GluR
Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.
Se han encontrado 265 productos de "GluR"
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ADX-47273
CAS:ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).Fórmula:C20H17F2N3O2Pureza:97% - 99.22%Forma y color:SolidPeso molecular:369.36JNJ16259685
CAS:JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19Fórmula:C20H23NO3Pureza:98.31%Forma y color:SolidPeso molecular:325.4Ref: TM-T5512
1mg46,00€2mg62,00€5mg95,00€1mL*10mM (DMSO)95,00€10mg133,00€25mg278,00€50mg424,00€100mg620,00€PHCCC
CAS:PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.Fórmula:C17H14N2O3Pureza:>99.99%Forma y color:SolidPeso molecular:294.3YM90K
CAS:YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.Fórmula:C11H8ClN5O4Pureza:98.23%Forma y color:SolidPeso molecular:309.66Ref: TM-T8435
1mg73,00€5mg160,00€1mL*10mM (DMSO)170,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€CX717
CAS:CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect.Fórmula:C11H11N3O3Pureza:99.81%Forma y color:SoildPeso molecular:233.23(S)-4CPG
CAS:(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.Fórmula:C9H9NO4Pureza:99.96%Forma y color:SolidPeso molecular:195.17VU0477886
CAS:VU0477886: Potent mGlu4 PAM, effective in preclinical Parkinson's model HIC.Fórmula:C20H13ClN4O3Pureza:98%Forma y color:SolidPeso molecular:392.80IEM 1754 2HBr
CAS:IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.Fórmula:C16H30N2·2HBrPureza:99.04% - 99.72%Forma y color:SolidPeso molecular:412.25(S)-4C3HPG
CAS:group I mGlu1a/1a receptor antagonist and mGluR2 agonistFórmula:C9H9NO5Pureza:98%Forma y color:SolidPeso molecular:211.17ACPT-I
CAS:Agonist for group III mGlu receptorsFórmula:C8H11NO6Pureza:98%Forma y color:SolidPeso molecular:217.18JNJ-46356479
CAS:JNJ-46356479: Selective, oral mGlu2 receptor PAM, EC50=78 nM, Emax=256%.Fórmula:C22H22F5N5Forma y color:SolidPeso molecular:451.44LSN2814617
CAS:LSN2814617: oral, brain-penetrant mGlu5 PAM, EC50 = 52 nM (human), 42 nM (rat). Promotes wakefulness, useful in schizophrenia study.Fórmula:C18H20FN5OPureza:98%Forma y color:SolidPeso molecular:341.38RO4988546
CAS:RO4988546 is a potent negative allosteric modulator of mGlu₂/₃.Fórmula:C21H10F6N4O3SPureza:98%Forma y color:SolidPeso molecular:512.38mGluR2 modulator 1
CAS:Potent mGluR2 modulator 1 crosses blood-brain barrier, EC50: 0.03 μM, useful for psychiatric research.Fórmula:C21H20F3N3O3Forma y color:SolidPeso molecular:419.4NPEC-caged-LY379268
CAS:NPEC-caged-LY379268 is a type II mGluR agonist [1].Fórmula:C16H16N2O9Forma y color:SolidPeso molecular:380.31A 841720
CAS:Potent, selective mGlu1 antagonist A-841720; IC50: 10 nM; 34x selectivity vs mGlu5; analgesic potential.Fórmula:C17H21N5OSForma y color:SolidPeso molecular:343.45RO5488608
CAS:RO5488608 is a new type of high-efficiency mGlu2/3 NAM.Fórmula:C23H17F3N2O4SForma y color:SolidPeso molecular:474.45Talaglumetad hydrochloride
