Beta amiloide
Beta amyloid inhibitors are compounds that specifically target and inhibit the formation or aggregation of beta-amyloid peptides, which are critically involved in the pathogenesis of Alzheimer's disease. The accumulation of beta-amyloid plaques in the brain is one of the key pathological features of Alzheimer's, contributing to neuronal dysfunction, synaptic loss, and cognitive decline. By preventing the aggregation of beta-amyloid, these inhibitors are being actively researched as potential therapeutic agents aimed at slowing down or even halting the progression of Alzheimer's disease. At CymitQuimica, we offer a variety of high-quality beta-amyloid inhibitors to support your research in neurodegenerative disorders, protein aggregation, and the development of Alzheimer's therapies.
Se han encontrado 228 productos de "Beta amiloide"
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4-Hydroxyindole
CAS:4-Hydroxyindole: aromatic, antioxidant, used in cancer treatment and preventing neurodegenerative diseases.Fórmula:C8H7NOPureza:97.05% - 98.13%Forma y color:Off-White Cyrstalline SolidPeso molecular:133.15Solanezumab
CAS:Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.Pureza:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.07 kDaγ-Secretase modulator 13
CAS:γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.Fórmula:C22H23FN6SPureza:99.79%Forma y color:SolidPeso molecular:422.52Dezamizumab
CAS:Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.Pureza:95% - 98.2% (SDS-PAGE); 98.7% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.82 kDaHomotaurine-d6
CAS:Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.Fórmula:C3D6H3NO3SForma y color:SolidPeso molecular:145.214-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).Fórmula:C14H11BrN2SPureza:98%Forma y color:SolidPeso molecular:319.22Nicardipine pyridine metabolite II
CAS:Nicardipine pyridine metabolite II is a biaoctive chemical.Fórmula:C26H27N3O6Forma y color:SolidPeso molecular:477.514-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.Fórmula:C13H9BrN2SPureza:98%Forma y color:SolidPeso molecular:305.19Aftin-5
CAS:Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.Fórmula:C19H26N6OForma y color:SolidPeso molecular:354.45Eprodisate
CAS:Eprodisate disrupts protein-glycosaminoglycan binding, halting amyloid fibril formation, potentially delaying AA amyloidosis progression.Fórmula:C3H8O6S2Forma y color:SolidPeso molecular:204.22LC kinetic stabilizer-2
CAS:LC Kinetic Stabilizer-2 is a powerful stabilizer for amyloidogenic immunoglobulin light chains (LC), demonstrating significant efficacy with an EC50 of 24 nM.Fórmula:C28H31N3O3Forma y color:SolidPeso molecular:457.56THK-523
CAS:THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.Fórmula:C17H15FN2OForma y color:SolidPeso molecular:282.31Neuroinflammatory-IN-2
CAS:Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.Fórmula:C25H27FN2O3Forma y color:SolidPeso molecular:422.49KMS88009
CAS:KMS88009 is an amyloid-β aggregation inhibitor that acts by ameliorating neurodegenerative disorder.Fórmula:C19H19NO2Forma y color:SolidPeso molecular:293.36ELND006
CAS:ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.Fórmula:C20H14F5N3O2SForma y color:SolidPeso molecular:455.4TC-E 5006
CAS:γ-secretase modulatorFórmula:C29H29F4NO2Pureza:98%Forma y color:SolidPeso molecular:499.54OAB-14
CAS:OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.Fórmula:C32H46N4O2Forma y color:SolidPeso molecular:518.73YIAD-0205
CAS:YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familialFórmula:C26H16Br2ClN3Forma y color:SolidPeso molecular:565.69BTA-1
CAS:BTA-1 is an uncharged derivative of thioflavin-T that has high affinity for Aβ fibrils and shows very good brain entry and clearance [1].Fórmula:C14H12N2SForma y color:SolidPeso molecular:240.32K 01-162
CAS:K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.Fórmula:C15H14BrNForma y color:SolidPeso molecular:288.18
