Receptor activado por proteasa
Los inhibidores del Receptor Activado por Proteasas (PAR) son compuestos que se dirigen e inhiben la actividad de los PARs, una familia de receptores acoplados a proteínas G que se activan por escisión proteolítica. Estos receptores desempeñan un papel en diversos procesos fisiológicos, incluidos la coagulación, la inflamación y la reparación de tejidos. Los inhibidores de PAR son herramientas valiosas para estudiar los mecanismos de estos procesos y su implicación en enfermedades como el cáncer, trastornos cardiovasculares y la inflamación crónica. En CymitQuimica, ofrecemos inhibidores de PAR para apoyar su investigación en transducción de señales, respuesta inmunitaria y descubrimiento terapéutico.
Se han encontrado 54 productos de "Receptor activado por proteasa"
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TRAP-6 amide
CAS:<p>TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.</p>Fórmula:C34H57N11O8Forma y color:SolidPeso molecular:747.899PAR-4 Agonist Peptide, amide
CAS:<p>PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).</p>Fórmula:C34H48N8O7Pureza:98%Forma y color:SolidPeso molecular:680.79Thrombin Receptor Activator for Peptide 5 (TRAP-5)
CAS:<p>Thrombin Receptor Activator for Peptide 5 (TRAP-5) is also called Coagulation Factor II Receptor (1-5), used in the research of coronary heart disease (CHD).</p>Fórmula:C30H50N8O7Pureza:98%Forma y color:SolidPeso molecular:634.77PAR650097
<p>PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.</p>Pureza:96.67% (SEC-HPLC) - 98.83% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.5kDaPAR-4 Agonist Peptide, amide acetate
<p>PAR-4 Agonist Peptide, amide acetate is an agonist of proteinase-activated receptor-4 (PAR-4).</p>Fórmula:C36H52N8O9Pureza:98%Forma y color:SolidPeso molecular:740.86PZ-128
CAS:<p>PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.</p>Fórmula:C55H99N13O9Pureza:98%Forma y color:SolidPeso molecular:1086.46Parstatin(mouse)
CAS:<p>Peptide inhibits endothelial migration/proliferation (IC50 ~20μM), induces cell cycle arrest, triggers apoptosis, and has cardioprotective effects.</p>Fórmula:C189H326N58O57S3Pureza:98%Forma y color:SolidPeso molecular:4419.19AC-264613
CAS:<p>AC-264613 is an agonist of the GPCR protease-activated receptor 2 (PAR2). AC-264613 suppresses interferon regulatory factor 5.</p>Fórmula:C19H18BrN3O2Pureza:98%Forma y color:SolidPeso molecular:400.28Parstatin(human)
CAS:<p>Cell-permeable PAR1-derived peptide; inhibits endothelial migration, proliferation (IC50 ~3μM), induces apoptosis, and has cardioprotective effects.</p>Fórmula:C191H330N64O53S3Pureza:98%Forma y color:SolidPeso molecular:4467.292-Furoyl-LIGRLO-amide
CAS:<p>2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.</p>Fórmula:C36H63N11O8Pureza:98%Forma y color:SolidPeso molecular:777.95Parstatin(human) TFA
<p>Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].</p>Fórmula:C193H331F3N64O55S3Forma y color:SolidPeso molecular:4581.28RAG8 peptide
<p>RAG8 peptide is an antagonist of protease-activated receptor 4 (PAR 4), which inhibits late-stage platelet activation and reduces thrombosis without altering hemostasis or increasing bleeding risk. It is applicable in atherosclerosis research.</p>Fórmula:C56H98N16O11Peso molecular:1170.7601tcY-NH2
CAS:<p>Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.</p>Fórmula:C40H49N7O7Pureza:98%Forma y color:SolidPeso molecular:739.87FSLLRY-NH2
CAS:<p>PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.</p>Fórmula:C39H60N10O8Pureza:98%Forma y color:SolidPeso molecular:796.97Protease-Activated Receptor-1, PAR-1 Agonist TFA
<p>PAR-1 Agonist TFA: Selective peptide, mimics thrombin, activates PAR-1 receptor.</p>Forma y color:LiquidAY 254
