AChR
Los inhibidores del receptor de acetilcolina (AChR) son compuestos que bloquean la actividad de los receptores de acetilcolina, que son críticos para la neurotransmisión en los sistemas nerviosos central y periférico. Los AChRs juegan un papel vital en la contracción muscular, la memoria y las funciones cognitivas. Los inhibidores de los AChRs se utilizan para estudiar afecciones como la miastenia gravis, la enfermedad de Alzheimer y otros trastornos neurológicos. Al modular la actividad de los AChRs, estos inhibidores pueden ayudar a desentrañar las complejidades de la señalización colinérgica en el cerebro. En CymitQuimica, ofrecemos una gama de inhibidores de AChR para apoyar su investigación en neurociencia, farmacología y enfermedades neurodegenerativas.
Se han encontrado 575 productos de "AChR"
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MC-Val-Cit-PAB
CAS:<p>MC-Val-Cit-PAB: cathepsin-cleavable ADC linker used in FDA-approved brentuximab vedotin.</p>Fórmula:C28H40N6O7Pureza:98.24%Forma y color:SolidPeso molecular:572.65Revefenacin
CAS:<p>Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.</p>Fórmula:C35H43N5O4Pureza:98.12%Forma y color:SolidPeso molecular:597.75Nitrocaramiphen hydrochloride
CAS:<p>Nitrocaramiphen hydrochloride is a selective M1 muscarinic antagonist and inhibits binding to sigma sites in brain.</p>Fórmula:C18H27ClN2O4Pureza:99.74%Forma y color:SolidPeso molecular:370.87Piperidolate
CAS:<p>Piperidolate inhibits intestinal cramp induced by acetylcholine</p>Fórmula:C21H25NO2Pureza:98.45%Forma y color:SolidPeso molecular:323.43PNU-282987 S enantiomer free base
CAS:<p>PNU-282987 S enantiomer free base is an agonist of α7 nicotinic acetylcholine receptor (α7 nAChR).</p>Fórmula:C14H17ClN2OPureza:99.74%Forma y color:SolidPeso molecular:264.75VU 0238429
CAS:<p>VU 0238429 (SCR-1481B1) is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).</p>Fórmula:C17H12F3NO4Pureza:>99.99%Forma y color:SolidPeso molecular:351.28Glycopyrrolate
CAS:<p>Glycopyrrolate: muscarinic antagonist, antispasmodic for GI issues, reduces salivation with anesthesia.</p>Fórmula:C19H28BrNO3Pureza:99.41% - 99.64%Forma y color:SolidPeso molecular:398.33CCMI
CAS:<p>CCMI (AVL-3288) is a potent and selective modulator of α7 nAChR-positive allosteric.</p>Fórmula:C19H15Cl2N3O2Pureza:>99.99%Forma y color:SolidPeso molecular:388.25W-84 dibromide
CAS:<p>W-84 dibromide (HDMPPA) is a M2-receptor selective modulator.</p>Fórmula:C32H44Br2N4O4Pureza:95.56%Forma y color:SolidPeso molecular:708.52Prifinium bromide
CAS:<p>Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action.</p>Fórmula:C22H28BrNPureza:97.99%Forma y color:SolidPeso molecular:386.37Nor-benzetimide
CAS:<p>Norbenzetimide, an organic compound, is prepared from benzetimide by catalytic transfer hydrogenolysis.</p>Fórmula:C16H20N2O2Pureza:98.63%Forma y color:SolidPeso molecular:272.34PNU-120596
CAS:<p>PNU-120596 (NSC-216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.</p>Fórmula:C13H14ClN3O4Pureza:99.82%Forma y color:SolidPeso molecular:311.72MC-Val-Cit-PABC-PNP
CAS:<p>MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker.</p>Fórmula:C35H43N7O11Pureza:97.2% - 98.055%Forma y color:SolidPeso molecular:737.76Blarcamesine
CAS:<p>Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.</p>Fórmula:C19H23NOPureza:99.87%Forma y color:SolidPeso molecular:281.39(S)-UFR2709
CAS:<p>(S)-UFR2709, a nAChR competitive antagonist, favors α4β2 over α7, reduces anxiety and alcohol use in rats.</p>Fórmula:C13H17NO2Forma y color:SolidPeso molecular:219.284Mc-Val-Ala-PAB
