Beta amiloide
Beta amyloid inhibitors are compounds that specifically target and inhibit the formation or aggregation of beta-amyloid peptides, which are critically involved in the pathogenesis of Alzheimer's disease. The accumulation of beta-amyloid plaques in the brain is one of the key pathological features of Alzheimer's, contributing to neuronal dysfunction, synaptic loss, and cognitive decline. By preventing the aggregation of beta-amyloid, these inhibitors are being actively researched as potential therapeutic agents aimed at slowing down or even halting the progression of Alzheimer's disease. At CymitQuimica, we offer a variety of high-quality beta-amyloid inhibitors to support your research in neurodegenerative disorders, protein aggregation, and the development of Alzheimer's therapies.
Se han encontrado 204 productos de "Beta amiloide"
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Semagacestat
CAS:<p>Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).</p>Fórmula:C19H27N3O4Pureza:97.1% - 99.9%Forma y color:SolidPeso molecular:361.44Aftin-4
CAS:<p>Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.</p>Fórmula:C20H28N6OPureza:98.51%Forma y color:SolidPeso molecular:368.48LX2343
CAS:<p>LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.</p>Fórmula:C22H19ClN2O6SPureza:99.45%Forma y color:SolidPeso molecular:474.91LY2811376
CAS:<p>LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).</p>Fórmula:C15H14F2N4SPureza:99% - 99.01%Forma y color:SolidPeso molecular:320.36Anle138b
CAS:<p>Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease</p>Fórmula:C16H11BrN2O2Pureza:98.88% - 99.82%Forma y color:SolidPeso molecular:343.17MK-0752
CAS:<p>MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).</p>Fórmula:C21H21ClF2O4SPureza:98% - 99.55%Forma y color:SolidPeso molecular:442.9PiB
CAS:<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Fórmula:C14H12N2OSPureza:97.02%Forma y color:SolidPeso molecular:256.32Frentizole
CAS:<p>Frentizole, an immunosuppressive agent, is an inhibitor of the Aβ-ABAD interaction</p>Fórmula:C15H13N3O2SPureza:99.82%Forma y color:SolidPeso molecular:299.35RO4929097
CAS:<p>RO4929097 (RG-4733), a γ secretase inhibitor (IC50: 4 nM), inhibits cellular processing of Aβ40 and Notch (EC50: 14/5 nM).</p>Fórmula:C22H20F5N3O3Pureza:98.5% - 99.51%Forma y color:SolidPeso molecular:469.4ARN2966
CAS:<p>ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.</p>Fórmula:C12H12N2OPureza:99.52% - 99.86%Forma y color:SolidPeso molecular:200.24CRANAD 2
CAS:<p>CRANAD-2, a near-infrared probe, detects amyloid-beta in vivo, increasing fluorescence 70x and shifting blue 90 nm upon binding.</p>Fórmula:C23H25BF2N2O2Pureza:99.44%Forma y color:Dark Blue To Black PowderPeso molecular:410.271,1'-Methylenedi-2-naphthol
CAS:<p>1,1'-Methylenedi-2-naphthol target CYP2C19 - cytochrome P450 family 2 subfamily C member 19 (human).</p>Fórmula:C21H16O2Pureza:98.91%Forma y color:Light Pink To Light Brown Crystalline PowderPeso molecular:300.35TAE-1
CAS:<p>TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.</p>Fórmula:C39H51I3N6O9Pureza:94.58%Forma y color:SolidPeso molecular:1128.57Pyridoxal 5'-phosphate hydrate
CAS:<p>Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,</p>Fórmula:C8H10NO6PPureza:97.52%Forma y color:SolidPeso molecular:247.14PBD-150
CAS:<p>PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)</p>Fórmula:C15H20N4O2SPureza:99.68%Forma y color:SolidPeso molecular:320.41Miridesap
CAS:<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Fórmula:C16H24N2O6Pureza:≥95%Forma y color:SolidPeso molecular:340.37Azeliragon HCl
CAS:<p>Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.</p>Fórmula:C32H40Cl3N3O2Forma y color:SolidPeso molecular:605.04EUK-134
CAS:<p>EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.</p>Fórmula:C18H18ClMnN2O4Pureza:98.39%Forma y color:SolidPeso molecular:416.74JLK6
CAS:<p>JLK6 was a gamma-secretase inhibitor that does not interfere with Notch signalling</p>Fórmula:C10H8ClNO3Pureza:96.50%Forma y color:SolidPeso molecular:225.63Cromoglicic acid
CAS:<p>Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells.</p>Fórmula:C23H16O11Pureza:99.55% - >99.99%Forma y color:Colorless Crystals From Ethanol + Ether Physical Description Solid (Ntp 1992)Peso molecular:468.37PE859
CAS:<p>PE859 is a potent inhibitor of both tau and Aβ aggregation.</p>Fórmula:C28H24N4O2Pureza:98.8% - 99.09%Forma y color:SolidPeso molecular:448.52Solanezumab
CAS:<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Pureza:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.1 (kDa)γ-Secretase modulator 13
CAS:<p>γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.</p>Fórmula:C22H23FN6SPureza:99.79%Forma y color:SolidPeso molecular:422.52Remternetug
