Wnt / beta-catenina
Los inhibidores de Wnt/beta-catenina son compuestos que inhiben la vía de señalización Wnt/beta-catenina, la cual es crucial para la regulación del desarrollo embrionario, la proliferación celular y el mantenimiento de las células madre. La desregulación de esta vía está relacionada con varios tipos de cáncer y enfermedades degenerativas. Los inhibidores de la señalización Wnt/beta-catenina son valiosos en la investigación enfocada en comprender el papel de esta vía en enfermedades y en el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos inhibidores de Wnt/beta-catenina para apoyar su investigación en biología de células madre, biología del desarrollo e investigación oncológica.
Se han encontrado 66 productos de "Wnt / beta-catenina"
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KY1220
CAS:<p>KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.</p>Fórmula:C14H10N4O3SPureza:99.9%Forma y color:SolidPeso molecular:314.32CCT251545
CAS:<p>CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).</p>Fórmula:C23H24ClN5OPureza:98.2% - 98.69%Forma y color:SolidPeso molecular:421.92Vantictumab
CAS:<p>Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.</p>Pureza:99% (SDS-PAGE); 97.7% (SEC-HPLC) - 99% (SDS-PAGE); 97.7% (SEC-HPLC)Forma y color:LiquidJW74
CAS:<p>JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).</p>Fórmula:C24H20N6O2SPureza:95.00%Forma y color:SolidPeso molecular:456.52BML-286
CAS:<p>BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.</p>Fórmula:C22H18N2O4Pureza:98.44%Forma y color:SolidPeso molecular:374.39TNIK-IN-5
CAS:<p>TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.</p>Fórmula:C22H17N3O3Pureza:99.58%Forma y color:SolidPeso molecular:371.39CWP232228
CAS:<p>CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.</p>Fórmula:C33H34N7Na2O7PPureza:98.87%Forma y color:SolidPeso molecular:717.63Nefopam hydrochloride
CAS:<p>Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.</p>Fórmula:C17H20ClNOPureza:99.32% - 99.85%Forma y color:SolidPeso molecular:289.8Romosozumab
CAS:<p>Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, which increases bone formation and decreases bone resorption.</p>Pureza:98.9% (SDS-PAGE); 98.2% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.2% (SEC-HPLC)Forma y color:LiquidABC99
CAS:<p>ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.</p>Fórmula:C22H21ClN4O5Pureza:99.89%Forma y color:SoildPeso molecular:456.88Ipafricept
CAS:<p>Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.</p>Pureza:99.2% (SDS-PAGE); 97.4% (SEC-HPLC) - 99.2% (SDS-PAGE); 97.4% (SEC-HPLC)Forma y color:LiquidCCT 031374 hydrobromide
CAS:<p>CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.</p>Fórmula:C23H20BrN3OPureza:99.50%Forma y color:SolidPeso molecular:434.33Carboxylesterase-IN-2
CAS:<p>Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.</p>Fórmula:C13H12N4OSPureza:99.92%Forma y color:SoildPeso molecular:272.33Wnt pathway inhibitor 3
CAS:<p>Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies</p>Fórmula:C21H17BrN2O5Pureza:99.69%Forma y color:SoildPeso molecular:457.27Tabituximab
CAS:<p>BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.</p>Pureza:98.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 98.7% (SDS-PAGE); 96.4% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.5 kDaFoxy-5
CAS:<p>Foxy-5 is a wnt5a peptide mimetic</p>Fórmula:C26H42N6O12S2Pureza:98%Forma y color:SolidPeso molecular:694.77NLS-StAx-h
<p>Wnt inhibitor; halts cancer cell growth & spread by blocking β-catenin, IC50=1.4μM, cell-permeable.</p>Fórmula:C161H275N55O29Pureza:98%Forma y color:SolidPeso molecular:3445.26Wnt/β-catenin agonist 3
CAS:<p>Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.</p>Fórmula:C16H15ClN4O2Pureza:99.52%Forma y color:SolidPeso molecular:330.77LP-922056
