Cisteína proteasa
Los inhibidores de proteasas de cisteína son compuestos que se dirigen e inhiben a las proteasas de cisteína, una clase de enzimas que descomponen proteínas al romper enlaces peptídicos en los que un residuo de cisteína actúa como nucleófilo. Estas enzimas están involucradas en varios procesos fisiológicos, como la apoptosis, la respuesta inmune y el recambio de proteínas. Los inhibidores de proteasas de cisteína son fundamentales para estudiar enfermedades como el cáncer, los trastornos neurodegenerativos y las infecciones parasitarias. En CymitQuimica, ofrecemos inhibidores de proteasas de cisteína para apoyar su investigación en proteólisis, regulación celular y descubrimiento de fármacos.
Se han encontrado 96 productos de "Cisteína proteasa"
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VEL-0230
CAS:<p>VEL-0230 (NC-2300) is a cathespin K inhibitor boosting bone growth and reducing loss, targeting bone diseases and developed by Velcura Therapeutics.</p>Fórmula:C14H24NNaO5Forma y color:SolidPeso molecular:309.33ASPER-29
CAS:<p>ASPER-29, an Asperphenamate analog, inhibits cathepsins L/S with IC50s of 6.03/5.02 μM, useful in cancer migration/invasion research.</p>Fórmula:C31H29BrN2O5SForma y color:SolidPeso molecular:621.54L-873724
CAS:<p>L-873724: Selective, reversible cathepsin K inhibitor; IC50s—cat K: 0.2 nM, cat S: 178 nM, cat L: 264 nM, cat B: 5239 nM; inhibits bone resorption.</p>Fórmula:C23H26F3N3O3SPureza:98%Forma y color:SolidPeso molecular:481.53CAA0225
CAS:<p>CAA0225 is a selective inhibitor of cathepsin L. CAA0225 is a probe for autophagic proteolysis.</p>Fórmula:C28H29N3O5Forma y color:SolidPeso molecular:487.55MDL 27399
CAS:<p>MDL 27399 suppresses human neutrophil cathepsin G.</p>Fórmula:C26H36N4O8Forma y color:SolidPeso molecular:532.59AM 4299 B
CAS:<p>AM 4299 B is a novel inhibitor of a thiol protease.</p>Fórmula:C16H27N3O7Pureza:98%Forma y color:SolidPeso molecular:373.4Cysteine Protease inhibitor hydrochloride
CAS:<p>Cysteine Protease inhibitor hydrochloride is a cysteine protease inhibitor.</p>Fórmula:C18H15ClN4OPureza:98%Forma y color:SolidPeso molecular:338.79NAAA-IN-2
CAS:<p>NAAA-IN-2, a selective inhibitor with 50 nM IC50, targets NAAA, an enzyme hydrolyzing PEA/OEA, and may aid inflammation and pain studies.</p>Fórmula:C11H13N3O2SForma y color:SolidPeso molecular:251.3SSAA09E1
CAS:<p>SSAA09E1 blocks SARS-CoV entry, lowers ACE2-mediated HEK293T cell infection (EC50 = 6.7 μM), and inhibits cathepsin L (IC50 = 5.33 μM).</p>Fórmula:C7H9N3S2Forma y color:SolidPeso molecular:199.3SQ 32602
CAS:<p>SQ 32602 is a cathepsin E inhibitor.</p>Fórmula:C32H52N3O7PForma y color:SolidPeso molecular:621.74Dutacatib
CAS:<p>Dutacatib is an inhibitor of SARS-CoV-2 3CLpro and cathepsin K, offering antiviral properties and potential benefits in treating cancer-induced bone disease.</p>Fórmula:C23H31N7OForma y color:SolidPeso molecular:421.54Cysteine protease inhibitor-2
CAS:<p>Cysteine protease inhibitor from US20070032499A1; halts DCT116 at 6.5μM, PC3 at 4.4μM.</p>Fórmula:C13H5N5OPureza:98%Forma y color:SolidPeso molecular:247.21Kgp-IN-1
CAS:<p>Kgp-IN-1 is an arginine-specific gingipain (Rgp) inhibitor.</p>Fórmula:C19H24F4N4O3Pureza:98%Forma y color:SolidPeso molecular:432.41LHVS
