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GluR

GluR

Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.

Se han encontrado 255 productos de "GluR"

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  • Troriluzole

    CAS:
    <p>Troriluzole is a glutamate modulator with anticancer activity and is used in the study of spinocerebellar ataxia.</p>
    Fórmula:C15H16F3N5O4S
    Pureza:97.14%
    Forma y color:Solid
    Peso molecular:419.38
  • Dipraglurant

    CAS:
    <p>Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.</p>
    Fórmula:C16H12FN3
    Pureza:98.7%
    Forma y color:Solid
    Peso molecular:265.29
  • LSN2463359

    CAS:
    <p>LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.</p>
    Fórmula:C16H15N3O
    Pureza:99.26%
    Forma y color:Solid
    Peso molecular:265.31
  • (E/Z)-SIB-1893

    CAS:
    <p>(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.</p>
    Fórmula:C14H13N
    Pureza:99.92%
    Forma y color:Solid
    Peso molecular:195.26
  • Dasolampanel

    CAS:
    <p>Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.</p>
    Fórmula:C17H20ClN5O3
    Pureza:98.70%
    Forma y color:Solid
    Peso molecular:377.83
  • LY-2300559

    CAS:
    <p>LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.</p>
    Fórmula:C26H26O6
    Pureza:99.51%
    Forma y color:Solid
    Peso molecular:434.48
  • Valiglurax

    CAS:
    <p>Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.</p>
    Fórmula:C16H10F3N5
    Pureza:98.29%
    Forma y color:Solid
    Peso molecular:329.28
  • CBiPES hydrochloride

    CAS:
    <p>CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.</p>
    Fórmula:C21H20ClN3O2S
    Pureza:99.66%
    Forma y color:Solid
    Peso molecular:413.92
  • CPCCOEt

    CAS:
    <p>CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1b</p>
    Fórmula:C13H13NO4
    Pureza:99.91%
    Forma y color:Solid
    Peso molecular:247.25
  • S 18986

    CAS:
    <p>S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in</p>
    Fórmula:C10H12N2O2S
    Pureza:99.64%
    Forma y color:Solid
    Peso molecular:224.28
  • VU 0285683

    CAS:
    <p>VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.</p>
    Fórmula:C14H7FN4O
    Pureza:99.98%
    Forma y color:Solid
    Peso molecular:266.23
  • ABP688

    CAS:
    <p>ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.</p>
    Fórmula:C15H16N2O
    Pureza:98.63%
    Forma y color:Solid
    Peso molecular:240.3
  • AZD 9272

    CAS:
    <p>AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.</p>
    Fórmula:C14H6F2N4O
    Pureza:98.29%
    Forma y color:Solid
    Peso molecular:284.22
  • AZD6538

    CAS:
    <p>AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.</p>
    Fórmula:C15H6FN5O
    Pureza:98.68%
    Forma y color:Solid
    Peso molecular:291.24
  • MNI 137

    CAS:
    <p>MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.</p>
    Fórmula:C15H9BrN4O
    Pureza:97.49%
    Forma y color:Solid
    Peso molecular:341.16
  • VU0029251

    CAS:
    <p>VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.</p>
    Fórmula:C10H11N3S2
    Forma y color:Solid
    Peso molecular:237.34
  • MTPG

    CAS:
    <p>Group II/group III metabotropic glutamate receptor antagonist</p>
    Fórmula:C10H11N5O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:233.23
  • L-AP4

    CAS:
    <p>L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).</p>
    Fórmula:C4H10NO5P
    Pureza:98%
    Forma y color:White To Off-White Crystalline Powder
    Peso molecular:183.1
  • mGluR5 antagonist-1

    CAS:
    <p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>
    Fórmula:C23H18N4O2
    Forma y color:Solid
    Peso molecular:382.41
  • VU0360172

    CAS:
    <p>VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).</p>
    Fórmula:C18H15FN2O
    Pureza:99.56%
    Forma y color:Solid
    Peso molecular:294.32
  • Biphenylindanone A

    CAS:
    <p>Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.</p>
    Fórmula:C30H30O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:454.56
  • MFZ 10-7

    CAS:
    <p>MFZ 10-7 is anegative allosteric modulator of the mGluR5.</p>
    Fórmula:C15H9FN2
    Pureza:99.80%
    Forma y color:Solid
    Peso molecular:236.24
  • JNJ-46281222

    CAS:
    <p>JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.</p>
    Fórmula:C23H25F3N4
    Forma y color:Solid
    Peso molecular:414.47
  • MGS-0039

    CAS:
    <p>MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.</p>
    Fórmula:C15H14Cl2FNO5
    Pureza:98%
    Forma y color:Solid
    Peso molecular:378.18
  • FPTQ

    CAS:
    <p>FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].</p>
    Fórmula:C17H12FN5
    Pureza:99.68% - 99.88%
    Forma y color:Solid
    Peso molecular:305.31
  • VU6005649

    CAS:
    <p>VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).</p>
    Fórmula:C16H12F5N3O
    Pureza:99.87%
    Forma y color:Solid
    Peso molecular:357.28
  • VU6012962

    CAS:
    <p>VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).</p>
    Fórmula:C21H19F3N4O4
    Pureza:99.61% - 99.74%
    Forma y color:Solid
    Peso molecular:448.4
  • Pomaglumetad methionil hydrochloride

