Células madre
Los inhibidores de células madre son compuestos que actúan específicamente sobre las células madre y sus vías de señalización, afectando su capacidad para autorrenovarse y diferenciarse. Estos inhibidores son cruciales en la investigación centrada en controlar el comportamiento de las células madre, comprender los procesos de desarrollo y desarrollar terapias para enfermedades como el cáncer, donde se cree que las células madre juegan un papel clave. En CymitQuimica, ofrecemos una variedad de inhibidores de células madre para apoyar su investigación en medicina regenerativa, biología del desarrollo y oncología.
Se han encontrado 486 productos de "Células madre"
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PF-670462
CAS:<p>PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.</p>Fórmula:C19H22Cl2FN5Pureza:99.42% - 99.72%Forma y color:SolidPeso molecular:410.32AZD1080
CAS:<p>AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.</p>Fórmula:C19H18N4O2Pureza:97.72% - 99.75%Forma y color:SolidPeso molecular:334.372,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:<p>2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.</p>Fórmula:C16H13Cl2N3O2Pureza:98.77%Forma y color:SolidPeso molecular:350.2GSK429286A
CAS:<p>GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).</p>Fórmula:C21H16F4N4O2Pureza:97.68% - 98.49%Forma y color:SolidPeso molecular:432.37SH-4-54
CAS:<p>SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.</p>Fórmula:C29H27F5N2O5SPureza:98% - 99.12%Forma y color:SolidPeso molecular:610.59ROCK-IN-2
CAS:<p>ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.</p>Fórmula:C18H13ClF2N6OPureza:97.29%Forma y color:SolidPeso molecular:402.79GS87
CAS:<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Fórmula:C16H11N5O2SPureza:98.86%Forma y color:SolidPeso molecular:337.36Tegatrabetan
CAS:<p>Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.</p>Fórmula:C28H36N4O6S2Pureza:98.01% - 99.18%Forma y color:SolidPeso molecular:588.74IWP-O1
CAS:<p>IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.</p>Fórmula:C26H20N6OPureza:99.12%Forma y color:SolidPeso molecular:432.48Hydroxyfasudil Hydrochloride
CAS:<p>Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).</p>Fórmula:C14H18ClN3O3SPureza:98.05%Forma y color:SolidPeso molecular:343.83VP3.15 dihydrobromide
CAS:<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Forma y color:SolidPeso molecular:528.3FM-381
CAS:<p>FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.</p>Fórmula:C24H24N6O2Pureza:98.44%Forma y color:SolidPeso molecular:428.49BIO-013077-01
CAS:<p>BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.</p>Fórmula:C17H13N5Pureza:99.87%Forma y color:SolidPeso molecular:287.32Ritlecitinib
CAS:<p>Ritlecitinib (PF-06651600) is an orally available, selective JAK3 inhibitor and does not affect the activity of JAK1/2.Cost-effective and quality-assured.</p>Fórmula:C15H19N5OPureza:98.82% - 99.92%Forma y color:SolidPeso molecular:285.34IQ 1
CAS:<p>IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.</p>Fórmula:C21H22N4O2Pureza:98.57% - ≥95%Forma y color:SolidPeso molecular:362.42CKI-7
CAS:<p>CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor.</p>Fórmula:C11H14Cl3N3O2SPureza:>99.99%Forma y color:SolidPeso molecular:358.67SAR407899
CAS:<p>SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.</p>Fórmula:C14H16N2O2Pureza:99.42%Forma y color:SolidPeso molecular:244.29Wnt-C59
CAS:<p>Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.</p>Fórmula:C25H21N3OPureza:99.56% - 99.95%Forma y color:SolidPeso molecular:379.45KenPaullone
CAS:<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Fórmula:C16H11BrN2OPureza:97.14% - 98.99%Forma y color:Tan SolidPeso molecular:327.18SR-3029
CAS:<p>SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor.</p>Fórmula:C23H19F3N8OPureza:99.64%Forma y color:SolidPeso molecular:480.45AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Forma y color:SolidPeso molecular:313.78CP21R7
CAS:<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Fórmula:C19H15N3O2Pureza:96.14% - 99.16%Forma y color:SolidPeso molecular:317.34Porcn-IN-1
CAS:<p>Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).</p>Fórmula:C25H19FN4OPureza:99.15%Forma y color:SolidPeso molecular:410.44Indirubin-3'-monoxime
CAS:<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Fórmula:C16H11N3O2Pureza:99.55%Forma y color:Dark Red SolidPeso molecular:277.28Adavivint
