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GluR

GluR

Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.

Se han encontrado 255 productos de "GluR"

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  • Chelidamic acid

    CAS:
    <p>Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.</p>
    Fórmula:C7H5NO5
    Pureza:98.11%
    Forma y color:Pale Yellow Powder
    Peso molecular:183.12
  • VU-1545

    CAS:
    <p>VU-1545 is mGlu5 positive allosteric modulator.</p>
    Fórmula:C22H15FN4O3
    Pureza:98.8%
    Forma y color:Solid
    Peso molecular:402.38
  • (RS)-3-Hydroxyphenylglycine

    CAS:
    <p>(RS)-3-Hydroxyphenylglycine is a PI-linked metabotropic glutamate receptors agonist.</p>
    Fórmula:C8H9NO3
    Pureza:99.29%
    Forma y color:Solid
    Peso molecular:167.16
  • FTIDC

    CAS:
    <p>FTIDC: potent, selective mGluR1 allosteric antagonist, weak on mGluR5. IC50: human 5.8 nM, mouse 3.1 nM. Noncompetitive.</p>
    Fórmula:C18H23FN6O
    Pureza:94.58%
    Forma y color:Solid
    Peso molecular:358.41
  • E4CPG

    CAS:
    <p>E4CPG is a novel group I/II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG.</p>
    Fórmula:C11H13NO4
    Pureza:99.96%
    Forma y color:Solid
    Peso molecular:223.23
  • DNQX

    CAS:
    <p>DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)</p>
    Fórmula:C8H4N4O6
    Pureza:97.27% - 99.1%
    Forma y color:Off-White Powder With A Yellow Tinge
    Peso molecular:252.14
  • VU-29

    CAS:
    <p>VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes.</p>
    Fórmula:C22H16N4O3
    Pureza:99.63%
    Forma y color:Solid
    Peso molecular:384.39
  • VU0361737

    CAS:
    <p>VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.</p>
    Fórmula:C13H11ClN2O2
    Pureza:99.60% - 99.85%
    Forma y color:Solid
    Peso molecular:262.69
  • (S)-ATPO

    CAS:
    <p>(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.</p>
    Fórmula:C11H19N2O7P
    Pureza:98.37% - 99.41%
    Forma y color:Solid
    Peso molecular:322.25
  • CX614

    CAS:
    <p>CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.</p>
    Fórmula:C13H13NO4
    Pureza:97.37%
    Forma y color:Solid
    Peso molecular:247.25
  • ADX-47273

    CAS:
    <p>ADX-47273 (BA 94673139) is a positive and selective allosteric modulator for the metabotropic glutamate receptor subtype mGluR5(EC50=170 nM).</p>
    Fórmula:C20H17F2N3O2
    Pureza:97% - 99.18%
    Forma y color:Solid
    Peso molecular:369.36
  • Farampator

    CAS:
    <p>Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.</p>
    Fórmula:C12H13N3O2
    Pureza:99.84% - >99.99%
    Forma y color:Solid
    Peso molecular:231.25
  • AZD-8529

    CAS:
    <p>AZD-8529: selective, oral mGluR2 modulator, EC50 285 nM; inactive on mGluR1,3-8 at 20-25 M.</p>
    Fórmula:C24H24F3N5O3
    Forma y color:Solid
    Peso molecular:487.47
  • NBQX

    CAS:
    <p>NBQX (FG9202) is a potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.</p>
    Fórmula:C12H8N4O6S
    Pureza:97.66% - 99.42%
    Forma y color:Solid
    Peso molecular:336.28
  • XAP044

    CAS:
    <p>XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.</p>
    Fórmula:C15H9IO4
    Pureza:97.41%
    Forma y color:Solid
    Peso molecular:380.13
  • ADX88178

    CAS:
    <p>ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.</p>
    Fórmula:C12H12N6S
    Pureza:99.55%
    Forma y color:Solid
    Peso molecular:272.33
  • SIB-1757

