BACE
Los inhibidores de BACE son compuestos que tienen como objetivo la enzima Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), que es crucial para la producción de beta-amiloide, una proteína asociada con la formación de placas amiloides en la enfermedad de Alzheimer. Al inhibir BACE, estos compuestos buscan reducir la producción de beta-amiloide y su acumulación en el cerebro, lo que podría ralentizar la progresión de la enfermedad de Alzheimer. Los inhibidores de BACE son un enfoque principal en el desarrollo de estrategias terapéuticas para las enfermedades neurodegenerativas. En CymitQuimica, ofrecemos inhibidores de BACE para apoyar su investigación en la enfermedad de Alzheimer, la biología amiloide y la neurodegeneración.
Se han encontrado 37 productos de "BACE"
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LY2811376
CAS:LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).Fórmula:C15H14F2N4SPureza:99% - 99.01%Forma y color:SolidPeso molecular:320.36Ref: TM-T2639
1mg50,00€2mg70,00€5mg116,00€1mL*10mM (DMSO)116,00€10mg195,00€25mg354,00€50mg530,00€100mg758,00€AZD3839 free base
CAS:AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.Fórmula:C24H16F3N5Pureza:99.93% - 99.96%Forma y color:SolidPeso molecular:431.41BACE-IN-1 acetate
BACE-IN-1 acetate (350228-37-4), a BACE1 inhibitor with three disulfide bonds and N-linked glycosylation, is used in assays.Fórmula:C75H122N16O29Pureza:96.98%Forma y color:SolidPeso molecular:1711.86Verubecestat
CAS:Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.Fórmula:C17H17F2N5O3SPureza:94.64% - 99.55%Forma y color:SolidPeso molecular:409.41Ref: TM-T7011
2mg38,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg84,00€25mg144,00€50mg205,00€100mg334,00€500mg782,00€Epiberberine chloride
CAS:Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.Fórmula:C20H18ClNO4Pureza:99.89%Forma y color:SolidPeso molecular:371.81DSS30
CAS:DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.Fórmula:C16H14ClNO3S2Pureza:99.19% - 99.4%Forma y color:SolidPeso molecular:367.87Lanabecestat
CAS:Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Fórmula:C26H28N4OPureza:98.55%Forma y color:SolidPeso molecular:412.53BACE1-IN-1
CAS:BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Fórmula:C18H14F3N5O2Pureza:98%Forma y color:SolidPeso molecular:389.33Atabecestat
CAS:Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.Fórmula:C18H14FN5OSPureza:99.21% - 99.77%Forma y color:SolidPeso molecular:367.4Ref: TM-T14338
1mg123,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg477,00€25mg954,00€50mg1.279,00€100mg1.728,00€BACE1-IN-2
CAS:BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).Fórmula:C19H15F4N5O2Pureza:98%Forma y color:SolidPeso molecular:421.35BACE1-IN-5
CAS:BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.Fórmula:C18H16F5N5O2SPureza:98%Forma y color:SolidPeso molecular:461.41PF-06751979
CAS:PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).Fórmula:C18H19F2N5O3S2Pureza:98%Forma y color:SolidPeso molecular:455.5AM-6494
CAS:AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Fórmula:C22H21F2N5O3SPureza:98%Forma y color:SolidPeso molecular:473.5BACE1-IN-4
CAS:BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.Fórmula:C21H23F2N5O4S2Pureza:98%Forma y color:SolidPeso molecular:511.57Umibecestat
CAS:Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.Fórmula:C19H15ClF7N5O2Pureza:99.88%Forma y color:SolidPeso molecular:513.8Ref: TM-T13253
1mg163,00€5mg334,00€1mL*10mM (DMSO)376,00€10mg485,00€25mg807,00€50mg1.099,00€100mg1.485,00€NB-360
CAS:NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.Fórmula:C21H19F4N5O2Pureza:99.72%Forma y color:SolidPeso molecular:449.4Ref: TM-T12188
1mg104,00€5mg215,00€1mL*10mM (DMSO)235,00€10mg318,00€25mg510,00€50mg692,00€100mg888,00€500mg1.783,00€
