
GluR
Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.
Se han encontrado 255 productos de "GluR"
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Troriluzole
CAS:<p>Troriluzole is a glutamate modulator with anticancer activity and is used in the study of spinocerebellar ataxia.</p>Fórmula:C15H16F3N5O4SPureza:97.14%Forma y color:SolidPeso molecular:419.38Dipraglurant
CAS:<p>Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.</p>Fórmula:C16H12FN3Pureza:98.7%Forma y color:SolidPeso molecular:265.29LSN2463359
CAS:<p>LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.</p>Fórmula:C16H15N3OPureza:99.26%Forma y color:SolidPeso molecular:265.31(E/Z)-SIB-1893
CAS:<p>(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.</p>Fórmula:C14H13NPureza:99.92%Forma y color:SolidPeso molecular:195.26Dasolampanel
CAS:<p>Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.</p>Fórmula:C17H20ClN5O3Pureza:98.70%Forma y color:SolidPeso molecular:377.83LY-2300559
CAS:<p>LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.</p>Fórmula:C26H26O6Pureza:99.51%Forma y color:SolidPeso molecular:434.48Valiglurax
CAS:<p>Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.</p>Fórmula:C16H10F3N5Pureza:98.29%Forma y color:SolidPeso molecular:329.28CBiPES hydrochloride
CAS:<p>CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.</p>Fórmula:C21H20ClN3O2SPureza:99.66%Forma y color:SolidPeso molecular:413.92CPCCOEt
CAS:<p>CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1b</p>Fórmula:C13H13NO4Pureza:99.91%Forma y color:SolidPeso molecular:247.25S 18986
CAS:<p>S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in</p>Fórmula:C10H12N2O2SPureza:99.64%Forma y color:SolidPeso molecular:224.28VU 0285683
CAS:<p>VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.</p>Fórmula:C14H7FN4OPureza:99.98%Forma y color:SolidPeso molecular:266.23ABP688
CAS:<p>ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.</p>Fórmula:C15H16N2OPureza:98.63%Forma y color:SolidPeso molecular:240.3AZD 9272
CAS:<p>AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.</p>Fórmula:C14H6F2N4OPureza:98.29%Forma y color:SolidPeso molecular:284.22AZD6538
CAS:<p>AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.</p>Fórmula:C15H6FN5OPureza:98.68%Forma y color:SolidPeso molecular:291.24MNI 137
CAS:<p>MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.</p>Fórmula:C15H9BrN4OPureza:97.49%Forma y color:SolidPeso molecular:341.16VU0029251
CAS:<p>VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.</p>Fórmula:C10H11N3S2Forma y color:SolidPeso molecular:237.34MTPG
CAS:<p>Group II/group III metabotropic glutamate receptor antagonist</p>Fórmula:C10H11N5O2Pureza:98%Forma y color:SolidPeso molecular:233.23L-AP4
CAS:<p>L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).</p>Fórmula:C4H10NO5PPureza:98%Forma y color:White To Off-White Crystalline PowderPeso molecular:183.1mGluR5 antagonist-1
CAS:<p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>Fórmula:C23H18N4O2Forma y color:SolidPeso molecular:382.41VU0360172
CAS:<p>VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).</p>Fórmula:C18H15FN2OPureza:99.56%Forma y color:SolidPeso molecular:294.32Biphenylindanone A
CAS:<p>Biphenylindanone A is a selective potentiator of human mGluR2 (hmGluR2),and for the treatment of neurological disorders.</p>Fórmula:C30H30O4Pureza:98%Forma y color:SolidPeso molecular:454.56MFZ 10-7
CAS:<p>MFZ 10-7 is anegative allosteric modulator of the mGluR5.</p>Fórmula:C15H9FN2Pureza:99.80%Forma y color:SolidPeso molecular:236.24JNJ-46281222
CAS:<p>JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.</p>Fórmula:C23H25F3N4Forma y color:SolidPeso molecular:414.47MGS-0039
CAS:<p>MGS-0039: Group II mGluR2/3 antagonist, non-serotonergic antidepressant-like effect, AMPA involvement, regulates dopamine in NAc.</p>Fórmula:C15H14Cl2FNO5Pureza:98%Forma y color:SolidPeso molecular:378.18FPTQ
CAS:<p>FPTQ is a highly effective antagonist of mGluR 1, displaying IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively [1].</p>Fórmula:C17H12FN5Pureza:99.68% - 99.88%Forma y color:SolidPeso molecular:305.31VU6005649
CAS:<p>VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).</p>Fórmula:C16H12F5N3OPureza:99.87%Forma y color:SolidPeso molecular:357.28VU6012962
CAS:<p>VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).</p>Fórmula:C21H19F3N4O4Pureza:99.61% - 99.74%Forma y color:SolidPeso molecular:448.4Pomaglumetad methionil hydrochloride
CAS:<p>LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.</p>Fórmula:C12H19ClN2O7S2Pureza:98.57%Forma y color:SolidPeso molecular:402.87Licostinel
CAS:<p>Licostinel (CGP 63446) is a glutamate receptor antagonist. Licostinel protects against permanent focal cerebral ischemia.</p>Fórmula:C8H3Cl2N3O4Pureza:98.02%Forma y color:SolidPeso molecular:276.03cis-PDA
CAS:<p>cis-PDA (cis PDA) is a general ionotropic receptor antagonist. cis-PDA acts by blocking NMDA, AMPA, and kainate-mediated responses.</p>Fórmula:C7H11NO4Pureza:98.71%Forma y color:White SolidPeso molecular:173.17(2R,4R)-APDC
