Células madre
Los inhibidores de células madre son compuestos que actúan específicamente sobre las células madre y sus vías de señalización, afectando su capacidad para autorrenovarse y diferenciarse. Estos inhibidores son cruciales en la investigación centrada en controlar el comportamiento de las células madre, comprender los procesos de desarrollo y desarrollar terapias para enfermedades como el cáncer, donde se cree que las células madre juegan un papel clave. En CymitQuimica, ofrecemos una variedad de inhibidores de células madre para apoyar su investigación en medicina regenerativa, biología del desarrollo y oncología.
Se han encontrado 234 productos de "Células madre"
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BMP signaling agonist sb4
CAS:BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)Fórmula:C14H10BrNOSPureza:99.48% - 99.805%Forma y color:SolidPeso molecular:320.2Ref: TM-T7799
5mg44,00€10mg57,00€25mg94,00€50mg119,00€100mg177,00€200mg268,00€500mg465,00€1mL*10mM (DMSO)48,00€BMS986260
CAS:BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor(IC50 = 1.6 nM).Fórmula:C18H12ClFN6OPureza:97.67%Forma y color:SolidPeso molecular:382.78ZINC00881524
CAS:ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
Fórmula:C21H20N2O3SPureza:99.48%Forma y color:SolidPeso molecular:380.46Adavivint
CAS:Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
Fórmula:C29H24FN7OPureza:98.27% - 98.6%Forma y color:SolidPeso molecular:505.55Porcn-IN-1
CAS:Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Fórmula:C25H19FN4OPureza:99.15%Forma y color:SolidPeso molecular:410.44BIO-013077-01
CAS:BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Fórmula:C17H13N5Pureza:99.87%Forma y color:SolidPeso molecular:287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Fórmula:C26H20N6OPureza:99.12%Forma y color:SolidPeso molecular:432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Fórmula:C28H36N4O6S2Pureza:98.01% - 99.18%Forma y color:SolidPeso molecular:588.74Ref: TM-T5642
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg210,00€50mg334,00€100mg565,00€1mL*10mM (DMSO)96,00€SRI-011381 hydrochloride
CAS:SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H32ClN3OPureza:99.32% - 99.41%Forma y color:SolidPeso molecular:365.94Ref: TM-T5129
1mg34,00€2mg44,00€5mg66,00€10mg105,00€25mg215,00€50mg334,00€100mg497,00€200mg755,00€1mL*10mM (DMSO)73,00€AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Forma y color:SolidPeso molecular:334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€IQ 1
CAS:IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.
Fórmula:C21H22N4O2Pureza:98.57% - ≥95%Forma y color:SolidPeso molecular:362.42ITD-1
CAS:ITD-1 is a potent and highly selective TGFβ pathway inhibitor.Fórmula:C27H29NO3Pureza:99.89% - >99.99%Forma y color:SolidPeso molecular:415.52β-catenin-IN-2
CAS:β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Fórmula:C15H14FN3Pureza:99.93%Forma y color:SolidPeso molecular:255.29Ref: TM-T9696
1mg96,00€5mg227,00€10mg359,00€25mg607,00€50mg868,00€100mg1.169,00€500mg2.365,00€1mL*10mM (DMSO)264,00€Afuresertib hydrochloride
CAS:Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
Fórmula:C18H18Cl3FN4OSPureza:99.96%Forma y color:SolidPeso molecular:463.8Galunisertib
CAS:Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.Fórmula:C22H19N5OPureza:97.09% - 99.98%Forma y color:SolidPeso molecular:369.42Ref: TM-T2510
1g657,00€5mg46,00€10mg52,00€25mg84,00€50mg114,00€100mg178,00€200mg269,00€500mg442,00€1mL*10mM (DMSO)52,00€I3MT-3
CAS:I3MT-3 (HMPSNE) is a selective inhibitor of 3MST, targeting active site cysteine residues and permeating cell membranes.Fórmula:C17H14N2O2SPureza:99.76%Forma y color:SolidPeso molecular:310.37exo-IWR-1
CAS:exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin
Fórmula:C25H19N3O3Pureza:97.41%Forma y color:SolidPeso molecular:409.44YO-01027
CAS:YO-01027 (DBZ) is a potent γ-secretase inhibitor.
