Wnt / beta-catenina
Los inhibidores de Wnt/beta-catenina son compuestos que inhiben la vía de señalización Wnt/beta-catenina, la cual es crucial para la regulación del desarrollo embrionario, la proliferación celular y el mantenimiento de las células madre. La desregulación de esta vía está relacionada con varios tipos de cáncer y enfermedades degenerativas. Los inhibidores de la señalización Wnt/beta-catenina son valiosos en la investigación enfocada en comprender el papel de esta vía en enfermedades y en el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos inhibidores de Wnt/beta-catenina para apoyar su investigación en biología de células madre, biología del desarrollo e investigación oncológica.
Se han encontrado 79 productos para "Wnt / beta-catenina".
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5T4_0108
5T4_0108 (MEDI0641 antibody) is a human monoclonal antibody (mAb) that targets TPBG. It is applicable for research in breast and prostate cancers.Wnt pathway activator 2
CAS:Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Fórmula:C17H15NO4Pureza:99.41%Forma y color:White SolidPeso molecular:297.3053Anti-Human LGR5/GPR49 Antibody (18G7H6A3)
Anti-LGR5/GPR49 Antibody (18G7H6A3) is a human-derived monoclonal antibody (mAb) that targets LGR5/GPR49. The recommended isotype control for this antibody is Human IgG1 kappa.PF-04840082
PF-04840082 is a humanized IgG2 monoclonal antibody inhibitor targeting Dkk-1. It binds to the physiological antagonist (Dkk-1) of the Wnt/LRP5 signaling pathway, which enhances bone mass and density by activating osteoblasts. PF-04840082 is applicable for osteoporosis research.TNKS-IN-1
CAS:TNKS-IN-1 is a tankyrase inhibitor used in Wnt/β-catenin signaling and colorectal cancer research models.Fórmula:C18H18N2OPureza:99.98%Forma y color:SolidPeso molecular:278.3483GB1874
CAS:GB1874 is an inhibitor of the Wnt pathway targeting β-catenin-TCF4 protein-protein interaction (PPI), affecting proliferation in Wnt-dependent CRC cells.Fórmula:C24H27N3O2SForma y color:Yellow SolidPeso molecular:421.555FJ9
CAS:FJ9 is an FZD7 inhibitor that disrupts the protein interaction between Frz7 and the DVL PDZ domain and induces apoptosis in melanoma and non-small cell lung cancer cell lines.Fórmula:C23H27NO3Pureza:99.41% - 99.60%Forma y color:White SolidPeso molecular:365.47FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Fórmula:C21H16N2O2SPureza:99.37% - 99.89%Forma y color:Yellow SolidPeso molecular:360.429Ref: TM-T24076
1mg39,00€1mL*10mM (DMSO)58,00€5mg60,00€10mg94,00€25mg178,00€50mg310,00€100mg500,00€500mg1.071,00€Wnt/β-catenin agonist 4
CAS:Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.Fórmula:C16H15FN4O2Pureza:99.96%Forma y color:SolidPeso molecular:314.3143Ref: TM-T60803
1mg34,00€5mg66,00€1mL*10mM (DMSO)77,00€10mg98,00€25mg172,00€50mg295,00€100mg485,00€200mg682,00€FzM1.8
CAS:FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.Fórmula:C18H14N2O4Pureza:99.89%Forma y color:SolidPeso molecular:322.3148Ref: TM-T15363
2mg38,00€5mg55,00€1mL*10mM (DMSO)60,00€10mg87,00€25mg165,00€50mg264,00€100mg411,00€200mg593,00€Pterostilbene-isothiocyanate
CAS:Pterostilbene-isothiocyanate is a Wnt/β-catenin inhibitor; disrupts β-catenin/TCF-4 binding; inhibits osteosarcoma cell proliferation.Fórmula:C18H19N3O3SPureza:99.81%Forma y color:Yellow SolidPeso molecular:357.43NRX-2663
CAS:NRX-2663 is an enhancer of β-catenin/SCFβ-TrCP interaction (Kd = 54.8 nM, EC50 = 22.9 nM), promoting β-catenin ubiquitination and degradation.Fórmula:C20H13F3N2O5Forma y color:SolidPeso molecular:418.3228JW 67
CAS:JW 67 is an inhibitor of canonical Wnt pathway signaling.Fórmula:C21H18N2O6Pureza:99.02%Forma y color:SolidPeso molecular:394.381(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.46BMD4503-1
CAS:BMD4503-1 is a quinoxaline derivative that can inhibit the interaction between LRP5/6 and sclerostin, thereby modulating the Wnt signaling pathway.Fórmula:C22H19N5O3SPeso molecular:433.483β-Catenin modulator-8
CAS:β-Catenin modulator-8 (Compound Ⅸa) is a specific β-catenin modulator for use in cancer research.Fórmula:C17H20N2O2SPureza:99.97%Forma y color:SolidPeso molecular:316.42E722-2648
CAS:E722-2648 is a potent inhibitor of the β-catenin/BCL9 complex, specifically preventing its formation and inhibiting Wnt activity. It disrupts cholesterol homeostasis through increased cholesterol esterification and accumulation of lipid droplets. Additionally, E722-2648 exhibits antitumor activity [1].Fórmula:C21H30N2OS2Peso molecular:390.61Basroparib
CAS:Basroparib is a TNKS1/2 inhibitor that stabilizes AXIN, blocks Wnt/β-catenin signaling, and shows antitumor activity in colorectal cancer xenografts.Fórmula:C18H21F2N7O3Pureza:98.24%Forma y color:SolidPeso molecular:421.40NRX-103095
CAS:NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Fórmula:C22H16Cl2F3N3O3SPureza:99.85% - 99.95%Forma y color:SolidPeso molecular:530.347Ref: TM-T63730
1mg142,00€5mg344,00€1mL*10mM (DMSO)404,00€10mg557,00€25mg1.108,00€50mg1.783,00€100mg2.673,00€
