Beta amiloide
Beta amyloid inhibitors are compounds that specifically target and inhibit the formation or aggregation of beta-amyloid peptides, which are critically involved in the pathogenesis of Alzheimer's disease. The accumulation of beta-amyloid plaques in the brain is one of the key pathological features of Alzheimer's, contributing to neuronal dysfunction, synaptic loss, and cognitive decline. By preventing the aggregation of beta-amyloid, these inhibitors are being actively researched as potential therapeutic agents aimed at slowing down or even halting the progression of Alzheimer's disease. At CymitQuimica, we offer a variety of high-quality beta-amyloid inhibitors to support your research in neurodegenerative disorders, protein aggregation, and the development of Alzheimer's therapies.
Se han encontrado 204 productos de "Beta amiloide"
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Semagacestat
CAS:<p>Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).</p>Fórmula:C19H27N3O4Pureza:97.1% - 99.9%Forma y color:SolidPeso molecular:361.44Aftin-4
CAS:<p>Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.</p>Fórmula:C20H28N6OPureza:98.51%Forma y color:SolidPeso molecular:368.48LX2343
CAS:<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Fórmula:C22H19ClN2O6SPureza:99.45%Forma y color:SolidPeso molecular:474.91LY2811376
CAS:<p>LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).</p>Fórmula:C15H14F2N4SPureza:99% - 99.01%Forma y color:SolidPeso molecular:320.36Anle138b
CAS:<p>Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease</p>Fórmula:C16H11BrN2O2Pureza:98.88% - 99.82%Forma y color:SolidPeso molecular:343.17MK-0752
CAS:<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Fórmula:C21H21ClF2O4SPureza:98% - 99.55%Forma y color:SolidPeso molecular:442.9PiB
CAS:<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Fórmula:C14H12N2OSPureza:97.02%Forma y color:SolidPeso molecular:256.32Frentizole
CAS:<p>Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction</p>Fórmula:C15H13N3O2SPureza:99.82%Forma y color:SolidPeso molecular:299.35RO4929097
CAS:<p>RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).</p>Fórmula:C22H20F5N3O3Pureza:98.5% - 99.51%Forma y color:SolidPeso molecular:469.4ARN2966
CAS:<p>ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.</p>Fórmula:C12H12N2OPureza:99.52% - 99.86%Forma y color:SolidPeso molecular:200.24CRANAD 2
CAS:<p>CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.</p>Fórmula:C23H25BF2N2O2Pureza:99.44%Forma y color:Dark Blue To Black PowderPeso molecular:410.271,1'-Methylenedi-2-naphthol
CAS:<p>1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).</p>Fórmula:C21H16O2Pureza:98.91%Forma y color:Light Pink To Light Brown Crystalline PowderPeso molecular:300.35TAE-1
CAS:<p>TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.</p>Fórmula:C39H51I3N6O9Pureza:94.58%Forma y color:SolidPeso molecular:1128.57Pyridoxal 5'-phosphate hydrate
CAS:<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Fórmula:C8H10NO6PPureza:97.52%Forma y color:SolidPeso molecular:247.14PBD-150
CAS:<p>PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)</p>Fórmula:C15H20N4O2SPureza:99.68%Forma y color:SolidPeso molecular:320.41Miridesap
CAS:<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Fórmula:C16H24N2O6Pureza:≥95%Forma y color:SolidPeso molecular:340.37Azeliragon HCl
CAS:<p>Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.</p>Fórmula:C32H40Cl3N3O2Forma y color:SolidPeso molecular:605.04EUK-134
CAS:<p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>Fórmula:C18H18ClMnN2O4Pureza:98.39%Forma y color:SolidPeso molecular:416.74JLK6
CAS:<p>JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling</p>Fórmula:C10H8ClNO3Pureza:96.50%Forma y color:SolidPeso molecular:225.63Cromoglicic acid
CAS:<p>Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.</p>Fórmula:C23H16O11Pureza:99.55% - >99.99%Forma y color:Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Peso molecular:468.37PE859
CAS:<p>PE859 is a potent inhibitor of both tau and Aβ aggregation.</p>Fórmula:C28H24N4O2Pureza:98.8% - 99.09%Forma y color:SolidPeso molecular:448.52Solanezumab
CAS:<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Pureza:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.1 (kDa)γ-Secretase modulator 13
