Cisteína proteasa
Los inhibidores de proteasas de cisteína son compuestos que se dirigen e inhiben a las proteasas de cisteína, una clase de enzimas que descomponen proteínas al romper enlaces peptídicos en los que un residuo de cisteína actúa como nucleófilo. Estas enzimas están involucradas en varios procesos fisiológicos, como la apoptosis, la respuesta inmune y el recambio de proteínas. Los inhibidores de proteasas de cisteína son fundamentales para estudiar enfermedades como el cáncer, los trastornos neurodegenerativos y las infecciones parasitarias. En CymitQuimica, ofrecemos inhibidores de proteasas de cisteína para apoyar su investigación en proteólisis, regulación celular y descubrimiento de fármacos.
Se han encontrado 96 productos de "Cisteína proteasa"
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Cathepsin Inhibitor 4
<p>Cathepsin Inhibitor 4 (Compound 45) is a selective inhibitor of Cathepsin S, with a Ki value of 0.04 nM.</p>Fórmula:C24H35N3O5Peso molecular:445.25767Cathepsin K inhibitor 7
Cathepsin K Inhibitor7 (compound 7) is an inhibitor of Cathepsin K, exhibiting a pKi value of 7.3. It is utilized in research on osteoporosis.Forma y color:Odour SolidCathepsin C-IN-6
<p>Cathepsin C-IN-6 (compound 2), an E-64c-hydrazideas-derived inhibitor of cathepsin C, possesses anti-inflammatory properties and impedes neutrophil elastase</p>Fórmula:C24H35N5O4·xC2HF3O2Forma y color:SolidLeupeptin
CAS:<p>Leupeptin, from actinomycetes, inhibits various proteases (e.g., trypsin, plasmin, kallikrein, papain, cathepsin B) but not α-chymotrypsin/thrombin.</p>Fórmula:C20H38N6O4Pureza:98%Forma y color:SolidPeso molecular:426.562PD150606
CAS:<p>PD150606 is a calpain inhibitor with neuroprotective activity that inhibits μ-calpains and interferes with excitotoxicity-dependent motor neuron death.</p>Fórmula:C9H7IO2SPureza:98.19%Forma y color:SolidPeso molecular:306.12Z-FG-NHO-Bz
CAS:<p>Z-FG-NHO-Bz is a selective inhibitor of cathepsin [1].</p>Fórmula:C26H25N3O6Forma y color:SolidPeso molecular:475.49VK13
<p>VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.</p>Fórmula:C24H28N4O5Forma y color:SolidPeso molecular:452.503Cathepsin D and E FRET Substrate
CAS:Mca-GKPILFFRL-Dpa-r-amide, FRET substrate for cathepsin D and E. Also cleaved by napsin A.Fórmula:C85H122N22O19Forma y color:SolidPeso molecular:1756.046Tacalcitol monohydrate
CAS:<p>Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.</p>Fórmula:C27H46O4Pureza:99.93%Forma y color:SolidPeso molecular:434.65Z-Phe-Tyr(tBu)-diazomethylketone
CAS:<p>Irreversible cathepsin L inhibitor which is ca 10'000 times more effective in inactivating cathepsin L than cathepsin S.</p>Fórmula:C31H34N4O5Forma y color:SolidPeso molecular:542.636Z-L(D-Val)G-CHN2
<p>Z-L(D-Val)G-CHN2, an isoform of Z-LVG-CHN2, serves as a cell-permeable and irreversible inhibitor of cysteine proteinase.</p>Fórmula:C22H31N5O5Pureza:98%Forma y color:SolidPeso molecular:445.51Relacatib
CAS:<p>Relacatib (SB-462795) is a potent cathepsins K, L, V inhibitor with high affinity (Ki: 41-68 pM) and reduces bone resorption effectively.</p>Fórmula:C27H32N4O6SForma y color:SolidPeso molecular:540.64Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Forma y color:Odour SolidN-CBZ-Phe-Arg-AMC TFA
<p>N-CBZ-Phe-Arg-AMC TFA (Z-FR-AMC TFA) is a fluorescent substrate for serine proteases. assess the activity of trypsin, plasmin, and cathepsin.</p>Fórmula:C35H37F3N6O8Pureza:99.88%Forma y color:SolidPeso molecular:726.7Dazcapistat
