CAMK
Calcium/Calmodulin-Dependent Protein Kinase (CaMK) inhibitors are specialized compounds that inhibit the activity of CaMK, a critical kinase involved in a range of cellular processes, particularly within the nervous system. CaMK is essential for translating calcium signals into various cellular responses, including synaptic plasticity, memory formation, and gene expression. Dysregulation of CaMK activity is linked to several neurological disorders, making these inhibitors valuable tools in the study of synaptic signaling, learning, and memory. By using CaMK inhibitors, researchers can explore the molecular mechanisms underlying cognitive function and synaptic plasticity. At CymitQuimica, we provide high-quality CaMK inhibitors to support your research in synaptic plasticity, cognitive function, and neuropharmacology.
Se han encontrado 69 productos de "CAMK"
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CBP501
CAS:<p>CBP501 peptide inhibits kinases like MAPKAP-K2/C-Tak1/CHK1, preventing Cdc25C function and blocking the entry into mitosis.</p>Fórmula:C86H122F5N29O17Forma y color:SolidPeso molecular:1929.06Ph-HTBA
CAS:<p>Ph-HTBA: high-affinity CaMKIIα modulator, brain-penetrant, Kd 757 nM, used in ischemia/neurodegeneration research.</p>Fórmula:C19H18O3Forma y color:SolidPeso molecular:294.34A-7 hydrochloride
CAS:<p>A-7 hydrochloride is a calmodulin antagonist and causes alterations in the subpopulation of CD44+CD24- in MDA-MB-231 cells.</p>Fórmula:C20H30Cl2N2O2SPureza:99.38%Forma y color:SolidPeso molecular:433.44RU 45144
CAS:<p>RU 45144 is an estradiol derivative with antiestrogenic activity.</p>Fórmula:C28H37NO3Pureza:98%Forma y color:SolidPeso molecular:435.6HOCPCA
CAS:<p>HOCPCA: potent, selective GHB site ligand; 27x higher affinity than GHB; crosses blood-brain barrier.</p>Fórmula:C6H8O3Pureza:98%Forma y color:SolidPeso molecular:128.13W-13 hydrochloride
CAS:<p>W-13 hydrochloride (W-13 HCl) is a calmodulin antagonist.</p>Fórmula:C14H18Cl2N2O2SPureza:98.51%Forma y color:White PowderPeso molecular:349.28Prenylamine lactate
CAS:<p>Prenylamine lactate, an ex-angina drug, depletes heart catecholamines and blocks calcium channels.</p>Fórmula:C27H33NO3Pureza:98%Forma y color:SolidPeso molecular:419.56Zaldaride maleate
CAS:<p>Zaldaride maleate blocks Ca2+, Na+, K+ currents, and nAChR; inhibits CaM cAMP PDE (IC50: 3.3 nM) and estrogen signaling.</p>Fórmula:C30H32N4O6Pureza:98%Forma y color:SolidPeso molecular:544.6TX-1123
CAS:<p>TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.</p>Fórmula:C20H24O3Forma y color:SolidPeso molecular:312.4CV-159
CAS:<p>CV-159 is a unique dihydropyridine Ca2+ antagonist with antiinflammatory activities. It has an anti-calmodulin (CaM) action.</p>Fórmula:C31H34N4O7Pureza:98%Forma y color:SolidPeso molecular:574.62W-9 hydrochloride
CAS:<p>W-9 hydrochloride is a calmodulin antagonist.</p>Fórmula:C16H22Cl2N2O2SPureza:98.9%Forma y color:SolidPeso molecular:377.33Calmidazolium chloride
CAS:<p>Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.</p>Fórmula:C31H23Cl7N2OPureza:98.53%Forma y color:SolidPeso molecular:687.7MCB-22-174
CAS:MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP).Fórmula:C16H14DCl2N5OS2Peso molecular:429.37PTCA
CAS:<p>PTCA is a potent ligand for Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), with a pKi value of 7.2.</p>Fórmula:C10H5Cl2NO2SForma y color:SolidPeso molecular:274.123CaMKK2-IN-1
CAS:<p>CaMKK2-IN-1 is a selective and potent inhibitor of CaMKK2, exhibiting an IC50 of 7 nM.</p>Fórmula:C22H22N2O3Peso molecular:362.42CaMKIIα-IN-1
<p>CaMKIIα-IN-1 (Compound 4d) is an orally active inhibitor of Ca 2+ /calmodulin-dependent protein kinase II α (CaMKIIα) with a Kd of 219 nM for CaMKIIα WT hub.</p>Fórmula:C14H11ClO4Forma y color:SolidPeso molecular:278.69FO-4-15
CAS:<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Fórmula:C18H20N4O4SForma y color:SolidPeso molecular:388.44BRD0418
CAS:<p>BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.</p>Fórmula:C29H32N2O5Pureza:99.57%Forma y color:SolidPeso molecular:488.57Calmodulin antagonist-1
CAS:<p>Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.</p>Fórmula:C14H18Cl2N2O2SForma y color:SolidPeso molecular:349.27
