
GluR
Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.
Se han encontrado 255 productos de "GluR"
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Chelidamic acid
CAS:<p>Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.</p>Fórmula:C7H5NO5Pureza:98.11%Forma y color:Pale Yellow PowderPeso molecular:183.12VU-1545
CAS:<p>VU-1545 is mGlu5 positive allosteric modulator.</p>Fórmula:C22H15FN4O3Pureza:98.8%Forma y color:SolidPeso molecular:402.38(RS)-3-Hydroxyphenylglycine
CAS:<p>(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.</p>Fórmula:C8H9NO3Pureza:99.29%Forma y color:SolidPeso molecular:167.16FTIDC
CAS:<p>FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.</p>Fórmula:C18H23FN6OPureza:94.58%Forma y color:SolidPeso molecular:358.41E4CPG
CAS:<p>E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.</p>Fórmula:C11H13NO4Pureza:99.96%Forma y color:SolidPeso molecular:223.23DNQX
CAS:<p>DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)</p>Fórmula:C8H4N4O6Pureza:97.27% - 99.1%Forma y color:Off-White Powder With A Yellow TingePeso molecular:252.14VU-29
CAS:<p>VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.</p>Fórmula:C22H16N4O3Pureza:99.63%Forma y color:SolidPeso molecular:384.39VU0361737
CAS:<p>VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.</p>Fórmula:C13H11ClN2O2Pureza:99.60% - 99.85%Forma y color:SolidPeso molecular:262.69(S)-ATPO
CAS:<p>(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.</p>Fórmula:C11H19N2O7PPureza:98.37% - 99.41%Forma y color:SolidPeso molecular:322.25CX614
CAS:<p>CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.</p>Fórmula:C13H13NO4Pureza:97.37%Forma y color:SolidPeso molecular:247.25ADX-47273
CAS:<p>ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).</p>Fórmula:C20H17F2N3O2Pureza:97% - 99.18%Forma y color:SolidPeso molecular:369.36Farampator
CAS:<p>Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.</p>Fórmula:C12H13N3O2Pureza:99.84% - >99.99%Forma y color:SolidPeso molecular:231.25AZD-8529
CAS:<p>AZD-8529: selective, oral mGluR2 modulator, EC50 285 nM; inactive on mGluR1,3-8 at 20-25 M.</p>Fórmula:C24H24F3N5O3Forma y color:SolidPeso molecular:487.47NBQX
CAS:<p>NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.</p>Fórmula:C12H8N4O6SPureza:97.66% - 99.42%Forma y color:SolidPeso molecular:336.28XAP044
CAS:<p>XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.</p>Fórmula:C15H9IO4Pureza:97.41%Forma y color:SolidPeso molecular:380.13ADX88178
CAS:<p>ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.</p>Fórmula:C12H12N6SPureza:99.55%Forma y color:SolidPeso molecular:272.33SIB-1757
CAS:<p>SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)</p>Fórmula:C12H11N3OPureza:97.37%Forma y color:SolidPeso molecular:213.24MPEP
CAS:<p>MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.</p>Fórmula:C14H11NPureza:99.54%Forma y color:SolidPeso molecular:193.24(RS)-MCPG
CAS:<p>(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.</p>Fórmula:C10H11NO4Pureza:99.96%Forma y color:SolidPeso molecular:209.2TCN238
CAS:<p>TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).</p>Fórmula:C12H11N3Pureza:99.9% - 99.92%Forma y color:SolidPeso molecular:197.24VU0364770
CAS:<p>VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu</p>Fórmula:C12H9ClN2OPureza:99.65% - >99.99%Forma y color:SolidPeso molecular:232.67CNQX
CAS:<p>CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)</p>Fórmula:C9H4N4O4Pureza:99.70%Forma y color:Pale Yellow SolidPeso molecular:232.15PHCCC
CAS:<p>PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.</p>Fórmula:C17H14N2O3Pureza:>99.99%Forma y color:SolidPeso molecular:294.31-BCP
CAS:<p>1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.</p>Fórmula:C13H15NO3Pureza:99.60%Forma y color:SolidPeso molecular:233.26(S)-3-Hydroxyphenylglycine
CAS:<p>(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).</p>Fórmula:C8H9NO3Pureza:99.65%Forma y color:SolidPeso molecular:167.16JNJ16259685
