p97
Los inhibidores de p97 son compuestos que inhiben p97, también conocido como Proteína Contenedora de Valosina (VCP), un ATPasa involucrado en diversos procesos celulares, como la degradación de proteínas, la regulación del ciclo celular y la reparación del ADN. p97 es un jugador clave en el sistema ubiquitina-proteasoma, y su inhibición es de gran interés en la investigación del cáncer, enfermedades neurodegenerativas y otros trastornos donde se ve alterada la homeostasis proteica. En CymitQuimica, ofrecemos inhibidores de p97 para apoyar su investigación en proteostasis, neurobiología y terapia contra el cáncer.
Se han encontrado 15 productos de "p97"
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UP12
CAS:UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C23H16ClN3O3SForma y color:SolidPeso molecular:449.91UP163
CAS:UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.Fórmula:C20H15ClN2O5SForma y color:SolidPeso molecular:430.86UP158
CAS:UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.Fórmula:C17H17ClN4O2Forma y color:SolidPeso molecular:344.8MSC1094308
CAS:MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.Fórmula:C29H29F3N2Forma y color:SolidPeso molecular:462.55CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Fórmula:C24H23N5O2Pureza:95.95% - 99.92%Forma y color:SolidPeso molecular:413.47Ref: TM-T6796
1mg43,00€2mg56,00€5mg93,00€10mg130,00€25mg281,00€50mg444,00€100mg650,00€500mg1.369,00€1mL*10mM (DMSO)92,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Fórmula:C23H25ClN4OPureza:99.91% - 99.96%Forma y color:SolidPeso molecular:408.92ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Fórmula:C23H24N4OPureza:98%Forma y color:SolidPeso molecular:372.46ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Fórmula:C23H20N6OPureza:99.73% - >99.99%Forma y color:SolidPeso molecular:396.44Ref: TM-T3535
1mg35,00€2mg50,00€5mg77,00€10mg105,00€25mg178,00€50mg295,00€100mg477,00€200mg677,00€1mL*10mM (DMSO)84,00€NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Fórmula:C27H28N4O3S2Pureza:99.05% - 99.85%Forma y color:SolidPeso molecular:520.67DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Fórmula:C22H20N4Pureza:98.93% - ≥95%Forma y color:SolidPeso molecular:340.42Ref: TM-T1969
2mg34,00€5mg52,00€10mg85,00€25mg152,00€50mg264,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)52,00€NPD8733
CAS:NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.
Fórmula:C18H15NO4Pureza:98.48%Forma y color:SolidPeso molecular:309.32CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].
Fórmula:C24H24N6OPureza:97.66%Forma y color:SoildPeso molecular:412.49UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Fórmula:C30H32F2N6O3SPureza:98%Forma y color:SolidPeso molecular:594.68VCP/p97 IN-2
CAS:VCP/p97 IN-2 (Compound V13) is a VCP/p97 inhibitor with an IC50 of 32 nM for p97. It exhibits excellent antitumor activity, significantly suppressing tumor growth in a Molm-13 xenograft mouse model. VCP/p97 IN-2 is applicable for research in acute myeloid leukemia (AML).Fórmula:C24H23N5O2Forma y color:SolidPeso molecular:413.47p97-IN-1
CAS:p97-IN-1 is an orally active inhibitor of p97 with an IC50 of 26 nM. It significantly impedes the proliferation of tumor cells and is applicable for research in acute myeloid leukemia (AML).Fórmula:C25H26N6O2Forma y color:SolidPeso molecular:442.51