CAS:<p>Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.</p>Fórmula:C21H18FN3O4Pureza:99.11%Forma y color:SolidPeso molecular:395.38Ac-PLVE-FMK
CAS:<p>Ac-PLVE-FMK (Ac-Pro-Leu-Val-Glu(OMe)-CH2F), a tetrapeptidyl fluoromethylketone (FMKs), serves as a cathepsin inhibitor. It is utilized in cancer research [1].</p>Fórmula:C25H41FN4O7Pureza:98%Forma y color:SolidPeso molecular:528.61FGA139
<p>FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.</p>Fórmula:C48H58BF2N7O5Forma y color:SolidPeso molecular:861.45605Mpro/Cathepsin L-IN-1
<p>Mpro/Cathepsin L-IN-1 (Compound 4d) is an inhibitor of SARS-CoV-2 Mpro and hCatL, with Ki values of 5.54 μM and 0.701 μM, respectively.</p>Fórmula:C24H32FN3O4Peso molecular:445.237686,6′-Dihydroxythiobinupharidine
CAS:<p>6,6′-Dihydroxythiobinupharidine, a cysteine proteases inhibitor, amplifies DNA cleavage facilitated by human topoisomerase IIα and IIβ by approximately 8-fold</p>Fórmula:C30H42N2O4SForma y color:SolidPeso molecular:526.73Cathepsin L-IN-3
CAS:<p>Cathepsin L-IN-3, a tripeptide-sized inhibitor of cathepsin L, effectively targets this specific enzyme.</p>Fórmula:C41H49N7O4SForma y color:SolidPeso molecular:735.94Z-Leu-Tyr-Chloromethylketone
CAS:<p>Z-Leu-Tyr-Chloromethylketone is a calpain inhibitor [1].</p>Fórmula:C24H29ClN2O5Forma y color:SolidPeso molecular:460.95N-CBZ-Phe-Arg-AMC
CAS:<p>Z-FR-AMC substrate for serine proteases; cathepsins, kallikrein, plasmin. Substrate: 330/390 nm; Product: 342/441 nm.</p>Fórmula:C33H36N6O6Pureza:98%Forma y color:White To Off-White PowderPeso molecular:612.68Gallinamide A TFA
CAS:<p>Gallinamide A TFA is a peptide that exhibits linear deposition and serves as a potent inhibitor of cathepsin L (CatL) with an IC50 of 17.6 pM. It inhibits SARS-CoV-2 infection by targeting CatL (EC50: 28 nM) and also inhibits Plasmodium falciparum with an IC50 of 50 nM [1] [2].</p>Fórmula:C33H53F3N4O9Forma y color:SolidPeso molecular:706.79Z-Arg-Arg-βNA acetate
CAS:<p>Z-Arg-Arg-βNA acetate serves as a sensitive dipeptide substrate for Cathepsin B protease, while demonstrating resistance to proteases H and L. This compound is crucial for differentiating non-Cathepsin B type proteins.</p>Fórmula:C32H43N9O6Forma y color:SolidPeso molecular:649.74Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
Fluorogenic substrate for cathepsins D & E; cleaves at Phe-Phe bond; not for B, H, L. Useful for assays and studies.Forma y color:Odour SolidHepcidin-1 (mouse)
CAS:<p>Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion.</p>Fórmula:C111H169N31O35S8Forma y color:SolidPeso molecular:2754.24LN5P45
<p>LN5P45, an OTUB2 inhibitor (IC50: 2.3 μM), promotes monoubiquitination of OTUB2 at lysine 31 and is utilized in the study of tumor progression and metastasis [1</p>Fórmula:C13H15ClN2O2Forma y color:SolidPeso molecular:266.72L-006235
CAS:L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.Fórmula:C24H30N6O2SPureza:99.37%Forma y color:SolidPeso molecular:466.6CA-074 methyl ester
CAS:<p>CA-074 methyl ester (Cathepsin B Inhibitor IV) is a selective inhibitor of Cathepsin B (IC50=36.3 nM). neuroprotective effect. High-Quality, Low-Cost!</p>Fórmula:C19H31N3O6Pureza:97.26% - 99.58%Forma y color:SolidPeso molecular:397.47Odanacatib