    CAS:
    <p>LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.</p>
    Fórmula:C12H19ClN2O7S2
    Pureza:98.57%
    Forma y color:Solid
    Peso molecular:402.87
  • Licostinel

    CAS:
    <p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>
    Fórmula:C8H3Cl2N3O4
    Pureza:98.02%
    Forma y color:Solid
    Peso molecular:276.03
  • cis-PDA

    CAS:
    <p>cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.</p>
    Fórmula:C7H11NO4
    Pureza:98.71%
    Forma y color:White Solid
    Peso molecular:173.17
  • (2R,4R)-APDC

    CAS:
    <p>(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.</p>
    Fórmula:C6H10N2O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:174.15
  • AMPA receptor modulator-2

    CAS:
    <p>AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.</p>
    Fórmula:C15H6F6N4OS
    Pureza:99.8%
    Forma y color:Solid
    Peso molecular:404.29
  • MK-8768

    CAS:
    <p>MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized by</p>
    Fórmula:C21H22F3N5O2
    Forma y color:Solid
    Peso molecular:433.43
  • Philanthotoxin 74 dihydrochloride

    CAS:
    <p>Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.</p>
    Fórmula:C24H44Cl2N4O3
    Pureza:99.75%
    Forma y color:Solid
    Peso molecular:507.54
  • VU6004909

    CAS:
    <p>VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.</p>
    Fórmula:C21H15FN2O4
    Pureza:96.68% - 98.44%
    Forma y color:Solid
    Peso molecular:378.35
  • Azotomycin

    CAS:
    <p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>
    Fórmula:C17H23N7O8
    Pureza:98%
    Forma y color:Solid
    Peso molecular:453.41
  • CVN636

    CAS:
    <p>CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for human</p>
    Fórmula:C19H20FNO4S
    Forma y color:Solid
    Peso molecular:377.43
  • LY2794193

    CAS:
    <p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>
    Fórmula:C16H18N2O6
    Pureza:98.15%
    Forma y color:Solid
    Peso molecular:334.32
  • LY367385 hydrochloride

    CAS:
    <p>LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.</p>
    Fórmula:C10H12ClNO4
    Forma y color:Solid
    Peso molecular:245.66
  • AZD 2066 hydrate


    <p>AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].</p>
    Fórmula:C19H18ClN5O3
    Forma y color:Solid
    Peso molecular:386.33
  • CPPG

    CAS:
    <p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>
    Fórmula:C11H14NO5P
    Forma y color:Solid
    Peso molecular:271.21
  • FP0429

    CAS:
    <p>FP0429 is an agonist of mGlu4.</p>
    Fórmula:C10H12N2O7
    Pureza:98%
    Forma y color:Solid
    Peso molecular:272.21
  • LY 541850

    CAS:
    <p>LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human</p>
    Fórmula:C9H13NO4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:199.2
  • LY3020371 hydrochloride

    CAS:
    <p>LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.</p>
    Fórmula:C15H16ClF2NO5S
    Forma y color:Solid
    Peso molecular:395.81
  • PF470

    CAS:
    <p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>
    Fórmula:C18H16N6O
    Forma y color:Solid
    Peso molecular:332.36
  • Pomaglumetad methionil

    CAS:
    <p>Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.</p>
    Fórmula:C12H20N2O8S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:384.43
  • YM 202074

    CAS:
    <p>metabotropic glutamate receptor type 1 (mGlu1) antagonist</p>
    Fórmula:C56H72N8O16S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:1177.34
  • LY2979165

    CAS:
    <p>LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.</p>
    Fórmula:C13H22N6O6S
    Pureza:98.41%
    Forma y color:Solid
    Peso molecular:390.42
  • Eglumegad

    CAS:
    <p>Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).</p>
    Fórmula:C8H11NO4
    Forma y color:Solid
    Peso molecular:185.18

    Ref: TM-T15817

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    Producto descatalogado
  • YM-298198 hydrochloride

    CAS:
    <p>mGlu1 receptor antagonist</p>
    Fórmula:C18H23ClN4OS
    Pureza:98%
    Forma y color:Solid
    Peso molecular:378.919

    Ref: TM-T23548

    1mg
    Descatalogado
    Producto descatalogado
  • (RS)-APICA

    CAS:
    <p>group II metabotropic glutamate receptor antagonist</p>
    Fórmula:C10H12NO5P
    Forma y color:Solid
    Peso molecular:257.18

    Ref: TM-T23268

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  • Eglumegad hydrochloride


    <p>Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, showing IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors in transfected human cells. This compound provides neuroprotection against NMDA-induced toxicity and exhibits anxiolytic- and antipsychotic-like properties [1].</p>
    Fórmula:C8H12ClNO4
    Forma y color:Solid
    Peso molecular:221.64

    Ref: TM-T78094

    ne
    Descatalogado
    Producto descatalogado
  • VU0080241

    CAS:
    <p>VU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).</p>
    Fórmula:C19H23N5
    Forma y color:Solid
    Peso molecular:321.42

    Ref: TM-T29121

    ne
    Descatalogado
    Producto descatalogado
  • CMPDA

    CAS:
    <p>CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].</p>
    Fórmula:C16H28N2O4S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:376.53

    Ref: TM-TQ0114

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  • UBP1112

    CAS:
    <p>group III mGlu receptor antagonist</p>
    Fórmula:C10H14NO5P
    Pureza:98%
    Forma y color:Solid
    Peso molecular:259.2

    Ref: TM-T23491

    25mg
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