CAS:<p>LHVS effectively blocks T.</p>Fórmula:C28H37N3O5SPureza:98%Forma y color:SolidPeso molecular:527.68CA 074
CAS:<p>CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates</p>Fórmula:C18H29N3O6Pureza:97.80%Forma y color:SolidPeso molecular:383.44Cathepsin X-IN-1
CAS:<p>Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].</p>Fórmula:C15H13N3O3SPureza:99.34%Forma y color:SolidPeso molecular:315.35JNJ-10311795
CAS:<p>JNJ-10311795 (RWJ-355871) is an inhibitor of neutrophil elastase G and mast cell chymase, demonstrating significant anti-inflammatory effects.</p>Fórmula:C40H35N2O6PPureza:97.43%Forma y color:SolidPeso molecular:670.69SPR38
<p>SPR38: SARS-CoV-2 protease inhibitor with Ki 0.260 μM; also blocks hCatL (Ki 1.92 μM) and hCatB (Ki 11.1 μM).</p>Fórmula:C24H33N3O5Forma y color:SolidPeso molecular:443.54Cathepsin K inhibitor 3
CAS:<p>Cathepsin K inhibitor 3: Selective, IC50 of 0.5 nM, good pharmacokinetics, potential for OA research.</p>Fórmula:C30H31FN4O4SForma y color:SolidPeso molecular:562.65ABP 25
CAS:<p>ABP 25 is a highly potent and selective activity-based probe (ABP) for cathepsin K imaging.</p>Fórmula:C55H66ClN5O3Forma y color:SolidPeso molecular:880.6SQ 32056
CAS:<p>SQ 32056 is a cathepsin E inhibitor.</p>Fórmula:C37H56N4O5Pureza:98%Forma y color:SolidPeso molecular:636.86Cathepsin Inhibitor 2
CAS:<p>Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).</p>Fórmula:C19H21F6N3OPureza:98%Forma y color:SolidPeso molecular:421.38MPI8
CAS:<p>MPI8 is a SARS-CoV-2 Protease inhibitor (IC50 = 105 nM).</p>Fórmula:C32H48N4O7Forma y color:SolidPeso molecular:600.75Z-DEVD-CMK
CAS:<p>Z-DEVD-CMK irreversibly inhibits various cathepsins in vitro [1].</p>Fórmula:C27H35ClN4O12Forma y color:SolidPeso molecular:643.04Petesicatib
CAS:<p>Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.</p>Fórmula:C25H23F6N5O4SPureza:99.76%Forma y color:SolidPeso molecular:603.54MeOSuc-AAPV-CMK
CAS:<p>MeOSuc-AAPV-CMK (Elastase Inhibitor III) serves as an inhibitor of elastase, as well as cathepsin G and proteinase 3, and impedes leukocyte elastase-mediated</p>Fórmula:C22H35ClN4O7Forma y color:SolidPeso molecular:502.99Z-FG-NHO-BzOME
CAS:<p>Z-FG-NHO-BzOME is a chemical compound functioning as a cysteine protease inhibitor, selectively targeting and inhibiting cathepsin B, cathepsin L, cathepsin S,</p>Fórmula:C27H27N3O7Forma y color:SolidPeso molecular:505.52SID 26681509
CAS:<p>SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).</p>Fórmula:C27H33N5O5SPureza:98.16%Forma y color:SolidPeso molecular:539.65MK-0674
CAS:<p>MK-0674 is a cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S for metabolism-related diseases.</p>Fórmula:C26H27F6N3O2Pureza:97.3% - 99.91%Forma y color:SolidPeso molecular:527.5VBY-825
CAS:<p>VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.</p>Fórmula:C23H29F4N3O5SPureza:99.91%Forma y color:SolidPeso molecular:535.55GB111-NH2
CAS:GB111-NH2, a cysteine cathepsin inhibitor, is applicable in cancer research [1].Fórmula:C33H39N3O6Forma y color:SolidPeso molecular:573.68Verducatib
CAS:<p>Verducatib is an inhibitor of cathepsins (cathepsin).</p>Fórmula:C31H35FN4O3Forma y color:SolidPeso molecular:530.633Cathepsin K inhibitor 2