CAS:<p>AY 254: Potent PAR2 agonist, ERK1/2 activation (EC50=2 nM), limits caspase 3/8, aids HT29 cell healing, boosts IL-8.</p>Fórmula:C30H49N9O6Forma y color:SolidPeso molecular:631.779Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
CAS:<p>Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtype</p>Fórmula:C42H63FN12O8Forma y color:SolidPeso molecular:883.02PAR-2 (1-6) (human)
CAS:<p>PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .</p>Fórmula:C28H53N7O8Forma y color:SolidPeso molecular:615.76SFNGGP-NH2
CAS:<p>SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.</p>Fórmula:C25H36N8O8Forma y color:SolidPeso molecular:576.6Protease-Activated Receptor-1, PAR-1 Agonist
CAS:<p>Selective peptide agonist that mimics thrombin to activate PAR-1 receptor, enabling targeted receptor activation.</p>Fórmula:C35H58N10O9Forma y color:SolidPeso molecular:762.91FLLRN
CAS:<p>FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.</p>Fórmula:C31H51N9O7Forma y color:SolidPeso molecular:661.79YFLLRNP
CAS:<p>YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.</p>Fórmula:C45H67N11O10Forma y color:SolidPeso molecular:922.08TRAP-5 amide
CAS:<p>TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].</p>Fórmula:C30H51N9O6Forma y color:SolidPeso molecular:633.78PAR 4 (1-6) (TFA)
<p>PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.</p>Fórmula:C28H41N7O9·xC2HF3O2Forma y color:SolidP4pal10 TFA
<p>P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.</p>Forma y color:Odour SolidTRAP-6 amide TFA
CAS:<p>TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.</p>Fórmula:C36H58F3N11O10Forma y color:SolidPeso molecular:861.922TFLLR-NH2(TFA)
CAS:<p>TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM. EC50: 1.9 μM (PAR1)</p>Fórmula:C33H54F3N9O8Pureza:98%Forma y color:SolidPeso molecular:761.83SLIGRL-NH2
CAS:<p>SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is a PAR-2 agonist that induces non-histaminergic pruritus.</p>Fórmula:C29H56N10O7Pureza:98.29%Forma y color:SolidPeso molecular:656.82Protease-Activated Receptor-2, amide
CAS:<p>Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)</p>Fórmula:C28H54N8O7Pureza:>99.99%Forma y color:SolidPeso molecular:614.78PAR-2-IN-1
CAS:<p>PAR-2-IN-1 (IUN76750) is a PAR- 2 signaling pathway inhibitor with anti-inflammatory and anticancer effects.</p>Fórmula:C12H14ClN3O2Pureza:99.75%Forma y color:SolidPeso molecular:267.71Vorapaxar
CAS:<p>Vorapaxar (MK-5348) (SCH 530348) is an effective and orally active thrombin receptor (PAR-1) antagonist (Ki: 8.1 nM).</p>Fórmula:C29H33FN2O4Pureza:98.77% - 99.93%Forma y color:SolidPeso molecular:492.58Vorapaxar sulfate
CAS:<p>Vorapaxar sulfate (Zontivity) is a potent and orally active thrombin receptor (PAR-1) antagonist.</p>Fórmula:C29H35FN2O8SPureza:99.9% - >99.99%Forma y color:SolidPeso molecular:590.66I-191
CAS:<p>I-191 is a potent antagonist of protease-activated receptor 2 (PAR2), inhibits multiple signaling functions in human cancer cells.</p>Fórmula:C23H26FN5O2Pureza:99.8%Forma y color:SolidPeso molecular:423.48TRAP-6
CAS:<p>TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is an agonist of protease-activated receptor 1 (PAR1).</p>Fórmula:C34H56N10O9Pureza:>99.99%Forma y color:SolidPeso molecular:748.87PAR-4 Agonist Peptide, amide TFA
CAS:<p>PAR-4 agonist peptide doesn't affect PAR-1/PAR-2; blocked by PAR-4 antagonist.</p>Fórmula:C36H49F3N8O9Pureza:99.72%Forma y color:SolidPeso molecular:794.82Protease-Activated Receptor-1, PAR-1 Agonist acetate
<p>PAR-1 Agonist acetate is a selective PAR-1 agonist that mimics thrombin action.</p>Fórmula:C37H62N10O11Pureza:98.1800%Forma y color:SolidPeso molecular:822.95PAR-2 Activating Peptide acetate
