CymitQuimica logo
Porcupine (Puerco espín)

Porcupine (Puerco espín)

Los inhibidores de Porcupine son compuestos que bloquean la actividad de Porcupine, una enzima esencial para la secreción y actividad de las proteínas Wnt, las cuales son reguladores clave de la vía de señalización Wnt. Esta vía está involucrada en varios procesos de desarrollo, incluyendo el mantenimiento y la diferenciación de las células madre. Inhibir Porcupine es una estrategia clave en la investigación del cáncer, ya que puede interrumpir la tumorogénesis impulsada por Wnt. En CymitQuimica, ofrecemos inhibidores de Porcupine para apoyar su investigación en biología de células madre, biología del desarrollo y terapia contra el cáncer.

Se han encontrado 9 productos de "Porcupine (Puerco espín)"

Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
  • ETC-159
    Targetmol
    + Info

    ETC-159

    CAS:
    ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
    Fórmula:C19H17N7O3
    Pureza:96.87% - 99.30%
    Forma y color:Solid
    Peso molecular:391.38

    Ref: TM-T4043

  • IWP L6
    Targetmol
    + Info

    IWP L6

    CAS:
    <p>IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).</p>
    Fórmula:C25H20N4O2S2
    Pureza:99.51% - >99.99%
    Forma y color:Solid
    Peso molecular:472.58

    Ref: TM-T2683

  • Wnt-C59
    Targetmol
    + Info

    Wnt-C59

    CAS:
    <p>Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.</p>
    Fórmula:C25H21N3O
    Pureza:99.56% - 99.95%
    Forma y color:Solid
    Peso molecular:379.45

    Ref: TM-T2242

  • Porcn-IN-1
    Targetmol
    + Info

    Porcn-IN-1

    CAS:
    Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
    Fórmula:C25H19FN4O
    Pureza:99.15%
    Forma y color:Solid
    Peso molecular:410.44

    Ref: TM-T4438

  • IWP-O1
    Targetmol
    + Info

    IWP-O1

    CAS:
    IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
    Fórmula:C26H20N6O
    Pureza:99.12%
    Forma y color:Solid
    Peso molecular:432.48

    Ref: TM-T5342

  • LGK974
    Targetmol
    + Info

    LGK974

    CAS:
    LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.
    Fórmula:C23H20N6O
    Pureza:98.8% - >99.99%
    Forma y color:Solid
    Peso molecular:396.44

    Ref: TM-T2618

  • IWP-2
    Targetmol
    + Info

    IWP-2

    CAS:
    IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.
    Fórmula:C22H18N4O2S3
    Pureza:96.1% - 99.49%
    Forma y color:Solid
    Peso molecular:466.6

    Ref: TM-T2702

  • GNF-6231
    Targetmol
    + Info

    GNF-6231

    CAS:
    GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
    Fórmula:C24H25FN6O2
    Pureza:99.74% - >99.99%
    Forma y color:Solid
    Peso molecular:448.49

    Ref: TM-T11444

  • WHN-88
    Targetmol
    + Info

    WHN-88

    CAS:
    <p>WHN-88, a Porcupine (PORCN) inhibitor, disrupts the palmitoylation of Wnt ligands, which inhibits their secretion and subsequent Wnt/β-catenin signaling. This compound has shown efficacy in reducing cancer cell stemness and suppressing the progression and development of breast tumors in MMTV-Wnt1 transgenic mice.</p>
    Fórmula:C18H13I2N3O2
    Forma y color:Solid
    Peso molecular:557.12

    Ref: TM-T89881

    10mg
    Descatalogado
    50mg
    Descatalogado
    Producto descatalogado