CAS:<p>LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.</p>Fórmula:C11H9ClN2O2S2Pureza:99.84%Forma y color:SolidPeso molecular:300.78F7H
CAS:<p>F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.</p>Fórmula:C24H18FN3O2S2Pureza:99.85%Forma y color:SoildPeso molecular:463.55β-catenin modulator IIa-661
CAS:<p>β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.</p>Fórmula:C19H23ClN2O3SPureza:99.58%Forma y color:SoildPeso molecular:394.92WIC1
CAS:<p>2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.</p>Fórmula:C22H23N3O3Pureza:99.82%Forma y color:SoildPeso molecular:377.44Blosozumab
CAS:<p>Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.</p>Pureza:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Forma y color:Liquid1(R),2(S)-epoxy Cannabidiol
CAS:<p>1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.</p>Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.46YW2036
CAS:<p>YW2036 is an inhibitor of Wnt signaling pathway.</p>Fórmula:C20H16N4OPureza:99.94%Forma y color:SoildPeso molecular:328.37IWP-3
CAS:<p>IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].</p>Fórmula:C22H17FN4O2S3Pureza:98%Forma y color:SolidPeso molecular:484.59FH535
CAS:<p>FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.</p>Fórmula:C13H10Cl2N2O4SPureza:98.25% - 99.5%Forma y color:SolidPeso molecular:361.2Cardiogenol C
CAS:<p>Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.</p>Fórmula:C13H16N4O2Pureza:98.46%Forma y color:SolidPeso molecular:260.29Cardiogenol C hydrochloride
CAS:<p>Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).</p>Fórmula:C13H17ClN4O2Pureza:99.89% - 99.94%Forma y color:SolidPeso molecular:296.75IWR-1
CAS:<p>IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).</p>Fórmula:C25H19N3O3Pureza:99.19% - 99.82%Forma y color:SolidPeso molecular:409.44LF3
CAS:<p>LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)</p>Fórmula:C20H24N4O2S2Pureza:99.63%Forma y color:SolidPeso molecular:416.56SKL2001
CAS:<p>SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.</p>Fórmula:C14H14N4O3Pureza:97.46% - 99.5%Forma y color:SolidPeso molecular:286.29Adavivint
CAS:<p>Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.</p>Fórmula:C29H24FN7OPureza:98.27% - 98.6%Forma y color:SolidPeso molecular:505.55Wnt-C59
CAS:<p>Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.</p>Fórmula:C25H21N3OPureza:99.56% - 99.95%Forma y color:SolidPeso molecular:379.45Teplinovivint
CAS:<p>Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy</p>Fórmula:C25H26N6O2Pureza:97.21%Forma y color:SolidPeso molecular:442.51iCRT 14
CAS:<p>iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).</p>Fórmula:C21H17N3O2SPureza:99.8% - 99.97%Forma y color:SolidPeso molecular:375.44BML-284
CAS:<p>BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.</p>Fórmula:C19H18N4O3Pureza:99.91% - 99.921%Forma y color:SolidPeso molecular:350.37KY02111
CAS:<p>KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.</p>Fórmula:C18H17ClN2O3SPureza:97.71% - 98.3%Forma y color:SolidPeso molecular:376.86β-catenin-IN-2
CAS:<p>β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.</p>Fórmula:C15H14FN3Pureza:99.93%Forma y color:SolidPeso molecular:255.29exo-IWR-1
CAS:<p>exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin</p>Fórmula:C25H19N3O3Pureza:97.41%Forma y color:SolidPeso molecular:409.44Wnt pathway activator 1
CAS:<p>Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.</p>Fórmula:C18H16O4Pureza:99.93%Forma y color:SolidPeso molecular:296.32IQ 1
CAS:<p>IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.</p>Fórmula:C21H22N4O2Pureza:98.57% - ≥95%Forma y color:SolidPeso molecular:362.42WAY 316606
CAS:<p>WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.</p>Fórmula:C18H19F3N2O4S2Pureza:99.65%Forma y color:SolidPeso molecular:448.48IWP-O1
