Neurociencia
Los inhibidores en neurociencia son compuestos diseñados para modular la actividad de proteínas, enzimas o receptores específicos dentro del sistema nervioso. Estos inhibidores son cruciales para estudiar los mecanismos moleculares subyacentes a la función neuronal, la transmisión sináptica y las enfermedades neurodegenerativas. Al dirigirse a los receptores de neurotransmisores, canales iónicos y vías de señalización, los inhibidores en neurociencia ayudan en la exploración de la función cerebral y en el desarrollo de estrategias terapéuticas para trastornos neurológicos como el Alzheimer, Parkinson y la epilepsia. En CymitQuimica, ofrecemos una amplia gama de inhibidores de neurociencia de alta calidad para apoyar su investigación en neurobiología, neurofarmacología y ciencias cognitivas.
Subcategorías de "Neurociencia"
- Receptor 5-HT(940 productos)
- ACK(1 productos)
- AChR(574 productos)
- ATP Citrato Liasa(16 productos)
- Receptor adrenérgico(2.939 productos)
- BACE(36 productos)
- Beta amiloide(204 productos)
- CAMK(68 productos)
- Inhibidores de ciclooxigenasa (COX)(562 productos)
- Receptor de dopamina(407 productos)
- Receptor GABA(336 productos)
- Gamma-secretasa(59 productos)
- GluR(255 productos)
- GlyT(24 productos)
- Receptor de histamina(358 productos)
- LRRK2(33 productos)
- Receptor de melatonina(24 productos)
- NMDAR(28 productos)
- Receptor de OX(40 productos)
- Receptor de opioides(296 productos)
Mostrar 12 subcategorías más
Se han encontrado 5400 productos de "Neurociencia"
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CEase-IN-1
<p>CEase-IN-1 (A1H3), potent CEase inhibitor, IC50 0.36μM, for hypercholesterolemia study.</p>Fórmula:C13H15F3N2O2Forma y color:SolidPeso molecular:288.27AAK1-IN-2 TFA
<p>AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.</p>Fórmula:C24H22F6N4O4Forma y color:SolidPeso molecular:544.45Terguride
CAS:<p>Terguride: treats hyperprolactinemia, blocks 5-HT2A/B, activates dopamine receptors, studied for PAH.</p>Fórmula:C20H28N4OForma y color:SolidPeso molecular:340.46AAK1-IN-3 TFA
<p>AAK1-IN-3 TFA, an AAK1 inhibitor with IC50 of 11 nM, crosses the blood-brain barrier, is a quinoline analogue, and may aid neuropathic pain research.</p>Fórmula:C24H22F6N4O4Forma y color:SolidPeso molecular:544.45LY 541850
CAS:<p>LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human</p>Fórmula:C9H13NO4Pureza:98%Forma y color:SolidPeso molecular:199.2Befiradol hydrochloride
CAS:<p>Befiradol HCl (NLX-112) is a selective 5-HT1A receptor agonist with anxiolytic effects and prevents ATXN3 aggregation.</p>Fórmula:C20H23Cl2F2N3OPureza:99.1%Forma y color:SolidPeso molecular:430.32LY3020371 hydrochloride
CAS:<p>LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.</p>Fórmula:C15H16ClF2NO5SForma y color:SolidPeso molecular:395.81Monoamine Oxidase B inhibitor 2
<p>MAO-B inhibitor 2: potent, reversible, oral, selective (IC50=1.33 nM), BBB-penetrant, with anti-oxidant and anti-inflammatory effects for Parkinson's study.</p>Fórmula:C19H19FO3Forma y color:SolidPeso molecular:314.35GABAA receptor agonist 2
<p>Compound 4c, a potent GABAA agonist with anti-depressive effects in mouse FST/TST, shows promise in depression research.</p>Fórmula:C22H36O5Forma y color:SolidPeso molecular:380.52(S)-Praziquantel
CAS:<p>(S)-Praziquantel is the inactive isomer of R-praziquantel.</p>Fórmula:C19H24N2O2Forma y color:SolidPeso molecular:312.406AChE-IN-84
CAS:<p>AChE-IN-84 (compound 21) is an inhibitor of AChE.</p>Fórmula:C6H15Br2NForma y color:SolidPeso molecular:260.998AChE-IN-8
<p>AChE-IN-8 (Compound 19), potent acetylcholinesterase blocker; IC50 = 1.95 μM; potential Alzheimer's treatment.</p>Fórmula:C20H22N4O2SForma y color:SolidPeso molecular:382.48Tebideutorexant
CAS:<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Fórmula:C23H16D2F4N4O2Pureza:98.89%Forma y color:SolidPeso molecular:460.42Amyloid-β-IN-3