    CAS:
    <p>SIB-1757 (6-methyl-2-[(E)-phenyldiazenyl]pyridin-3) is a selective antagonist of mGlu5 metabotropic glutamate receptor subtype (hmGlu5, IC50 : 0.4 μM)</p>
    Fórmula:C12H11N3O
    Pureza:97.37%
    Forma y color:Solid
    Peso molecular:213.24
  • MPEP

    CAS:
    <p>MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibits no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors.</p>
    Fórmula:C14H11N
    Pureza:99.54%
    Forma y color:Solid
    Peso molecular:193.24
  • (RS)-MCPG

    CAS:
    <p>(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.</p>
    Fórmula:C10H11NO4
    Pureza:99.96%
    Forma y color:Solid
    Peso molecular:209.2
  • TCN238

    CAS:
    <p>TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).</p>
    Fórmula:C12H11N3
    Pureza:99.9% - 99.92%
    Forma y color:Solid
    Peso molecular:197.24
  • VU0364770

    CAS:
    <p>VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu</p>
    Fórmula:C12H9ClN2O
    Pureza:99.65% - >99.99%
    Forma y color:Solid
    Peso molecular:232.67
  • CNQX

    CAS:
    <p>CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)</p>
    Fórmula:C9H4N4O4
    Pureza:99.70%
    Forma y color:Pale Yellow Solid
    Peso molecular:232.15
  • PHCCC

    CAS:
    <p>PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.</p>
    Fórmula:C17H14N2O3
    Pureza:>99.99%
    Forma y color:Solid
    Peso molecular:294.3
  • 1-BCP

    CAS:
    <p>1-BCP (Piperonylic acid piperidide) is a centrally active drug that modulates AMPA receptor gated currents.</p>
    Fórmula:C13H15NO3
    Pureza:99.60%
    Forma y color:Solid
    Peso molecular:233.26
  • (S)-3-Hydroxyphenylglycine

    CAS:
    <p>(S)-3-Hydroxyphenylglycine is an agonist of group I metabotropic glutamate receptors (mGluRs).</p>
    Fórmula:C8H9NO3
    Pureza:99.65%
    Forma y color:Solid
    Peso molecular:167.16
  • JNJ16259685

    CAS:
    <p>JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19</p>
    Fórmula:C20H23NO3
    Pureza:98.31%
    Forma y color:Solid
    Peso molecular:325.4
  • Lu AF21934

    CAS:
    <p>Lu AF21934 is a brain-penetrant and selective mGlu4 receptor positive allosteric modulator (IC50: 500 nM, human).</p>
    Fórmula:C14H16Cl2N2O2
    Pureza:99.79%
    Forma y color:Solid
    Peso molecular:315.2
  • LY-404187

    CAS:
    <p>LY404187 is a positive allosteric modulator of AMPA receptors</p>
    Fórmula:C19H22N2O2S
    Pureza:99.34%
    Forma y color:Solid
    Peso molecular:342.46
  • IDRA-21

    CAS:
    <p>IDRA-21 is a positive AMPA receptor modulator.</p>
    Fórmula:C8H9ClN2O2S
    Pureza:99.73%
    Forma y color:Solid
    Peso molecular:232.69
  • trans-ACPD

    CAS:
    <p>trans-ACPD ((±)-trans-ACPD) is an equimolecular mixture of (1S, 3R)- and (1R, 3S)-ACPD.</p>
    Fórmula:C7H11NO4
    Pureza:99.53%
    Forma y color:Solid
    Peso molecular:173.17
  • Ro0711401

    CAS:
    <p>Ro0711401 is an agonist of mGlu1 receptor.</p>
    Fórmula:C18H11F3N2O3
    Pureza:97.57%
    Forma y color:Solid
    Peso molecular:360.29
  • YM90K

    CAS:
    <p>YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor.</p>
    Fórmula:C11H8ClN5O4
    Pureza:98.23%
    Forma y color:Solid
    Peso molecular:309.66
  • HBT1

    CAS:
    <p>HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons</p>
    Fórmula:C16H17F3N4O2S
    Pureza:99.52%
    Forma y color:Solid
    Peso molecular:386.39
  • 3-MATIDA

