BACE

Elenbecestat is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of …

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and …

Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.

7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.

NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, …

Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.

Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of …

Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent …

Isorubrofusarin-6-O-β-gentiobioside is derived from from Cassia obtusifolia Linn seeds and shows promising inhibitory activity against …

Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via …

LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: …

LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts …

1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic …

LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.

1. Aloenin and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in …

Eslicarbazepine acetate (ESL) is an anticonvulsant medication approved for use in Europe, the United States …

Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).

Verubecestat (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor …

AZD3839 is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold …

Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its …

Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent …

8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it …

Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the …

β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor …

Loganin, an iridoid glucoside, has been reported to be an inhibitor of Cox-1 and also …

Timosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 …

Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol …

Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: …

Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme …

PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of …

AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo …

BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human …

BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), …

BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).

BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with …