Forma y color:SolidPeso molecular:280.32MDH1/2-IN-1
CAS:<p>MDH1/2-IN-1 is an MDH1/2 inhibitor with IC50 values of 1.07 nM and 1.06 nM, respectively. It suppresses mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 exhibits significant antitumor potential and offers new avenues for developing drugs targeting cancer metabolism.</p>Fórmula:C25H33NO4Forma y color:SolidPeso molecular:411.534FXR/HSD17B13 modulator 1
CAS:FXR/HSD17B13 modulator 1 (compound 6) is an effective modulator of FXR/HSD17B13, playing a significant role in studies related to metabolic dysfunction-associated steatohepatitis (MASH).Fórmula:C26H19Cl2NO4Forma y color:SolidPeso molecular:480.339RORγt/DHODH-IN-1
CAS:RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significantFórmula:C24H26ClF6N3O3SForma y color:SolidPeso molecular:585.99Indoluidin E
Indoluidin E selectively inhibits DHODH and has an inhibitory effect on cancer cell growth.Fórmula:C28H30N4O2Forma y color:SolidPeso molecular:454.56PDHK-IN-4
PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.Fórmula:C24H25N5O3Forma y color:SolidPeso molecular:431.49hDHODH-IN-10
hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.Fórmula:C21H15ClF4N2O4Forma y color:SolidPeso molecular:470.8PDHK-IN-5
PDHK-IN-5, potent PDHK2 (0.006 μM IC50) & PDHK4 (0.0329 μM IC50) inhibitor, may be explored for cancer and diabetes treatment.Fórmula:C30H31N5O2Forma y color:SolidPeso molecular:493.6PHGDH-IN-2
PHGDH-IN-2: potent PHGDH inhibitor, IC50=5.2μM; hinders PHGDH cancer cell growth & serine synthesis in MDA-MB-468.Fórmula:C22H20N4O3SForma y color:SolidPeso molecular:420.48AKR1C3-IN-7
AKR1C3-IN-7 (Compound 13) is an effective and selective AKR1C3 inhibitor (IC50=0.19 μM). AKR1C3-IN-7 has antitumor activity.Fórmula:C24H20N2O4Forma y color:SolidPeso molecular:400.43AKR1C3-IN-8
AKR1C3-IN-8 (Compound 5) is an effective and selective AKR1C3 inhibitor (IC50=0.069 μM). AKR1C3-IN-8 has antitumor activity.Fórmula:C23H20N4O3Forma y color:SolidPeso molecular:400.43(6S)-CP-470711
CAS:(6S)-CP-470711 (Compound 8) acts as an inhibitor of sorbitol dehydrogenase (SDH) in both humans and rats, exhibiting inhibitory concentrations (IC50) of 19 nM and 27 nM, respectively. Additionally, (6S)-CP-470711 has been shown to ameliorate diabetes in rats induced by Streptozotocin.Fórmula:C18H26N6O2Forma y color:SolidPeso molecular:358.44LDHA-IN-5
CAS:LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primaryFórmula:C27H22FN7O6S3Forma y color:SolidPeso molecular:655.7HSD17B13-IN-28
CAS:HSD17B13-IN-28 (compound 47) is a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), with an IC50 of < 0.1 μM using estradiol as a substrate. HSD17B13-IN-28 plays an important role in nonalcoholic fatty liver diseases (NAFLDs), including NASH (nonalcoholic steatohepatitis) [1].Fórmula:C23H16Cl2FN3O3Forma y color:SolidPeso molecular:472.3HSD17B13-IN-17
CAS:HSD17B13-IN-17 (compound 9) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13). It demonstrates inhibitory efficacy with IC50 values of ＜0.1 μM for estradiol and ＜1 μM for Leukotriene B3 as substrates. This compound is significant in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C20H16ClFN2O3SPeso molecular:418.87HSD17B13-IN-19
CAS:HSD17B13-IN-19 (compound 16) acts as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting IC50 values under 0.1 μM and under 1 μM when using estradiol and Leukotriene B3 as substrates, respectively. This compound is crucial in the treatment of nonalcoholic fatty liver diseases (NAFLDs), such as nonalcoholic steatohepatitis (NASH) [1].Fórmula:C23H23FN2O4SPeso molecular:442.5HSD17B13-IN-44
CAS:HSD17B13-IN-44 (Compound 23) functions as an inhibitor targeting hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of < 0.1 μM against estradiol. This compound is applicable in the study of liver diseases or metabolic disorders [1].Fórmula:C18H14FNO5S2Peso molecular:407.4417β-HSD1-IN-1
17β-HSD1-IN-1 (Compound 1) can be used in the non-small cell lung cancer (NSCLC) research.Fórmula:C21H21NO3Forma y color:SolidPeso molecular:335.4HSD17B13-IN-30
CAS:HSD17B13-IN-30 (compound 64) serves as a potent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), exhibiting an IC 50 value of less than 0.1 μM? with estradiol? as substrates. This compound is significantly implicated in the management of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C24H16Cl2F3N3O4Forma y color:SolidPeso molecular:538.315-epi-PGE1
CAS:15-epi-PGE1 (15R-Prostaglandin E1; 15-Epiprostaglandin E1), a stereoisomer of PGE1, exhibits reduced biological activity [2]. This compound acts as a non-competitive inhibitor of human placental 15-Hydroxyprostaglandin dehydrogenase (15-PGDH), with an inhibitory concentration 50 (IC50) value of 170 μM [1].Fórmula:C20H34O5Peso molecular:354.48HSD17B13-IN-32
CAS:HSD17B13-IN-32 (Compound 67) is an inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13) with an IC50 value of ≤0.1 μM for estradiol. It can be used for research on liver diseases, metabolic diseases, or cardiovascular diseases, such as NAFLD or NASH, as well as drug-induced liver injury (DILI) [1].Fórmula:C23H15Cl2N5O3Peso molecular:480.3HSD17B13-IN-40
CAS:HSD17B13-IN-40 (compound 6) serves as a potent inhibitor of hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), exhibiting an IC50 value of less than 0.1 μM using estradiol as substrates. This compound is significant in the treatment of nonalcoholic fatty liver diseases (NAFLDs), including nonalcoholic steatohepatitis (NASH) [1].Fórmula:C23H14Cl2F3N3O3Peso molecular:508.28RORγt/DHODH-IN-3
RORγt/DHODH-IN-3 (compound (S)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.098 μM) and DHODH (IC50: 0.432 μM).RORγt/DHODH-IN-1 hasFórmula:C24H26ClF6N3O3SForma y color:SolidPeso molecular:585.99Etamicastat hydrochloride
CAS:<p>Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.</p>Fórmula:C14H16ClF2N3OSPureza:98.54%Forma y color:SolidPeso molecular:347.81CP-642931
CAS:CP-642931 (Sorbitol dehydrogenase-IN-1) is a sorbitol dehydrogenase inhibitor used in the study of diabetes mellitus and cardiovascular disease.Fórmula:C17H25N7OPureza:99.67% - >99.99%Forma y color:SolidPeso molecular:343.43GNE-140 racemate
CAS:GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.Fórmula:C25H23ClN2O3S2Forma y color:SolidPeso molecular:499.04(S)-GNE-140
CAS:(S)-GNE-140 is the less active enantiomer of GNE-140.Fórmula:C25H23ClN2O3S2Forma y color:SolidPeso molecular:499.0511β-HSD1-IN-8
CAS:11β-HSD1-IN-8 is a useful organic compound for research related to life sciences. The catalog number is T65743 and the CAS number is 386704-15-0.Fórmula:C10H8F3NO3Forma y color:SolidPeso molecular:247.173