CAS:<p>Cathepsin K inhibitor 2 targets CTSK gene, may treat osteoporosis and osteoarthritis, detailed in patent WO2021147882A1.</p>Fórmula:C30H33F4N5O3Forma y color:SolidPeso molecular:587.61BI-1915
CAS:<p>BI-1915 is a selective inhibitor of Cathepsin S, with an IC50 of 17 nM. It is utilized in the research of autoimmune diseases.</p>Fórmula:C21H37N5O3Forma y color:SolidPeso molecular:407.55Cathepsin C-IN-3
<p>Cathepsin C-IN-3 is a potent inhibitor of histone C (IC50: 61.79 nM) and also inhibits THP-1 cells (IC50: 101.5 nM) and U937 cells (IC50: 86.5 nM).</p>Fórmula:C28H21F3N6OSForma y color:SolidPeso molecular:546.57RO5461111
CAS:<p>RO5461111: Oral Cathepsin S inhibitor, IC50 of 0.4 nM (human) & 0.5 nM (mouse), reduces T/B cell activation, treats lung inflammation & lupus nephritis.</p>Fórmula:C27H24F6N4O4SForma y color:SolidPeso molecular:614.56SID 26681509 quarterhydrate
<p>SID 26681509 is a selective inhibitor of cathepsin L (IC50: 56 nM) and blocks Plasmodium falciparum (IC50: 15.4 μM) and Leishmania major (IC50: 12.5 μM).</p>Fórmula:C27H35N5O6SForma y color:SolidPeso molecular:544.16Dual Cathepsin L/JAK-IN-1
CAS:<p>DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).</p>Fórmula:C19H18ClN5Forma y color:SolidPeso molecular:351.833Cathepsin C-IN-5
CAS:<p>Cathepsin C-IN-5 (SF38) is a potent, oral Cathepsin C blocker with an IC50 of 59.9 nM; less active against Cat L/S/B/K; has anti-inflammatory effects.</p>Fórmula:C21H17ClN6OSForma y color:SolidPeso molecular:436.92Z-FY-CHO
CAS:<p>Pyridoxal (Pyridoxaldehyde), a component of vitamin B6, is an aldehyde obtained by oxidizing pyridoxine and is widely found in plants and animals.</p>Fórmula:C26H26N2O5Pureza:95.88%Forma y color:SolidPeso molecular:446.5CTSL/CAPN1-IN-2
CAS:<p>CTSL/CAPN1-IN-2 (Compound 14b) serves as an orally active inhibitor targeting both CTSL and CAPN1, manifesting IC50 values of 6.88 nM for CTSL and 347.6 nM for CAPN1 respectively. This compound not only displays anti-inflammatory attributes but also features favorable pharmacokinetic properties. Moreover, CTSL/CAPN1-IN-2 shows extensive antiviral effects against coronaviruses by inhibiting viral entry [1].</p>Fórmula:C34H40N4O6Forma y color:SolidPeso molecular:600.7CatD-IN-1
CAS:<p>CatD-IN-1 (Compound 5) is a Cathepsin D inhibitor with an IC50 of 0.44 μM, and it shows potential for research in the field of osteoarthritis.</p>Fórmula:C18H18Cl2N4O5Forma y color:SolidPeso molecular:441.265Cathepsin C-IN-4
<p>Cathepsin C-IN-4 is a potent inhibitor (IC50: 65.6 nM) of histone C. Cathepsin C-IN-4 inhibits THP-1 cells (IC50: 203.4 nM) and U937 cells (IC50: 177.6 nM).</p>Fórmula:C21H14ClF3N4SForma y color:SolidPeso molecular:446.88MIV-247
CAS:<p>MIV-247 is a cathepsin S inhibitor that attenuates mechanically abnormal pain in preclinical neuropathic pain models and can be used to study myocardial injury.</p>Fórmula:C17H24F3N3O4Pureza:99.27%Forma y color:SolidPeso molecular:391.39PD 151746
CAS:<p>PD151746: calpain inhibitor, Ki μ-calpain=0.26μM, Ki m-calpain=5.33μM; reduces oxLDL cytotoxicity.</p>Fórmula:C11H8FNO2SPureza:98.63% - ≥95%Forma y color:SolidPeso molecular:237.25ALLM
CAS:<p>ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].</p>Fórmula:C19H35N3O4SPureza:98%Forma y color:White PowderPeso molecular:401.56