<p>PAR-2 Activating Peptide acetate (SLIGRL-NH2 acetate) is an agonist of Protease-Activated Receptor-2 (PAR-2).</p>Fórmula:C31H60N10O9Pureza:98.5% - 99.92%Forma y color:SolidPeso molecular:716.88AC-55541
CAS:<p>AC-55541 (AOB2796), a PAR2 agonist, activates PAR2 in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays.</p>Fórmula:C25H20BrN5O3Pureza:98% - 99.33%Forma y color:SolidPeso molecular:518.36VKGILS-NH2 Acetate
<p>VKGILS-NH2 Acetate is a reversed amino acid sequence control peptide for SLIGKV-NH2, a protease-activated receptor 2 (PAR2) agonist.</p>Fórmula:C30H58N8O9Pureza:98.83%Forma y color:SolidPeso molecular:674.83LRGILS-NH2 acetate
<p>LRGILS-NH2 acetate is a PAR-2-inactive reversed peptide.</p>Fórmula:C29H56N10O7Pureza:96.65%Forma y color:SolidPeso molecular:656.82FSLLRY-NH2 TFA(245329-02-6 free base)
<p>FSLLRY-NH2 TFA inhibits PAR2, reverses taxol-induced pain, and reduces itch in mice; blocks ERK and collagen in fibroblasts.</p>Fórmula:C41H61F3N10O10Pureza:99.32%Forma y color:SolidPeso molecular:910.99tcY-NH2 TFA(327177-34-4 free base)
<p>tcY-NH2 TFA is a selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.</p>Fórmula:C42H50F3N7O9Pureza:>99.99%Forma y color:SolidPeso molecular:853.9Thrombin Receptor Activator for Peptide
<p>Thrombin Receptor Activator (TRAP) or Coagulation Factor II (1-5), used in CHD research.</p>Fórmula:C32H51F3N8O9Pureza:99.88%Forma y color:SolidPeso molecular:748.79Parmodulin 2
CAS:<p>ML161 (Parmodulin 2) inhibits PAR1, blocking platelet activation and thrombin-induced activity (IC50: 0.26μM).</p>Fórmula:C17H17BrN2O2Pureza:97.35% - 99.95%Forma y color:SolidPeso molecular:361.23AZ3451
CAS:<p>AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).</p>Fórmula:C30H27BrN4O3Pureza:98.12%Forma y color:SolidPeso molecular:571.46Protease-Activated Receptor-4 diTFA
<p>Protease-Activated Receptor-4 diTFA,2454 is the proteinase-activated receptor-4 (PAR4)agonist</p>Fórmula:C37H48F6N8O11Pureza:98.54%Forma y color:SolidPeso molecular:894.812-Furoyl-LIGRLO-amide TFA(729589-58-6 free base)
<p>2-Furoyl-LIGRLO-amide TFA(729589-58-6 free base) is a potent and selective protease-activated receptor 2 (PAR2) agonist.</p>Fórmula:C38H64F3N11O10Pureza:>99.99%Forma y color:SolidPeso molecular:891.98ML-354
CAS:<p>ML354 is a selective antagonist of PAR4 with an IC 50 of 140 nM [1].</p>Fórmula:C16H14N2O3Pureza:99.44%Forma y color:SolidPeso molecular:282.29iso-TRAP-6
CAS:<p>iso-TRAP-6 (iso-SFLLRN), a hexapeptide made from isoserine instead of serine, is a PAR1 agonist that activates platelets via PAR-1.</p>Fórmula:C34H56N10O9Pureza:98.55%Forma y color:SolidPeso molecular:748.87PAR4 antagonist 3
CAS:<p>PAR4 antagonist3 (Compound 36) is a selective antagonist of protease-activated receptor 4 (PAR4). It exhibits antiplatelet activity with an IC50 of 26.1 nM and enhances metabolic stability in human liver microsomes, with a half-life (T1/2) of 97.6 minutes.</p>Fórmula:C22H16FN3O5SPeso molecular:453.44PAR-2-IN-2
CAS:<p>PAR-2-IN-2 (compound P-596) is an inhibitor of protease-activated receptor 2 (PAR-2), with an IC50 of 10.79 μM for SLIGKV and an IC50 greater than 200 μM for trypsin.</p>Fórmula:C25H20F3N5O2Forma y color:SolidPeso molecular:479.454BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Fórmula:C27H23N5O5S2Pureza:98.43% - 99.26%Forma y color:SolidPeso molecular:561.63Protease-Activated Receptor-4
CAS:<p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>Fórmula:C33H46N8O7Pureza:98%Forma y color:SolidPeso molecular:666.77TFLLR-NH2 2TFA(197794-83-5(free base))
<p>TFLLR-NH2 2TFA(197794-83-5(free base)) is an agonist of PAR1 (EC50 :1.9 μM).</p>Fórmula:C35H55F6N9O10Pureza:99.56%Forma y color:SolidPeso molecular:875.87
