Deshidrogenasa
Las deshidrogenasas son enzimas involucradas en las reacciones de oxidación-reducción de las vías metabólicas, desempeñando un papel central en la producción de energía y la respiración celular. Estas enzimas son cruciales para procesos como el ciclo del ácido cítrico, la glucólisis y la oxidación de ácidos grasos. Los inhibidores de deshidrogenasas son herramientas importantes en el estudio de enfermedades metabólicas, cáncer y estrés oxidativo. En CymitQuimica, ofrecemos una selección completa de inhibidores de deshidrogenasas para apoyar su investigación en metabolismo, biología del cáncer y bioquímica.
Se han encontrado 269 productos de "Deshidrogenasa"
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DHODH-IN-8
CAS:<p>DHODH-IN-8 is a DHODH inhibitor with antimalarial properties, IC50: 0.13 μM (human), 47.4 μM (P. falciparum); Ki: 0.016 μM (human), 5.6 μM (P. falciparum).</p>Fórmula:C17H13ClN2O2Pureza:99.78%Forma y color:SolidPeso molecular:312.75BI-135585
CAS:<p>BI-135585 is an orally active, selective and potent inhibitor of human 11β-hydroxysteroid dehydrogenase-1 (HSD1) for the study of type 2 diabetes.</p>Fórmula:C28H32N2O4Pureza:99.45% - 99.57%Forma y color:SolidPeso molecular:460.57Manitimus
CAS:<p>Manitimus is a potent immunosuppressive drug, and is an inhibitor of dehydroorotate dehydrogenase,.</p>Fórmula:C15H11F3N2O2Pureza:99.75% - 99.75%Forma y color:SolidPeso molecular:308.26DHODH-IN-21
CAS:<p>DHODH-IN-21, orally active DHODH blocker with 1.1 nM IC50, shows anticancer activity, potential for AML research.</p>Fórmula:C20H19ClF4N6O4Forma y color:SolidPeso molecular:518.85P1788
CAS:<p>P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor that can induce DNA damage [1].</p>Fórmula:C15H17NO3Forma y color:SolidPeso molecular:259.3Epostane
CAS:<p>Epostane is a 3β-hydroxysteroid dehydrogenase inhibitor that blocks the biosynthesis of progesterone and pregnenolone.Cost-effective and quality-assured.</p>Fórmula:C22H31NO3Pureza:>99.99%Forma y color:SolidPeso molecular:357.49CM026
CAS:<p>CM026 inhibits ALDH1A1 selectively, binds to its aldehyde pocket uncompetitively.</p>Fórmula:C22H30N6O4Forma y color:SolidPeso molecular:442.5111β-HSD1-IN-9
CAS:<p>11β-HSD1-IN-9 is a potent inhibitor of 11β-HSD1, displaying IC50 values of 0.48 µM for human and 1.3 µM for murine variants, respectively.</p>Fórmula:C13H9F3N2OForma y color:SolidPeso molecular:266.22ML387
CAS:<p>ML387 is an inhibitor of human NAD(+)- dependent 15- hydroxyprostaglandin dehydrogenase.</p>Fórmula:C20H21N3O2Pureza:98%Forma y color:SolidPeso molecular:335.4ALDH3A1-IN-2
CAS:<p>ALDH3A1-IN-2 is a potent inhibitor targeting ALDH3A1 (IC50=1.29µM), potentially useful in cancer research.</p>Fórmula:C11H14N2O3Forma y color:SolidPeso molecular:222.24Oxycinchophen
CAS:<p>Oxycinchophen: Quinoline-based anti-rheumatic with P-selectin inhibition, DHOD blockade, and anti-inflammatory impacts on vascular muscle.</p>Fórmula:C16H11NO3Pureza:98%Forma y color:SolidPeso molecular:265.26GW648495
CAS:<p>GW648495 is a PfDHODH inhibitor that shows greater than 4,000-fold selectivity for the malarial enzyme.</p>Fórmula:C16H13N5Pureza:98%Forma y color:SolidPeso molecular:275.31BVT-116429
CAS:<p>BVT-116429 is an inhibitor of 11β-HSD1.</p>Fórmula:C13H12F4N2OSPureza:98%Forma y color:SolidPeso molecular:320.31AGI-14100
CAS:<p>AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.</p>Fórmula:C29H22ClF4N5O3Pureza:99.91%Forma y color:SolidPeso molecular:599.96DHODH-IN-3