CAS:Talaglumetad hydrochloride, a prodrug of Eglumegad, targets mGluR2/3 to treat psychiatric disorders.Fórmula:C11H17ClN2O5Forma y color:SolidPeso molecular:292.72mGluR2 modulator 2
CAS:mGluR2 modulator 2: potent, selective, oral, EC50 = 0.13 μM, for antipsychotic research.Fórmula:C20H22FN3Forma y color:SolidPeso molecular:323.41UPF-523
CAS:group I metabotropic glutamate receptors (mGlu1a) antagonistFórmula:C11H11NO4Pureza:98%Forma y color:White SolidPeso molecular:221.21VU0418506
CAS:VU0418506 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4).Fórmula:C12H8ClFN4Pureza:98%Forma y color:SolidPeso molecular:262.67ACDPP hydrochloride
CAS:mGlu5 receptor antagonistFórmula:C12H13ClN6OPureza:98%Forma y color:SolidPeso molecular:292.72Ro 64-5229
CAS:mGlu2 antagonistFórmula:C17H19Cl2N3OPureza:98%Forma y color:SolidPeso molecular:352.26DL-AP4 Sodium salt
CAS:Broad spectrum EAA ligandFórmula:C4H10NNaO5PPureza:98%Forma y color:SolidPeso molecular:206.09VU6001966
CAS:VU6001966: potent, selective mGlu2 inhibitor (IC50=78 nM), negative modulator, with good CNS penetration.Fórmula:C17H15FN4O2Pureza:98%Forma y color:SolidPeso molecular:326.33VU6010572
CAS:VU6010572: potent, selective mGlu3 modulator, IC50 245 nM, high CNS penetration.Fórmula:C20H18FNO3Forma y color:SolidPeso molecular:339.36VU0463841
CAS:VU0463841 is a mGlu5 negative allosteric modulators.Fórmula:C13H8ClFN4OForma y color:SolidPeso molecular:290.68VU 0360172 hydrochloride
CAS:positive allosteric modulator of mGlu5 receptorsFórmula:C18H16ClFN2OPureza:98%Forma y color:SolidPeso molecular:330.78ACPT-II
CAS:metabotropic receptor antagonistFórmula:C8H11NO6Pureza:98%Forma y color:SolidPeso molecular:217.18mGluR2 modulator 4
CAS:Compound 47 is a potent mGluR2 enhancer with an EC50 of 0.8 μM, potentially useful for antipsychotic research.Fórmula:C18H18BrN3Forma y color:SolidPeso molecular:356.26VU0400195
CAS:VU0400195 is a oral effective, positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)).Fórmula:C21H16ClN3O3Pureza:98%Forma y color:SolidPeso molecular:393.82VU0404251
CAS:VU0404251 is a positive allosteric modulator of mGlu5.Fórmula:C19H23FN2O2Forma y color:SolidPeso molecular:330.4VU0364289
CAS:VU0364289 is a positive allosteric modulator of mGlu5.Fórmula:C20H21N3O2Forma y color:SolidPeso molecular:335.4VU0361747
CAS:VU0361747 is a positive allosteric modulators (PAM) of metabotropic glutamate receptor subtype 5 (mGlu5).Fórmula:C19H17FN2O2Forma y color:SolidPeso molecular:324.35MSOP
CAS:MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).Fórmula:C4H10NO6PPureza:98%Forma y color:SolidPeso molecular:199.1LY487379 hydrochloride
CAS:Positive allosteric modulator of mGlu2 receptorsFórmula:C21H20ClF3N2O4SPureza:98%Forma y color:SolidPeso molecular:488.91AZ12216052
CAS:AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.Fórmula:C19H22BrNOSPureza:99.29%Forma y color:SolidPeso molecular:392.35CFMMC
CAS:CFMMC is an allosteric mGluR1 antagonist agent.