CAS:<p>Mc-Val-Ala-PAB, an effective linker, is utilized in antibody-drug-conjugate (ADC).</p>Fórmula:C25H34N4O6Pureza:98.34% - 99.24%Forma y color:SolidPeso molecular:486.56PHA 568487
CAS:<p>PHA 568487: α-7 nAChR agonist, rapid brain uptake, lessens oxidative stress & neuroinflammation.</p>Fórmula:C20H24N2O7Forma y color:SolidPeso molecular:404.419VU0152099
CAS:<p>VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).</p>Fórmula:C18H17N3O3SPureza:98.46%Forma y color:SolidPeso molecular:355.41Bestim
CAS:<p>Bestim is an immunomodulatory dipeptide that is synthetic.</p>Fórmula:C16H19N3O5Pureza:99.76%Forma y color:SolidPeso molecular:333.34Oxyphenonium bromide
CAS:<p>Oxyphenonium bromide is an anticholinergic used to study and treat ulcers and relieve visceral spasms.</p>Fórmula:C21H34BrNO3Pureza:98.96%Forma y color:SolidPeso molecular:428.404Nitrobenzylthioinosine
CAS:<p>Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.</p>Fórmula:C17H17N5O6SPureza:99.69% - 99.74%Forma y color:Off-White SolidPeso molecular:419.41Monepantel
CAS:<p>Monepantel (AAD1566) is an organic anthelmintic and an antagonist of nAChRs from roundworms and esophageostomy.</p>Fórmula:C20H13F6N3O2SPureza:99.83%Forma y color:White PowderPeso molecular:473.39Velufenacin
CAS:<p>Velufenacin is an antagonist of muscarinic receptor[1].</p>Fórmula:C19H20ClFN2O2Pureza:99.65%Forma y color:SolidPeso molecular:362.83Pentoxyverine
CAS:<p>Pentoxyverine (Carbetapentan) is an orally available cough suppressant, an antagonist of muscarinic receptor M1 and an agonist of the σ1 receptor.</p>Fórmula:C20H31NO3Pureza:97.11%Forma y color:SolidPeso molecular:333.47Xanomeline tartrate
CAS:<p>Xanomeline tartrate (LY 246708 tartrate) 是 M1和 M4 mAChR 激动剂，具有抗精神病样活性，可改善认知，可用于研究精神分裂症和阿尔茨海默病。</p>Fórmula:C18H29N3O7SPureza:99.19%Forma y color:SolidPeso molecular:431.5AF-710B
CAS:<p>AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors agonist.</p>Fórmula:C20H27N3OSPureza:98.62% - 99.89%Forma y color:SolidPeso molecular:357.51Mepenzolate Bromide
CAS:<p>Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions.</p>Fórmula:C21H26BrNO3Pureza:95.73% - 99.21%Forma y color:SolidPeso molecular:420.34Pipecuronium bromide
CAS:<p>Pipecuronium bromide (RGH-1106) is an nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker that causes muscle relaxation.</p>Fórmula:C35H62Br2N4O4Pureza:>99.99%Forma y color:PowderPeso molecular:762.7Varenicline
CAS:<p>Varenicline (CP 526555) is a selective partial agonist of the α4β2 nAChR and a full agonist of the α3β4 nAChR and α7 nAChR.</p>Fórmula:C13H13N3Pureza:99.76%Forma y color:SolidPeso molecular:211.26Atropine hydrobromide
CAS:<p>Atropine hydrobromide is a biochemical.</p>Fórmula:C17H24BrNO3Forma y color:SolidPeso molecular:370.28Anatabine dicitrate
<p>Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.</p>Fórmula:C22H28N2O14Pureza:98%Forma y color:SolidPeso molecular:544.46Pyrantel
CAS:<p>Pyrantel: Nicotinic agonist; causes spastic paralysis in nematodes by depolarizing block.</p>Fórmula:C11H14N2SPureza:98%Forma y color:Crystals From Methanol Yellowish Crystalline PowderPeso molecular:206.31Flavoxate
CAS:<p>Flavoxate is an anticholinergic with antimuscarinic effects.</p>Fórmula:C24H25NO4Forma y color:SolidPeso molecular:391.46(±)-Atropine-d3 (N-methyl-d3)
