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Células madre y Derivados

Células madre y Derivados

Los inhibidores de células madre son compuestos que se dirigen específicamente a las vías de señalización y proteínas involucradas en el mantenimiento, diferenciación y proliferación de células madre. Estos inhibidores son cruciales para comprender la biología de las células madre y para desarrollar estrategias que permitan manipularlas con fines terapéuticos, como en la medicina regenerativa y el tratamiento del cáncer. Al controlar el destino de las células madre, estos inhibidores pueden ayudar a guiar la diferenciación de células madre en tipos celulares específicos o prevenir el crecimiento celular no deseado. En CymitQuimica, ofrecemos una selección de inhibidores de células madre de alta calidad para apoyar su investigación en biología de células madre, biología del desarrollo y medicina regenerativa.

Subcategorías de "Células madre y Derivados"

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Se han encontrado 695 productos de "Células madre y Derivados"

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  • ROCK-IN-1
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    ROCK-IN-1

    CAS:
    <p>ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological</p>
    Fórmula:C20H18FN3O
    Pureza:>99.99%
    Forma y color:Solid
    Peso molecular:335.37

    Ref: TM-T13419

  • JAK-IN-3
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    JAK-IN-3

    CAS:
    <p>JAK-IN-3 is a potent JAK inhibitor that inhibits JAK3, JAK1, TYK2, and JAK2, and can be used for the study of immune system disorders.</p>
    Fórmula:C18H20N4O3
    Pureza:98.04% - 98.19%
    Forma y color:Solid
    Peso molecular:340.38

    Ref: TM-T11704

  • GSK-3 inhibitor 1
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    GSK-3 inhibitor 1

    CAS:
    <p>GSK-3 inhibitor 1 is a GSK-3 inhibitor.</p>
    Fórmula:C22H17ClFN5O2
    Pureza:98.42%
    Forma y color:Solid
    Peso molecular:437.85

    Ref: TM-T11468

  • PT109
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    PT109

    CAS:
    <p>PT109 is a multikinase inhibitor that targets JNK and other kinases, playing a crucial role in anti-inflammatory, antioxidative, neurogenic, and synaptogenic processes. Specifically, PT109 inhibits JNK isoforms with the following IC50 values: JNK1 at 0.143 μM, JNK2 at 0.831 μM, and JNK3 at 0.285 μM. It also inhibits SGK isoforms (SGK1: IC50=1.34 μM; SGK2: IC50=5.6 μM; SGK3: IC50=26.4 μM) and ROCK2 (IC50=34 μM). Additionally, PT109 reprograms polymorphic glioblastoma multiforme (GBM) into oligodendroglia via the PTBP1/PKM1/2 pathway and alters the metabolic pattern of GBM to exhibit antiglioma activity.</p>
    Fórmula:C23H31N3OS2
    Forma y color:Solid
    Peso molecular:429.64

    Ref: TM-T201273

  • LNK01004
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    LNK01004

    CAS:
    <p>LNK01004 is a JAK inhibitor that exhibits potent inhibitory effects on JAK1 (IC50: 10 nM), JAK2 (IC50: ＜0.51 nM), and TYK2 (IC50: 1.0 nM). It can concurrently inhibit multiple cytokine-induced p-STAT signaling pathways and is applicable for research on diseases such as atopic dermatitis.</p>
    Fórmula:C26H31N7O2
    Forma y color:Solid
    Peso molecular:473.57

    Ref: TM-T205387

  • Milpecitinib
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    Milpecitinib

    CAS:
    <p>Milpecitinib (Compound 21a) is a potent and selective Janus tyrosine kinase (JAK) inhibitor with anti-inflammatory properties. It shows promise for research in cancer and inflammatory diseases.</p>
    Fórmula:C20H20N4O2S
    Forma y color:Solid
    Peso molecular:380.463

    Ref: TM-T205326

  • JAK3 covalent inhibitor-1
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    JAK3 covalent inhibitor-1

    CAS:
    <p>JAK3 Covalent Inhibitor-1 is a compound characterized by its potent and selective inhibition of Janus kinase 3 (JAK3), possessing an IC50 of 11 nM and</p>
    Fórmula:C22H17FN6O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:448.47

    Ref: TM-T11709

  • JAK3-IN-11
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    JAK3-IN-11

    CAS:
    <p>JAK3-IN-11: potent oral JAK3 inhibitor (IC50=1.7 nM), noncytotoxic, &gt;588-fold selectivity, blocks T-cell growth; useful in autoimmune research.</p>
    Fórmula:C23H23N5O2
    Forma y color:Solid
    Peso molecular:401.46