CAS:<p>Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.</p>Fórmula:C25H27F4N3O3SPureza:98.53% - 99.53%Forma y color:SolidPeso molecular:525.56LY 3000328
CAS:<p>LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S.Cost-effective and quality-assured.</p>Fórmula:C25H29FN4O5Pureza:97.83% - 99.54%Forma y color:SolidPeso molecular:484.52E-64
CAS:<p>E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.</p>Fórmula:C15H27N5O5Pureza:98% - 99.95%Forma y color:White SolidPeso molecular:357.41MDL-28170
CAS:<p>MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.</p>Fórmula:C22H26N2O4Pureza:95.06%Forma y color:SolidPeso molecular:382.45JTE-607
CAS:<p>JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.</p>Fórmula:C25H33Cl4N3O5Pureza:97.88%Forma y color:SolidPeso molecular:597.36KGP94
CAS:<p>KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.</p>Fórmula:C14H12BrN3OSPureza:99.6%Forma y color:SolidPeso molecular:350.23Balicatib
CAS:<p>Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.</p>Fórmula:C23H33N5O2Pureza:97.78% - 98.17%Forma y color:White To Off-White Solid PowderPeso molecular:411.542-Cyanopyrimidine
CAS:<p>2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)</p>Fórmula:C5H3N3Pureza:99.27%Forma y color:Crystalline SolidPeso molecular:105.1(1S,2R)-Alicapistat
CAS:<p>(1S,2R)-Alicapistat inhibits calpains 1 and 2, shows promise for Alzheimer's, and has an IC50 of 395 nM.</p>Fórmula:C25H27N3O4Pureza:99.60%Forma y color:SoildPeso molecular:433.5Cathepsin Inhibitor 1
CAS:<p>Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.</p>Fórmula:C20H24ClN5O2Pureza:99.78%Forma y color:SolidPeso molecular:401.89Calpain Inhibitor XII
CAS:<p>Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a calpain I inhibitor that inhibits calpain II and cathepsin B.</p>Fórmula:C26H34N4O5Forma y color:SolidPeso molecular:482.57LmCPB-IN-1
CAS:<p>LmCPB-IN-1, compound 35, is a reversible inhibitor of LmCPB with strong binding (pKi 9.7).</p>Fórmula:C18H30N6O2Forma y color:SolidPeso molecular:362.47DTS
CAS:<p>DTS is a selective and isoform-specific RSK1 kinase inhibitor. It also has broad cancer therapeutic potential.</p>Fórmula:C14H14S3Pureza:98%Forma y color:SolidPeso molecular:278.46Cathepsin L/S-IN-1
<p>Cathepsin L/S-IN-1 inhibits Cathepsin L & S (IC50: 4.10 & 1.79 μM) and reduces metastasis in pancreatic cancer cells.</p>Fórmula:C29H33BrN4O4SForma y color:SolidPeso molecular:613.57JPM-OEt
CAS:<p>JPM-OEt: broad-spectrum, covalent cysteine cathepsin inhibitor with antitumor effects.</p>Fórmula:C20H28N2O6Pureza:98%Forma y color:SolidPeso molecular:392.45GSK-2793660
CAS:<p>GSK-2793660, an oral, irreversible CTSC inhibitor, aids bronchiectasis research.</p>Fórmula:C20H27N3O3Pureza:98%Forma y color:SolidPeso molecular:357.45Gü1303
CAS:<p>Gü1303 is a highly potent and reversible inhibitor of Cathepsin K (CatK), with a Ki value of 0.91 nM for mature CatK (mCatK).</p>Fórmula:C20H22N4O3Forma y color:SolidPeso molecular:366.41Cysteine Protease inhibitor
CAS:<p>Cysteine protease inhibitors are inhibitors of cysteine proteases. Target: Cysteine Protease</p>Fórmula:C18H14N4OPureza:98%Forma y color:SolidPeso molecular:302.33GSK2793660 HCl
CAS:<p>GSK2793660 is a irreversible covalent α,β-unsaturated amide based DPP1 inhibitor.</p>Fórmula:C22H32ClN3O3Forma y color:SolidPeso molecular:421.96JNJ-10329670
CAS:<p>JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.</p>Fórmula:C30H34ClF3N6O3SForma y color:SolidPeso molecular:651.14Gü2602