CAS:<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>Fórmula:C22H23FN6SPureza:99.79%Forma y color:SolidPeso molecular:422.52Remternetug
CAS:<p>Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42.</p>Pureza:95% - 95%Forma y color:LiquidDezamizumab
CAS:<p>Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.</p>Pureza:95% - 95%Forma y color:LiquidBapineuzumab
CAS:<p>Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).</p>Pureza:95%Forma y color:LiquidHomotaurine-d6
CAS:<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Fórmula:C3D6H3NO3SForma y color:SolidPeso molecular:145.214-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Fórmula:C13H9BrN2SPureza:98%Forma y color:SolidPeso molecular:305.19Nicardipine pyridine metabolite II
CAS:<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Fórmula:C26H27N3O6Forma y color:SolidPeso molecular:477.514-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).</p>Fórmula:C14H11BrN2SPureza:98%Forma y color:SolidPeso molecular:319.22Aftin-5
CAS:<p>Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.</p>Fórmula:C19H26N6OForma y color:SolidPeso molecular:354.45AZ4800
CAS:<p>AZD4800 is a gamma secretase modulators.</p>Fórmula:C24H29N5O3Forma y color:SolidPeso molecular:435.52THK-523
CAS:<p>THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.</p>Fórmula:C17H15FN2OForma y color:SolidPeso molecular:282.31BChE-IN-8
CAS:<p>BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.</p>Fórmula:C18H12BrN7O2Forma y color:SolidPeso molecular:438.24JNJ-40418677
CAS:<p>JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.</p>Fórmula:C26H22F6O2Pureza:98%Forma y color:SolidPeso molecular:480.44Glutaminyl Cyclase Inhibitor 2
CAS:<p>Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).</p>Fórmula:C19H20FN3Pureza:98%Forma y color:SolidPeso molecular:309.38Chrysamine G
CAS:<p>Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.</p>Fórmula:C26H16N4Na2O6Forma y color:SolidPeso molecular:526.416K 01-162
CAS:<p>K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.</p>Fórmula:C15H14BrNForma y color:SolidPeso molecular:288.18YIAD-0205
CAS:<p>YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial</p>Fórmula:C26H16Br2ClN3Forma y color:SolidPeso molecular:565.69OAB-14
CAS:<p>OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.</p>Fórmula:C32H46N4O2Forma y color:SolidPeso molecular:518.73TC-E 5006
CAS:<p>γ-secretase modulator</p>Fórmula:C29H29F4NO2Pureza:98%Forma y color:SolidPeso molecular:499.54ELND006
CAS:<p>ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.</p>Fórmula:C20H14F5N3O2SForma y color:SolidPeso molecular:455.4Neuroinflammatory-IN-2
CAS:<p>Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.</p>Fórmula:C25H27FN2O3Forma y color:SolidPeso molecular:422.49Aβ Fibrillization modulator 1
CAS:<p>Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.</p>Fórmula:C17H12N4O3SSeForma y color:SolidPeso molecular:431.33Astrophloxine
CAS:<p>Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and</p>Fórmula:C27H33IN2Pureza:99.89%Forma y color:SolidPeso molecular:512.47RU-505
CAS:<p>RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.</p>Fórmula:C28H32FN5OPureza:98%Forma y color:SolidPeso molecular:473.58γ-Secretase modulator 12
CAS:<p>γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.</p>Fórmula:C25H23N3O2Forma y color:SolidPeso molecular:397.47Glutaminyl Cyclase Inhibitor 5
<p>Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of</p>Fórmula:C22H30N6OForma y color:SolidPeso molecular:394.51AY1511
CAS:<p>AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].</p>Fórmula:C17H14O6Forma y color:SolidPeso molecular:314.29SEN-1269
CAS:<p>SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.</p>Fórmula:C18H18N4O2Pureza:98%Forma y color:SolidPeso molecular:322.36BACE1/2-IN-1
CAS:<p>BACE1/2-IN-1 inhibits BACE1/2 with IC50s of 0.01μM/0.0053μM, has better permeability and lower Pgp efflux but reduced metabolic stability.</p>Fórmula:C21H31N5OSForma y color:SolidPeso molecular:401.57Antioxidant agent-2
CAS:<p>Antioxidant agent-2 (3c), BBB-permeable, selectively chelates metals; shows neuroprotection, fights liver damage in Alzheimer's research.</p>Fórmula:C23H26N2O7Forma y color:SolidPeso molecular:442.46SV5
