Células madre
Los inhibidores de células madre son compuestos que actúan específicamente sobre las células madre y sus vías de señalización, afectando su capacidad para autorrenovarse y diferenciarse. Estos inhibidores son cruciales en la investigación centrada en controlar el comportamiento de las células madre, comprender los procesos de desarrollo y desarrollar terapias para enfermedades como el cáncer, donde se cree que las células madre juegan un papel clave. En CymitQuimica, ofrecemos una variedad de inhibidores de células madre para apoyar su investigación en medicina regenerativa, biología del desarrollo y oncología.
Se han encontrado 129 productos para "Células madre".
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HC-258
CAS:HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.Fórmula:C20H24N2O2Forma y color:Yellow SolidPeso molecular:324.42MSC-1254
MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.Fórmula:C25H22F2N4O4SForma y color:SolidPeso molecular:512.53LY2382770
LY2382770 is a human monoclonal antibody (mAb) that specifically targets TGFB1. It is utilized in the study of diabetic nephropathy.TGF-β1/Smad3-IN-1
CAS:TGF-β1/Smad3-IN-1 is an orally administrable dual inhibitor of TGF-β1/Smad3 with anti-fibrotic activity, idiopathic pulmonary fibrosis (IPF).Fórmula:C30H34N4O6SPureza:99.83%Peso molecular:578.68Depiperazine-DM3189
CAS:Depiperazine-DM3189 inhibits the phosphorylation of SMAD 1/5/8 induced by bone morphogenetic protein 4 and can be used in biochemical experiments .Fórmula:C21H14N4Pureza:99.69%Peso molecular:322.36ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Fórmula:C20H23N7O2SForma y color:SolidPeso molecular:425.51YAP/TAZ inhibitor-4
YAP/TAZ Inhibitor-4 (Compound 45) acts as an inhibitor of YAP/TAZ, exhibiting inhibitory activity on TEAD transcriptional activation by preventing the interaction between YAP or TAZ and TEAD.Fórmula:C28H28F3N3O3Forma y color:SolidPeso molecular:511.54Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Fórmula:C70H113N17O24S2Pureza:95.77%Forma y color:White SolidPeso molecular:1640.88DC-TEADin02
CAS:DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.Fórmula:C19H17NO2SPureza:99.83%Forma y color:SolidPeso molecular:323.41YAP-TEAD-IN-3
CAS:YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferationFórmula:C27H26ClF2N3O4Pureza:97.55% - 98.71%Forma y color:SolidPeso molecular:529.96SLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:SLLK is a control peptide for LSKL.Fórmula:C21H41N5O6Pureza:98%Forma y color:SolidPeso molecular:459.58OPN-9652
CAS:OPN-9652 is a covalent TEAD inhibitor reversing drug resistance in BRAF-mutant tumors.Fórmula:C19H15F4NO2Pureza:99.78%Forma y color:White SolidPeso molecular:365.32Ref: TM-T212610
1mg49,00€5mg92,00€1mL*10mM (DMSO)104,00€10mg145,00€25mg255,00€50mg378,00€100mg573,00€TEAD-IN-16
TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD, with an IC50 of 72.43 μM. This compound plays a significant role in cancer research.Fórmula:C16H14F3NO3Forma y color:SolidPeso molecular:325.09258YAP/TEAD-IN-1
YAP/TEAD-IN-1 (compound 4) is a potent inhibitor of YAP and TEAD, exhibiting antioxidant properties. It demonstrates antiproliferative effects on tumor cells while showing minimal cytotoxic activity towards normal human cells.Fórmula:C32H30N8OForma y color:SolidPeso molecular:542.634YAP-TEAD-IN-1 acetate
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.Fórmula:C95H148ClN23O23S2Pureza:98.11% - 99.98%Forma y color:SoildPeso molecular:2079.92TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Fórmula:C27H32N6O2Forma y color:SolidPeso molecular:472.582YAP-IN-1
YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.Forma y color:Odour SolidWnt/Hedgehog/Notch Compound Library
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
Forma y color:Odour SolidTubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Fórmula:C21H22N2O2Pureza:98.23%Forma y color:SolidPeso molecular:334.41Super-TDU (1-31) (TFA)
Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.Fórmula:C141H218N40O48·C2HF3O2Forma y color:SolidPeso molecular:3355.5