CAS:<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Fórmula:C22H21F2N3O2Forma y color:SolidPeso molecular:397.42CPPG
CAS:<p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>Fórmula:C11H14NO5PForma y color:SolidPeso molecular:271.21(RS)-AMPA hydrochloride
CAS:<p>(RS)-AMPA ((±)-AMPA) hydrochloride is a glutamate analog and serves as an efficient selective agonist for the excitatory neurotransmitter L-glutamic acid (L-glutamic acid). It does not interfere with the binding sites of alginate or NMDA receptors.</p>Fórmula:C7H11ClN2O4Forma y color:SolidPeso molecular:222.63Aβ42-IN-1
CAS:<p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>Fórmula:C29H27ClN4O2Pureza:98%Forma y color:SolidPeso molecular:499GABA-IN-4
CAS:<p>GABA-IN-4 (Compound 17) is a derivative of N-(indol-3-ylglyoxylyl)benzylamine. It exhibits high affinity for the benzodiazepine receptor (BzR), the binding site within the GABAA receptor complex, with a Ki value of 67 nM. Benzodiazepines are widely used as anxiolytic, sedative-hypnotic, and anticonvulsant agents.</p>Fórmula:C17H13ClN2O2Forma y color:SolidPeso molecular:312.75DAPM
CAS:<p>DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.</p>Fórmula:C20H20F2N2O4Pureza:99.76%Forma y color:SolidPeso molecular:390.38R-96544 hydrochloride
CAS:<p>5-HT2 receptor antagonist</p>Fórmula:C22H29NO3Pureza:98%Forma y color:SolidPeso molecular:355.47HW161023
CAS:<p>HW161023 (compound) is an orally active inhibitor of AP2 associated protein kinase 1 (AAK1), exhibiting IC50 values of 5.4 nM for AAK1 and 11.9 μM for hERG. HW161023 can suppress pain response in a rat model of chronic sciatic nerve compression injury.</p>Fórmula:C20H24F2N4OForma y color:SolidPeso molecular:374.428MADAM
CAS:<p>MADAM demonstrates high affinity and selectivity for 5-HTT, with a Ki value of 1.6 nM. It is utilized as a PET radiotracer for visualizing serotonin transporters.</p>Fórmula:C16H20N2SForma y color:SolidPeso molecular:272.408PF470
CAS:<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Fórmula:C18H16N6OForma y color:SolidPeso molecular:332.36Fletazepam
CAS:<p>Fletazepam, a benzodiazepine derivative, exhibits sedative, anti-anxiety, and muscle-relaxant properties. It is utilized in neurological research.</p>Fórmula:C17H13ClF4N2Forma y color:SolidPeso molecular:356.74Glutaminyl Cyclase Inhibitor 3
CAS:<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Fórmula:C24H32N6O2SPureza:98%Forma y color:SolidPeso molecular:468.61SB 243213 hydrochloride
CAS:<p>SB 243213 hydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8).It</p>Fórmula:C22H20ClF3N4O2Pureza:98%Forma y color:SolidPeso molecular:464.87DL-Thyroxine
CAS:<p>DL-Thyroxine is a thyroid hormone that acts as a monoamine oxidase (monoamine oxidase) inhibitor.</p>Fórmula:C15H11I4NO4Forma y color:SolidPeso molecular:776.87Remlifanserin
CAS:<p>Remlifanserin is a potent inverse agonist of the serotonin receptor (5-HT2A).</p>Fórmula:C24H29F2N3O2Forma y color:SolidPeso molecular:429.50PXS-4787 hydrochloride
CAS:<p>PXS-4787 hydrochloride is a specific and potent pan-lysyl oxidase inhibitor that effectively eliminates the activity of lysyl oxidase. It exhibits varying IC50 values against different forms of the enzyme, including 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), and 0.2 μM (rh LOXL4). In addition, PXS-4787 hydrochloride reduces the deposition and cross-linking of collagen I secreted by human fibroblasts.</p>Fórmula:C10H13ClFNO2SForma y color:SolidPeso molecular:265.73SB 243213 dihydrochloride
CAS:<p>SB 243213 dihydrochloride is an orally active, selective and high-affinity antagonist of 5-hydroxytryptamine (5-HT)2C receptor(pKi of 9.37 and a pKb of 9.8 for</p>Fórmula:C22H21Cl2F3N4O2Pureza:98%Forma y color:SolidPeso molecular:501.335-HT6/5-HT2AR antagonist-1
<p>Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.</p>Fórmula:C21H26N6SForma y color:SolidPeso molecular:394.54Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Fórmula:C21H30N2O5SForma y color:SolidPeso molecular:422.538(9R)-RO7185876
