Células madre
Los inhibidores de células madre son compuestos que actúan específicamente sobre las células madre y sus vías de señalización, afectando su capacidad para autorrenovarse y diferenciarse. Estos inhibidores son cruciales en la investigación centrada en controlar el comportamiento de las células madre, comprender los procesos de desarrollo y desarrollar terapias para enfermedades como el cáncer, donde se cree que las células madre juegan un papel clave. En CymitQuimica, ofrecemos una variedad de inhibidores de células madre para apoyar su investigación en medicina regenerativa, biología del desarrollo y oncología.
Se han encontrado 228 productos de "Células madre"
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TBCA
CAS:TBCA: selective CK2 inhibitor, IC50=110 nM, Ki=77 nM, favors CK2 over CK1, DYRK1A, and 27 other kinases.Fórmula:C9H4Br4O2Pureza:99.3%Forma y color:SolidPeso molecular:463.74WIC1
CAS:2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.
Fórmula:C22H23N3O3Pureza:99.82%Forma y color:SoildPeso molecular:377.44P17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Fórmula:C95H139N27O21Forma y color:SolidPeso molecular:1995.29MR24
CAS:MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.Fórmula:C26H29ClN6O3Peso molecular:509.00SLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:SLLK is a control peptide for LSKL.
Fórmula:C21H41N5O6Pureza:98%Forma y color:SolidPeso molecular:459.58Emugrobart
Emugrobart is a humanized IgG1κ antibody targeted at GDF8, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.Forma y color:Odour LiquidYAP-IN-1
YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.Forma y color:Odour SolidDC-TEADin02
CAS:DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.
Fórmula:C19H17NO2SPureza:99.83%Forma y color:SoildPeso molecular:323.41HC-258
CAS:HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.Fórmula:C20H24N2O2Forma y color:SolidPeso molecular:324.42ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Fórmula:C20H23N7O2SForma y color:SolidPeso molecular:425.51JAK2-IN-6
CAS:JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Fórmula:C14H10ClN3OS2Pureza:99.64%Forma y color:SolidPeso molecular:335.83Prafnosbart
CAS:Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized inForma y color:LiquidLX-7101 hydrochloride
CAS:LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1/2, ROCK, PKA, and can be used to study glaucoma.
Fórmula:C23H29N7O3xHClPureza:98.96%Forma y color:SolidPeso molecular:487.99TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Fórmula:C27H32N6O2Forma y color:SolidPeso molecular:472.582YAP-TEAD-IN-3
CAS:YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferationFórmula:C27H26ClF2N3O4Pureza:97.55% - 98.71%Forma y color:SoildPeso molecular:529.96Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Fórmula:C70H113N17O24S2Pureza:95.11%Forma y color:SoildPeso molecular:1640.88LP-922056
CAS:LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.
Fórmula:C11H9ClN2O2S2Pureza:99.84%Forma y color:SolidPeso molecular:300.78TEAD-IN-19
TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, showing inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% for TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at 10 μM. It exhibits strong antiproliferative and antimigratory effects on prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds potential for research in the field of cancer therapeutics.Forma y color:Odour SolidWAY-297174
CAS:WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
Fórmula:C11H12N2O2S2Pureza:99.53%Forma y color:SoildPeso molecular:268.36Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.