    CAS:
    <p>3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a).</p>
    Fórmula:C8H9NO4S
    Pureza:99.75% - 99.96%
    Forma y color:Solid
    Peso molecular:215.23
  • VU 0357121

    CAS:
    <p>VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.</p>
    Fórmula:C17H17F2NO2
    Pureza:99% - >99.99%
    Forma y color:Solid
    Peso molecular:305.32
  • MTEP hydrochloride

    CAS:
    <p>MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)</p>
    Fórmula:C11H9ClN2S
    Pureza:99.58%
    Forma y color:Solid
    Peso molecular:236.72
  • FITM

    CAS:
    <p>FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM).</p>
    Fórmula:C18H18FN5OS
    Pureza:97.25%
    Forma y color:Solid
    Peso molecular:371.43
  • ML 254

    CAS:
    <p>是一种化学合成中的砌块</p>
    Fórmula:C18H15FN2O2
    Pureza:98.09%
    Forma y color:Solid
    Peso molecular:310.32
  • AMN082 free base

    CAS:
    <p>AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist.</p>
    Fórmula:C28H28N2
    Pureza:97.75% - 97.79%
    Forma y color:Solid
    Peso molecular:392.54
  • MPEP hydrochloride

    CAS:
    <p>MPEP hydrochloride is an effective and highly specific non-competitive antagonist at the mGlu5 receptor subtype (IC50: 36 nM).</p>
    Fórmula:C14H12ClN
    Pureza:99.87% - >99.99%
    Forma y color:Solid
    Peso molecular:229.7
  • CX516

    CAS:
    <p>CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and MCI.</p>
    Fórmula:C14H15N3O
    Pureza:99.04% - ≥95%
    Forma y color:Tan Solid
    Peso molecular:241.29
  • MTEP

    CAS:
    <p>MTEP: potent, selective mGluR5 antagonist; IC50=5 nM, Ki=16 nM; may have antidepressant/anxiolytic effects; useful in Parkinson's research.</p>
    Fórmula:C11H8N2S
    Forma y color:Solid
    Peso molecular:200.26
  • Ro 67-7476

    CAS:
    <p>Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.</p>
    Fórmula:C17H18FNO2S
    Pureza:99.69%
    Forma y color:Solid
    Peso molecular:319.39
  • CTEP

    CAS:
    <p>CTEP (RO 4956371) (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows &gt;1000-fold</p>
    Fórmula:C19H13ClF3N3O
    Pureza:99.17%
    Forma y color:Solid
    Peso molecular:391.77
  • VU0155094

    CAS:
    <p>VU0155094 (ML 397) is a positive allosteric modulator with differential activity at the various group III mGluRs.</p>
    Fórmula:C24H24N2O4S
    Pureza:97.21%
    Forma y color:Solid
    Peso molecular:436.52
  • Caroverine hydrochloride

    CAS:
    <p>Caroverine HCL: Blocks NMDA/AMPA receptors, antioxidant, calcium-blocker, and vasorelaxant, used for tinnitus research.</p>
    Fórmula:C22H28ClN3O2
    Pureza:98.37% - 98.75%
    Forma y color:Solid
    Peso molecular:401.9
  • VU 0364439

    CAS:
    <p>VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).</p>
    Fórmula:C18H13Cl2N3O3S
    Pureza:97.9%
    Forma y color:Solid
    Peso molecular:422.29
  • JNJ-42153605

    CAS:
    <p>JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).</p>
    Fórmula:C22H23F3N4
    Pureza:97.25% - 98.57%
    Forma y color:Solid
    Peso molecular:400.44
  • VU0155041

    CAS:
    <p>VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).</p>
    Fórmula:C14H15Cl2NO3
    Pureza:99.52% - 99.56%
    Forma y color:Solid
    Peso molecular:316.18
  • JNJ-40411813

    CAS:
    <p>JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).</p>
    Fórmula:C20H25ClN2O
    Pureza:99.74%
    Forma y color:Solid
    Peso molecular:344.88