CAS:<p>Gü2602 inhibits the cathepsin K zymogen autocatalytic activation that is a potent, reversible inhibitor of cathepsin K (CatK) with a Ki of 0.013 nM for mature</p>Fórmula:C16H22N4O3Forma y color:SolidPeso molecular:318.37VEL-0230
CAS:<p>VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.</p>Fórmula:C14H24NNaO5Forma y color:SolidPeso molecular:309.33ASPER-29
CAS:<p>ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.</p>Fórmula:C31H29BrN2O5SForma y color:SolidPeso molecular:621.54L-873724
CAS:<p>L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.</p>Fórmula:C23H26F3N3O3SPureza:98%Forma y color:SolidPeso molecular:481.53CAA0225
CAS:<p>CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.</p>Fórmula:C28H29N3O5Forma y color:SolidPeso molecular:487.55MDL 27399
CAS:<p>MDL 27399 suppresses human neutrophil cathepsin G.</p>Fórmula:C26H36N4O8Forma y color:SolidPeso molecular:532.59AM 4299 B
CAS:<p>AM 4299 B is a novel inhibitor of a thiol protease.</p>Fórmula:C16H27N3O7Pureza:98%Forma y color:SolidPeso molecular:373.4Cysteine Protease inhibitor hydrochloride
CAS:<p>Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.</p>Fórmula:C18H15ClN4OPureza:98%Forma y color:SolidPeso molecular:338.79NAAA-IN-2
CAS:<p>NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.</p>Fórmula:C11H13N3O2SForma y color:SolidPeso molecular:251.3SSAA09E1
CAS:<p>SSAA09E1 blocks SARS-CoV entry, lowers ACE2-mediated HEK293T cell infection (EC50 = 6.7 μM), and inhibits cathepsin L (IC50 = 5.33 μM).</p>Fórmula:C7H9N3S2Forma y color:SolidPeso molecular:199.3SQ 32602
CAS:<p>SQ 32602 is a cathepsin E inhibitor.</p>Fórmula:C32H52N3O7PForma y color:SolidPeso molecular:621.74Dutacatib
CAS:<p>Dutacatib is an inhibitor of SARS-CoV-2 3CLpro and cathepsin K, offering antiviral properties and potential benefits in treating cancer-induced bone disease.</p>Fórmula:C23H31N7OForma y color:SolidPeso molecular:421.54Cysteine protease inhibitor-2
CAS:<p>Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.</p>Fórmula:C13H5N5OPureza:98%Forma y color:SolidPeso molecular:247.21Kgp-IN-1
CAS:<p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>Fórmula:C19H24F4N4O3Pureza:98%Forma y color:SolidPeso molecular:432.41LHVS
CAS:<p>LHVS effectively blocks T.</p>Fórmula:C28H37N3O5SPureza:98%Forma y color:SolidPeso molecular:527.68CA 074
CAS:<p>CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates</p>Fórmula:C18H29N3O6Pureza:97.80%Forma y color:SolidPeso molecular:383.44Cathepsin X-IN-1
CAS:<p>Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].</p>Fórmula:C15H13N3O3SPureza:99.34%Forma y color:SolidPeso molecular:315.35JNJ-10311795
CAS:<p>JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.</p>Fórmula:C40H35N2O6PPureza:97.43%Forma y color:SolidPeso molecular:670.69SPR38
<p>SPR38: SARS-CoV-2 protease inhibitor with Ki 0.260 μM; also blocks hCatL (Ki 1.92 μM) and hCatB (Ki 11.1 μM).</p>Fórmula:C24H33N3O5Forma y color:SolidPeso molecular:443.54Cathepsin K inhibitor 3
CAS:<p>Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.</p>Fórmula:C30H31FN4O4SForma y color:SolidPeso molecular:562.65ABP 25
CAS:<p>ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.</p>Fórmula:C55H66ClN5O3Forma y color:SolidPeso molecular:880.6SQ 32056
CAS:<p>SQ 32056 is a cathepsin E inhibitor.</p>Fórmula:C37H56N4O5Pureza:98%Forma y color:SolidPeso molecular:636.86Cathepsin Inhibitor 2