CAS:<p>Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.</p>Fórmula:C29H24FN7OPureza:98.27% - 98.6%Forma y color:SolidPeso molecular:505.55Galunisertib
CAS:<p>Galunisertib (LY2157299) is a selective TGF-β receptor type I (TGF-βRI) inhibitor. Galunisertib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C22H19N5OPureza:97.09% - 99.98%Forma y color:SolidPeso molecular:369.42Avagacestat
CAS:<p>Avagacestat (BMS-708163) (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM,</p>Fórmula:C20H17ClF4N4O4SPureza:98.87% - 99.73%Forma y color:SolidPeso molecular:520.89SH5-07
CAS:<p>SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).</p>Fórmula:C29H28F5N3O5SPureza:95.54%Forma y color:SolidPeso molecular:625.61IHR-1
CAS:<p>IHR-1, a Smo inhibitor (IC50 7.6 nM), blocks Hedgehog pathway, not Wnt/Notch, and prevents Smo in primary cilium.</p>Fórmula:C20H12Cl4N2O2Pureza:97.02%Forma y color:SolidPeso molecular:454.13CHIR-99021
CAS:<p>View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.</p>Fórmula:C22H18Cl2N8Pureza:97.94% - ≥95%Forma y color:SolidPeso molecular:465.34S3I-201
CAS:<p>S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.</p>Fórmula:C16H15NO7SPureza:97.83%Forma y color:SolidPeso molecular:365.363,5-Bis(4-nitrophenoxy)benzoic acid
CAS:<p>3,5-Bis(4-nitrophenoxy)benzoic acid (Compound W) is an inhibitor of γ-secretase. It decreases the released levels of Aβ42 and notch-1 Aβ-like peptide 25.</p>Fórmula:C19H12N2O8Pureza:99.14%Forma y color:SolidPeso molecular:396.31KYA1797K
CAS:<p>KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.</p>Fórmula:C17H11N2O6S2·KPureza:97.57% - 99.33%Forma y color:SolidPeso molecular:442.51LGK974
CAS:<p>LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.</p>Fórmula:C23H20N6OPureza:98.8% - >99.99%Forma y color:SolidPeso molecular:396.44Jagged-1 (188-204) TFA(219127-21-6 free base)
<p>Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.</p>Fórmula:C95H128F3N25O28S3Pureza:99.48%Forma y color:SolidPeso molecular:2221.37SKL2001
CAS:<p>SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.</p>Fórmula:C14H14N4O3Pureza:97.46% - 99.5%Forma y color:SolidPeso molecular:286.29FH535
CAS:<p>FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.</p>Fórmula:C13H10Cl2N2O4SPureza:98.25% - 99.5%Forma y color:SolidPeso molecular:361.2JANEX-1
CAS:<p>JANEX-1: cell-permeable, reversible Jak3 inhibitor (IC50: 78 μM), ATP-competitive, selective; weak on JAK1/2, Zap/Syk, SRC.</p>Fórmula:C16H15N3O3Pureza:98% - 99.81%Forma y color:SolidPeso molecular:297.31Wnt pathway activator 1
CAS:<p>Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.</p>Fórmula:C18H16O4Pureza:99.93%Forma y color:SolidPeso molecular:296.32(E/Z)-GSK-3β inhibitor 1
CAS:<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Fórmula:C14H10N2OPureza:98.60%Forma y color:SolidPeso molecular:222.24Belumosudil
CAS:<p>Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).</p>Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Forma y color:SolidPeso molecular:452.51IWR-1
CAS:<p>IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).</p>Fórmula:C25H19N3O3Pureza:99.19% - 99.82%Forma y color:SolidPeso molecular:409.44Pyrvinium pamoate
CAS:<p>Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug</p>Fórmula:C26H28N3C23H14O6Pureza:99.76% - >99.99%Forma y color:SolidPeso molecular:575.71WHI-P97
CAS:<p>WHI-P97 is a rationally designed potent inhibitor of JAK-3.</p>Fórmula:C16H13Br2N3O3Pureza:99.93%Forma y color:SolidPeso molecular:455.1GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Forma y color:SolidPeso molecular:494.52YO-01027
CAS:<p>YO-01027 (DBZ) is a potent γ-secretase inhibitor.</p>Fórmula:C26H23F2N3O3Pureza:97.21% - 99.58%Forma y color:SolidPeso molecular:463.48ZINC00881524
CAS:<p>ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.</p>Fórmula:C21H20N2O3SPureza:99.48%Forma y color:SolidPeso molecular:380.46exo-IWR-1
CAS:<p>exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin</p>Fórmula:C25H19N3O3Pureza:97.41%Forma y color:SolidPeso molecular:409.44AS1517499
CAS:<p>AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM). High-Quality, Low-Cost!</p>Fórmula:C20H20ClN5O2Pureza:98.27% - 98.7%Forma y color:SolidPeso molecular:397.86Epiblastin A
CAS:<p>Epiblastin A inhibits CK1, targets its isoenzymes, and converts EpiSCs to cESCs.</p>Fórmula:C12H10ClN7Pureza:99.45%Forma y color:SolidPeso molecular:287.71