CAS:(±)-Atropine-d3 (N-methyl-d3) is a deuterated compound of (±)-Atropine. (±)-Atropine has a CAS number of 51-55-8. Atropine Sulfate is the sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna. Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation.Fórmula:C17H20D3NO3Peso molecular:292.39Oxantel
CAS:<p>Oxantel is a fumarate reductase inhibitor with anthelmintic activity.</p>Fórmula:C13H16N2OPureza:98%Forma y color:SolidPeso molecular:216.28Aprofene
CAS:<p>Aprofene blocks acetylcholine receptors, used for peptic ulcers, endarteritis, cholecystitis, and colitis.</p>Fórmula:C21H27NO2Forma y color:SolidPeso molecular:325.44Catestatin
CAS:Non-competitive inhibitor of nicotinic receptors; blocks cationic signalling and catecholamine release; stimulates histamine release. IC50 ~200-250nM.Fórmula:C107H173N37O26SPureza:98%Forma y color:SolidPeso molecular:2425.84Dianicline dihydrochloride
CAS:<p>Dianicline dihydrochloride is a partial agonist of α4β2 nicotinic acetylcholine receptor. It increases cessation rates in a dose-dependent manner.</p>Fórmula:C13H16N2OPureza:98%Forma y color:SolidPeso molecular:216.28Biperiden lactate
CAS:<p>Biperiden lactate is a biochemical.</p>Fórmula:C24H35NO4Forma y color:SolidPeso molecular:401.54VU0029767
CAS:<p>VU0029767 is an allosteric enhancer of the M1 muscarinic receptor, capable of modulating the receptor's activity. This compound enhances M1 receptor activity by increasing agonist affinity. However, VU0029767 demonstrates distinct characteristics from other compounds, particularly under varying experimental conditions such as its interaction with mutated M1 receptors and its effects on downstream signaling pathways.</p>Fórmula:C21H21N3O3Forma y color:SolidPeso molecular:363.41Azacyclonol hydrochloride
CAS:<p>Azacyclonol hydrochloride can be used in the treatment of chronic schizophrenia.</p>Fórmula:C18H22ClNOForma y color:Off White Crystalline PowderPeso molecular:303.83Diphenidol
CAS:<p>Diphenidol, a muscarinic antagonist, is employed as an antivertigo and antiemetic agent.</p>Fórmula:C21H27NOForma y color:Needles From Petroleum Ether SolidPeso molecular:309.45Sulindac sulfide
CAS:<p>Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.</p>Fórmula:C20H17FO2SPureza:99.35%Forma y color:SolidPeso molecular:340.41N-0861 racemate
CAS:<p>N-0861 racemate is the racemate of N-0861.</p>Fórmula:C13H17N5Pureza:98%Forma y color:SolidPeso molecular:243.31Sulfoxaflor
CAS:<p>Sulfoxaflor (GF 2032) is an agonist of nAChR1 and nAChR2 subtypes and a systemic insecticide. Cost-effective and quality-assured.</p>Fórmula:C10H10F3N3OSPureza:99.56%Forma y color:SolidPeso molecular:277.27Sch412348
CAS:<p>Sch412348: potent A2A receptor antagonist, Ki=0.6 nM, >1000-fold selectivity vs. other adenosine receptors.</p>Fórmula:C22H21F2N9OPureza:98%Forma y color:SolidPeso molecular:465.46SR 16584
CAS:<p>α3β4 nAChR antagonist</p>Fórmula:C17H22N2OPureza:99.84%Forma y color:SolidPeso molecular:270.37Tarafenacin
CAS:<p>Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over the M2 receptor.</p>Fórmula:C21H20F4N2O2Pureza:98%Forma y color:SolidPeso molecular:408.39Meseclazone
CAS:<p>Meseclazone has anti-inflammatory, analgesic, and antipyretic activity. Meseclazone shows inhibitory potency of secondary phase ADP aggregation.</p>Fórmula:C11H10ClNO3Pureza:98%Forma y color:SolidPeso molecular:239.654-DAMP
CAS:<p>4-DAMP (4-DAMP methiodide) is a selective muscarinic M1 and M3 subtype receptor antagonist used in the study of allergic rhinitis and cardiovascular disease.</p>Fórmula:C21H26INO2Pureza:98%Forma y color:SolidPeso molecular:451.34
