Gamma-secretasa
Inhibidores de la gamma-secretasa son compuestos que se dirigen al complejo enzimático de la gamma-secretasa, involucrado en la escisión de la proteína precursora de amiloide (APP) para producir péptidos beta-amiloides. Estos péptidos pueden agregarse y formar placas amiloides, una característica distintiva de la enfermedad de Alzheimer. Al inhibir la gamma-secretasa, estos compuestos buscan reducir la producción de beta-amiloide y su acumulación en el cerebro, convirtiéndose en un enfoque clave en la investigación sobre la enfermedad de Alzheimer. En CymitQuimica, ofrecemos una selección de inhibidores de la gamma-secretasa para apoyar su investigación en biología del amiloide, terapia para el Alzheimer y enfermedades neurodegenerativas.
Se han encontrado 60 productos de "Gamma-secretasa"
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RR-11a
CAS:RR-11a is a synthetic enzyme Legumain inhibitor.
Fórmula:C24H28N6O10Pureza:98%Forma y color:SolidPeso molecular:560.51Aβ42-IN-1 free base
CAS:Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091Fórmula:C29H26N4O2Pureza:98%Forma y color:SolidPeso molecular:462.54BPN-15606
CAS:BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.Fórmula:C23H23FN6OForma y color:SolidPeso molecular:418.47γ-Secretase modulator 11
CAS:5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency andFórmula:C28H22F2N4O2Forma y color:SolidPeso molecular:484.5Yhhu-3792
CAS:Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.Fórmula:C24H24N4O2Forma y color:SolidPeso molecular:400.47Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Fórmula:C24H26N6O2Pureza:98.09% - 99.87%Forma y color:SolidPeso molecular:430.5Ref: TM-T9641
1mg42,00€5mg94,00€10mg134,00€25mg215,00€50mg304,00€100mg420,00€200mg582,00€1mL*10mM (DMSO)93,00€JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Fórmula:C22H24N2O3Pureza:≥98% - ≥98.0%Forma y color:SolidPeso molecular:364.44BT-GSI
BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.Fórmula:C26H46BrN5O10P2Forma y color:SolidPeso molecular:730.52BMS-932481
CAS:BMS-932481 is a γ-secretase modulator.Fórmula:C24H24FN7OForma y color:SolidPeso molecular:445.49Yhhu-3792 hydrochloride
CAS:Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].Fórmula:C24H25ClN4O2Forma y color:SolidPeso molecular:436.93GSM-1
CAS:GSM-1 is a modulator of γ-Secretase.Fórmula:C26H31ClF3NO2Forma y color:SolidPeso molecular:481.98BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Fórmula:C26H26F4N4O3Forma y color:SolidPeso molecular:518.5HDAC6-IN-9
CAS:HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.Fórmula:C19H16N2O3Pureza:98.84%Forma y color:SolidPeso molecular:320.34PF-06442609
CAS:PF-06442609 is an orally active γ-secretase modulator with an IC50 value of 6 nM for Aβ42. It exhibits good CNS permeability.Fórmula:C24H24F4N4O3Peso molecular:492.47DAPM
CAS:DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Fórmula:C20H20F2N2O4Pureza:99.76%Forma y color:SolidPeso molecular:390.38γ-Secretase modulator 11 hydrochloride
CAS:γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).Fórmula:C28H23ClF2N4O2Forma y color:SolidPeso molecular:520.96BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Fórmula:C29H29FN6O4SForma y color:SolidPeso molecular:576.64PF-06648671
CAS:PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.Fórmula:C25H23ClF4N4O3Pureza:98%Forma y color:SolidPeso molecular:538.92Notch inhibitor 1
CAS:Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.Fórmula:C26H25F7N4O3Pureza:98%Forma y color:SolidPeso molecular:574.49Aβ42-IN-1
CAS:Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).Fórmula:C29H27ClN4O2Pureza:98%Forma y color:SolidPeso molecular:499