CAS:<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Fórmula:C25H28F3N7Forma y color:SolidPeso molecular:483.532Rodatristat
CAS:<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Fórmula:C27H27ClF3N5O3Pureza:98%Forma y color:SolidPeso molecular:561.98RO-1-5237
CAS:<p>RO-1-5237, a cholinergic compound and a metabolic product of Pyridostigmine Bromide, is utilized in research for myasthenia gravis.</p>Fórmula:C6H8BrNOForma y color:SolidPeso molecular:190.048 Hydroxy PIPAT oxalate
CAS:<p>8 Hydroxy PIPAT oxalate is a selective 5-HT1A receptor agonist that enhances the spontaneous release of histamine by promoting the degranulation of mast cells in guinea pig and human intestinal preparations. By activating the serotonin signaling pathway, this compound demonstrates potential in regulating gastrointestinal functions and offers insight into the management and suppression of functional gastrointestinal disorders such as irritable bowel syndrome. Its effects in increasing histamine release could play a crucial role in gastrointestinal regulation.</p>Fórmula:C18H24INO5Forma y color:SolidPeso molecular:461.29MAO-B-IN-34
CAS:<p>MAO-B-IN-34 (compound 3d) is an inhibitor of monoamine oxidase B.</p>Fórmula:C15H9Cl2NO3Forma y color:SolidPeso molecular:322.14U92016A hydrochloride
CAS:<p>U92016A hydrochloride: potent, orally active 5-HT1A agonist, metabolically stable, high intrinsic activity, Ki=0.2 nM.</p>Fórmula:C19H26ClN3Forma y color:SolidPeso molecular:331.89ChE/Aβ1-42-IN-1
<p>ChE/Aβ1-42-IN-1 (compound 28) is a potent aggregation inhibitor of ChE and Aβ 1-42 with excellent BBB permeability.</p>Fórmula:C19H24N2O3Forma y color:SolidPeso molecular:328.41Lu 26-046
CAS:<p>Lu 26-046 is a muscarinic receptor agonist.</p>Fórmula:C10H12N2OSForma y color:SolidPeso molecular:208.28AChE/BACE1/GSK3β-IN-1
<p>AChE/BACE1/GSK3β-IN-1 is an orally active, blood-brain barrier-transparent, moderately bioavailable triple inhibitor of AChE/BACE1/GSK3β.</p>Fórmula:C26H27FN2O4Forma y color:SolidPeso molecular:450.5Zanapezil fumarate
CAS:<p>Zanapezil is an acetylcholinesterase (AChE) inhibitor. Zanapezil increases choline acetyltransferase activity in cultured rat septal cholinergic neurons.</p>Fórmula:C29H36N2O5Forma y color:SolidPeso molecular:492.61FCOB02
CAS:<p>FCOB02 is a monoamine oxidase B (MAO-B) ligand. It can be labeled as [18F]FCOB02, serving as a 4-methylcoumarin-like targeting probe. [18F]FCOB02 demonstrates high affinity for MAO-B, with an IC50 of 10.68 nM. It is utilized for specific imaging and quantitative analysis of MAO-B in vivo.</p>Fórmula:C16H12FNO3Forma y color:SolidPeso molecular:285.27(S)-YNT-3708
CAS:<p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>Fórmula:C35H36N4O6SForma y color:SolidPeso molecular:640.749AGH-107
CAS:<p>AGH-107 is a highly selective 5-HT7 receptor agonist that can cross the blood-brain barrier, featuring a Ki value of 6 nM and an EC50 value of 19 nM. Demonstrating high selectivity for central nervous system targets, AGH-107 also exhibits high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures.</p>Fórmula:C13H12IN3Forma y color:SolidPeso molecular:337.16(+)-Sparteine sulfate pentahydrate
<p>(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.</p>Fórmula:C15H38N2O9SForma y color:SolidPeso molecular:422.54Notch inhibitor 1
CAS:<p>Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.</p>Fórmula:C26H25F7N4O3Pureza:98%Forma y color:SolidPeso molecular:574.49LB-102
CAS:<p>LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.</p>Fórmula:C18H29N3O4SForma y color:SolidPeso molecular:383.51SZ1676
CAS:<p>SZ1676 is a derivative of SZ1677, which is an agent of neuromuscular blocking.</p>Fórmula:C37H59BrN2O6Pureza:98%Forma y color:SolidPeso molecular:707.78AChE-IN-24
<p>AChE-IN-24: Strong AChE blocker, crosses blood-brain barrier, IC50=0.053 μM, useful for AD research.</p>Fórmula:C22H30N2O4S2Forma y color:SolidPeso molecular:450.61