Fórmula:C26H23F2N3O3Pureza:97.21% - 99.58%Forma y color:SolidPeso molecular:463.48Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Forma y color:SolidPeso molecular:452.51Ref: TM-T6867
2mg48,00€5mg73,00€10mg90,00€25mg166,00€50mg250,00€100mg376,00€500mg895,00€1mL*10mM (DMSO)79,00€GSK269962A
CAS:GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Fórmula:C29H30N8O5Pureza:99.14% - 99.71%Forma y color:SolidPeso molecular:570.6IHR-1
CAS:IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.Fórmula:C20H12Cl4N2O2Pureza:97.02%Forma y color:SolidPeso molecular:454.13Ref: TM-T24159
2mg33,00€5mg50,00€10mg80,00€25mg131,00€50mg193,00€100mg290,00€200mg416,00€1mL*10mM (DMSO)55,00€MRT-14
CAS:MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.Fórmula:C24H24N4O5Pureza:99.54%Forma y color:SolidPeso molecular:448.47Lats-IN-1
CAS:Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Fórmula:C18H14N4OSPureza:97.54% - 99.79%Forma y color:SolidPeso molecular:334.39Ref: TM-T9053
1mg52,00€2mg73,00€5mg105,00€10mg167,00€25mg309,00€50mg416,00€100mg592,00€200mg842,00€1mL*10mM (DMSO)118,00€LY3200882
CAS:LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).Fórmula:C24H29N5O3Pureza:99.46% - 99.63%Forma y color:SolidPeso molecular:435.52XMU-MP-1
CAS:XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!Fórmula:C17H16N6O3S2Pureza:99.68% - 99.86%Forma y color:SolidPeso molecular:416.48Ref: TM-T4212
1mg52,00€2mg79,00€5mg97,00€10mg153,00€25mg305,00€50mg512,00€100mg663,00€1mL*10mM (DMSO)95,00€Fosciclopirox
CAS:Fosciclopirox (CPX-POM), the phosphoryloxymethyl ester of CPX (Ciclopirox Prodrug, CPX-POM), selectively delivers the active metabolite, CPX, to the entireFórmula:C13H20NO6PPureza:99.83%Forma y color:SolidPeso molecular:317.27Ref: TM-T9422
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€AR-A014418
CAS:AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.Fórmula:C12H12N4O4SPureza:>99.99% - ≥95%Forma y color:SolidPeso molecular:308.31SRI-011381
CAS:SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H31N3OPureza:98.64%Forma y color:SolidPeso molecular:329.48SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Forma y color:SolidPeso molecular:371.22Ref: TM-T3077
2mg39,00€5mg52,00€10mg79,00€25mg131,00€50mg197,00€100mg334,00€500mg803,00€1mL*10mM (DMSO)52,00€PF-5274857
CAS:PF-5274857: selective hedgehog pathway inhibitor (IC50: 5.8 nM, Ki: 4.6 nM), treats brain tumors, crosses blood-brain barrier, orally stable.Fórmula:C20H25ClN4O3SPureza:98.53%Forma y color:SolidPeso molecular:436.96MYF-01-37
CAS:MYF-01-37 (1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one) is a novel covalent TEAD inhibitor.Fórmula:C15H17F3N2OPureza:99.46% - 99.5%Forma y color:SolidPeso molecular:298.3Ref: TM-T22372
2mg38,00€5mg57,00€10mg90,00€25mg166,00€50mg281,00€100mg421,00€500mg888,00€1mL*10mM (DMSO)63,00€SD-208
CAS:SD-208 (ALK5 Inhibitor V), a selective TGF-βRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-βRII.Fórmula:C17H10ClFN6Pureza:98.72% - 99.65%Forma y color:SolidPeso molecular:352.75VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Forma y color:SolidPeso molecular:528.3LGK974
CAS:LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Fórmula:C23H20N6OPureza:98.8% - >99.99%Forma y color:SolidPeso molecular:396.44Ref: TM-T2618
1mg46,00€2mg62,00€5mg90,00€10mg156,00€25mg288,00€50mg515,00€100mg737,00€1mL*10mM (DMSO)90,00€SJ000291942
CAS:SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway.Fórmula:C16H15FN2O4Pureza:99.66%Forma y color:SolidPeso molecular:318.3Ref: TM-T4662
1mg34,00€2mg44,00€5mg63,00€10mg100,00€25mg205,00€50mg349,00€100mg557,00€200mg790,00€1mL*10mM (DMSO)71,00€Indirubin-3′-oxime