    Ref: TM-T9811

  • M3686
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    M3686

    CAS:
    <p>M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.</p>
    Fórmula:C21H18F3N5O2
    Forma y color:Solid
    Peso molecular:429.395

    Ref: TM-T205477

  • lirucitinib
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    lirucitinib

    CAS:
    <p>Lirucitinib is a JAK inhibitor known for its anti-inflammatory properties.</p>
    Fórmula:C16H25N5OS
    Forma y color:Solid
    Peso molecular:335.468

    Ref: TM-T205259

  • TEAD-IN-10
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    TEAD-IN-10

    CAS:
    <p>TEAD-IN-10 (compound 15), a covalent inhibitor, exhibits selective and potent inhibitory activity against TEAD1 (IC 50 =14 nM), TEAD2 (IC 50 =179 nM), and TEAD3 (IC 50 =4 nM). This compound is utilized in cancer research [1].</p>
    Fórmula:C15H14F3NO
    Forma y color:Solid
    Peso molecular:281.27

    Ref: TM-T87500

  • Tyk2-IN-15
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    Tyk2-IN-15

    CAS:
    <p>Tyk2-IN-15 (Compound 97) is a selective inhibitor of tyrosine kinase 2 (Tyk2) with an IC50 value ≤ 10 nM for Tyk2-JH2. It is utilized in the research of inflammatory and autoimmune diseases [1].</p>
    Fórmula:C21H25F2N7O
    Forma y color:Solid
    Peso molecular:429.47

    Ref: TM-T87584

  • TEAD-IN-1
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    TEAD-IN-1

    CAS:
    <p>TEAD-IN-1 (Compound 2) is an effective inhibitor of TEAD auto-palmitoylation with an IC50 of 603 nM. It enhances the interaction between TEAD and VGLL4, while diminishing the interaction between YAP and TEAD. TEAD-IN-1 is applicable for cancer research.</p>
    Fórmula:C15H20F2N2O3S
    Forma y color:Solid
    Peso molecular:346.393

    Ref: TM-T204883

  • YAP/TAZ inhibitor-3
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    YAP/TAZ inhibitor-3

    CAS:
    <p>YAP/TAZ inhibitor-3 (Compound 24) is a YAP/TAZ inhibitor applicable for relevant research within the life sciences field.</p>
    Fórmula:C21H18F3NO3
    Pureza:99.63%
    Forma y color:Solid
    Peso molecular:389.37

    Ref: TM-T87651

  • (3S,4R)-Tofacitinib
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    (3S,4R)-Tofacitinib

    CAS:
    <p>(3S,4R)-Tofacitinib is an less active enantiomer of Tofacitinib. Tofacitinib is a JAK3 inhibitor(IC50 : 1 nM).</p>
    Fórmula:C16H20N6O
    Pureza:98%
    Forma y color:Solid
    Peso molecular:312.37

    Ref: TM-T13427

  • Tyk2-IN-17
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    Tyk2-IN-17

    CAS:
    <p>Tyk2-IN-17 (compound 185) effectively inhibits TYK2 [1].</p>
    Fórmula:C20H20F2N8O
    Forma y color:Solid
    Peso molecular:426.42

    Ref: TM-T87586

  • Londamocitinib
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    Londamocitinib

    CAS:
    <p>Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.</p>
    Fórmula:C28H31F2N7O4S
    Pureza:98.64% - 99.56%
    Forma y color:Solid
    Peso molecular:599.65

    Ref: TM-T11706

  • CDK8-IN-11
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    CDK8-IN-11

    CAS:
    <p>CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.</p>
    Fórmula:C19H15F3N4O2
    Pureza:99.74%
    Forma y color:Solid
    Peso molecular:388.34

    Ref: TM-T61742

  • JAK3-IN-7
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    JAK3-IN-7

    CAS:
    <p>JAK3-IN-7 is a potent and selective JAK3 inhibitor (IC50&lt;0.01 μM) for the treatment of rejection in organ transplantation, graft-versus-host reaction after</p>
    Fórmula:C17H20N6O
    Pureza:98.81%
    Forma y color:Solid
    Peso molecular:324.38

    Ref: TM-T10009

  • Tyk2-IN-3
    Targetmol
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    Tyk2-IN-3

    CAS:
    <p>Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).</p>
    Fórmula:C25H24N6O3S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:520.63

    Ref: TM-T13233