PKM
La Piruvato Quinasa M2 (PKM2) es una isoforma de la piruvato quinasa que desempeña un papel crucial en la glucólisis, convirtiendo fosfoenolpiruvato en piruvato. PKM2 está involucrada en la regulación de la reprogramación metabólica en células cancerosas, lo que la convierte en un objetivo potencial para la terapia contra el cáncer. Los inhibidores de PKM2 pueden alterar las vías metabólicas, reducir el crecimiento tumoral e inducir la muerte celular en las células cancerosas. En CymitQuimica, ofrecemos inhibidores de PKM2 para apoyar su investigación en metabolismo del cáncer, oncología y desarrollo terapéutico.
Se han encontrado 17 productos de "PKM"
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PKR-IN-2
CAS:PKR-IN-2 is a activator of pyruvate kinase (PKR).Fórmula:C24H28N4O4SPureza:99.14%Forma y color:SolidPeso molecular:468.57Dimethylaminomicheliolide HCl
CAS:Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvateFórmula:C17H28ClNO3Pureza:99.91%Forma y color:SoildPeso molecular:329.86PKM2 inhibitor G
CAS:<p>PKM2 inhibitor G is a inhibitor of pyruvate kinase.</p>Fórmula:C16H15NO3SPureza:99.89%Forma y color:SoildPeso molecular:301.36PKM2 activator 7
PKM2 activator 7 (Compd B4) is a PKM2 activator with an AC50 value of 0.144 μM. It functions by inhibiting the growth of T cells, thereby alleviating DSS-induced colitis in mice.Fórmula:C16H19F3O4Peso molecular:332.12354PKM2-IN-10
PKM2-IN-10 is a PKM2 inhibitor. It effectively suppresses the proliferation of A549 and HCC1833 cell lines with IC50 values of 3.36 μM and 9.20 μM, respectively. PKM2-IN-10 demonstrates antitumor activity in human non-small cell lung cancer (NSCLC) and mouse lung adenocarcinoma models. It is applicable for research in lung cancer.Fórmula:C21H15F4N5Forma y color:SolidPeso molecular:413.12636PKCζ/ι pseudosubstrate inhibitor
CAS:PKCζ/ι pseudosubstrate inhibitor demonstrates comprehensive inhibitory activity across the protein kinase C (PKC) family and is associated with the induction ofFórmula:C76H128N30O16Forma y color:SolidPeso molecular:1718.02Mitapivat sulfate hydrate
CAS:Mitapivat sulfate hydrate (AG 348 sulfate hydrate) is a pyruvate kinase (PK) allosteric activator, used to study pyruvate kinase deficiency.Fórmula:C24H26N4O3S1H2SO43H2OPureza:99.22%Forma y color:SolidPeso molecular:526.6DASA-58
CAS:DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.Fórmula:C19H23N3O6S2Pureza:96.96% - 99.28%Forma y color:SolidPeso molecular:453.53Mitapivat
CAS:Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.Fórmula:C24H26N4O3SPureza:99.47% - 99.83%Forma y color:SolidPeso molecular:450.55PKM2-IN-1
CAS:PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.Fórmula:C18H19NO2S2Pureza:99.49% - 99.68%Forma y color:SolidPeso molecular:345.48TEPP-46
CAS:TEPP-46 (ML265) is an activator of pyruvate kinase M2 (PKM2), selective for PKM1, PKL and PKR. TEPP-46 has antitumor activity. Cost-effective and quality-assured.Fórmula:C17H16N4O2S2Pureza:98.21% - 99.65%Forma y color:SolidPeso molecular:372.46PKM2 activator 5
CAS:PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.Fórmula:C18H19FN2O6S2Pureza:98%Forma y color:SolidPeso molecular:442.48PKM2 activator 2
CAS:<p>PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates</p>Fórmula:C20H18F2N2O4S2Pureza:99.92%Forma y color:SolidPeso molecular:452.49NPD10084
CAS:NPD10084 is an inhibitor of pyruvate kinase PKM2 that blocks non-glycolytic signaling in cancer cells by disrupting PKM2's interaction with β-catenin or STAT3, thus inhibiting downstream pathways. It demonstrates antiproliferative effects against colorectal cancer cells both in vitro and in vivo [1].Fórmula:C21H19N3O2Peso molecular:345.39Mitapivat hydrochloride
CAS:Mitapivat (AG-348) hydrochloride is an orally active and selective allosteric activator of pyruvate kinase R (PK-R). It enhances the PK-R-catalyzed conversion of phosphoenolpyruvate to pyruvate, thereby promoting the glycolysis pathway, increasing ATP production in red blood cells, and decreasing 2,3-diphosphoglycerate (2,3-DPG) levels. Mitapivat hydrochloride is being investigated for potential use in the study of pyruvate kinase deficiency and other anemia-related disorders.Fórmula:C24H27ClN4O3SForma y color:SolidPeso molecular:487.014PKM2-IN-9
CAS:PKM2-IN-9 (compound C1) is a potent inhibitor of PKM2, demonstrating a 75% inhibition rate at 50 μM. It plays a significant role in cancer research.Fórmula:C24H22N4O2Forma y color:SolidPeso molecular:398.457PKR Inhibitor, negative control
CAS:<p>The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.</p>Fórmula:C15H8Cl3NO2Peso molecular:340.59
