Inhibidores de ciclooxigenasa (COX)
Cyclooxygenase (COX) inhibitors are a class of compounds that inhibit the activity of COX enzymes, which play a critical role in the biosynthesis of prostaglandins—lipid compounds that mediate inflammation, pain, and fever. In the field of neuroscience, COX inhibitors are extensively studied for their potential to alleviate neuroinflammation, a key factor in the progression of various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By blocking COX activity, these inhibitors may help reduce inflammation in the brain, thereby protecting neurons from damage and slowing disease progression. At CymitQuimica, we offer a wide range of high-quality COX inhibitors to support your research in neuroinflammation, pain management, and the study of neurodegenerative disorders.
Se han encontrado 562 productos de "Inhibidores de ciclooxigenasa (COX)"
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Indobufen
CAS:<p>Indobufen (Ibustrin) is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor.</p>Fórmula:C18H17NO3Pureza:99.27% - 99.44%Forma y color:SolidPeso molecular:295.33Salicylic acid
CAS:<p>Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.</p>Fórmula:C7H6O3Pureza:98.04% - 98.83%Forma y color:White Solid PowderPeso molecular:138.12Lornoxicam
CAS:<p>Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and</p>Fórmula:C13H10ClN3O4S2Pureza:98.74% - 99.28%Forma y color:Crystalline SolidPeso molecular:371.82(R)-Naproxen
CAS:<p>(R)-Naproxen: anti-inflammatory with antipyretic and analgesic effects; treats gout, dysmenorrhea, rheumatoid arthritis.</p>Fórmula:C14H14O3Pureza:99.62% - 99.94%Forma y color:SolidPeso molecular:230.26Nepafenac
CAS:<p>Nepafenac (AHR 9434) is an NSAID that acts as a cyclooxygenase inhibitor.</p>Fórmula:C15H14N2O2Pureza:98.94% - 99.43%Forma y color:SolidPeso molecular:254.28Fenbufen
CAS:<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>Fórmula:C16H14O3Pureza:98.35% - 98.46%Forma y color:White SolidPeso molecular:254.28(Iso)-Samixogrel
CAS:<p>(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.</p>Fórmula:C25H25ClN2O4SPureza:98.80%Forma y color:SolidPeso molecular:484.99Timegadine hydrochloride
CAS:<p>Timegadine hydrochloride (SR1368 hydrochloride) is the hydrochloride salt form of Timegadine. It is an orally active inhibitor of COX and lipo-oxygenase, effectively suppressing COX in rabbit platelets and rat brain with IC50 values of 5 nM and 20 μM, respectively, and inhibiting lipo-oxygenase in horse and rabbit platelets with an IC50 of 100 μM. Timegadine hydrochloride also exhibits anti-arthritis activity.</p>Fórmula:C20H24ClN5SForma y color:SolidPeso molecular:401.9615-LOX-IN-2
<p>15-LOX-IN-2 (Compound 2a) is an orally active inhibitor of COX-2/15-LOX and a partial agonist of PPARγ. It exhibits anti-inflammatory activity by inhibiting levels of 20-HETE, IL-1β, and TNF-α in LPS-treated RAW 264.7 cells. Additionally, it significantly enhances glucose uptake without the presence of insulin and is applicable in metabolic disease research.</p>Forma y color:Odour SolidAntiviral agent 61