CAS:<p>Remternetug is a humanized IgG1-kappa monoclonal antibody that targets the N3pGlu peptide of the amyloid beta A4 precursor protein (APP) Aβ42.</p>Pureza:95% - 95%Forma y color:LiquidDezamizumab
CAS:<p>Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.</p>Pureza:95% - 95%Forma y color:LiquidBapineuzumab
CAS:<p>Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).</p>Pureza:95%Forma y color:LiquidHomotaurine-d6
CAS:<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Fórmula:C3D6H3NO3SForma y color:SolidPeso molecular:145.214-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.</p>Fórmula:C13H9BrN2SPureza:98%Forma y color:SolidPeso molecular:305.19Nicardipine pyridine metabolite II
CAS:<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Fórmula:C26H27N3O6Forma y color:SolidPeso molecular:477.514-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:<p>4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).</p>Fórmula:C14H11BrN2SPureza:98%Forma y color:SolidPeso molecular:319.22Aftin-5
CAS:<p>Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.</p>Fórmula:C19H26N6OForma y color:SolidPeso molecular:354.45AZ4800
CAS:<p>AZD4800 is a gamma secretase modulators.</p>Fórmula:C24H29N5O3Forma y color:SolidPeso molecular:435.52THK-523
CAS:<p>THK-523 selectively binds to tau in Alzheimer's, potent in vitro/vivo. 18F-THK523 excels in tau imaging.</p>Fórmula:C17H15FN2OForma y color:SolidPeso molecular:282.31BChE-IN-8
CAS:<p>BChE-IN-8, compound 20, is a potent oral BChE inhibitor effective on eqBChE and hBChE, crosses blood-brain barrier, and may help in Alzheimer's research.</p>Fórmula:C18H12BrN7O2Forma y color:SolidPeso molecular:438.24JNJ-40418677
CAS:<p>JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting the processing of Notch.</p>Fórmula:C26H22F6O2Pureza:98%Forma y color:SolidPeso molecular:480.44Glutaminyl Cyclase Inhibitor 2
CAS:<p>Glutaminyl Cyclase Inhibitor 2 is a glutaminyl cyclase inhibitor (IC50: 1.23 μM).</p>Fórmula:C19H20FN3Pureza:98%Forma y color:SolidPeso molecular:309.38Chrysamine G
CAS:<p>Chrysamine G, Congo red analog, blocks Aβ toxicity, probes Alzheimer's amyloid.</p>Fórmula:C26H16N4Na2O6Forma y color:SolidPeso molecular:526.416K 01-162
CAS:<p>K 01-162 binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM.</p>Fórmula:C15H14BrNForma y color:SolidPeso molecular:288.18YIAD-0205
CAS:<p>YIAD-0205, an orally administered inhibitor of Aβ(1-42) aggregation, has exhibited in vivo efficacy in a 5XFAD transgenic mouse model that harbors five familial</p>Fórmula:C26H16Br2ClN3Forma y color:SolidPeso molecular:565.69OAB-14
CAS:<p>OAB-14, a Bexarotene derivative, enhances β-amyloid clearance and cognitive function in APP/PS1 mice, improving Alzheimer's symptoms.</p>Fórmula:C32H46N4O2Forma y color:SolidPeso molecular:518.73TC-E 5006
CAS:<p>γ-secretase modulator</p>Fórmula:C29H29F4NO2Pureza:98%Forma y color:SolidPeso molecular:499.54ELND006
CAS:<p>ELND006, an oral Alzheimer's drug, has improved bioavailability as a nanosuspension, and food doesn't affect it.</p>Fórmula:C20H14F5N3O2SForma y color:SolidPeso molecular:455.4Neuroinflammatory-IN-2
CAS:<p>Neuroinflammatory-IN-2: anti-neuroinflammatory, inhibits MAO-B (IC50: 10.30µM), 96.33% Aβ1-42 aggregation reduction, neuroprotective in PC-12 cells.</p>Fórmula:C25H27FN2O3Forma y color:SolidPeso molecular:422.49Aβ Fibrillization modulator 1
CAS:<p>Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.</p>Fórmula:C17H12N4O3SSeForma y color:SolidPeso molecular:431.33Astrophloxine
CAS:<p>Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers.Astrophloxine can be used to detect aggregated Aβ in brain tissue and</p>Fórmula:C27H33IN2Pureza:99.89%Forma y color:SolidPeso molecular:512.47RU-505
CAS:<p>RU-505 is an interaction inhibitor of Aβ-fibrinogen that acts by rescuing altered thrombosis and cognitive decline in Alzheimer's disease mice.</p>Fórmula:C28H32FN5OPureza:98%Forma y color:SolidPeso molecular:473.58γ-Secretase modulator 12
CAS:<p>γ-Secretase modulator 12 (Compound 1a) is a selective compound that effectively reduces amyloid-β42 (Aβ42) levels with an IC50 of 0.39 μM.</p>Fórmula:C25H23N3O2Forma y color:SolidPeso molecular:397.47Glutaminyl Cyclase Inhibitor 5
<p>Glutaminyl Cyclase Inhibitor 5 is a potent, selective inhibitor of human glutaminyl cyclase (hQC), demonstrating an inhibition concentration half-max (IC 50) of</p>Fórmula:C22H30N6OForma y color:SolidPeso molecular:394.51AY1511
CAS:<p>AY1511 is a low cytotoxic inhibitor of amyloid β (Aβ) aggregation [1].</p>Fórmula:C17H14O6Forma y color:SolidPeso molecular:314.29SEN-1269
CAS:<p>SEN-1269 prevents amyloid-β aggregation, shields neurons, and improves memory by hindering Aβ(1-42)-induced issues.</p>Fórmula:C18H18N4O2Pureza:98%Forma y color:SolidPeso molecular:322.36
