Glutaminasa
Los inhibidores de la glutaminasa son compuestos que inhiben la glutaminasa, una enzima que cataliza la conversión de glutamina en glutamato, un paso crítico en el metabolismo celular, especialmente en las células cancerosas. La glutaminasa desempeña un papel clave en la provisión de energía y precursores biosintéticos para las células en rápida proliferación. Los inhibidores de la glutaminasa son importantes para explorar las dependencias metabólicas en las células cancerosas y desarrollar posibles estrategias terapéuticas. En CymitQuimica, proporcionamos inhibidores de la glutaminasa para apoyar su investigación en metabolismo del cáncer, bioenergética celular y descubrimiento terapéutico.
Se han encontrado 40 productos de "Glutaminasa"
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BJJF078
CAS:<p>BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.</p>Fórmula:C27H29N3O6SPureza:98.19%Forma y color:SoildPeso molecular:523.6LDN-27219
CAS:<p>LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.</p>Fórmula:C20H16N4O2S2Pureza:99.01% - 99.38%Forma y color:SolidPeso molecular:408.5Glutaminase C-IN-2
<p>Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.</p>Fórmula:C24H23N7O2SPureza:98%Forma y color:SolidPeso molecular:473.55L-Methionine-DL-sulfoximine
CAS:<p>MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.</p>Fórmula:C5H12N2O3SPureza:99.56% - ≥98%Forma y color:White Crystalline PowderPeso molecular:180.23PROTAC TG2 degrader-1
<p>PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.</p>Fórmula:C55H73N9O10SPureza:98%Forma y color:SolidPeso molecular:1052.29PROTAC TG2 degrader-2
<p>PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.</p>Fórmula:C47H57N9O6SPureza:98%Forma y color:SolidPeso molecular:876.08LM11
<p>LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.</p>Fórmula:C26H18Cl2N4O5Peso molecular:536.06543Trivalent hydroxyarsinothricn
<p>Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.</p>Fórmula:C4H10AsNO4Peso molecular:210.982586-Diazo-5-oxo-L-nor-Leucine
CAS:<p>6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).</p>Fórmula:C6H9N3O3Pureza:98.04% - 98.93%Forma y color:SolidPeso molecular:171.15GLS1 Inhibitor-7
<p>GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, and</p>Fórmula:C20H17F3N4O3S2Pureza:98%Forma y color:SolidPeso molecular:482.5Glutaminase-IN-1
CAS:<p>Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.</p>Fórmula:C26H24F3N7O3SePureza:98.65% - 98.65%Forma y color:SolidPeso molecular:618.47Glutaminase-IN-3
CAS:<p>Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.</p>Fórmula:C19H19F3N6O2SPureza:98.51%Forma y color:SolidPeso molecular:452.45Glutaminase C-IN-1
CAS:<p>Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.</p>Fórmula:C27H27BrN2OPureza:99.68% - >99.99%Forma y color:SolidPeso molecular:475.42GK921
CAS:<p>GK921 is a transglutaminase 2 (TGase) inhibitor.</p>Fórmula:C21H20N4OPureza:97.44% - 99.49%Forma y color:SolidPeso molecular:344.41BPTES
CAS:<p>BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.</p>Fórmula:C24H24N6O2S3Pureza:95.83% - 99.64%Forma y color:SolidPeso molecular:524.68Telaglenastat
CAS:<p>Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.</p>Fórmula:C26H24F3N7O3SPureza:97.57% - 99.89%Forma y color:SolidPeso molecular:571.57L-Albizziin
CAS:<p>L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.</p>Fórmula:C4H9N3O3Pureza:99.98%Forma y color:White PowderPeso molecular:147.13Zampilimab
CAS:<p>Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.</p>Pureza:95%Forma y color:LiquidIrbesartan-d4
CAS:<p>Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.</p>Fórmula:C25H28N6OPureza:>99.99%Forma y color:SolidPeso molecular:432.55VA4 TG2 inhibitor
CAS:<p>VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.</p>Fórmula:C33H41N5O6SForma y color:SolidPeso molecular:635.77GLS1 Inhibitor-3
CAS:<p>GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.</p>Fórmula:C30H32N10O2SForma y color:SolidPeso molecular:596.71α-Glucosidase-IN-5
CAS:<p>α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.</p>Fórmula:C15H13NO3Forma y color:SolidPeso molecular:255.27Glutaminase-IN-4
CAS:<p>Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor (IC50: 2.3 μM).</p>Fórmula:C23H22N6O2S2Forma y color:SolidPeso molecular:478.59AA10 TG2 inhibitor
CAS:<p>AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).</p>Fórmula:C32H36N4O5Forma y color:SolidPeso molecular:556.65Duazomycin
CAS:<p>Duazomycin, an antitumor substance and glutamine antagonist, is used as a chemotherapeutic agent.</p>Fórmula:C8H11N3O4Forma y color:SolidPeso molecular:213.19AA9 TG2 inhibitor
CAS:<p>AA9 is a novel transglutaminase (TG2) inhibitor.</p>Fórmula:C32H36N4O5Forma y color:SolidPeso molecular:556.65JHU-083
CAS:<p>JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.</p>Fórmula:C14H24N4O4Pureza:97.89% - 99.53%Forma y color:SolidPeso molecular:312.37GLS1 Inhibitor
CAS:<p>GLS1 inhibitor blocks glutaminase 1 (IC50=0.021 μM), hinders NCI H1703 NSCLC cell growth in vitro (GI50=0.011 μM), and suppresses tumors in mice.</p>Fórmula:C19H21N7O2SForma y color:SolidPeso molecular:411.48NC9 TG2 inhibitor
CAS:<p>NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).</p>Fórmula:C35H47N5O8SPureza:98%Forma y color:SolidPeso molecular:697.84IPN60090
CAS:<p>IPN60090: potent oral GLS1 inhibitor, IC50 of 31 nM, potential for anticancer and immunomodulation.</p>Fórmula:C24H27F3N8O3Pureza:99.76%Forma y color:SolidPeso molecular:532.52UPGL00004
CAS:<p>UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.</p>Fórmula:C25H26N8O2S2Pureza:97.93%Forma y color:SolidPeso molecular:534.66Sirpiglenastat
CAS:<p>Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.</p>Fórmula:C22H27N5O5Pureza:98.01% - 98.37%Forma y color:SolidPeso molecular:441.48TG2-IN-3h
CAS:<p>TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitor</p>Fórmula:C21H26N4O4SPureza:99.34% - 99.76%Forma y color:SolidPeso molecular:430.52TG-2-IN-1
CAS:<p>TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].</p>Fórmula:C8H13ClN2OSPureza:98.43%Forma y color:SolidPeso molecular:220.72KCC009
CAS:<p>KCC009 is a potent and selective Transglutaminase 2 Inhibitor.</p>Fórmula:C21H22BrN3O5Forma y color:SolidPeso molecular:476.32ZED-1227
CAS:<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Fórmula:C26H36N6O6Pureza:99.04%Forma y color:SolidPeso molecular:528.6TG-2-IN-4
CAS:<p>TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].</p>Fórmula:C34H40N6O5Forma y color:SolidPeso molecular:612.72TGase2-IN-1
CAS:<p>TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.</p>Fórmula:C23H25N3O3Forma y color:SolidPeso molecular:391.46GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Fórmula:C26H25FN4OSForma y color:SolidPeso molecular:460.57IPN60090 dihydrochloride
CAS:<p>IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.</p>Fórmula:C24H29Cl2F3N8O3Forma y color:SolidPeso molecular:605.44