CAS:<p>IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.</p>Fórmula:C26H20N6OPureza:99.12%Forma y color:SolidPeso molecular:432.48Tegatrabetan
CAS:<p>Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.</p>Fórmula:C28H36N4O6S2Pureza:98.01% - 99.18%Forma y color:SolidPeso molecular:588.74KYA1797K
CAS:<p>KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.</p>Fórmula:C17H11N2O6S2·KPureza:97.57% - 99.33%Forma y color:SolidPeso molecular:442.51Pyrvinium pamoate
CAS:<p>Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug</p>Fórmula:C26H28N3C23H14O6Pureza:99.76% - >99.99%Forma y color:SolidPeso molecular:575.71ETC-159
CAS:<p>ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.</p>Fórmula:C19H17N7O3Pureza:96.87% - 99.30%Forma y color:SolidPeso molecular:391.38BML-284 hydrochloride
CAS:<p>BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.</p>Fórmula:C19H19ClN4O3Pureza:99.80%Forma y color:SolidPeso molecular:386.84WAY-262611
CAS:<p>WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.</p>Fórmula:C20H22N4Pureza:98.09% - 99.09%Forma y color:SolidPeso molecular:318.42MSAB
CAS:<p>MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.</p>Fórmula:C15H15NO4SPureza:99.76%Forma y color:SolidPeso molecular:305.35IWP-4
CAS:<p>IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.</p>Fórmula:C23H20N4O3S3Pureza:98% - 99.59%Forma y color:SolidPeso molecular:496.62PRI-724
CAS:<p>PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.</p>Fórmula:C33H35N6O7PPureza:98.25% - 99.11%Forma y color:SoildPeso molecular:658.64Wnt pathway activator 2
CAS:<p>Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.</p>Fórmula:C17H15NO4Pureza:99.41%Forma y color:SolidPeso molecular:297.31ZW4864 free base
CAS:<p>ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor.</p>Fórmula:C33H42N6O3Pureza:99.81%Forma y color:SolidPeso molecular:570.72β-catenin/CBP-IN-1
CAS:<p>β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin</p>Fórmula:C33H35N6O7PPureza:98%Forma y color:SolidPeso molecular:658.64GB1874
CAS:<p>GB1874 is an inhibitor of the Wnt pathway targeting β-catenin-TCF4 protein-protein interaction (PPI), affecting proliferation in Wnt-dependent CRC cells.</p>Fórmula:C24H27N3O2SForma y color:SolidPeso molecular:421.56Wnt/β-catenin agonist 4
CAS:<p>Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.</p>Fórmula:C16H15FN4O2Pureza:99.61%Forma y color:SolidPeso molecular:314.31FzM1
CAS:<p>FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)</p>Fórmula:C21H16N2O2SPureza:99.37% - 99.89%Forma y color:SolidPeso molecular:360.43FzM1.8
CAS:<p>FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.</p>Fórmula:C18H14N2O4Pureza:99.89%Forma y color:SolidPeso molecular:322.31Miclxin
CAS:<p>Miclxin (DS37262926) is a novel MIC60 inhibitor that induces apoptosis through mitochondrial stress in mutant tumor cells via β-catenin.Miclxin is a potent</p>Fórmula:C26H27N5O2Pureza:99.17% - 99.99%Forma y color:SolidPeso molecular:441.52JW 67
CAS:<p>JW 67 is an inhibitor of canonical Wnt pathway signaling.</p>Fórmula:C21H18N2O6Pureza:99.02%Forma y color:SolidPeso molecular:394.38CDK8-IN-11
CAS:<p>CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.</p>Fórmula:C19H15F3N4O2Pureza:99.74%Forma y color:SolidPeso molecular:388.34Carboxylesterase-IN-3
CAS:<p>Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.</p>Fórmula:C11H6Cl2N4OSPureza:97.49% - 98.47%Forma y color:SolidPeso molecular:313.16β-Catenin modulator-8
CAS:<p>β-Catenin modulator-8 (Compound Ⅸa) is a specific β-catenin modulator for use in cancer research.</p>Fórmula:C17H20N2O2SPureza:99.97%Forma y color:SolidPeso molecular:316.42NRX-103095
CAS:<p>NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.</p>Fórmula:C22H16Cl2F3N3O3SPureza:99.58% - 99.95%Forma y color:SolidPeso molecular:530.35
