Beta amiloide

β-Amyloid(1-42), human, Ala-13C3,15N trifluoroacetic acid is a β-Amyloid (1-42), human marked with 13C and 15N. This unprocessed HFIP peptide comprises 42 amino acids and is a brain-permeable amyloid fragment, useful for researching Alzheimer's and Down syndrome. In monomer form, β-Amyloid (1-42), human provides antioxidant and neuroprotective effects. Upon HFIP monomerization and DMSO solvent preparation, it forms soluble oligomers (AβOs) at 4°C, which exhibit synaptotoxicity and neurotoxicity, while at 37°C it forms insoluble fibrils with lower neurotoxicity, involved in oxidative damage. Aβ42 oligomers interact with neuronal surface receptors such as PrPc, mGluR5, and NMDA receptor, activating signaling pathways that induce oxidative stress, calcium imbalance, synaptotoxicity, leading to neuronal dysfunction and death.

The QSH peptide is a polypeptide that specifically binds to Aβ1-42, and is employed in the synthesis of siRNA delivery complexes. It is applicable in research related to Alzheimer's disease (AD).

Amyloid β-Protein (1-46) is a segment of the Aβ peptide.

Amyloid β-Protein (16-22) is a segment of the Aβ peptide.

APP669-711 is a peptide fragment comprising amino acids 669 to 711 of the amyloid precursor protein (APP). This peptide serves as a biomarker in Alzheimer's disease (AD) research and is useful for diagnosing amyloid deposition in the brain.

Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS.

(Gln22)β-Amyloid (1-40) human is a peptide containing amyloid β-protein (Aβ), which can be utilized in Alzheimer's disease research.

Aducanumab (BIIB037) is an IgG1 antibody targeting amyloid beta to treat Alzheimer's; it's brain-permeable.

Amyloid β-Protein (10-20) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.Amyloid β protein fragment containing the α-

β-Amyloid (33-40) is a peptide comprising amino acids 33 to 40 of the beta-amyloid protein.

Amilo-5MER sodium salt is an oral SAA inhibitor that reduces IL-6 and IL-1β release and is used in inflammation research.

β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells.

Nivegacetor(RG6289) is a selective and orally administrable γ-secretase regulator that can affect the production of amyloid-β in cerebrospinal fluid.

CCKBRagonist-1 (Compound 3r1) is a selective agonist for the cholecystokinin B receptor (CCKBR) that preferentially activates the Gq protein, with an EC50 of 35 pM. It significantly enhances neuronal survival at an EC50 of 37 pM. CCKBRagonist-1 improves cognitive decline in mice by upregulating α-secretase (ADAM10) and the calcium signaling molecule PLCB4, reduces the number of amyloid β (Aβ) plaques, and promotes long-term potentiation (LTP). This compound is useful for Alzheimer's disease research.

Glimepiride-D4-1 is the deuterated form of Glimepiride. Glimepiride (T0127) (Glimperide) is an antidiabetic compound belonging to the medium- to long-acting sulfonylurea class, with an ED50 of 182 μg/kg.

Amyloid beta-protein(1-40) Arctic variant (Ab40ARC (E22G)), featuring a glycine at position 22 (Gly22), is a peptide utilized in Alzheimer's disease research [1

(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β peptide structure found deposited in the brains of individuals with Alzheimer's disease and Down syndrome. It is thought that (Pyr3)-Amyloid β-Protein (3-42) accumulates in the brain, leading to the formation of insoluble amyloid β-peptide deposits.

5-TAMRA-Amyloid β-Protein (1-40) is a TAMRA-labeled variant of Amyloid β-Protein (1-40), featuring an absorption/emission spectrum at 544/572 nm [1].

Donanemab (Mouse IgG2a) is a mouse-derived IgG2a monoclonal antibody targeting a specific N-terminal epitope of amyloid-β (Aβ) associated with Alzheimer’s disease. Donanemab not only prevents the deposition and accumulation of Aβ plaques but also targets existing amyloid plaques to promote the clearance of amyloid burden in the brain. Donanemab can be used in research on Alzheimer’s disease.

Compound 5936-0108对β-淀粉样蛋白可能具有调节作用。