<p>Antiviralagent 61 (compound Z40) serves as an effective antiviral agent with activity against Tomato Spotted Wilt Virus (TSWV), exhibiting an EC50 value of 252 µg/mL. It increases the RNA expression of Ndufb9, COX6B, 7.1.2.2, E, COX5B, Ndufs4, and SDHB, while reducing the expression of Ndufb7, Ndufa5, and G.</p>Fórmula:C22H23N5O4SForma y color:SolidPeso molecular:453.51Feladilimab
CAS:<p>Feladilimab (GSK3359609) is an IgG4 monoclonal antibody that is an ICOS agonist.</p>Pureza:SDS-PAGE:95% SEC-HPLC:98%Forma y color:LiquidPeso molecular:145.24 kDa4-ACETAMIDOANTIPYRINE
CAS:<p>4-ACETAMIDOANTIPYRINE, with CAS No. 83-15-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-ACETAMIDOANTIPYRINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>Fórmula:C13H15N3O2Forma y color:SolidPeso molecular:245.28Lonazolac Calcium
CAS:<p>Lonazolac Calcium, a nonsteroidal anti-inflammatory drug (NSAID), is used to treat inflammation and pain.</p>Fórmula:C34H24CaCl2N4O4Pureza:98%Forma y color:SolidPeso molecular:663.56Amfenac sodium
CAS:<p>Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.</p>Fórmula:C15H12NNaO3Pureza:98%Forma y color:SolidPeso molecular:277.26COX-2/NLRP3-IN-1
<p>COX-2/NLRP3-IN-1 (Compound 6k) is an inhibitor that targets COX-2 and NLRP3, exhibiting an IC50 value of 1.53 μM for COX-2. This compound exerts anti-inflammatory effects by inhibiting the NF-κB/NLRP3 signaling pathway.</p>Fórmula:C24H19Cl2N5OSPeso molecular:495.06874Tebufelone
CAS:<p>Tebufelone is a potent NSAID, inhibits CO, has anti-inflammatory and analgesic properties, and blocks lipoxygenase products (IC50 ~20-22 microM).</p>Fórmula:C20H28O2Pureza:99.32%Forma y color:SolidPeso molecular:300.44M-5011
CAS:<p>M-5011: NSAID and immunomodulator for pain and inflammation; ED50 0.63mg/kg; reduces bone loss in arthritis; low ulcer risk.</p>Fórmula:C14H14O2SPureza:98%Forma y color:SolidPeso molecular:246.32Anti-inflammatory agent 78
<p>Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. It effectively inhibits PGE2, PGE1, COX-2, and COX-1. Additionally, Anti-inflammatory agent 78 suppresses the release of NO in LPS-stimulated RAW 264.7 cell lines.</p>Fórmula:C19H14ClNO4Peso molecular:355.06114Flunixin
CAS:<p>Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle.</p>Fórmula:C14H11F3N2O2Forma y color:SolidPeso molecular:296.24Pemedolac
CAS:<p>Pemedolac (Dexpemedolac) is a small molecule COX inhibitor used to treat neurological disorders, skin and musculoskeletal disorders.</p>Fórmula:C22H23NO3Pureza:>99.99%Forma y color:SolidPeso molecular:349.42Etofenamate
CAS:<p>Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.</p>Fórmula:C18H18F3NO4Pureza:98% - 99.97%Forma y color:SolidPeso molecular:369.33Ketoprofen lysine salt
CAS:<p>Ketoprofen lysine salt is a lysine salt of ketoprofen, a Non-Steroidal Anti-Inflammatory Drug</p>Fórmula:C22H28N2O5Forma y color:SolidPeso molecular:400.48Fentiazac
CAS:<p>Fentiazac (BR-700) is an oral NSAID for pain, inflammation, fever, studied for arthritis and tendonitis.</p>Fórmula:C17H12ClNO2SPureza:99.83%Forma y color:SolidPeso molecular:329.8COX-2-IN-35
<p>COX-2-IN-35 (compound 7) is a selective inhibitor of COX-2, demonstrating anti-inflammatory activity, with an inhibitory concentration (IC 50) of 4.37 nM [1].</p>Fórmula:C22H19NO2S2Pureza:98%Forma y color:SolidPeso molecular:393.52COX-2/15-LOX-IN-3