CAS:<p>DHODH-IN-3: Human DHODH inhibitor with IC50 of 261 nM, Kiapp 32 nM, potential anti-malaria drug.</p>Fórmula:C17H13ClN2O2Pureza:98%Forma y color:SolidPeso molecular:312.75GA11
CAS:<p>GA11is an inhibitor of ALDH1. It also displays anti-GBM effects in vitro and in vivo.</p>Fórmula:C19H14N2Pureza:98%Forma y color:SolidPeso molecular:270.33RS6212
CAS:<p>RS6212 is a specific lactate dehydrogenase (LDH) inhibitor (IC50=12.03 μ M）。 RS6212 shows strong anticancer activity in a variety of cancer cell lines.</p>Fórmula:C20H22N4O3SForma y color:SolidPeso molecular:398.48TM-1
CAS:<p>TM-1: PDHK inhibitor, IC50 - PDHK1: 2.97μM, PDHK2: 5.2μM, prevents PDHC phosphorylation, inhibits cancer cell growth.</p>Fórmula:C26H32N2O6Forma y color:SolidPeso molecular:468.54RORγt/DHODH-IN-2
CAS:<p>RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor that can be used in the study of inflammatory bowel disease (IBD).</p>Fórmula:C25H30N4OSForma y color:SolidPeso molecular:434.6ASP3662
CAS:<p>ASP3662/SPI-62: Potent, selective CNS-penetrable 11β-HSD1 inhibitor; potential neuropathic pain treatment.</p>Fórmula:C19H16ClF3N4O2Forma y color:SolidPeso molecular:424.8Metapramine
CAS:<p>Metapramine, a tricyclic antidepressant, blocks norepinephrine reuptake and is a low-affinity NMDA antagonist.</p>Fórmula:C16H18N2Pureza:99.03% - 99.67%Forma y color:SolidPeso molecular:238.33DHODH-IN-19
CAS:<p>DHODH-IN-19, a strong DHODH blocker, may help treat cancer and inflammation. (Patent WO2021238881A1)</p>Fórmula:C22H18ClF6N3O3Forma y color:SolidPeso molecular:521.84673-A
CAS:<p>673-A inhibits ALDH1A, depletes ovarian CSCs, induces necroptosis, and reverses chemo resistance.</p>Fórmula:C15H13NOForma y color:SolidPeso molecular:223.2711β-HSD1-IN-10
CAS:<p>11β-HSD1-IN-10, a potent inhibitor of 11β-HSD1 with an IC50 value of 1.8 µM for humans, is suitable for research into obesity, hyperglycemia, and cognitive</p>Fórmula:C16H10F3NO2Forma y color:SolidPeso molecular:305.25AMG-221
CAS:<p>AMG-221: potent 11β-HSD1 inhibitor, lowers glucose & insulin, reduces obesity in mice.</p>Fórmula:C14H22N2OSPureza:98%Forma y color:SolidPeso molecular:266.4UCK2 Inhibitor-2
CAS:<p>UCK2 Inhibitor-2 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2) with IC50=3.8 µM that inhibits UCK2-mediated nucleoside recycling in cells.</p>Fórmula:C28H23N3O4SPureza:98.76% - 99.25%Forma y color:SolidPeso molecular:497.57DHODH-IN-12
CAS:<p>DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.</p>Fórmula:C10H9N3O2Pureza:99.53%Forma y color:SolidPeso molecular:203.2BRD9185
CAS:<p>BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.</p>Fórmula:C23H21F6N3O2Pureza:98%Forma y color:SolidPeso molecular:485.42DHODH-IN-20
CAS:<p>Dhodh-in-20 (Compound 133), a potent DHODH inhibitor, may help study acute myeloid leukemia and inhibit tumor growth.</p>Fórmula:C24H25F4N3O3Forma y color:SolidPeso molecular:479.47hDHODH-IN-4
CAS:<p>hDHODH-IN-4, a potent DHODH inhibitor, has a pIC50 of 7.8 and blocks measles virus replication with a pMIC50 of 8.8.</p>Fórmula:C21H24N4O2Pureza:99.87%Forma y color:SolidPeso molecular:364.44ALDH1A1-IN-3
CAS:<p>ALDH1A1-IN-3 selectively inhibits ALDH1A1, enhances HepG2 glucose consumption for metabolic research.</p>Fórmula:C31H36F3N5O4Forma y color:SolidPeso molecular:599.64BI-4924
CAS:<p>BI-4924 is a PHGDH inhibitor that disrupts serine biosynthesis by intracellular trapping and can be used to study metabolic disorders.</p>Fórmula:C21H20Cl2N2O6SPureza:99.55%Forma y color:SolidPeso molecular:499.36AZD8329