CAS:<p>SV5: potent anti-Alzheimer's, protects SHSY-5Y from Aβ1-42 death, stable with optimal pharmacology in plasma, antioxidant, neuroprotective.</p>Fórmula:C21H30N2O4S2Forma y color:SolidPeso molecular:438.6TML-6
CAS:<p>TML-6, an oral derivative of curcumin, may help in Alzheimer's research by targeting amyloid production and various molecular pathways.</p>Fórmula:C30H37NO7Pureza:99.71%Forma y color:SolidPeso molecular:523.62BuChE-IN-2
CAS:<p>BuChE-IN-2 inhibits BuChE (IC50: 1.28 μM), NO (0.67 μM), Aβ, ROS, chelates Cu2+, penetrates BBB, used in Alzheimer's research.</p>Fórmula:C28H20F4N6O3Forma y color:SolidPeso molecular:564.49Caprospinol
CAS:<p>Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.</p>Fórmula:C33H52O4Pureza:98%Forma y color:SolidPeso molecular:512.76RS-0466
CAS:<p>RS-0466 is an β-amyloid-induced cytotoxicity inhibitor.</p>Fórmula:C17H17N5O2Pureza:98%Forma y color:SolidPeso molecular:323.35KMS88009
CAS:<p>KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.</p>Fórmula:C19H19NO2Forma y color:SolidPeso molecular:293.36Ezeprogind disulfate
CAS:<p>Ezeprogind disulfate: neurotrophic inducer targeting neurodegeneration causes like Abeta, tau; for neurological disorder research.</p>Fórmula:C25H48N6O8S2Pureza:99.72%Forma y color:SolidPeso molecular:624.81Aleplasinin
CAS:<p>Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic</p>Fórmula:C28H27NO3Pureza:99.21%Forma y color:SolidPeso molecular:425.52PPI-1019
CAS:<p>PPI-1019 is an APP (β-amyloid A4) inhibitor for the treatment of neurological disorders and the study of Alzheimer's disease (AD).</p>Fórmula:C36H54N6O5Pureza:95.16% - 98.16%Forma y color:SolidPeso molecular:650.85Buntanetap
CAS:<p>Buntanetap ((+)-Phenserine) is an inhibitor of TINAPs used in the study of neurological disorders, endocrine and metabolic disorders, and cardiovascular disease</p>Fórmula:C20H23N3O2Pureza:98.2%Forma y color:SolidPeso molecular:337.42Fenlean
CAS:<p>"Fenlean (FLZ) in phase I trial at Chinese Academy's Institute of Pharmacy for Parkinson's treatment."</p>Fórmula:C26H27NO6Pureza:98.99%Forma y color:SolidPeso molecular:449.5Aβ-IN-1
CAS:<p>Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM).</p>Fórmula:C35H49NPureza:99.1%Forma y color:SoildPeso molecular:483.77MK-3328
CAS:<p>MK-3328, a potential Alzheimer's drug, binds β-Amyloid with strong affinity (IC50:10.5 nM) and may serve as a PET ligand to gauge plaque load.</p>Fórmula:C14H9FN4OPureza:99.70% - >99.99%Forma y color:SolidPeso molecular:268.25Glutaminyl Cyclase Inhibitor 1
CAS:<p>Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.</p>Fórmula:C21H24FN3O2Pureza:99.81%Forma y color:SolidPeso molecular:369.43MAO-B-IN-9
CAS:<p>MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence.</p>Fórmula:C18H24N2O2Pureza:99.93%Forma y color:SolidPeso molecular:300.4DSS30
CAS:<p>DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.</p>Fórmula:C16H14ClNO3S2Pureza:99.19% - 99.4%Forma y color:SolidPeso molecular:367.87BI-1408
CAS:<p>BI-1408 is a modulator potent of γ secretase (IC50: 0.04 μM for Aβ42).</p>Fórmula:C22H23FN6Pureza:99.63%Forma y color:SolidPeso molecular:390.46amyloid P-IN-1
CAS:<p>amyloid P-IN-1 can be used in studies about diseases with depletion of serum amyloid P components such as Alzheimer's disease, amyloidosis, osteoarthritis, and</p>Fórmula:C30H44N2O14Pureza:99.76%Forma y color:SolidPeso molecular:656.68Anti-amyloid agent-1
CAS:<p>Anti-amyloid agent-1 is a potent compound that inhibits amyloid aggregation, offering a promising approach for research into the treatment of amyloidosis [1].</p>Fórmula:C21H17F3N2O3Forma y color:SolidPeso molecular:402.37Aβ/tau aggregation-IN-3
CAS:<p>Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 µM in an Aβ-Thioflavin T (Aβ-ThT) functional</p>Fórmula:C23H22N4O3Forma y color:SolidPeso molecular:402.45QM-FN-SO3
CAS:<p>QM-FN-SO3 is a blood-brain barrier (BBB)-penetrable, near-infrared (NIR) probe with aggregation-induced emission (AIE) activity, specifically designed for the detection of Aβ plaques. It exhibits ultra-high signal-to-noise (S/N) ratio, binding affinity, and high-performance NIR emission, making it suitable for in vivo detection of Aβ plaques [1].</p>Fórmula:C29H25N4NaO3S2Forma y color:SolidPeso molecular:564.65BMS 433796