<p>COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM,</p>Fórmula:C25H24FN3O3SPureza:98%Forma y color:SolidPeso molecular:465.54MCI
<p>MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation</p>Fórmula:C45H52ClN7O13Pureza:98%Forma y color:SolidPeso molecular:934.391-Hydroxy-ibuprofen
CAS:<p>1-Hydroxy Ibuprofen, a metabolite in P. australis, targets COX-1/COX-2 with IC50s: 13 μM/370 μM.</p>Fórmula:C13H18O3Forma y color:SolidPeso molecular:222.28025-LOX/sEH-IN-1
<p>Compound 8o (5-LOX/sEH-IN-1) is a dual inhibitor with cardioprotective properties, targeting both 5-LOX and sEH with IC50 values of 3.05 μM and 2.20 nM respectively. It also inhibits the activity of COX-2 (IC50=10.50 μM). Possessing analgesic and anti-inflammatory properties, 5-LOX/sEH-IN-1 reduces ulcerogenicity, making it a potential candidate for developing anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects.</p>Forma y color:Odour SolidAkt/NF-κB/MAPK-IN-1
<p>Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.</p>Fórmula:C38H56N2O4Pureza:98%Forma y color:SolidPeso molecular:604.86Guaiacol-d3
CAS:<p>Guaiacol-d3 is a deuterated form of Guaiacol, which is a phenolic compound known for its ability to inhibit COX-2 expression and NF-κB activation in response to LPS stimulation, exhibiting anti-inflammatory properties.</p>Fórmula:C7H8O2Forma y color:SolidPeso molecular:127.16Vedaprofen
CAS:<p>Vedaprofen (PM 150) is a COX-1 inhibitor with anti-inflammatory effects, blocking E. coli clamp at IC50 222 μM, Ki 131 μM.</p>Fórmula:C19H22O2Pureza:99.24% - 99.70%Forma y color:SolidPeso molecular:282.38COX-2-IN-46
<p>COX-2-IN-46 (compound 5m) serves as a potent anti-inflammatory and analgesic agent. It demonstrates a significant inhibitory action on COX-2, with an IC 50 value of 87.74 nM.</p>Fórmula:C28H19F2N3SForma y color:SolidPeso molecular:467.53COX-2-IN-34
CAS:<p>COX-2-IN-34 is a selective, orally potent COX-2 inhibitor that shows anti-inflammatory activity without gastric ulcer toxicity during experiments in mice.</p>Fórmula:C13H11NO4Pureza:98.08%Forma y color:SoildPeso molecular:245.23COX-1-IN-2
<p>COX-1-IN-2 (compound 5h) serves as a potent anti-inflammatory and analgesic agent. This compound demonstrates a significant inhibitory effect on COX-1, with an IC 50 value of 38.76 nM.</p>Fórmula:C29H22FN3OSForma y color:SolidPeso molecular:479.572-(Phosphonooxy)benzoic acid
CAS:<p>2-(Phosphonooxy)benzoic acid (Fosfosal), used as the anti-inflammatory agent, has the anti-bacterial effect.</p>Fórmula:C7H7O6PPureza:99.83%Forma y color:SolidPeso molecular:218.1SARS-CoV-2 Mpro-IN-41
<p>SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor targeting COX-2 and SARS-CoV-2 Mpro, with respective IC50 values of 9.66 μM and 13.24 μM. It also demonstrates inhibitory activity against COX-1 (IC50: 46.11 μM). This compound significantly suppresses the expression of inflammation-related cytokines such as TNF-α, IL-6, and IL-1β, exhibiting anti-inflammatory properties. By selectively inhibiting COX-2 and SARS-CoV-2 Mpro, SARS-CoV-2 Mpro-IN-41 exerts both anti-inflammatory and antiviral effects, making it a potential candidate for research in inflammation and COVID-19 treatment.</p>Fórmula:C27H23ClN4O3SForma y color:SolidPeso molecular:518.11794COX-1/2-IN-9