CAS:<p>(2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. It has anticonvulsant and neuroprotective effects.</p>Fórmula:C6H10N2O4Pureza:98%Forma y color:SolidPeso molecular:174.15AMPA receptor modulator-2
CAS:<p>AMPA receptor modulator-2 is a modulator of AMPA receptor. The pIC50 value for TARPγ2 dependent AMPA receptor is 10.1.</p>Fórmula:C15H6F6N4OSPureza:99.8%Forma y color:SolidPeso molecular:404.29MK-8768
CAS:<p>MK-8768 is a potent, selective, and orally bioavailable negative allosteric modulator of the mGluR2 class, exhibiting an IC50 of 9.6 nM and characterized by</p>Fórmula:C21H22F3N5O2Forma y color:SolidPeso molecular:433.43Philanthotoxin 74 dihydrochloride
CAS:<p>Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.</p>Fórmula:C24H44Cl2N4O3Pureza:99.75%Forma y color:SolidPeso molecular:507.54VU6004909
CAS:<p>VU6004909 is an mGlu5 receptor orthosteric modulator that reverses MK801-induced increased cortical activity and cognitive dysfunction.</p>Fórmula:C21H15FN2O4Pureza:96.68% - 98.44%Forma y color:SolidPeso molecular:378.35Azotomycin
CAS:<p>Azotomycin is an antagonist of L-glutamine and may be used as an immunosuppressant.</p>Fórmula:C17H23N7O8Pureza:98%Forma y color:SolidPeso molecular:453.41CVN636
CAS:<p>CVN636, a potent and selective allosteric agonist for the mGluR7 receptor, exhibits oral activity and CNS permeability [1], with an EC50 of 7 nM for human</p>Fórmula:C19H20FNO4SForma y color:SolidPeso molecular:377.43LY2794193
CAS:<p>LY2794193, a potent and selective mGlu3 receptor agonist, reduces akathisia seizures and increases GAT1, GLAST and GLT-1 protein levels in rats.</p>Fórmula:C16H18N2O6Pureza:98.15%Forma y color:SolidPeso molecular:334.32LY367385 hydrochloride
CAS:<p>LY367385 hydrochloride: selective mGluR1a antagonist, IC50 = 8.8 μM, neuroprotective, anticonvulsant, antiepileptic.</p>Fórmula:C10H12ClNO4Forma y color:SolidPeso molecular:245.66AZD 2066 hydrate
<p>AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].</p>Fórmula:C19H18ClN5O3Forma y color:SolidPeso molecular:386.33CPPG
CAS:<p>CPPG: potent group II/III mGlu receptor antagonist, 20x more selective for group III (IC50: 2.2 nM) than II (46.2 nM) in rat cortex.</p>Fórmula:C11H14NO5PForma y color:SolidPeso molecular:271.21FP0429
CAS:<p>FP0429 is an agonist of mGlu4.</p>Fórmula:C10H12N2O7Pureza:98%Forma y color:SolidPeso molecular:272.21LY 541850
CAS:<p>LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human</p>Fórmula:C9H13NO4Pureza:98%Forma y color:SolidPeso molecular:199.2LY3020371 hydrochloride
CAS:<p>LY3020371 HCl: potent mGlu2/3 antagonist, antidepressant-like; Ki: 5.3/2.5 nM, IC50: 16.2 nM for cAMP inhibition.</p>Fórmula:C15H16ClF2NO5SForma y color:SolidPeso molecular:395.81PF470
CAS:<p>PF470 (PF-06297470) is a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5), which demonstrated significant therapeutic effects in Parkinson's disease models. However, its clinical development was halted due to potential issues identified in toxicological studies.</p>Fórmula:C18H16N6OForma y color:SolidPeso molecular:332.36Pomaglumetad methionil
CAS:<p>Pomaglumetad methionil is an oral methionine prodrug of the potent specific agonist of mGlu2/3 receptor LY404039.</p>Fórmula:C12H20N2O8S2Pureza:98%Forma y color:SolidPeso molecular:384.43YM 202074
CAS:<p>metabotropic glutamate receptor type 1 (mGlu1) antagonist</p>Fórmula:C56H72N8O16S2Pureza:98%Forma y color:SolidPeso molecular:1177.34LY2979165
CAS:<p>LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.</p>Fórmula:C13H22N6O6SPureza:98.41%Forma y color:SolidPeso molecular:390.42Eglumegad
CAS:<p>Eglumegad is a highly effective and selective agonist of group II (mGlu2/3) receptor (IC50s: 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively).</p>Fórmula:C8H11NO4Forma y color:SolidPeso molecular:185.18YM-298198 hydrochloride
CAS:<p>mGlu1 receptor antagonist</p>Fórmula:C18H23ClN4OSPureza:98%Forma y color:SolidPeso molecular:378.919(RS)-APICA
CAS:<p>group II metabotropic glutamate receptor antagonist</p>Fórmula:C10H12NO5PForma y color:SolidPeso molecular:257.18Eglumegad hydrochloride
<p>Eglumegad (LY354740) hydrochloride is a potent, selective agonist for group II (mGlu2/3) receptors, showing IC50 values of 5 nM for mGlu2 and 24 nM for mGlu3 receptors in transfected human cells. This compound provides neuroprotection against NMDA-induced toxicity and exhibits anxiolytic- and antipsychotic-like properties [1].</p>Fórmula:C8H12ClNO4Forma y color:SolidPeso molecular:221.64VU0080241
CAS:<p>VU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).</p>Fórmula:C19H23N5Forma y color:SolidPeso molecular:321.42CMPDA
CAS:<p>CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].</p>Fórmula:C16H28N2O4S2Pureza:98%Forma y color:SolidPeso molecular:376.53UBP1112
CAS:<p>group III mGlu receptor antagonist</p>Fórmula:C10H14NO5PPureza:98%Forma y color:SolidPeso molecular:259.2

