Wnt / beta-catenina
Los inhibidores de Wnt/beta-catenina son compuestos que inhiben la vía de señalización Wnt/beta-catenina, la cual es crucial para la regulación del desarrollo embrionario, la proliferación celular y el mantenimiento de las células madre. La desregulación de esta vía está relacionada con varios tipos de cáncer y enfermedades degenerativas. Los inhibidores de la señalización Wnt/beta-catenina son valiosos en la investigación enfocada en comprender el papel de esta vía en enfermedades y en el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos inhibidores de Wnt/beta-catenina para apoyar su investigación en biología de células madre, biología del desarrollo e investigación oncológica.
Se han encontrado 79 productos para "Wnt / beta-catenina".
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WIC1
CAS:2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.Fórmula:C22H23N3O3Pureza:99.82%Forma y color:Orange SolidPeso molecular:377.4363QPH-FR
QPH-FR is a quinoa peptide and acts as an inhibitor of the G protein-coupled receptor 5 (LGR5) that is abundant in leucine repeat sequences. By binding to LGR5, QPH-FR competitively inhibits the formation of the LGR5/RSPO1 complex. This interaction leads to the ubiquitination of FZD receptors by RNF43/ZNRF3, thereby inhibiting the Wnt/β-catenin signaling pathway and exerting stem cell suppression.Fórmula:C81H124N26O25Peso molecular:1862.01β-catenin peptide
CAS:β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.Fórmula:C49H76N12O15Pureza:98%Forma y color:SolidPeso molecular:1073.2YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Fórmula:C20H16N4OPureza:99.94%Forma y color:SolidPeso molecular:328.3672ABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Fórmula:C22H21ClN4O5Pureza:99.89%Forma y color:SolidPeso molecular:456.879Ref: TM-T23602
1mg114,00€2mg155,00€5mg222,00€1mL*10mM (DMSO)224,00€10mg334,00€25mg595,00€50mg893,00€100mg1.243,00€200mg1.674,00€Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Pureza:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.88 kDa (Predicted)IWP-3
CAS:IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Fórmula:C22H17FN4O2S3Pureza:98.54%Forma y color:White SolidPeso molecular:484.589Anti-Human DKK1 Antibody (3N570)
Anti-DKK1 Antibody (3N570) is a Rabbit IgG monoclonal antibody targeting Human DKK1.Anti-Human FZD7 Antibody
Anti-FZD7 Antibody serves as a functional therapeutic tool specifically designed to enable the precise detection and neutralization of the Frizzled-7 transmembrane receptor which plays a pivotal role in the maintenance of cancer stemness and promotes the epithelial-to-mesenchymal transition of diverse solid tumors during strictly monitored laboratory observation periods and molecular investigations to evaluate the pharmacological efficacy of targeted GPCR modulation.β-catenin-IN-2
CAS:β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Fórmula:C15H14FN3Pureza:99.93%Forma y color:SolidPeso molecular:255.2902Cardiogenol C
CAS:Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.Fórmula:C13H16N4O2Pureza:98.46%Forma y color:SolidPeso molecular:260.2917Cardiogenol C hydrochloride
CAS:Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).Fórmula:C13H17ClN4O2Pureza:99.89% - 99.94%Forma y color:SolidPeso molecular:296.75IWR-1
CAS:IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Fórmula:C25H19N3O3Pureza:99.19% - 99.82%Forma y color:SolidPeso molecular:409.4367LF3
CAS:LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)Fórmula:C20H24N4O2S2Pureza:99.63%Forma y color:SolidPeso molecular:416.56SKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Fórmula:C14H14N4O3Pureza:97.46% - 99.99%Forma y color:SolidPeso molecular:286.286Ref: TM-T6989
5mg38,00€1mL*10mM (DMSO)44,00€10mg57,00€25mg102,00€50mg175,00€100mg321,00€200mg484,00€500mg755,00€Adavivint
CAS:Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.Fórmula:C29H24FN7OPureza:98.6% - 99.54%Forma y color:SolidPeso molecular:505.5456Teplinovivint
CAS:Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathyFórmula:C25H26N6O2Pureza:97.21%Forma y color:SolidPeso molecular:442.5129iCRT 14
CAS:iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).Fórmula:C21H17N3O2SPureza:99.85% - 99.97%Forma y color:SolidPeso molecular:375.444BML-284
CAS:BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Fórmula:C19H18N4O3Pureza:99.91% - 99.92%Forma y color:SolidPeso molecular:350.3712Ref: TM-T3144
5mg57,00€1mL*10mM (DMSO)63,00€10mg84,00€25mg133,00€50mg240,00€100mg405,00€200mg583,00€500mg888,00€KY02111
CAS:KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.Fórmula:C18H17ClN2O3SPureza:97.71% - 98.3%Forma y color:White SolidPeso molecular:376.86
