Wnt / beta-catenina
Los inhibidores de Wnt/beta-catenina son compuestos que inhiben la vía de señalización Wnt/beta-catenina, la cual es crucial para la regulación del desarrollo embrionario, la proliferación celular y el mantenimiento de las células madre. La desregulación de esta vía está relacionada con varios tipos de cáncer y enfermedades degenerativas. Los inhibidores de la señalización Wnt/beta-catenina son valiosos en la investigación enfocada en comprender el papel de esta vía en enfermedades y en el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos inhibidores de Wnt/beta-catenina para apoyar su investigación en biología de células madre, biología del desarrollo e investigación oncológica.
Se han encontrado 63 productos para "Wnt / beta-catenina".
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JW74
CAS:JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Fórmula:C24H20N6O2SPureza:95.00%Forma y color:SolidPeso molecular:456.52CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Fórmula:C23H24ClN5OPureza:98.29% - 98.69%Forma y color:White SolidPeso molecular:421.92LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.Fórmula:C11H9ClN2O2S2Pureza:99.84%Forma y color:White SolidPeso molecular:300.78Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Pureza:99% (SDS-PAGE); 97.7% (SEC-HPLC) - 99% (SDS-PAGE); 97.7% (SEC-HPLC)Forma y color:LiquidPeso molecular:142.69 kDaBML-286
CAS:BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.Fórmula:C22H18N2O4Pureza:98.44%Forma y color:SolidPeso molecular:374.39CWP232228
CAS:CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Fórmula:C33H34N7Na2O7PPureza:98.87%Forma y color:SolidPeso molecular:717.63KY1220
CAS:KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.Fórmula:C14H10N4O3SPureza:99.9%Forma y color:Yellow SolidPeso molecular:314.32Ref: TM-T15677
2mg34,00€5mg66,00€1mL*10mM (DMSO)70,00€10mg101,00€25mg200,00€50mg319,00€100mg515,00€200mg702,00€TNIK-IN-5
CAS:TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Fórmula:C22H17N3O3Pureza:99.58%Forma y color:SolidPeso molecular:371.39Foxy-5 acetate
Foxy-5 acetate: Wnt 5A agonist, inhibits cancer cell migration/invasion, boosts calcium signaling, doesn't activate β-catenin.Fórmula:C28H46N6O14S2Pureza:98%Forma y color:SolidPeso molecular:754.83Romosozumab
CAS:Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, which increases bone formation and decreases bone resorption.Pureza:98.9% (SDS-PAGE); 98.2% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.2% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.87 kDaβ-catenin peptide
CAS:β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.Fórmula:C49H76N12O15Pureza:98%Forma y color:SolidPeso molecular:1073.2NLS-StAx-h
Wnt inhibitor; halts cancer cell growth & spread by blocking β-catenin, IC50=1.4μM, cell-permeable.Fórmula:C161H275N55O29Pureza:98%Forma y color:SolidPeso molecular:3445.26ABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Fórmula:C22H21ClN4O5Pureza:99.89%Forma y color:SolidPeso molecular:456.88Ref: TM-T23602
1mg114,00€2mg155,00€5mg222,00€1mL*10mM (DMSO)224,00€10mg334,00€25mg595,00€50mg893,00€100mg1.243,00€200mg1.674,00€Wnt/β-catenin agonist 3
CAS:Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.Fórmula:C16H15ClN4O2Pureza:99.52%Forma y color:SolidPeso molecular:330.77Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Pureza:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.88 kDaβ-catenin modulator IIa-661
CAS:β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Fórmula:C19H23ClN2O3SPureza:99.58%Forma y color:SolidPeso molecular:394.92WIC1
CAS:2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.Fórmula:C22H23N3O3Pureza:99.82%Forma y color:Orange SolidPeso molecular:377.44CCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Fórmula:C23H20BrN3OPureza:99.50%Forma y color:Yellow SolidPeso molecular:434.33Ref: TM-T21685
1mg35,00€5mg67,00€1mL*10mM (DMSO)82,00€10mg100,00€25mg197,00€50mg313,00€100mg447,00€200mg587,00€Foxy-5 Ammonium Salt
Foxy-5 Ammonium Salt, a WNT5A mimetic, blocks epithelial cancer cell migration without β-catenin impact and curbs prostate cancer spread.Fórmula:C26H46N7O12S2Pureza:99.26%Forma y color:White SolidPeso molecular:712.26Ref: TM-TP1565L1
1mg90,00€5mg288,00€1mL*10mM (DMSO)309,00€10mg430,00€25mg705,00€50mg982,00€100mg1.324,00€1(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.46YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Fórmula:C20H16N4OPureza:99.94%Forma y color:SolidPeso molecular:328.37Tabituximab
CAS:BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Pureza:98.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 98.7% (SDS-PAGE); 96.4% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.63 kDaIpafricept
CAS:Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Pureza:99.2% (SDS-PAGE); 97.4% (SEC-HPLC) - 99.2% (SDS-PAGE); 97.4% (SEC-HPLC)Forma y color:Transparent LiquidPeso molecular:41.12 kDaFoxy-5
