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Porcupine (Puerco espín)

Porcupine (Puerco espín)

Los inhibidores de Porcupine son compuestos que bloquean la actividad de Porcupine, una enzima esencial para la secreción y actividad de las proteínas Wnt, las cuales son reguladores clave de la vía de señalización Wnt. Esta vía está involucrada en varios procesos de desarrollo, incluyendo el mantenimiento y la diferenciación de las células madre. Inhibir Porcupine es una estrategia clave en la investigación del cáncer, ya que puede interrumpir la tumorogénesis impulsada por Wnt. En CymitQuimica, ofrecemos inhibidores de Porcupine para apoyar su investigación en biología de células madre, biología del desarrollo y terapia contra el cáncer.

Se han encontrado 9 productos para "Porcupine (Puerco espín)".

  • Logo de CymitQuimica
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    WNT3Ap

    WNT3Ap is a peptide of the hairpin 2 domain of the WNT3A protein. It undergoes palmitoylation catalyzed by PORCN. WNT3Ap is crucial for elucidating the molecular mechanisms of the Wnt signaling pathway and acts as a key compound in the study of PORCN inhibitors.

    Ref: TM-TP4335

  • Porcn-IN-1
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    Porcn-IN-1

    CAS:
    Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).
    Fórmula:C25H19FN4O
    Pureza:99.15%
    Forma y color:Solid
    Peso molecular:410.443

    Ref: TM-T4438

  • IWP-O1
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    IWP-O1

    CAS:
    IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
    Fórmula:C26H20N6O
    Pureza:99.12%
    Forma y color:Solid
    Peso molecular:432.4766

    Ref: TM-T5342

  • LGK974
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    LGK974

    CAS:
    LGK974 (NVP-LGK974) is a selective PORCN inhibitor that blocks Wnt signaling, used in metastatic colorectal and head/neck cancer trials. IC50: 0.4 nM.
    Fórmula:C23H20N6O
    Pureza:99.04% - >99.99%
    Forma y color:Solid
    Peso molecular:396.4445

    Ref: TM-T2618

  • Wnt-C59
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    Wnt-C59

    CAS:
    Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.
    Fórmula:C25H21N3O
    Pureza:99.56% - 99.97%
    Forma y color:Solid
    Peso molecular:379.45

    Ref: TM-T2242

  • IWP L6
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    IWP L6

    CAS:
    IWP L6 (Porcn Inhibitor III) is an extremely effective Porcn inhibitor (EC50: 0.5 nM).
    Fórmula:C25H20N4O2S2
    Pureza:99.51% - >99.99%
    Forma y color:White Solid
    Peso molecular:472.58

    Ref: TM-T2683

  • ETC-159
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    ETC-159

    CAS:
    ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.
    Fórmula:C19H17N7O3
    Pureza:96.87% - 99.30%
    Forma y color:Solid
    Peso molecular:391.3834

    Ref: TM-T4043

  • IWP-2
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    IWP-2

    CAS:
    IWP-2 is a Wnt pathway inhibitor and an ATP-competitive CK1δ inhibitor. IWP-2 inhibits self-renewal of embryonic stem cells. Cost effective and quality assured.
    Fórmula:C22H18N4O2S3
    Pureza:96.1% - 99.86%
    Forma y color:White Solid
    Peso molecular:466.599

    Ref: TM-T2702

  • GNF-6231
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    GNF-6231

    CAS:
    GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.
    Fórmula:C24H25FN6O2
    Pureza:99.74% - >99.99%
    Forma y color:Solid
    Peso molecular:448.4927

    Ref: TM-T11444