CAS:<p>AZD8329 is an 11β-HSD1 inhibitor that inhibits 11β-HSD2, 17β-HSD1, 17β-HSD3, and can be used to study allergic reactions in humans.</p>Fórmula:C25H31N3O3Pureza:99.31%Forma y color:SolidPeso molecular:421.53KM04416
CAS:<p>KM04416 is a GPD2 inhibitor that inhibits LUAD progression by modulating immune cell infiltration.</p>Fórmula:C12H11NO3SPureza:99.88%Forma y color:SolidPeso molecular:249.29ALDH1A1-IN-2
CAS:<p>ALDH1A1-IN-2 is an aldehyde dehydrogenase 1a1 inhibitor with anticancer activity.ALDH1A1-IN-2 may be used in the study of breast cancer, inflammation or obesity</p>Fórmula:C25H23ClN4O3SPureza:99.48%Forma y color:SolidPeso molecular:494.99M77976
CAS:<p>M77976 inhibits PDK4 with an IC50 of 648 μM, targeting obesity and diabetes research.</p>Fórmula:C17H16N2O3Pureza:99.43%Forma y color:SolidPeso molecular:296.32Laflunimus
CAS:<p>Laflunimus (HR325) is a DHODH inhibitor that inhibits immunoglobulin secretion in vitro and in vivo,by interfering with pyrimidine metabolism,neuralgia.</p>Fórmula:C15H13F3N2O2Pureza:99.86%Forma y color:SolidPeso molecular:310.27hDHODH-IN-9
CAS:<p>hDHODH-IN-9 is a potent hDHODH inhibitor, IC50=0.34 μM, toxic to MCF-7/A375 cells, promising for cancer research.</p>Fórmula:C21H21NO4Forma y color:SolidPeso molecular:351.411β-HSD1-IN-12
CAS:<p>11β-HSD1-IN-12 is an 11β-HSD1 inhibitor.11β-HSD1-IN-12 is implicated in the conversion of glucocorticoids in vivo and can be used to study metabolic syndrome</p>Fórmula:C19H27ClN2O3SPureza:99.68%Forma y color:SolidPeso molecular:398.95hDHODH-IN-11
CAS:<p>hDHODH-IN-11: potent hDHODH inhibitor, IC50 7.2 nM, low cytotoxicity, for AML research.</p>Fórmula:C24H23N3O3Forma y color:SolidPeso molecular:401.46DHODH-IN-4
CAS:<p>DHODH-IN-4 inhibits human & Plasmodium DHODH; IC50: 4 μM (Pf), 0.18 μM (Hs). It has antimalarial properties.</p>Fórmula:C17H12Cl2N2O2Pureza:99.34%Forma y color:SolidPeso molecular:347.2RV01
CAS:<p>RV01, a resveratrol-like quinoline, inhibits DNA damage, ALDH2 expression, and has antioxidant and anti-inflammatory properties.</p>Fórmula:C17H13NO2Pureza:99.93%Forma y color:SolidPeso molecular:263.29hDHODH-IN-3
CAS:<p>hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.</p>Fórmula:C18H19BrN4O2Pureza:99.871%Forma y color:SolidPeso molecular:403.27Genz-669178
CAS:<p>Genz-669178 is a wild-type inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).</p>Fórmula:C17H14N4OSPureza:98%Forma y color:SolidPeso molecular:322.38DHODH-IN-24
CAS:<p>DHODH-IN-24 (compound 16) serves as a powerful inhibitor of human dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value of 91 nM [1].</p>Fórmula:C26H26N4Forma y color:SolidPeso molecular:394.51ML-148
CAS:<p>ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM).</p>Fórmula:C20H21N3OPureza:99.88%Forma y color:SolidPeso molecular:319.4EN40
CAS:<p>EN40, as a covalent ligand, is a selective inhibitor of aldehyde dehydrogenase 3A1 (IC50: 2 uM).</p>Fórmula:C13H15NO2Forma y color:SolidPeso molecular:217.26DHODH-IN-13
CAS:<p>DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.</p>Fórmula:C10H6F3N3O3Pureza:99.66%Forma y color:SolidPeso molecular:273.17MEDS433
CAS:<p>MEDS433 inhibits dihydroorotate dehydrogenase (IC50 1.2 nM) and blocks replication of hCoV-OC43, hCoV-229E, SARS-CoV-2 at nanomolar levels.</p>Fórmula:C20H11F4N3O2Forma y color:SolidPeso molecular:401.31CM39
CAS:<p>CM39 inhibits ALDH, linked to cancer stem-like cells & chemoresistance.</p>Fórmula:C19H15FN4OSForma y color:SolidPeso molecular:366.41