CAS:<p>Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).</p>Fórmula:C19H21F6N3OPureza:98%Forma y color:SolidPeso molecular:421.38MPI8
CAS:<p>MPI8 is a SARS-CoV-2 Protease inhibitor (IC50 = 105 nM).</p>Fórmula:C32H48N4O7Forma y color:SolidPeso molecular:600.75Z-DEVD-CMK
CAS:<p>Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].</p>Fórmula:C27H35ClN4O12Forma y color:SolidPeso molecular:643.04Petesicatib
CAS:<p>Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.</p>Fórmula:C25H23F6N5O4SPureza:99.76%Forma y color:SolidPeso molecular:603.54MeOSuc-AAPV-CMK
CAS:<p>MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated</p>Fórmula:C22H35ClN4O7Forma y color:SolidPeso molecular:502.99Z-FG-NHO-BzOME
CAS:<p>Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,</p>Fórmula:C27H27N3O7Forma y color:SolidPeso molecular:505.52SID 26681509
CAS:<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Fórmula:C27H33N5O5SPureza:98.16%Forma y color:SolidPeso molecular:539.65MK-0674
CAS:<p>MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.</p>Fórmula:C26H27F6N3O2Pureza:97.3% - 99.91%Forma y color:SolidPeso molecular:527.5VBY-825
CAS:<p>VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.</p>Fórmula:C23H29F4N3O5SPureza:99.91%Forma y color:SolidPeso molecular:535.55GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Fórmula:C33H39N3O6Forma y color:SolidPeso molecular:573.68Verducatib
CAS:<p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>Fórmula:C31H35FN4O3Forma y color:SolidPeso molecular:530.633Cathepsin K inhibitor 2
CAS:<p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>Fórmula:C30H33F4N5O3Forma y color:SolidPeso molecular:587.61BI-1915
CAS:<p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>Fórmula:C21H37N5O3Forma y color:SolidPeso molecular:407.55Cathepsin C-IN-3
<p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>Fórmula:C28H21F3N6OSForma y color:SolidPeso molecular:546.57RO5461111
CAS:<p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.</p>Fórmula:C27H24F6N4O4SForma y color:SolidPeso molecular:614.56SID 26681509 quarterhydrate
<p>SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).</p>Fórmula:C27H35N5O6SForma y color:SolidPeso molecular:544.16Dual Cathepsin L/JAK-IN-1
CAS:<p>DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).</p>Fórmula:C19H18ClN5Forma y color:SolidPeso molecular:351.833Cathepsin C-IN-5
CAS:<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Fórmula:C21H17ClN6OSForma y color:SolidPeso molecular:436.92Z-FY-CHO
CAS:<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Fórmula:C26H26N2O5Pureza:95.88%Forma y color:SolidPeso molecular:446.5CTSL/CAPN1-IN-2
CAS:<p>CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].</p>Fórmula:C34H40N4O6Forma y color:SolidPeso molecular:600.7CatD-IN-1
CAS:<p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>Fórmula:C18H18Cl2N4O5Forma y color:SolidPeso molecular:441.265Cathepsin C-IN-4
<p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>Fórmula:C21H14ClF3N4SForma y color:SolidPeso molecular:446.88MIV-247
CAS:<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Fórmula:C17H24F3N3O4Pureza:99.27%Forma y color:SolidPeso molecular:391.39PD 151746
CAS:<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Forma y color:SolidPeso molecular:237.25ALLM
CAS:<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Fórmula:C19H35N3O4SPureza:98%Forma y color:White PowderPeso molecular:401.56