Fórmula:C22H28FNO4Forma y color:SolidPeso molecular:389.46YM 230888
CAS:Selective mGlu1 antagonistFórmula:C19H28N4OSPureza:98%Forma y color:SolidPeso molecular:360.52LY2607540
CAS:LY2607540 is a metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties (EC(50) = 23 and 13 nM, respectively).Fórmula:C24H24F3N3O4Pureza:98%Forma y color:SolidPeso molecular:475.46VU0410425
CAS:VU0410425 is a metabotropic glutamate receptor subtype 1 negative allosteric modulator.Fórmula:C19H16ClN3O3Pureza:98%Forma y color:SolidPeso molecular:369.8(S)-HexylHIBO
CAS:Group I mGlu receptor antagonistFórmula:C12H20N2O4Pureza:98%Forma y color:SolidPeso molecular:256.3LSP1-2111
CAS:LSP1-2111 is a mGlu4 receptor subtype agonist.Fórmula:C12H17N2O9PForma y color:SolidPeso molecular:364.25Lu-AF11205
CAS:Lu-AF11205 is a potent positive allosteric modulator (PAM) of mGlu5 receptor.Fórmula:C17H16N2OSPureza:98%Forma y color:SolidPeso molecular:296.39(RS)-4-Carboxyphenylglycine
CAS:(RS)-4-Carboxyphenylglycine is a racemic mixture. (S)-4-Carboxyphenylglycine is a selective mGlu1α receptor antagonist.Fórmula:C9H9NO4Pureza:97.22% - >99.99%Forma y color:SolidPeso molecular:195.17(R)-4-Carboxyphenylglycine
CAS:(R)-4-Carboxyphenylglycine is a NMDA receptor antagonist.Fórmula:C9H9NO4Pureza:98%Forma y color:SolidPeso molecular:195.17DCG-IV
CAS:DCG-IV: Class II mGluR agonist; anticonvulsant; neuroprotective; EC50: mGlu2R-0.35μM, mGlu3R-0.09μM; antagonizes Group I/III mGluRs.Fórmula:C7H9NO6Pureza:98%Forma y color:SolidPeso molecular:203.15VU0652835
CAS:VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).Fórmula:C16H19N3O3SPureza:98%Forma y color:SolidPeso molecular:333.41VU0486321
CAS:VU0486321: potent mGlu1 PAM, rat PK CLp 13.3 mL/min/kg, t1/2 54 min, human fu 0.05, rat fu 0.03, great CNS penetration Kp 1.02.Fórmula:C20H12ClFN2O4Forma y color:SolidPeso molecular:398.77A-850002
CAS:A-850002 is a bioactive chemical.Fórmula:C18H16N4OSForma y color:SolidPeso molecular:336.41VU0431316
CAS:VU0431316 is a negative mGlu5 allosteric modulator. It has activity in a mouse model of anxiety.Fórmula:C14H9ClN6O2Pureza:98%Forma y color:SolidPeso molecular:328.71(RS)-PPG
CAS:(RS)-PPG: Potent, selective III mGluRs agonist; EC50s: hmGluR4a 5.2μM, hmGluR6 4.7μM, hmGluR7b 185μM, hmGluR8a 0.2μM; neuroprotective, anticonvulsive.Fórmula:C8H10NO5PPureza:98%Forma y color:SolidPeso molecular:231.14JNJ-55511118
CAS:JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.Fórmula:C14H8ClF3N2O2Forma y color:SolidPeso molecular:328.67DCB
CAS:DCB is an mGluR5 allosteric ligand that blocks mGluR modulation, countering DMeOB and DFB effects.Fórmula:C14H10Cl2N2Pureza:99.12% - 99.9%Forma y color:SolidPeso molecular:277.15HTL14242
CAS:HTL14242 is a mGlu5 Negative Allosteric Modulator.Fórmula:C16H8ClFN4Forma y color:SolidPeso molecular:310.71N,N-Dipropyldopamine (hydrobromide)