CAS:Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Fórmula:C16H11N3O2Pureza:98.34%Forma y color:SolidPeso molecular:277.28RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFórmula:C17H16N4O2SPureza:99.53% - ≥95%Forma y color:SolidPeso molecular:340.4Ref: TM-T2011
1mg70,00€5mg142,00€10mg207,00€25mg369,00€50mg540,00€100mg772,00€500µg49,00€1mL*10mM (DMSO)160,00€LSKL, Inhibitor of Thrombospondin TSP-1 2TFA
LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .Fórmula:C25H44F6N6O9Pureza:99.75%Forma y color:SolidPeso molecular:686.64Ref: TM-T7676
2mg42,00€5mg54,00€10mg84,00€25mg138,00€50mg207,00€100mg316,00€200mg442,00€1mL*10mM (DMSO)93,00€Kartogenin
CAS:Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Fórmula:C20H15NO3Pureza:96.25% - 97.79%Forma y color:SolidPeso molecular:317.34TBB
CAS:TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
Fórmula:C6HBr4N3Pureza:98.51% - 99.45%Forma y color:Off-White SolidPeso molecular:434.71BML-284
CAS:BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Fórmula:C19H18N4O3Pureza:99.91% - 99.921%Forma y color:SolidPeso molecular:350.37Ref: TM-T3144
5mg60,00€10mg88,00€25mg140,00€50mg253,00€100mg427,00€200mg615,00€500mg938,00€1mL*10mM (DMSO)66,00€IWP L6
CAS:IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
Fórmula:C25H20N4O2S2Pureza:99.51% - >99.99%Forma y color:SolidPeso molecular:472.58PF-4800567
CAS:PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.Fórmula:C17H18ClN5O2Pureza:99.74% - 99.76%Forma y color:SolidPeso molecular:359.81PRI-724
CAS:PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.
Fórmula:C33H35N6O7PPureza:98.25% - 99.11%Forma y color:SoildPeso molecular:658.64EasyStep Human Cys-C(CystatinC) ELISA Kit
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Cys-C, and the Human Cys-C standard plate wells that pre-coated using protein-related techniques are provided separately. Standard/Sample Diluent Buffer or samples are added to the appropriate microtiter plate wells ,then added a HRP-conjugated antibody specific to Human Cys-C. After TMB substrate solution is added, only those wells that contain Human Cys-C and HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human Cys-C in the samples is then determined by comparing the OD of the samples to the standard curve.Forma y color:Colourless TransparentliquidVT107
CAS:VT107 is a potent pan-TEAD autopalmitoylation inhibitor. VT-107 can be used in cancer therapy research.Cost-effective and quality-assured.Fórmula:C25H20F3N3OPureza:99.72% - 99.92%Forma y color:SolidPeso molecular:435.44Ref: TM-T35545
1mg130,00€5mg314,00€10mg477,00€25mg768,00€50mg1.045,00€100mg1.406,00€200mg1.882,00€1mL*10mM (DMSO)343,00€RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Fórmula:C25H28F3N7Pureza:99.50%Forma y color:SolidPeso molecular:483.532CHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Fórmula:C20H17Cl2N9O2Pureza:99.45%Forma y color:SolidPeso molecular:486.31Ref: TM-T3074
1mg44,00€2mg55,00€5mg96,00€10mg153,00€25mg298,00€50mg487,00€100mg705,00€1mL*10mM (DMSO)97,00€YAP/TAZ inhibitor-2
CAS:Potent oral TEAD-YAP/TAZ inhibitor-2 with 3 nM EC50; exhibits anti-proliferative and antitumor effects.Fórmula:C19H14F4N4OPureza:98.65%Forma y color:SoildPeso molecular:390.33Ref: TM-T60218
1mg87,00€2mg113,00€5mg177,00€10mg281,00€25mg475,00€50mg687,00€100mg964,00€500mg1.918,00€1mL*10mM (DMSO)197,00€Ginisortamab
CAS:Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, IC50=8.2 nM and 9 nM against human and mouse Gremlin-1, respectively.Pureza:95% - 96.0% (SDS-PAGE); 97.0% (SEC-HPLC)Forma y color:LiquidPeso molecular:147.55 kDa
