PAI-1
El Plasminogen Activator Inhibitor-1 (PAI-1) es un inhibidor de la serina proteasa que regula la fibrinólisis al inhibir el activador del plasminógeno tisular (tPA) y la uroquinasa (uPA). Niveles elevados de PAI-1 están asociados con un mayor riesgo de trombosis, enfermedades cardiovasculares y síndrome metabólico. Los inhibidores de PAI-1 están siendo investigados por su potencial en el tratamiento de estas condiciones. En CymitQuimica, ofrecemos inhibidores de PAI-1 para apoyar su investigación en hematología, salud cardiovascular y enfermedades metabólicas.
Se han encontrado 25 productos de "PAI-1"
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Upamostat
CAS:<p>Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.</p>Fórmula:C32H47N5O6SPureza:99.41%Forma y color:SolidPeso molecular:629.81Angstrom6
CAS:<p>Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade</p>Fórmula:C39H62N10O15Pureza:99.36%Forma y color:SolidPeso molecular:910.97CT140
<p>CT140 is a human IgG4 monoclonal antibody (mAb) that specifically targets PAI-1. The suggested isotype control for this compound is Human IgG4 kappa, Isotype Control.</p>Forma y color:Odour LiquidGGACK hydrochloride
<p>GGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>Fórmula:C14H26Cl2N6O5Forma y color:SolidPeso molecular:428.13417Nattokinase
CAS:<p>Nattokinase is a serine protease derived from nattō, oral， fibrinolytic/anticoagulant properties. It degrades fibrin, fibrinolytic substrates, and PAI-1.</p>Forma y color:SolidUK140
<p>UK140 is an inhibitor of the urokinase-type plasminogen activator (uPA), with Ki values of 0.20 µM for human uPA (huPA) and 2.79 µM for mouse uPA (muPA). UK140 is applicable in studies related to tumor metastasis.</p>Fórmula:C72H105N19O25S3Forma y color:SolidPeso molecular:1732.91Bicyclic UK18
CAS:<p>Bicyclic UK18 is a competitive inhibitor of human urokinase-type plasminogen activator (uPA) with a Ki value of 53 nM.</p>Fórmula:C77H118N26O25S3Forma y color:SolidPeso molecular:1904.11UK-371804
CAS:<p>UK-371804: potent uPA blocker; candidate for chronic skin ulcer preclinical studies.</p>Fórmula:C14H16ClN5O4SPureza:95.81% - 99.77%Forma y color:SolidPeso molecular:385.83Loureirin B
CAS:<p>Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.</p>Fórmula:C18H20O5Pureza:99.33% - 99.86%Forma y color:SolidPeso molecular:316.35TM5441
CAS:<p>TM5441 is an orally bioavailable fibrinogen activator inhibitor-1 inhibitor that inhibits several cancer cell lines with IC50 values ranging from 13.9 to 51.1 μM.Cost-effective and quality-assured.Cost-effective and quality-assured.</p>Fórmula:C21H17ClN2O6Pureza:97.62% - 99.09%Forma y color:SolidPeso molecular:428.82TM5007
CAS:<p>TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).</p>Fórmula:C24H20N2O6S4Pureza:96.91%Forma y color:SolidPeso molecular:560.69Tiplaxtinin
CAS:<p>Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.</p>Fórmula:C24H16F3NO4Pureza:99.16% - 99.93%Forma y color:SolidPeso molecular:439.38Toddalolactone
CAS:<p>Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.</p>Fórmula:C16H20O6Pureza:99.06% - 99.85%Forma y color:SolidPeso molecular:308.33TM5275 sodium
CAS:<p>TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).</p>Fórmula:C28H27ClN3NaO5Pureza:98.8% - 99.74%Forma y color:SolidPeso molecular:543.98MDI-2268
CAS:<p>MDI-2268, an inhibitor of plasma kallikrein inhibitor 1 (PAI-1), exhibits strong antithrombotic properties. It plays a role in regulating blood coagulation by promoting fibrinolysis and is applicable in research related to deep vein thrombosis.</p>Fórmula:C10H10F3N3O3Forma y color:SolidPeso molecular:277.20SK-216
CAS:<p>SK-216,PAI-1 inhibitor. Reduces tumor angiogenesis. Inhibits VEGF-induced endothelial cell migration. Alleviates pulmonary fibrosis.</p>Fórmula:C29H29NNa2O6Pureza:98.29%Forma y color:SolidPeso molecular:533.52UK-371804 HCl
CAS:<p>UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (2700-</p>Fórmula:C14H17Cl2N5O4SPureza:98%Forma y color:SolidPeso molecular:422.29Diaplasinin
CAS:<p>Diaplasinin (PAI-749) is a potent inhibitor of plasminogen activator inhibitor-1 (PAI-1) with antithrombotic activity, used in cardiovascular disease research.</p>Fórmula:C32H31N5OPureza:99.02%Forma y color:SolidPeso molecular:501.62Aleplasinin
CAS:<p>Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic</p>Fórmula:C28H27NO3Pureza:99.21%Forma y color:SolidPeso molecular:425.52AZ3976
CAS:<p>AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.</p>Fórmula:C15H19N5O3Pureza:98.14%Forma y color:SolidPeso molecular:317.34PPACK
CAS:<p>PPACK: synthetic peptide, irreversibly inhibits thrombin (Ki = 0.24 nM), prevents platelet activation.</p>Fórmula:C21H31ClN6O3Pureza:98%Forma y color:SolidPeso molecular:450.96GW-6604
CAS:<p>GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.</p>Fórmula:C19H14N4Pureza:99.6%Forma y color:SolidPeso molecular:298.34ZK824190
CAS:<p>ZK824190: oral uPA inhibitor, IC50 - uPA 237 nM, tPA 1600 nM, Plasmin 1850 nM.</p>Fórmula:C22H20F2N2O4Pureza:98.84%Forma y color:SolidPeso molecular:414.4BT-114143
CAS:<p>BT-114143 is a plasminogen activator inhibitor with an IC50 of 8.42 μM. It is applicable in research related to hemorrhagic diseases caused by excessive fibrinolysis, including traumatic bleeding, severe menorrhagia, postpartum hemorrhage, and complications of hemophilia.</p>Fórmula:C8H11N2O3PForma y color:SolidPeso molecular:214.158GGACK
CAS:<p>GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>Fórmula:C14H25ClN6O5Peso molecular:392.84
