AChR
Los inhibidores del receptor de acetilcolina (AChR) son compuestos que bloquean la actividad de los receptores de acetilcolina, que son críticos para la neurotransmisión en los sistemas nerviosos central y periférico. Los AChRs juegan un papel vital en la contracción muscular, la memoria y las funciones cognitivas. Los inhibidores de los AChRs se utilizan para estudiar afecciones como la miastenia gravis, la enfermedad de Alzheimer y otros trastornos neurológicos. Al modular la actividad de los AChRs, estos inhibidores pueden ayudar a desentrañar las complejidades de la señalización colinérgica en el cerebro. En CymitQuimica, ofrecemos una gama de inhibidores de AChR para apoyar su investigación en neurociencia, farmacología y enfermedades neurodegenerativas.
Se han encontrado 623 productos de "AChR"
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TAAR1 agonist 2
CAS:TAAR1 agonist 2 (compound 30), a full agonist at trace amine-associated receptor 1 (TAAR1) (pEC50=7.5), also displays agonistic properties at H1 receptors and activates various muscarinic acetylcholine receptors, including the M2 receptor (pEC50=5). This compound is utilized in researching neuropsychiatric diseases.Fórmula:C9H11NOForma y color:SolidPeso molecular:149.19VU6016235
CAS:VU6016235 is a structurally unique, orally available, and highly selective tricyclic M4 muscarinic acetylcholine receptor positive allosteric modulator.Fórmula:C21H22N4OSForma y color:SolidPeso molecular:378.49Dihydro-β-erythroidine hydrobromide
CAS:Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs).Fórmula:C16H22BrNO3Pureza:98%Forma y color:White SolidPeso molecular:356.26p-F-HHSiD hydrochloride
CAS:p-F-HHSiD (p-Fluorohexahydrosiladifenidol) hydrochloride is a selective M3mAChR antagonist. It is capable of inhibiting acetylcholine-mediated vasodilation in human umbilical vein endothelial cells (HUVEC).Fórmula:C20H33ClFNOSiPeso molecular:386.019(S)-Albuterol
CAS:(S)-Albuterol functions as a muscarinic receptor and phospholipase C activator, enhancing the intracellular free calcium concentration in airway smooth muscle cells.Fórmula:C13H21NO3Forma y color:SolidPeso molecular:239.311Acetylethylcholine mustard hydrochloride
CAS:Acetylethylcholine mustard hydrochloride is a choline acetyl-transferase inhibitor that decreases muscle contraction frequency by inhibiting the synthesis of acetyl-beta-methylcholine (Ach), with a half-maximal inhibitory concentration (IC50) of 1.22 mM. It serves as an irreversible ligand for the high-affinity choline transport system and functions as a specific presynaptic long-acting cholinergic toxin. Additionally, acetylethylcholine mustard hydrochloride is a precursor to the ethylcholine mustard aziridinium ion.Fórmula:C8H17Cl2NO2Peso molecular:230.132Metoquizine
CAS:Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.Fórmula:C22H27N5OPureza:98%Forma y color:SolidPeso molecular:377.48VU6005806
CAS:VU6005806 is a potent M4 PAM with EC50s: 94 nM (human), 28 nM (rat), 87 nM (dog), 68 nM (cyno); studied for neuropsychiatric disorders.Fórmula:C17H16F3N7O2SPureza:98%Forma y color:SolidPeso molecular:439.41(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.Fórmula:C10H19ClNO1·5SPureza:98%Forma y color:SolidPeso molecular:244.78YM-49598 iodide
CAS:YM-49598 iodide is a tachykinin NK-1 receptor antagonist. It inhibits drug-induced bladder contractions in rats with an IC50 of 11 μg/kg.Fórmula:C36H45Cl2IN2O2Forma y color:SolidPeso molecular:735.57TDI-11861
CAS:TDI-11861 is a second-gen sAC (ADCY10) inhibitor with an IC50 of 5.5 nM and slow dissociation.Fórmula:C22H25ClF2N6O3Forma y color:SolidPeso molecular:494.92Dihydro-β-erythroidine
CAS:Dihydro-β-erythroidine, a competitive nicotinic receptor antagonist, effectively blocks the discriminative stimulus properties and inhibits the anxiolyticFórmula:C16H21NO3Forma y color:SolidPeso molecular:275.34(+)-Sparteine sulfate pentahydrate
(+)-sparteine (sulfate pentahydrate) is a ganglion blocker that competitively blocks nicotinic acetylcholine receptors in neurons.Fórmula:C15H38N2O9SForma y color:SolidPeso molecular:422.54Lu 26-046
CAS:Lu 26-046 is a muscarinic receptor agonist.Fórmula:C10H12N2OSForma y color:SolidPeso molecular:208.281,9-Dideoxyforskolin
CAS:The compound is an inactive analog of forskolin(an adenylyl cyclase activator).Fórmula:C22H34O5Pureza:98%Forma y color:SolidPeso molecular:378.5nAChR antagonist 1
CAS:Compound B15, a potent α7 nAChR antagonist, IC50 = 3.3 μM, promising for research on schizophrenia, Alzheimer's, and inflammation.Fórmula:C19H22N4O2Forma y color:SolidPeso molecular:338.4UB 165
CAS:Subtype-selective nicotinic agonistFórmula:C13H15ClN2Pureza:98%Forma y color:SolidPeso molecular:234.72(+)-Cevimeline hydrochloride hemihydrate
(+)-Cevimeline HCl hemihydrate is a muscarinic agonist for dry mouth in Sjogren's with rapid absorption, differing metabolism in species.Fórmula:C10H19ClNO1·5SPureza:98%Forma y color:SolidPeso molecular:244.78AChE/BChE-IN-10
CAS:<p>AChE/BChE-IN-10 inhibits AChE/BChE (IC50: 0.176/0.47 μM), crosses the blood-brain barrier, and prevents Aβ-aggregation.</p>Fórmula:C26H30N2O2Pureza:99.55% - 99.88%Forma y color:SoildPeso molecular:402.53VU6000918
CAS:VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.Fórmula:C18H17F2N5OSForma y color:SolidPeso molecular:389.42Lupinine
CAS:<p>Lupinine is an alkaloid capable of counteracting ethanol anesthesia. Lupinine is an AChE and BChE inhibitor and potential CD69 activator found in species of Loranthus, Calia, and Lupinus. It may also inhibit heparin.</p>Fórmula:C10H19NOPureza:99.95%Forma y color:SolidPeso molecular:169.26Oxitropium Bromide
CAS:Oxitropium bromide, a mAChR blocker, treats asthma and COPD as an anticholinergic bronchodilator.Fórmula:C19H26BrNO4Pureza:98%Forma y color:SolidPeso molecular:412.32
