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Inhibidores de ciclooxigenasa (COX)

Inhibidores de ciclooxigenasa (COX)

Cyclooxygenase (COX) inhibitors are a class of compounds that inhibit the activity of COX enzymes, which play a critical role in the biosynthesis of prostaglandins—lipid compounds that mediate inflammation, pain, and fever. In the field of neuroscience, COX inhibitors are extensively studied for their potential to alleviate neuroinflammation, a key factor in the progression of various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By blocking COX activity, these inhibitors may help reduce inflammation in the brain, thereby protecting neurons from damage and slowing disease progression. At CymitQuimica, we offer a wide range of high-quality COX inhibitors to support your research in neuroinflammation, pain management, and the study of neurodegenerative disorders.

Se han encontrado 562 productos de "Inhibidores de ciclooxigenasa (COX)"

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  • LM-1685

    CAS:
    <p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂,IC50分别为0.65 µM 和IC50 = 4.3 μM,是治疗炎症的潜在化合物。</p>
    Fórmula:C18H16ClNO4S
    Pureza:98.16%
    Forma y color:Solid
    Peso molecular:377.84
  • SC-75416

    CAS:
    <p>SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.</p>
    Fórmula:C15H14ClF3O3
    Pureza:98.67% - 98.67%
    Forma y color:Solid
    Peso molecular:334.72
  • BN-82451 2HCl

    CAS:
    <p>BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.</p>
    Fórmula:C18H28Cl2N2OS
    Pureza:99.84% - >99.99%
    Forma y color:Solid
    Peso molecular:391.4
  • Indazole-Cl

    CAS:
    <p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>
    Fórmula:C13H9ClN2O2
    Pureza:99.02% - 99.86%
    Forma y color:Solid
    Peso molecular:260.68
  • Biofor 389

    CAS:
    <p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>
    Fórmula:C20H29NO3
    Pureza:98.84% - 99.97%
    Forma y color:Solid
    Peso molecular:331.45
  • L 651896

    CAS:
    <p>L 651896 is an inhibitor of 5-lipoxygenase.</p>
    Fórmula:C18H18O3
    Pureza:96.06% - 99.85%
    Forma y color:Solid
    Peso molecular:282.33
  • Prostaglandin E2 Ethanolamide

    CAS:
    <p>Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].</p>
    Fórmula:C22H37NO5
    Forma y color:Solid
    Peso molecular:395.54
  • Benoxaprofen

    CAS:
    <p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>
    Fórmula:C16H12ClNO3
    Pureza:98.87%
    Forma y color:Solid
    Peso molecular:301.72
  • BW 755C

    CAS:
    <p>BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.</p>
    Fórmula:C10H10F3N3
    Pureza:96.52%
    Forma y color:Solid
    Peso molecular:229.2
  • Antioxidant agent-15

    CAS:
    <p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>
    Fórmula:C19H14O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:274.31
  • Thioflosulide

    CAS:
    <p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>
    Fórmula:C16H13F2NO3S2
    Pureza:>99.99%
    Forma y color:Solid
    Peso molecular:369.41
  • Thromboxane B3

    CAS:
    <p>Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.</p>
    Fórmula:C20H32O6
    Forma y color:Solid
    Peso molecular:368.5
  • Amtolmetin guacil

    CAS:
    <p>Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性,具有额外的镇痛、解热和胃保护特性。</p>
    Fórmula:C24H24N2O5
    Pureza:99.85%
    Forma y color:White Needle-Shaped Crystal
    Peso molecular:420.46
  • (-)-Bornyl ferulate

    CAS:
    <p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>
    Fórmula:C20H26O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:330.42
  • Cimicoxib

    CAS:
    <p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>
    Fórmula:C16H13ClFN3O3S
    Pureza:98.22%
    Forma y color:Solid
    Peso molecular:381.81
  • COX-2-IN-10


    <p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>
    Fórmula:C31H32FN5O2S
    Forma y color:Solid
    Peso molecular:557.68
  • COX-2-IN-12


    <p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>
    Fórmula:C17H19NO3
    Forma y color:Solid
    Peso molecular:285.34
  • COX-2-IN-13


    <p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>
    Fórmula:C19H18N2O5S
    Forma y color:Solid
    Peso molecular:386.42
  • COX-2-IN-8


    <p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>
    Fórmula:C19H19N3O4S2
    Forma y color:Solid
    Peso molecular:417.5
  • Anti-inflammatory agent 9


    <p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects &amp; is orally bioavailable.</p>
    Fórmula:C18H15N5O2S
    Forma y color:Solid
    Peso molecular:365.41