CAS:<p>BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer's disease.</p>Fórmula:C21H20F2N4O4Pureza:99.17%Forma y color:SolidPeso molecular:430.4RAGE/SERT-IN-1
CAS:<p>RAGE/SERT-IN-1 is a potent, orally active inhibitor of advanced glycation end products (RAGE) and serotonin transporter (SERT), with IC50 values of 8.26 μM and</p>Fórmula:C38H41ClN4OSForma y color:SolidPeso molecular:637.28QR-0217
CAS:<p>QR-0217 is a potent inhibitor of both Aβ1-40 and α-synuclein aggregation, exhibiting an IC50 of 7.5 µM for Aβ1-40.</p>Fórmula:C19H13NO3Forma y color:SolidPeso molecular:303.31ELND007
CAS:<p>ELND007 is a Gamma secretase inhibitor.</p>Fórmula:C19H14F4N4O2SForma y color:SolidPeso molecular:438.4PQM130
CAS:<p>PQM130 is a Feruloyl-Donepezil Hybrid compound against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity.</p>Fórmula:C23H27NO4Pureza:98.73%Forma y color:SolidPeso molecular:381.46TRV-1387
CAS:<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Fórmula:C23H25F3N4O2Forma y color:SolidPeso molecular:446.47NNC 26-9100
CAS:<p>Somatostatin sst4 receptor agonist</p>Fórmula:C22H25BrCl2N6SPureza:98%Forma y color:SolidPeso molecular:556.35γ-Secretase-IN-1
CAS:<p>γ-Secretase-IN-1 is a γ-secretase inhibitor that displays partial antiproliferative activity against T-47D cells.</p>Fórmula:C27H24F2N4O3Pureza:99.56%Forma y color:SolidPeso molecular:490.5MDR-1339
CAS:<p>MDR-1339 is a blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.</p>Fórmula:C20H22O4Pureza:98.57%Forma y color:SolidPeso molecular:326.39BF-168
CAS:<p>BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).</p>Fórmula:C18H17FN2O2Forma y color:SolidPeso molecular:312.34Amyloid-β-IN-3
CAS:<p>Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.</p>Fórmula:C22H21F2N3O2Forma y color:SolidPeso molecular:397.42(9R)-RO7185876
CAS:<p>(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.</p>Fórmula:C25H28F3N7Forma y color:SolidPeso molecular:483.532cSPM
<p>cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.</p>Fórmula:C27H57N7Forma y color:SolidPeso molecular:479.79Aβ-IN-2
<p>Aβ-IN-2 is a peptide inhibitor of Aβ1-42.</p>Fórmula:C37H51NOForma y color:SolidPeso molecular:525.81Amilo-5MER
CAS:<p>Amilo-5MER (5-MP) is an orally active and selective inhibitor of serum amyloid A (SAA). It specifically suppresses the release of pro-inflammatory cytokines IL-6 and IL-1β in SAA-activated cells. Amilo-5MER reduces chronic inflammation and alleviates symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It holds potential for research in autoimmune and chronic inflammatory diseases.</p>Fórmula:C23H40N6O9SForma y color:SolidPeso molecular:576.664γ-secretase modulator 6
CAS:<p>Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.</p>Fórmula:C25H26N6O2Forma y color:SolidPeso molecular:442.513Antioxidant agent-8
<p>Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.</p>Fórmula:C13H12O5Forma y color:SolidPeso molecular:248.23MAO-B-IN-10
<p>MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.</p>Fórmula:C23H26N2O4Forma y color:SolidPeso molecular:394.46Aβ aggregation-IN-1
CAS:<p>Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.</p>Fórmula:C9H8BF3O2Forma y color:SolidPeso molecular:215.965Amyloid-β-IN-2
CAS:<p>Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.</p>Fórmula:C22H21F2N3O2Forma y color:SolidPeso molecular:397.42Anti-Aβ agent 1A
<p>Anti-Aβ agent 1A is a potent anti-amyloid-β agent.</p>Fórmula:C35H49NO4Forma y color:SolidPeso molecular:547.77QP5020
CAS:<p>QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.</p>Fórmula:C20H19FN6Peso molecular:362.40Buntanetap L-Tartrate
CAS:<p>Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].</p>Fórmula:C24H29N3O8Forma y color:SolidPeso molecular:487.50Aβ42 agonist-1
CAS:<p>Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.</p>Fórmula:C15H11NO2Pureza:99.77%Forma y color:SolidPeso molecular:237.252002-G12
CAS:<p>2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.</p>Fórmula:C20H16N6Forma y color:SolidPeso molecular:340.381Glutaminyl Cyclase Inhibitor 3
CAS:<p>Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.</p>Fórmula:C24H32N6O2SPureza:98%Forma y color:SolidPeso molecular:468.61γ-secretase modulator 5
<p>Compound 22d is a GSM that crosses the blood-brain barrier, inhibits Aβ42 production (IC50: 60 nM), and may help study Alzheimer's.</p>Forma y color:Solid