CAS:N,N-Dipropyldopamine is a dopamine agonist reducing DOPA and locomotion in rats and mice, reversible by spiroperidol.Fórmula:C14H24BrNO2Forma y color:SolidPeso molecular:318.255(S)-3,5-DHPG
CAS:group I mGlu receptor agonistFórmula:C8H9NO4Pureza:98%Forma y color:SolidPeso molecular:183.16TASP0433864
CAS:TASP0433864 enhances mGlu2 activity; EC50: 199 nM (human), 206 nM (rat); not an agonist.Fórmula:C18H23N3O3Pureza:98%Forma y color:SolidPeso molecular:329.39ML337
CAS:ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.Fórmula:C21H20FNO3Pureza:99.83%Forma y color:SolidPeso molecular:353.39Ref: TM-T23003
100mgA consultar1mg34,00€5mg60,00€1mL*10mM (DMSO)72,00€10mg92,00€25mg195,00€50mg293,00€JNJ-40068782
CAS:JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor.Fórmula:C21H23N3OPureza:98%Forma y color:SolidPeso molecular:333.43LY456066
CAS:LY456066 is a mGluR1 receptor-selective, negative allosteric modulator.Fórmula:C19H23N3OSPureza:98%Forma y color:SolidPeso molecular:341.47Z-Cyclopentyl-AP4
CAS:Group III mGlu receptor agonistFórmula:C6H12NO5PPureza:98%Forma y color:SolidPeso molecular:209.14DFMTI
CAS:DFMTI can completely block the rmGlu1 L757V glutamate response.Fórmula:C20H18F2N4OForma y color:SolidPeso molecular:368.38LY382884
CAS:LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.Fórmula:C18H23NO4Pureza:98.32% - 98.71%Forma y color:SolidPeso molecular:317.38GRN-529
CAS:GRN-529 is a selective negative allosteric modulator of the mGluR5 receptor.Fórmula:C22H15F2N3O2Pureza:98%Forma y color:SolidPeso molecular:391.37MAP4
CAS:metabotropic glutamate receptor modulatorFórmula:C5H12NO5PPureza:98%Forma y color:White SolidPeso molecular:197.13mGlu4 receptor agonist 1
CAS:Compound 62, an mGlu4 agonist, has a 308 nM EC50 with anxiolytic and antipsychotic effects.Fórmula:C21H15ClN4O2Forma y color:SolidPeso molecular:390.82ADX71743
CAS:ADX71743 is a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7.Fórmula:C17H19NO2Pureza:99.27%Forma y color:SolidPeso molecular:269.34VU 0360223
CAS:VU 0360223 is a negative allosteric modulator of mGlu5.Fórmula:C15H9FN2SPureza:98%Forma y color:SolidPeso molecular:268.31L-AP4 monohydrate
CAS:L-AP4 (L-APB) is a group III mGluR agonist with EC50s: 0.13μM (mGlu4), 0.29μM (mGlu8), 1.0μM (mGlu6), 249μM (mGlu7).Fórmula:C4H12NO6PForma y color:SolidPeso molecular:201.115VU0366248
CAS:VU0366248 is a mGlu5 negative allosteric modulator.Fórmula:C14H7ClF2N2OPureza:98%Forma y color:SolidPeso molecular:292.673,3'-Difluorobenzaldazine
CAS:allosteric potentiator of mGlu5Fórmula:C14H10F2N2Pureza:98%Forma y color:SolidPeso molecular:244.24TC-N 22A
CAS:TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier.Fórmula:C14H13N5SPureza:99.95%Forma y color:SolidPeso molecular:283.35(RS)-MCPG disodium salt
CAS:group I/group II metabotropic glutamate receptor antagonistFórmula:C10H11NNaO4Pureza:98%Forma y color:SolidPeso molecular:232.19CPPHA
CAS:CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.