CAS:<p>JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19</p>Fórmula:C20H23NO3Pureza:98.31%Forma y color:SolidPeso molecular:325.4Lu AF21934
CAS:<p>Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).</p>Fórmula:C14H16Cl2N2O2Pureza:99.79%Forma y color:SolidPeso molecular:315.2LY-404187
CAS:<p>LY404187 is a positive allosteric modulator of AMPA receptors</p>Fórmula:C19H22N2O2SPureza:99.34%Forma y color:SolidPeso molecular:342.46IDRA-21
CAS:<p>IDRA-21 is a positive AMPA receptor modulator.</p>Fórmula:C8H9ClN2O2SPureza:99.73%Forma y color:SolidPeso molecular:232.69trans-ACPD
CAS:<p>trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD.</p>Fórmula:C7H11NO4Pureza:99.53%Forma y color:SolidPeso molecular:173.17Ro0711401
CAS:<p>Ro0711401 is an agonist of mGlu1 receptor.</p>Fórmula:C18H11F3N2O3Pureza:97.57%Forma y color:SolidPeso molecular:360.29YM90K
CAS:<p>YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.</p>Fórmula:C11H8ClN5O4Pureza:98.23%Forma y color:SolidPeso molecular:309.66HBT1
CAS:<p>HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons</p>Fórmula:C16H17F3N4O2SPureza:99.52%Forma y color:SolidPeso molecular:386.393-MATIDA
CAS:<p>3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a).</p>Fórmula:C8H9NO4SPureza:99.75% - 99.96%Forma y color:SolidPeso molecular:215.23VU 0357121
CAS:<p>VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.</p>Fórmula:C17H17F2NO2Pureza:99% - >99.99%Forma y color:SolidPeso molecular:305.32MTEP hydrochloride
CAS:<p>MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)</p>Fórmula:C11H9ClN2SPureza:99.58%Forma y color:SolidPeso molecular:236.72FITM
CAS:<p>FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).</p>Fórmula:C18H18FN5OSPureza:97.25%Forma y color:SolidPeso molecular:371.43ML 254
CAS:<p>是一种化学合成中的砌块</p>Fórmula:C18H15FN2O2Pureza:98.09%Forma y color:SolidPeso molecular:310.32AMN082 free base
CAS:<p>AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.</p>Fórmula:C28H28N2Pureza:97.75% - 97.79%Forma y color:SolidPeso molecular:392.54MPEP hydrochloride
CAS:<p>MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).</p>Fórmula:C14H12ClNPureza:99.87% - >99.99%Forma y color:SolidPeso molecular:229.7CX516
CAS:<p>CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and MCI.</p>Fórmula:C14H15N3OPureza:99.04% - ≥95%Forma y color:Tan SolidPeso molecular:241.29MTEP
CAS:<p>MTEP: potent, selective mGluR5 antagonist; IC50=5 nM, Ki=16 nM; may have antidepressant/anxiolytic effects; useful in Parkinson's research.</p>Fórmula:C11H8N2SForma y color:SolidPeso molecular:200.26Ro 67-7476
CAS:<p>Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.</p>Fórmula:C17H18FNO2SPureza:99.69%Forma y color:SolidPeso molecular:319.39CTEP
CAS:<p>CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold</p>Fórmula:C19H13ClF3N3OPureza:99.17%Forma y color:SolidPeso molecular:391.77VU0155094
CAS:<p>VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.</p>Fórmula:C24H24N2O4SPureza:97.21%Forma y color:SolidPeso molecular:436.52Caroverine hydrochloride
CAS:<p>Caroverine HCL: Blocks NMDA/AMPA receptors, antioxidant, calcium-blocker, and vasorelaxant, used for tinnitus research.</p>Fórmula:C22H28ClN3O2Pureza:98.37% - 98.75%Forma y color:SolidPeso molecular:401.9VU 0364439
CAS:<p>VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).</p>Fórmula:C18H13Cl2N3O3SPureza:97.9%Forma y color:SolidPeso molecular:422.29JNJ-42153605
CAS:<p>JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).</p>Fórmula:C22H23F3N4Pureza:97.25% - 98.57%Forma y color:SolidPeso molecular:400.44VU0155041
CAS:<p>VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).</p>Fórmula:C14H15Cl2NO3Pureza:99.52% - 99.56%Forma y color:SolidPeso molecular:316.18JNJ-40411813
CAS:<p>JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).</p>Fórmula:C20H25ClN2OPureza:99.74%Forma y color:SolidPeso molecular:344.88