<p>COX-1/2-IN-9 (Compound 3n) serves as a selective and potent inhibitor of both COX-1 and COX-2, demonstrating IC 50 values of 0.031 µM for COX-1 and 0.01 µM for COX-2. This compound exhibits antibacterial and anti-inflammatory properties, effectively targeting MRSA 1478 (MIC=50 μg/mL) and multidrug-resistant S. lentus (MIC=50 μg/mL). Furthermore, COX-1/2-IN-9 shows promise in relieving MRSA-induced pneumonia in conditions of compromised immunity.</p>Fórmula:C30H20IN9O13S2Forma y color:SolidPeso molecular:905.57COX-2/15-LOX-IN-2
<p>COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX.</p>Fórmula:C27H26N6OS2Pureza:98%Forma y color:SolidPeso molecular:514.66COX-2-IN-49
<p>COX-2-IN-49 (compound 6c) is a potent inhibitor of cyclooxygenase-2 (COX-2), displaying an IC50 value of 2.671 µM. This compound exhibits anti-proliferative properties and holds potential for use in cancer research.</p>Forma y color:Odour SolidBMP-4
CAS:<p>BMP-4, a heparin-binding peptide, exhibits anti-inflammatory and anti-chondrogenic properties. In murine chondrocytes and macrophages, it effectively mitigates inflammation and alleviates symptoms of various arthritides by dose-dependently suppressing the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6 through modulation of the iNOS-IFN-IL6 signaling pathway.</p>Fórmula:C52H93N25O13SForma y color:SolidPeso molecular:1308.52NF157
CAS:<p>NF157, a selective P2Y11 antagonist with pKi 7.35, lowers MMP-3/MMP-13, aiding OA treatment; IC50s: P2Y11 463 nM, P2Y1 1811 μM, P2Y2 170 μM.</p>Fórmula:C49H28F2N6Na6O23S6Pureza:98%Forma y color:SolidPeso molecular:1437.14-Methylamino antipyrine hydrochloride
CAS:<p>4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole.</p>Fórmula:C12H16ClN3OPureza:98%Forma y color:SolidPeso molecular:253.73Multinoside A
CAS:<p>Multinoside A is a useful organic compound for research related to life sciences. The catalog number is T124593 and the CAS number is 59262-54-3.</p>Fórmula:C27H30O16Forma y color:SolidPeso molecular:610.521Lobuprofen
CAS:<p>Lobuprofen is a small molecule COX inhibitor that is used to treat neurological disorders.</p>Fórmula:C25H33ClN2O2Pureza:99.18%Forma y color:SolidPeso molecular:428.99Anti-inflammatory agent 50
<p>Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and</p>Fórmula:C40H55N3O6Pureza:98%Forma y color:SolidPeso molecular:673.88Hamaline
CAS:<p>Hamaline (9-(4-chlorobenzyl)-6-methoxy-1-methyl-4,9-dihydro-3H-pyrido[3,4-b]indole) is a substrate-selective cyclooxygenase-2 (COX-2) inhibitor.</p>Fórmula:C20H19ClN2OPureza:99.88%Forma y color:SoildPeso molecular:338.83COX-1/2-IN-5
<p>COX-1/2-IN-5 (compound 2a) functions as a dual inhibitor of COX1/2, demonstrating inhibitory concentrations (IC50) of 2.650 μM and 0.958 μM, respectively, and</p>Fórmula:C21H22N2O5SPureza:98%Forma y color:SolidPeso molecular:414.47COX-2-IN-52
<p>COX-2-IN-52 (Compound 5l) is an orally active and selective COX-2 inhibitor with an IC50 of 54 nM. It can suppress the release of NO in cells, exhibiting anti-inflammatory properties. COX-2-IN-52 offers high gastrointestinal safety and is suitable for research on oral anti-inflammatory drugs.</p>Fórmula:C16H13IN4O4S2Forma y color:SolidPeso molecular:516.333