Fórmula:C22H15ClN2O4Pureza:98.07%Forma y color:SolidPeso molecular:406.82ML289
CAS:ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.Fórmula:C22H23NO3Pureza:99.54%Forma y color:SolidPeso molecular:349.42Ref: TM-T23000
5mg48,00€1mL*10mM (DMSO)49,00€10mg75,00€25mg138,00€50mg212,00€100mg320,00€200mg445,00€LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Fórmula:C29H29N7O4Pureza:98%Forma y color:SolidPeso molecular:539.59Methoxy-PEPy
CAS:Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.Fórmula:C13H10N2OPureza:98.66%Forma y color:SolidPeso molecular:210.23(1R,2S)-VU0155041
CAS:(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.Fórmula:C14H15Cl2NO3Pureza:98.85%Forma y color:SolidPeso molecular:316.18VU 0469650
CAS:VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).Fórmula:C22H28N4OPureza:98.03%Forma y color:SolidPeso molecular:364.48Ref: TM-T29118
1mg42,00€5mg79,00€1mL*10mM (DMSO)90,00€10mg108,00€25mg210,00€50mg313,00€100mg464,00€200mg640,00€Foliglurax
CAS:Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).Fórmula:C23H23N3O3SPureza:98%Forma y color:SolidPeso molecular:421.51VU6001376
CAS:VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).Fórmula:C18H14F2N6OSPureza:98%Forma y color:SolidPeso molecular:400.41LY392098
CAS:LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.Fórmula:C18H22FNO2SPureza:99.86%Forma y color:SolidPeso molecular:335.44Ref: TM-T27951
1mg39,00€5mg93,00€1mL*10mM (DMSO)96,00€10mg133,00€25mg215,00€50mg306,00€100mg414,00€200mg573,00€NS 1209
CAS:NS 1209 (SPD 502) is a AMPA receptor antagonist.Fórmula:C24H27N4NaO7SPureza:98%Forma y color:SolidPeso molecular:538.55Ro 67-4853
CAS:Ro 67-4853 is a positive allosteric modulator of mGluR1, selectively enhancing the response to the agonist (S)-3,5-dihydroxy-phenylglycine (DHPG).Fórmula:C19H19NO4Pureza:98.57%Forma y color:SolidPeso molecular:325.36VU0155041 sodium
CAS:VU0155041 sodium is a positive allosteric modulator of mGluR4 that promotes extinction in male rats.Fórmula:C14H14Cl2NNaO3Pureza:98%Forma y color:SolidPeso molecular:338.16HexylHIBO
CAS:HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.Fórmula:C12H20N2O4Pureza:99.55%Forma y color:SolidPeso molecular:256.3(S)-MCPG
CAS:(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.Fórmula:C10H11NO4Pureza:98.72%Forma y color:SolidPeso molecular:209.20MFZ 10-7 hydrochloride
CAS:MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAMFórmula:C15H10ClFN2Pureza:98%Forma y color:SolidPeso molecular:272.71DMeOB
CAS:DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.Fórmula:C16H16N2O2Pureza:98.34%Forma y color:SolidPeso molecular:268.31BMT-145027
CAS:BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).Fórmula:C23H14ClF3N4Pureza:99.62%Forma y color:SolidPeso molecular:438.83A-794282
CAS:A-794282 is a selective antagonist of mGluR1.Fórmula:C19H18N4OSPureza:99.87%Forma y color:SolidPeso molecular:350.44(RS)-4-Carboxy-3-hydroxyphenylglycine
CAS:broad spectrum EAA agonist/antagonistFórmula:C9H9NO5Pureza:98%Forma y color:SolidPeso molecular:211.17Ro4491533
CAS:Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3).Fórmula:C24H20F3N3OForma y color:SolidPeso molecular:423.43MMPIP
CAS:allosteric mGlu7-selective receptor antagonistFórmula:C19H15N3O3Pureza:98%Forma y color:SolidPeso molecular:333.34LSP4-2022
CAS:LSP4-2022, a mGlu4 selective agonist, increases behavioral despair in mouse models of antidepressant action.Fórmula:C13H18NO8PPureza:100%Forma y color:SolidPeso molecular:347.26VU0409106
CAS:VU0409106 is a potent, mGlu5-selective inhibitor.Fórmula:C15H11FN4O2SPureza:98%Forma y color:SolidPeso molecular:330.34Remeglurant
CAS:Remeglurant is used as a selective antagonist of the mGlu5 receptor.Fórmula:C17H15BrN4OForma y color:SolidPeso molecular:371.23IEM 1925 dihydrobromide
CAS:AMPA receptor antagonistFórmula:C17H30Br2N2Pureza:98%Forma y color:SolidPeso molecular:422.24PHCCC(4Me)
CAS:THCCC, a PHCCC analog, is a dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulator.Fórmula:C18H16N2O3Forma y color:SolidPeso molecular:308.33