CAS:Foxy-5 is a wnt5a peptide mimeticFórmula:C26H42N6O12S2Pureza:98%Forma y color:SolidPeso molecular:694.77IWP-3
CAS:IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Fórmula:C22H17FN4O2S3Pureza:98.54%Forma y color:White SolidPeso molecular:484.59WAY-262611
CAS:WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.Fórmula:C20H22N4Pureza:98.09% - 99.09%Forma y color:SolidPeso molecular:318.42Cardiogenol C
CAS:Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.Fórmula:C13H16N4O2Pureza:98.46%Forma y color:SolidPeso molecular:260.29Cardiogenol C hydrochloride
CAS:Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).Fórmula:C13H17ClN4O2Pureza:99.89% - 99.94%Forma y color:SolidPeso molecular:296.75IWR-1
CAS:IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Fórmula:C25H19N3O3Pureza:99.19% - 99.82%Forma y color:SolidPeso molecular:409.44LF3
CAS:LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)Fórmula:C20H24N4O2S2Pureza:99.63%Forma y color:SolidPeso molecular:416.56SKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Fórmula:C14H14N4O3Pureza:97.46% - 99.99%Forma y color:SolidPeso molecular:286.29Ref: TM-T6989
5mg38,00€10mg57,00€1mL*10mM (DMSO)63,00€25mg102,00€50mg175,00€100mg321,00€200mg484,00€500mg755,00€Adavivint
CAS:Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.Fórmula:C29H24FN7OPureza:98.6% - 99.54%Forma y color:SolidPeso molecular:505.55Teplinovivint
CAS:Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathyFórmula:C25H26N6O2Pureza:97.21%Forma y color:SolidPeso molecular:442.51iCRT 14
CAS:iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).Fórmula:C21H17N3O2SPureza:99.85% - 99.97%Forma y color:SolidPeso molecular:375.44BML-284
CAS:BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Fórmula:C19H18N4O3Pureza:99.91% - 99.92%Forma y color:SolidPeso molecular:350.37Ref: TM-T3144
5mg57,00€1mL*10mM (DMSO)63,00€10mg84,00€25mg133,00€50mg240,00€100mg405,00€200mg583,00€500mg888,00€KY02111
CAS:KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.Fórmula:C18H17ClN2O3SPureza:97.71% - 98.3%Forma y color:White SolidPeso molecular:376.86β-catenin-IN-2
CAS:β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Fórmula:C15H14FN3Pureza:99.93%Forma y color:SolidPeso molecular:255.29exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-cateninFórmula:C25H19N3O3Pureza:97.41%Forma y color:SolidPeso molecular:409.44Wnt pathway activator 1
CAS:Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.Fórmula:C18H16O4Pureza:99.93%Forma y color:SolidPeso molecular:296.32Ref: TM-T17256
2mg33,00€5mg49,00€1mL*10mM (DMSO)50,00€10mg75,00€25mg124,00€50mg200,00€100mg299,00€200mg430,00€WAY 316606
CAS:WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.Fórmula:C18H19F3N2O4S2Pureza:99.65%Forma y color:SolidPeso molecular:448.48Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Fórmula:C28H36N4O6S2Pureza:98.47% - 99.95%Forma y color:SolidPeso molecular:588.74Ref: TM-T5642
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)92,00€10mg117,00€25mg198,00€50mg316,00€100mg535,00€Fz7-21
CAS:Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.Fórmula:C83H114N18O23S2Pureza:99.8%Forma y color:White SolidPeso molecular:1796.03KYA1797K
CAS:KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.Fórmula:C17H11N2O6S2·KPureza:97.57% - 99.33%Forma y color:SolidPeso molecular:442.51Ref: TM-T6868
2mg39,00€5mg56,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg178,00€50mg301,00€100mg485,00€200mg690,00€Pyrvinium pamoate
CAS:Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drugFórmula:C26H28N3C23H14O6Pureza:99.76% - >99.99%Forma y color:Red SolidPeso molecular:575.71BML-284 hydrochloride
CAS:BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.Fórmula:C19H19ClN4O3Pureza:99.80%Forma y color:SolidPeso molecular:386.84Ref: TM-T8820
1mg34,00€5mg64,00€10mg84,00€1mL*10mM (DMSO)94,00€25mg142,00€50mg253,00€100mg439,00€200mg615,00€500mg964,00€IQ 1
CAS:IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.Fórmula:C21H22N4O2Pureza:98.57% - ≥95%Forma y color:Orange SolidPeso molecular:362.42Ref: TM-T3635
5mg49,00€1mL*10mM (DMSO)54,00€10mg73,00€25mg133,00€50mg185,00€100mg333,00€200mg474,00€500mg767,00€MSAB
CAS:MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.Fórmula:C15H15NO4SPureza:99.76%Forma y color:SolidPeso molecular:305.35Ref: TM-T8710
1mg34,00€2mg47,00€5mg70,00€1mL*10mM (DMSO)78,00€10mg113,00€25mg222,00€50mg334,00€100mg507,00€500mg1.063,00€IWP-4
CAS:IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.Fórmula:C23H20N4O3S3Pureza:98% - 99.59%Forma y color:Yellow SolidPeso molecular:496.62PRI-724
CAS:PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.Fórmula:C33H35N6O7PPureza:98.25% - 98.38%Forma y color:White SolidPeso molecular:658.64Setrusumab
CAS:Setrusumab (BPS 804) is a fully humanized monoclonal antibody targeting sclerostin, effectively enhancing bone strength.Pureza:95% - >95% (SDS-PAGE); 97.8% (SEC-HPLC)Forma y color:Liquid