Fórmula:C17H20N8O2SPureza:99.94%Forma y color:SoildPeso molecular:400.461(R),2(S)-epoxy Cannabidiol
CAS:1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.Fórmula:C21H30O3Forma y color:SolidPeso molecular:330.46Rilogrotug
CAS:Rilogrotug is a humanized IgG1κ monoclonal antibody targeting GDF15, with its corresponding isotype control being HumanIgG1kappa, Isotype Control.Forma y color:SoildNIBR-LTSi
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.Fórmula:C18H20N4OPureza:99.87%Forma y color:SolidPeso molecular:308.38CCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Fórmula:C23H20BrN3OPureza:99.50%Forma y color:SolidPeso molecular:434.33Ref: TM-T21685
1mg38,00€5mg71,00€10mg105,00€25mg207,00€50mg329,00€100mg472,00€200mg620,00€1mL*10mM (DMSO)87,00€Super-TDU (1-31) (TFA)
Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.Fórmula:C141H218N40O48·C2HF3O2Forma y color:SolidPeso molecular:3355.5BAY-593
CAS:BAY-593 is an orally active GGTase-I inhibitor capable of blocking YAP1/TAZ signaling in vivo, exhibiting antitumor activity.Fórmula:C26H31F3N2O3Forma y color:SolidPeso molecular:476.53YAP/TAZ inhibitor-1
CAS:YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.Fórmula:C33H39N3O5S2Pureza:99.72%Forma y color:SolidPeso molecular:621.81Anti-GPC3 Antibody (4L576)
Anti-GPC3 Antibody (4L576) is an antibody targeting GPC3. Anti-GPC3 Antibody (4L576) can be used in ELISA, WB, IF.Forma y color:Odour LiquidAnti-SOST Antibody (3R170)
Anti-SOST Antibody (3R170) is an antibody targeting SOST. Anti-SOST Antibody (3R170) can be used in ELISA, IHC.Forma y color:Odour LiquidIBS008738
CAS:IBS008738 is a TAZ activator that stabilises TAZ and increases unphosphorylated TAZ levels in C2C12 cells, upregulates MyoD-dependent gene transcription.Fórmula:C22H22N4O2Pureza:99.44%Forma y color:SolidPeso molecular:374.44Anti-NANOG Antibody (1M448)
Anti-NANOG Antibody (1M448) is a Mouse antibody targeting NANOG. Anti-NANOG Antibody (1M448) can be used in ELISA, WB, ICC, IF, FCM.Pureza:>95%Forma y color:Odour LiquidAnti-5T4/TPBG Antibody (9P872)
Anti-5T4/TPBG Antibody (9P872) is an antibody targeting 5T4/TPBG. Anti-5T4/TPBG Antibody (9P872) can be used in ELISA, FCM.Forma y color:Odour LiquidCotosudil
CAS:Cotosudil is a ROCK kinase inhibitor with antihypertensive activity used to treat or prevent neurodegenerative diseases.Fórmula:C16H21N3O2SPureza:98.41%Forma y color:SolidPeso molecular:319.42Thiazovivin
CAS:Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.Fórmula:C15H13N5OSPureza:98.00%Forma y color:SolidPeso molecular:311.36Ref: TM-T2155
1mg35,00€2mg48,00€5mg67,00€10mg103,00€25mg190,00€50mg321,00€100mg469,00€1mL*10mM (DMSO)73,00€GSK429286A
CAS:GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).Fórmula:C21H16F4N4O2Pureza:97.68% - 98.49%Forma y color:SolidPeso molecular:432.37AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Forma y color:SolidPeso molecular:334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C22H19N5OPureza:97.09% - 99.98%Forma y color:SolidPeso molecular:369.42Ref: TM-T2510
1g657,00€5mg46,00€10mg52,00€25mg84,00€50mg114,00€100mg178,00€200mg269,00€500mg442,00€1mL*10mM (DMSO)52,00€SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Forma y color:SolidPeso molecular:371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Fórmula:C28H36N4O6S2Pureza:98.01% - 99.18%Forma y color:SolidPeso molecular:588.74Ref: TM-T5642
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg210,00€50mg334,00€100mg565,00€1mL*10mM (DMSO)96,00€IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Fórmula:C26H20N6OPureza:99.12%Forma y color:SolidPeso molecular:432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Forma y color:SolidPeso molecular:528.3Fosciclopirox
CAS:Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entireFórmula:C13H20NO6PPureza:99.83%Forma y color:SolidPeso molecular:317.27Ref: TM-T9422
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€XMU-MP-1
CAS:XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!Fórmula:C17H16N6O3S2Pureza:99.68% - 99.86%Forma y color:SolidPeso molecular:416.48Ref: TM-T4212
1mg52,00€2mg79,00€5mg97,00€10mg153,00€25mg305,00€50mg512,00€100mg663,00€1mL*10mM (DMSO)95,00€BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Fórmula:C17H13N5Pureza:99.87%Forma y color:SolidPeso molecular:287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Fórmula:C27H29NO3Pureza:99.89% - >99.99%Forma y color:SolidPeso molecular:415.52MYF-01-37
CAS:MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Fórmula:C15H17F3N2OPureza:99.46% - 99.5%Forma y color:SolidPeso molecular:298.3Ref: TM-T22372
2mg38,00€5mg57,00€10mg90,00€25mg166,00€50mg281,00€100mg421,00€500mg888,00€1mL*10mM (DMSO)63,00€Porcn-IN-1
CAS:Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Fórmula:C25H19FN4OPureza:99.15%Forma y color:SolidPeso molecular:410.44Adavivint
CAS:Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
Fórmula:C29H24FN7OPureza:98.27% - 98.6%Forma y color:SolidPeso molecular:505.55LY3200882
CAS:LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Fórmula:C24H29N5O3Pureza:99.46% - 99.63%Forma y color:SolidPeso molecular:435.52PF-670462
CAS:PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.Fórmula:C19H22Cl2FN5Pureza:99.42% - 99.72%Forma y color:SolidPeso molecular:410.32
