Porcupine (Puerco espín)
Los inhibidores de Porcupine son compuestos que bloquean la actividad de Porcupine, una enzima esencial para la secreción y actividad de las proteínas Wnt, las cuales son reguladores clave de la vía de señalización Wnt. Esta vía está involucrada en varios procesos de desarrollo, incluyendo el mantenimiento y la diferenciación de las células madre. Inhibir Porcupine es una estrategia clave en la investigación del cáncer, ya que puede interrumpir la tumorogénesis impulsada por Wnt. En CymitQuimica, ofrecemos inhibidores de Porcupine para apoyar su investigación en biología de células madre, biología del desarrollo y terapia contra el cáncer.
Se han encontrado 9 productos de "Porcupine (Puerco espín)"
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ETC-159
CAS:ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.Fórmula:C19H17N7O3Pureza:96.87% - 99.30%Forma y color:SolidPeso molecular:391.38IWP L6
CAS:IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
Fórmula:C25H20N4O2S2Pureza:99.51% - >99.99%Forma y color:SolidPeso molecular:472.58Wnt-C59
CAS:Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.Fórmula:C25H21N3OPureza:99.56% - 99.95%Forma y color:SolidPeso molecular:379.45Porcn-IN-1
CAS:Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).Fórmula:C25H19FN4OPureza:99.15%Forma y color:SolidPeso molecular:410.44IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Fórmula:C26H20N6OPureza:99.12%Forma y color:SolidPeso molecular:432.48Ref: TM-T5342
2mg37,00€5mg60,00€1mL*10mM (DMSO)66,00€10mg96,00€25mg155,00€50mg215,00€100mg304,00€200mg434,00€LGK974
CAS:LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.Fórmula:C23H20N6OPureza:98.8% - >99.99%Forma y color:SolidPeso molecular:396.44Ref: TM-T2618
1mg46,00€2mg62,00€5mg90,00€1mL*10mM (DMSO)90,00€10mg156,00€25mg288,00€50mg515,00€100mg737,00€IWP-2
CAS:IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.Fórmula:C22H18N4O2S3Pureza:96.1% - 99.49%Forma y color:SolidPeso molecular:466.6GNF-6231
CAS:GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.Fórmula:C24H25FN6O2Pureza:99.74% - >99.99%Forma y color:SolidPeso molecular:448.49WHN-88
CAS:WHN-88, a Porcupine (PORCN) inhibitor, disrupts the palmitoylation of Wnt ligands, which inhibits their secretion and subsequent Wnt/β-catenin signaling. This compound has shown efficacy in reducing cancer cell stemness and suppressing the progression and development of breast tumors in MMTV-Wnt1 transgenic mice.
Fórmula:C18H13I2N3O2Forma y color:SolidPeso molecular:557.12
